{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9P2K9","secondaryAccessions":["Q5VTU9","Q9UJD6"],"uniProtkbId":"DISP3_HUMAN","entryAudit":{"firstPublicDate":"2007-10-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-10-23","entryVersion":152,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15645143"}],"value":"Protein dispatched homolog 3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Patched domain-containing protein 2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15645143"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:29251"}],"value":"DISP3"},"synonyms":[{"value":"KIAA1337"},{"value":"PTCHD2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B9U3F2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25281927"}],"value":"Plays a role in neuronal proliferation and differentiation (PubMed:25281927). Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation (PubMed:25281927). May contribute to cholesterol homeostasis in neuronal cells (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B9U3F2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19179482"}],"value":"Predominantly localized to cholesterol-enriched domains within the membrane (PubMed:19179482). Localizes to cytoplasmic punctate vesicular structures (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19179482"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19179482"}],"value":"Nucleus membrane","id":"SL-0182"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B9U3F2"}],"value":"Cytoplasmic vesicle membrane","id":"SL-0089"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9P2K9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9P2K9-2"],"sequenceIds":["VSP_028966"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15645143"}],"value":"Expressed in brain and testis (PubMed:15645143)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15645143"}],"value":"Expressed in fetal brain (PubMed:15645143)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19179482"}],"value":"Up-regulated by thyroid hormone T3 (PubMed:19179482)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"B9U3F2"}],"value":"The SSD (sterol-sensing) domain is necessary for the increase in cellular cholesterol uptake"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the patched family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA92575.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAB55303.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Protein dispatched homolog 3","featureId":"PRO_0000308329"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":485,"modifier":"EXACT"},"end":{"value":505,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":506,"modifier":"EXACT"},"end":{"value":508,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":573,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":594,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":595,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":617,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":1182,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1183,"modifier":"EXACT"},"end":{"value":1203,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1204,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1205,"modifier":"EXACT"},"end":{"value":1225,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1226,"modifier":"EXACT"},"end":{"value":1291,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1292,"modifier":"EXACT"},"end":{"value":1312,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1320,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1321,"modifier":"EXACT"},"end":{"value":1341,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1342,"modifier":"EXACT"},"end":{"value":1358,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":1359,"modifier":"EXACT"},"end":{"value":1379,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":1380,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Domain","location":{"start":{"value":457,"modifier":"EXACT"},"end":{"value":615,"modifier":"EXACT"}},"description":"SSD","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00199"}]},{"type":"Region","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_028966","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"in dbSNP:rs41274528","featureCrossReferences":[{"database":"dbSNP","id":"rs41274528"}],"featureId":"VAR_061496","alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"in dbSNP:rs3738159","featureCrossReferences":[{"database":"dbSNP","id":"rs3738159"}],"featureId":"VAR_036796","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"in dbSNP:rs2817580","featureCrossReferences":[{"database":"dbSNP","id":"rs2817580"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10718198"}],"featureId":"VAR_036797","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"in dbSNP:rs2072994","featureCrossReferences":[{"database":"dbSNP","id":"rs2072994"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10718198"}],"featureId":"VAR_036798","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":661,"modifier":"EXACT"},"end":{"value":661,"modifier":"EXACT"}},"description":"in dbSNP:rs2072993","featureCrossReferences":[{"database":"dbSNP","id":"rs2072993"}],"featureId":"VAR_036799","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":948,"modifier":"EXACT"},"end":{"value":948,"modifier":"EXACT"}},"description":"in dbSNP:rs12096312","featureCrossReferences":[{"database":"dbSNP","id":"rs12096312"}],"featureId":"VAR_036800","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0153","category":"Biological process","name":"Cholesterol metabolism"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0221","category":"Biological process","name":"Differentiation"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0443","category":"Biological process","name":"Lipid metabolism"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0753","category":"Biological process","name":"Steroid metabolism"},{"id":"KW-1207","category":"Biological process","name":"Sterol metabolism"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10718198","citationType":"journal article","authors":["Nagase T.","Kikuno R.","Ishikawa K.","Hirosawa M.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10718198"},{"database":"DOI","id":"10.1093/dnares/7.1.65"}],"title":"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"2000","journal":"DNA Res.","firstPage":"65","lastPage":"73","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","VARIANTS SER-182 AND THR-650"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-FMTUTG1AHSV0N","citationType":"submission","authors":["Rhodes S.","Huckle E."],"publicationDate":"SEP-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-1392 (ISOFORM 2)"]},{"referenceNumber":4,"citation":{"id":"15645143","citationType":"journal article","authors":["Katoh Y.","Katoh M."],"citationCrossReferences":[{"database":"PubMed","id":"15645143"},{"database":"DOI","id":"10.3892/ijo.26.2.551"}],"title":"Identification and characterization of DISP3 gene in silico.","publicationDate":"2005","journal":"Int. J. Oncol.","firstPage":"551","lastPage":"556","volume":"26"},"referencePositions":["IDENTIFICATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]},{"referenceNumber":5,"citation":{"id":"19179482","citationType":"journal article","authors":["Zikova M.","Corlett A.","Bendova Z.","Pajer P.","Bartunek P."],"citationCrossReferences":[{"database":"PubMed","id":"19179482"},{"database":"DOI","id":"10.1210/me.2008-0271"}],"title":"DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.","publicationDate":"2009","journal":"Mol. Endocrinol.","firstPage":"520","lastPage":"528","volume":"23"},"referencePositions":["SUBCELLULAR LOCATION","INDUCTION"]},{"referenceNumber":6,"citation":{"id":"25281927","citationType":"journal article","authors":["Zikova M.","Konirova J.","Ditrychova K.","Corlett A.","Kolar M.","Bartunek P."],"citationCrossReferences":[{"database":"PubMed","id":"25281927"},{"database":"DOI","id":"10.1016/j.febslet.2014.09.036"}],"title":"DISP3 promotes proliferation and delays differentiation of neural progenitor cells.","publicationDate":"2014","journal":"FEBS Lett.","firstPage":"4071","lastPage":"4077","volume":"588"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB037758","properties":[{"key":"ProteinId","value":"BAA92575.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL031735","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL590989","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL117236","properties":[{"key":"ProteinId","value":"CAB55303.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41247.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9P2K9-1"},{"database":"RefSeq","id":"NP_065831.1","properties":[{"key":"NucleotideSequenceId","value":"NM_020780.2"}],"isoformId":"Q9P2K9-1"},{"database":"RefSeq","id":"XP_011540130.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011541828.4"}],"isoformId":"Q9P2K9-1"},{"database":"RefSeq","id":"XP_054193797.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337822.1"}],"isoformId":"Q9P2K9-1"},{"database":"AlphaFoldDB","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"121599","properties":[{"key":"Interactions","value":"9"}]},{"database":"FunCoup","id":"Q9P2K9","properties":[{"key":"Number of interactors","value":"253"}]},{"database":"IntAct","id":"Q9P2K9","properties":[{"key":"Interactions","value":"6"}]},{"database":"STRING","id":"9606.ENSP00000294484","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9P2K9","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9P2K9","properties":[{"key":"glycosylation","value":"4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DISP3","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"160017977","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000294484","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"83841","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9P2K9-1"},{"database":"ProteomicsDB","id":"83842","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9P2K9-2"},{"database":"Antibodypedia","id":"57337","properties":[{"key":"antibodies","value":"151 antibodies from 25 providers"}]},{"database":"DNASU","id":"57540","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000294484.7","properties":[{"key":"ProteinId","value":"ENSP00000294484.6"},{"key":"GeneId","value":"ENSG00000204624.9"}],"isoformId":"Q9P2K9-1"},{"database":"Ensembl","id":"ENST00000922103.1","properties":[{"key":"ProteinId","value":"ENSP00000592162.1"},{"key":"GeneId","value":"ENSG00000204624.9"}],"isoformId":"Q9P2K9-1"},{"database":"GeneID","id":"57540","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:57540","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000294484.7","properties":[{"key":"ProteinId","value":"ENSP00000294484.6"},{"key":"RefSeqNucleotideId","value":"NM_020780.2"},{"key":"RefSeqProteinId","value":"NP_065831.1"}]},{"database":"UCSC","id":"uc001ash.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9P2K9-1"},{"database":"AGR","id":"HGNC:29251","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142671116","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"57540","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"57540","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DISP3","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:29251","properties":[{"key":"GeneName","value":"DISP3"}]},{"database":"HPA","id":"ENSG00000204624","properties":[{"key":"ExpressionPatterns","value":"Group enriched (brain, pituitary gland, retina, testis)"}]},{"database":"MIM","id":"611251","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000204624","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204624","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3664","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157931","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_007038_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RWDYSRT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"429851at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9P2K9","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000204624","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"57540","properties":[{"key":"hits","value":"10 hits in 1142 CRISPR screens"}]},{"database":"GenomeRNAi","id":"57540","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9P2K9","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9P2K9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q9P2K9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000204624","properties":[{"key":"ExpressionPatterns","value":"Expressed in ganglionic eminence and 81 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9P2K9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25281927"}]},{"database":"GO","id":"GO:0030659","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"19179482"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19179482"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15645143"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"19179482"}]},{"database":"GO","id":"GO:0042632","properties":[{"key":"GoTerm","value":"P:cholesterol homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"19179482"}]},{"database":"GO","id":"GO:0045665","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron differentiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25281927"}]},{"database":"GO","id":"GO:0045834","properties":[{"key":"GoTerm","value":"P:positive regulation of lipid metabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25281927"}]},{"database":"GO","id":"GO:2000179","properties":[{"key":"GoTerm","value":"P:positive regulation of neural precursor cell proliferation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25281927"}]},{"database":"GO","id":"GO:0032368","properties":[{"key":"GoTerm","value":"P:regulation of lipid transport"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15645143"}]},{"database":"GO","id":"GO:0007224","properties":[{"key":"GoTerm","value":"P:smoothened signaling pathway"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16258256"}]},{"database":"FunFam","id":"1.20.1640.10:FF:000015","properties":[{"key":"EntryName","value":"Dispatched RND transporter family member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.1640.10:FF:000022","properties":[{"key":"EntryName","value":"Dispatched RND transporter family member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1640.10","properties":[{"key":"EntryName","value":"Multidrug efflux transporter AcrB transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR042480","properties":[{"key":"EntryName","value":"DISP3"}]},{"database":"InterPro","id":"IPR053954","properties":[{"key":"EntryName","value":"DUF7023"}]},{"database":"InterPro","id":"IPR053958","properties":[{"key":"EntryName","value":"HMGCR/SNAP/NPC1-like_SSD"}]},{"database":"InterPro","id":"IPR004869","properties":[{"key":"EntryName","value":"MMPL_dom"}]},{"database":"InterPro","id":"IPR000731","properties":[{"key":"EntryName","value":"SSD"}]},{"database":"PANTHER","id":"PTHR46687","properties":[{"key":"EntryName","value":"PROTEIN DISPATCHED HOMOLOG 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46687:SF1","properties":[{"key":"EntryName","value":"PROTEIN DISPATCHED HOMOLOG 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22894","properties":[{"key":"EntryName","value":"DUF7023"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03176","properties":[{"key":"EntryName","value":"MMPL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12349","properties":[{"key":"EntryName","value":"Sterol-sensing"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82866","properties":[{"key":"EntryName","value":"Multidrug efflux transporter AcrB transmembrane domain"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50156","properties":[{"key":"EntryName","value":"SSD"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQSGYKIPLPAGASL","length":1392,"molWeight":153048,"crc64":"D72303B2F94CD5DF","md5":"512719E196A237EB0DE4D0B452A05C11"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Topological domain":13,"Transmembrane":12,"Domain":1,"Region":2,"Compositional bias":1,"Glycosylation":2,"Alternative sequence":1,"Natural variant":6},"uniParcId":"UPI00001C1D7A"}}