ID   SPT4_SCHPO              Reviewed;         105 AA.
AC   Q9P7K8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JUL-2024, entry version 138.
DE   RecName: Full=Transcription elongation factor spt4;
DE   AltName: Full=Chromatin elongation factor spt4;
GN   Name=spt4; ORFNames=SPBC21C3.16c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   INTERACTION WITH SPT5.
RX   PubMed=11893740; DOI=10.1074/jbc.m200015200;
RA   Pei Y., Shuman S.;
RT   "Interactions between fission yeast mRNA capping enzymes and elongation
RT   factor Spt5.";
RL   J. Biol. Chem. 277:19639-19648(2002).
CC   -!- FUNCTION: The spt4-spt5 complex mediates both activation and inhibition
CC       of transcription elongation, and plays a role in pre-mRNA processing.
CC       This complex seems to be important for the stability of the RNA
CC       polymerase II elongation machinery on the chromatin template but not
CC       for the inherent ability of this machinery to translocate down the gene
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the spt4-spt5 complex. Interacts with RNA
CC       polymerase II (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere
CC       {ECO:0000250}. Note=Centromere and heterochromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPT4 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAB76052.1; -; Genomic_DNA.
DR   PIR; T50360; T50360.
DR   RefSeq; NP_596596.1; NM_001022516.2.
DR   AlphaFoldDB; Q9P7K8; -.
DR   SMR; Q9P7K8; -.
DR   BioGRID; 277224; 3.
DR   STRING; 284812.Q9P7K8; -.
DR   iPTMnet; Q9P7K8; -.
DR   PaxDb; 4896-SPBC21C3-16c-1; -.
DR   EnsemblFungi; SPBC21C3.16c.1; SPBC21C3.16c.1:pep; SPBC21C3.16c.
DR   GeneID; 2540700; -.
DR   KEGG; spo:SPBC21C3.16c; -.
DR   PomBase; SPBC21C3.16c; spt4.
DR   VEuPathDB; FungiDB:SPBC21C3.16c; -.
DR   eggNOG; KOG3490; Eukaryota.
DR   HOGENOM; CLU_138052_2_0_1; -.
DR   InParanoid; Q9P7K8; -.
DR   OMA; WACLLCS; -.
DR   PhylomeDB; Q9P7K8; -.
DR   Reactome; R-SPO-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-SPO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR   PRO; PR:Q9P7K8; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0000785; C:chromatin; IC:PomBase.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0032044; C:DSIF complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR   GO; GO:0003711; F:transcription elongation factor activity; EXP:PomBase.
DR   GO; GO:0008270; F:zinc ion binding; ISO:PomBase.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006368; P:transcription elongation by RNA polymerase II; IGI:PomBase.
DR   GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR   CDD; cd07973; Spt4; 1.
DR   Gene3D; 3.30.40.210; -; 1.
DR   InterPro; IPR029040; RPABC4/Spt4.
DR   InterPro; IPR009287; Spt4.
DR   InterPro; IPR022800; Spt4/RpoE2_Znf.
DR   InterPro; IPR038510; Spt4_sf.
DR   PANTHER; PTHR12882; SUPPRESSOR OF TY 4; 1.
DR   PANTHER; PTHR12882:SF1; TRANSCRIPTION ELONGATION FACTOR SPT4; 1.
DR   Pfam; PF06093; Spt4; 1.
DR   PIRSF; PIRSF025023; Spt4; 1.
DR   SMART; SM01389; Spt4; 1.
DR   SUPFAM; SSF63393; RNA polymerase subunits; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; mRNA processing; Nucleus; Reference proteome;
KW   Transcription.
FT   CHAIN           1..105
FT                   /note="Transcription elongation factor spt4"
FT                   /id="PRO_0000238553"
SQ   SEQUENCE   105 AA;  11879 MW;  E1EA5500FC619723 CRC64;
     MDKLNRTRSR ACLICGIVLP HSVFANKGCP NDGVDDVETF TSPVFEGIMA MMSPTESWVA
     RWQRIDTFTP GIYATRVQGV LNEDVVESLR RRGINYRPRN GTSWD
//