{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NZV8","secondaryAccessions":["O95012","O95021","Q2TBD3","Q9UBY7","Q9UN98","Q9UNH9"],"uniProtkbId":"KCND2_HUMAN","entryAudit":{"firstPublicDate":"2003-11-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-11-07","entryVersion":210,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"A-type voltage-gated potassium channel KCND2"}},"alternativeNames":[{"fullName":{"value":"Potassium voltage-gated channel subfamily D member 2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Voltage-gated potassium channel subunit Kv4.2"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:6238"}],"value":"KCND2"},"synonyms":[{"value":"KIAA1044"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10729221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24811166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"}],"value":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:11507158, PubMed:14623880, PubMed:14695263, PubMed:14980201, PubMed:15454437, PubMed:16934482, PubMed:19171772, PubMed:24501278, PubMed:24811166, PubMed:34552243, PubMed:35597238). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:14623880, PubMed:14980201, PubMed:15454437, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity). Upon depolarization, the channel goes from a resting closed state (C state) to an activated but non-conducting state (C* state), from there, the channel may either inactivate (I state) or open (O state) (PubMed:35597238)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24811166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17917103"}],"value":"Homotetrameric channels activate rapidly, i.e within a few msec. After that, they inactivate rapidly, i.e within about 50-100 msec. The voltage-dependence of activation and inactivation and other channel characteristics vary depending on the experimental conditions, the expression system and the presence or absence of ancillary subunits. Homotetrameric channels have a unitary conductance of about 4 pS when expressed in a heterologous system. For the activation of homotetrameric channels expressed in xenopus oocytes, the voltage at half-maximal amplitude is about -10 mV. The time constant for inactivation is about 20 msec. For inactivation, the voltage at half-maximal amplitude is -62 mV. The time constant for recovery after inactivation is about 70 msec."}]}}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10676964"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11287421"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11847232"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12451113"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980207"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15358149"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19213956"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24811166"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19171772"}],"value":"Homotetramer or heterotetramer with KCND1 or KCND3 (PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:34552243, PubMed:35597238). Associates with the regulatory subunits KCNIP2, KCNIP3 and KCNIP4 (PubMed:11287421, PubMed:11847232, PubMed:12451113, PubMed:14623880, PubMed:14980201, PubMed:15358149, PubMed:24811166, PubMed:35597238). Interacts with the regulatory subunit KCNIP1; this interaction mediates the capture of both the N- and C-terminus of KCND2, preventing N-type inactivation and stabilizing the S6 conformation, thereby accelerating closed state inactivation and recovery (PubMed:10676964, PubMed:14980207, PubMed:15358149, PubMed:34552243). In vivo, probably exists as heteromeric complex containing variable proportions of KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (PubMed:19171772). The tetrameric channel can associate with up to four regulatory subunits, such as KCNIP2 or KCNIP4 (PubMed:14623880, PubMed:14980201, PubMed:24811166). Interaction with four KCNIP4 chains does not reduce interaction with DPP10 (PubMed:24811166). Interacts with DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1 (PubMed:19213956). Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed:15358149). Interacts with FLNA, FLNC and DPP10 (PubMed:11102480, PubMed:15454437). Interacts (via S1 and S2 helices) with DPP6; this interaction stabilizes the conformation of the S1-S2 helices and facilitates S4 conformational change, including S4 sliding up and down, thereby accelerating activation, inactivation, and recovery (PubMed:15454437, PubMed:34552243, PubMed:35597238)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NZV8","intActId":"EBI-1646745"},"interactantTwo":{"uniProtKBAccession":"Q9NZI2","geneName":"KCNIP1","intActId":"EBI-2120635"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZV8","intActId":"EBI-1646745"},"interactantTwo":{"uniProtKBAccession":"Q9NS61","geneName":"KCNIP2","intActId":"EBI-1052975"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZV8","intActId":"EBI-1646745"},"interactantTwo":{"uniProtKBAccession":"Q9NS61-3","geneName":"KCNIP2","intActId":"EBI-1053010"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24811166"}],"value":"In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (PubMed:15454437). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:15454437, PubMed:24811166). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24811166"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"}],"value":"Cell projection, dendrite","id":"SL-0283"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Synapse","id":"SL-0258"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Perikaryon","id":"SL-0197"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Postsynaptic cell membrane","id":"SL-0219"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Cell projection, dendritic spine","id":"SL-0284"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Cell junction","id":"SL-0038"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10729221"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12395204"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15991246"}],"value":"Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63142"}],"value":"The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"15358149"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18357523"}],"value":"The N-terminal cytoplasmic region can mediate N-type inactivation by physically blocking the channel (PubMed:14695263). This probably does not happen in vivo, where the N-terminal region mediates interaction with regulatory subunits, such as KCNIP1 and KCNIP2 (PubMed:15358149). The zinc binding sites in the N-terminal domain are important for tetramerization and assembly of a functional channel complex (By similarity). The channel undergoes closed-state inactivation, where conformation changes lead to inactivation through an intermediate state involving breakdown of its 4-fold symmetry. that governs the distinct transient, fast-inactivating currents (Probable) (PubMed:35597238)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"}],"value":"The C-terminal cytoplasmic region is important for normal expression at the cell membrane and modulates the voltage-dependence of channel activation and inactivation (PubMed:16934482). It is required for interaction with KCNIP2, and probably other family members as well (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"}],"value":"Phosphorylation at Ser-438 in response to MAPK activation is increased in stimulated dendrites. Interaction with KCNIP2 and DPP6 propomtes phosphorylation by PKA at Ser-552. Phosphorylation at Ser-552 has no effect on interaction with KCNIP3, but is required for the regulation of channel activity by KCNIP3. Phosphorylation at Ser-552 leads to KCND2 internalization (By similarity). Phosphorylated by MAPK in response to signaling via the metabotropic glutamate receptor GRM5 (By similarity). Phosphorylation at Ser-616 is required for the down-regulation of neuronal A-type currents in response to signaling via GRM5 (By similarity)"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24501278"}],"value":"KNCD2 mutations have been found in a family with autism and epilepsy and may play a role in disease pathogenesis. Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Epilepsy is characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system"}]}},{"commentType":"DISEASE","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16934482"}],"value":"A KCND2 mutation leading to the production of a C-terminally truncated protein has been identified in a patient with epilepsy. Epilepsy is characterized by paroxysmal transient disturbances of the electrical activity of the brain that may be manifested as episodic impairment or loss of consciousness, abnormal motor phenomena, psychic or sensory disturbances, or perturbation of the autonomic nervous system"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"17917103"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"18357523"}],"value":"The transient neuronal A-type potassium current called I(SA) is triggered at membrane potentials that are below the threshold for action potentials. It inactivates rapidly and recovers rapidly from inactivation. It regulates the firing of action potentials and plays a role in synaptic integration and plasticity. Potassium channels containing KCND2 account for about 80% of the neuronal A-type potassium current. In contrast, the potassium channel responsible for the cardiac I(to) current differs between species; it is mediated by KCND2 in rodents. In human and other non-rodents KCND3 may play an equivalent role"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}],"value":"Is specifically and reversibly inhibited by the scorpion toxin Ts8 (AC P69940)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA82996.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"A-type voltage-gated potassium channel KCND2","featureId":"PRO_0000054064"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":226,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":345,"modifier":"EXACT"}},"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":346,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Intramembrane","location":{"start":{"value":358,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"Helical; Name=Pore helix","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63142"}]},{"type":"Intramembrane","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63142"}]},{"type":"Topological domain","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Transmembrane","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}]},{"type":"Topological domain","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34552243"}]},{"type":"Region","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"Interaction with KCNIP1, KCNIP2, and other family members","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Region","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Interaction with KCNIP1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Region","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"S4-S5 linker","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63142"}]},{"type":"Region","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"16934482"}]},{"type":"Region","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"Required for dendritic targeting","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Region","location":{"start":{"value":600,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P63142"}]},{"type":"Motif","location":{"start":{"value":627,"modifier":"EXACT"},"end":{"value":630,"modifier":"EXACT"}},"description":"PDZ-binding","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Binding site","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":111,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"in chain B","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in chain A","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":370,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UK5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKF"}],"ligand":{"name":"K(+)","id":"ChEBI:CHEBI:29103","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKG"}],"ligand":{"name":"K(+)","id":"ChEBI:CHEBI:29103","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":372,"modifier":"EXACT"},"end":{"value":372,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UK5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKG"}],"ligand":{"name":"K(+)","id":"ChEBI:CHEBI:29103","note":"ligand shared between homotetrameric partners"}},{"type":"Binding site","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":373,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35597238"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UK5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKF"}],"ligand":{"name":"K(+)","id":"ChEBI:CHEBI:29103","note":"ligand shared between homotetrameric partners"}},{"type":"Modified residue","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Modified residue","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":438,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Modified residue","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Modified residue","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":552,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"}]},{"type":"Modified residue","location":{"start":{"value":572,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"}]},{"type":"Modified residue","location":{"start":{"value":575,"modifier":"EXACT"},"end":{"value":575,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"}]},{"type":"Modified residue","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":602,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Modified residue","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63881"}]},{"type":"Modified residue","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z0V2"}]},{"type":"Natural variant","location":{"start":{"value":404,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"found in a family with atypical autism and severe epilepsy; likely pathogenic; disrupts potassium current inactivation; dbSNP:rs587777631","featureCrossReferences":[{"database":"dbSNP","id":"rs587777631"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24501278"}],"featureId":"VAR_072076","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Mutagenesis","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a negative shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"No effect on peak current amplitude, but causes a positive shift in the voltage-dependence of activation. May increase the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Causes a positive shift in the voltage-dependence of activation. May decrease the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":314,"modifier":"EXACT"},"end":{"value":314,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":315,"modifier":"EXACT"}},"description":"Increases peak current amplitude but has a minor effect on the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":317,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Increases peak current amplitude and slows the onset of inactivation at low voltage, but has no effect on the voltage-dependence of activation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}},{"type":"Mutagenesis","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Increases peak current amplitude and causes a positive shift in the voltage-dependence of activation. May increase the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Slightly increases peak current amplitude and causes a negative shift in the voltage-dependence of activation. May decrease the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":327,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":397,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":398,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":399,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":401,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":404,"modifier":"EXACT"}},"description":"Increases pak current amplitude and causes a positive shift in the voltage-dependence of activation and steady-state inactivation. May increase the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"VPV","alternativeSequences":["IPI"]}},{"type":"Mutagenesis","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":403,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":405,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":406,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"Loss of channel activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"Increases peak current amplitude but has no effect on the voltage-dependence of activation. May increase the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"Decreases peak current amplitude and causes a positive shift in the voltage-dependence of activation. May increase the affinity for the closed-inactivated state of the channel.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":409,"modifier":"EXACT"}},"description":"May impair protein folding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19171772"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":604,"modifier":"EXACT"}},"description":"Abolishes interaction with FLNC.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11102480"}],"alternativeSequence":{"originalSequence":"PTPP","alternativeSequences":["ATAA"]}},{"type":"Sequence conflict","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"in Ref. 1; AAD22053","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"in Ref. 1; AAD22053","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":550,"modifier":"EXACT"},"end":{"value":550,"modifier":"EXACT"}},"description":"in Ref. 1; AAD22053","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"in Ref. 1; AAD22053","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Helix","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Turn","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Beta strand","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Beta strand","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Turn","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Turn","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Beta strand","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":85,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Beta strand","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7F0J"}]},{"type":"Helix","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7F0J"}]},{"type":"Helix","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Turn","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":180,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Beta strand","location":{"start":{"value":207,"modifier":"EXACT"},"end":{"value":211,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Beta strand","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":220,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":254,"modifier":"EXACT"},"end":{"value":258,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Beta strand","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":285,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":319,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Beta strand","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":351,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7F0J"}]},{"type":"Helix","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Beta strand","location":{"start":{"value":374,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":423,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKG"}]},{"type":"Helix","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]},{"type":"Helix","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7UKH"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1269","category":"Disease","name":"Autism"},{"id":"KW-1268","category":"Disease","name":"Autism spectrum disorder"},{"id":"KW-0965","category":"Cellular component","name":"Cell junction"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0887","category":"Disease","name":"Epilepsy"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0628","category":"Cellular component","name":"Postsynaptic cell membrane"},{"id":"KW-0630","category":"Ligand","name":"Potassium"},{"id":"KW-0631","category":"Molecular function","name":"Potassium channel"},{"id":"KW-0633","category":"Biological process","name":"Potassium transport"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0851","category":"Molecular function","name":"Voltage-gated channel"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"9843794","citationType":"journal article","authors":["Kong W.","Po S.","Yamagishi T.","Ashen M.D.","Stetten G.","Tomaselli G.F."],"citationCrossReferences":[{"database":"PubMed","id":"9843794"},{"database":"DOI","id":"10.1152/ajpheart.1998.275.6.h1963"}],"title":"Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.","publicationDate":"1998","journal":"Am. J. Physiol.","firstPage":"H1963","lastPage":"H1970","volume":"275"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10470851","citationType":"journal article","authors":["Kikuno R.","Nagase T.","Ishikawa K.","Hirosawa M.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"10470851"},{"database":"DOI","id":"10.1093/dnares/6.3.197"}],"title":"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"1999","journal":"DNA Res.","firstPage":"197","lastPage":"205","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"10551270","citationType":"journal article","authors":["Zhu X.-R.","Wulf A.","Schwarz M.","Isbrandt D.","Pongs O."],"citationCrossReferences":[{"database":"PubMed","id":"10551270"}],"title":"Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.","publicationDate":"1999","journal":"Recept. Channels","firstPage":"387","lastPage":"400","volume":"6"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","FUNCTION","TRANSPORTER ACTIVITY"]},{"referenceNumber":4,"citation":{"id":"10729221","citationType":"journal article","authors":["Isbrandt D.","Leicher T.","Waldschuetz R.","Zhu X.-R.","Luhmann U.","Michel U.","Sauter K.","Pongs O."],"citationCrossReferences":[{"database":"PubMed","id":"10729221"},{"database":"DOI","id":"10.1006/geno.2000.6117"}],"title":"Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).","publicationDate":"2000","journal":"Genomics","firstPage":"144","lastPage":"154","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Brain cortex","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"12853948","citationType":"journal article","authors":["Hillier L.W.","Fulton R.S.","Fulton L.A.","Graves T.A.","Pepin K.H.","Wagner-McPherson C.","Layman D.","Maas J.","Jaeger S.","Walker R.","Wylie K.","Sekhon M.","Becker M.C.","O'Laughlin M.D.","Schaller M.E.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Cordes M.","Du H.","Sun H.","Edwards J.","Bradshaw-Cordum H.","Ali J.","Andrews S.","Isak A.","Vanbrunt A.","Nguyen C.","Du F.","Lamar B.","Courtney L.","Kalicki J.","Ozersky P.","Bielicki L.","Scott K.","Holmes A.","Harkins R.","Harris A.","Strong C.M.","Hou S.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Leonard S.","Rohlfing T.","Rock S.M.","Tin-Wollam A.-M.","Abbott A.","Minx P.","Maupin R.","Strowmatt C.","Latreille P.","Miller N.","Johnson D.","Murray J.","Woessner J.P.","Wendl M.C.","Yang S.-P.","Schultz B.R.","Wallis J.W.","Spieth J.","Bieri T.A.","Nelson J.O.","Berkowicz N.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Bedell J.A.","Mardis E.R.","Clifton S.W.","Chissoe S.L.","Marra M.A.","Raymond C.","Haugen E.","Gillett W.","Zhou Y.","James R.","Phelps K.","Iadanoto S.","Bubb K.","Simms E.","Levy R.","Clendenning J.","Kaul R.","Kent W.J.","Furey T.S.","Baertsch R.A.","Brent M.R.","Keibler E.","Flicek P.","Bork P.","Suyama M.","Bailey J.A.","Portnoy M.E.","Torrents D.","Chinwalla A.T.","Gish W.R.","Eddy S.R.","McPherson J.D.","Olson M.V.","Eichler E.E.","Green E.D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"12853948"},{"database":"DOI","id":"10.1038/nature01782"}],"title":"The DNA sequence of human chromosome 7.","publicationDate":"2003","journal":"Nature","firstPage":"157","lastPage":"164","volume":"424"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":7,"citation":{"id":"11102480","citationType":"journal article","authors":["Petrecca K.","Miller D.M.","Shrier A."],"citationCrossReferences":[{"database":"PubMed","id":"11102480"},{"database":"DOI","id":"10.1523/jneurosci.20-23-08736.2000"}],"title":"Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.","publicationDate":"2000","journal":"J. Neurosci.","firstPage":"8736","lastPage":"8744","volume":"20"},"referencePositions":["MUTAGENESIS OF 601-PRO--PRO-604","SUBCELLULAR LOCATION","INTERACTION WITH FLNA AND FLNC"]},{"referenceNumber":8,"citation":{"id":"10676964","citationType":"journal article","authors":["An W.F.","Bowlby M.R.","Betty M.","Cao J.","Ling H.-P.","Mendoza G.","Hinson J.W.","Mattsson K.I.","Strassle B.W.","Trimmer J.S.","Rhodes K.J."],"citationCrossReferences":[{"database":"PubMed","id":"10676964"},{"database":"DOI","id":"10.1038/35000592"}],"title":"Modulation of A-type potassium channels by a family of calcium sensors.","publicationDate":"2000","journal":"Nature","firstPage":"553","lastPage":"556","volume":"403"},"referencePositions":["INTERACTION WITH KCNIP1"]},{"referenceNumber":9,"citation":{"id":"11287421","citationType":"journal article","authors":["Baehring R.","Dannenberg J.","Peters H.C.","Leicher T.","Pongs O.","Isbrandt D."],"citationCrossReferences":[{"database":"PubMed","id":"11287421"},{"database":"DOI","id":"10.1074/jbc.m101320200"}],"title":"Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"23888","lastPage":"23894","volume":"276"},"referencePositions":["INTERACTION WITH KCNIP2"]},{"referenceNumber":10,"citation":{"id":"11507158","citationType":"journal article","authors":["Baehring R.","Boland L.M.","Varghese A.","Gebauer M.","Pongs O."],"citationCrossReferences":[{"database":"PubMed","id":"11507158"},{"database":"DOI","id":"10.1111/j.1469-7793.2001.00065.x"}],"title":"Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels.","publicationDate":"2001","journal":"J. Physiol. (Lond.)","firstPage":"65","lastPage":"81","volume":"535"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","BIOPHYSICOCHEMICAL PROPERTIES","DOMAIN"]},{"referenceNumber":11,"citation":{"id":"12395204","citationType":"journal article","authors":["Bertaso F.","Sharpe C.C.","Hendry B.M.","James A.F."],"citationCrossReferences":[{"database":"PubMed","id":"12395204"},{"database":"DOI","id":"10.1007/s00395-002-0377-4"}],"title":"Expression of voltage-gated K+ channels in human atrium.","publicationDate":"2002","journal":"Basic Res. Cardiol.","firstPage":"424","lastPage":"433","volume":"97"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":12,"citation":{"id":"11847232","citationType":"journal article","authors":["Morohashi Y.","Hatano N.","Ohya S.","Takikawa R.","Watabiki T.","Takasugi N.","Imaizumi Y.","Tomita T.","Iwatsubo T."],"citationCrossReferences":[{"database":"PubMed","id":"11847232"},{"database":"DOI","id":"10.1074/jbc.m200897200"}],"title":"Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.","publicationDate":"2002","journal":"J. Biol. Chem.","firstPage":"14965","lastPage":"14975","volume":"277"},"referencePositions":["INTERACTION WITH KCNIP4"]},{"referenceNumber":13,"citation":{"id":"12451113","citationType":"journal article","authors":["Schrader L.A.","Anderson A.E.","Mayne A.","Pfaffinger P.J.","Sweatt J.D."],"citationCrossReferences":[{"database":"PubMed","id":"12451113"},{"database":"DOI","id":"10.1523/jneurosci.22-23-10123.2002"}],"title":"PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex.","publicationDate":"2002","journal":"J. Neurosci.","firstPage":"10123","lastPage":"10133","volume":"22"},"referencePositions":["INTERACTION WITH KCNIP3"]},{"referenceNumber":14,"citation":{"id":"14695263","citationType":"journal article","authors":["Gebauer M.","Isbrandt D.","Sauter K.","Callsen B.","Nolting A.","Pongs O.","Baehring R."],"citationCrossReferences":[{"database":"PubMed","id":"14695263"},{"database":"DOI","id":"10.1016/s0006-3495(04)74097-7"}],"title":"N-type inactivation features of Kv4.2 channel gating.","publicationDate":"2004","journal":"Biophys. J.","firstPage":"210","lastPage":"223","volume":"86"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","DOMAIN"]},{"referenceNumber":15,"citation":{"id":"15454437","citationType":"journal article","authors":["Jerng H.H.","Qian Y.","Pfaffinger P.J."],"citationCrossReferences":[{"database":"PubMed","id":"15454437"},{"database":"DOI","id":"10.1529/biophysj.104.042358"}],"title":"Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).","publicationDate":"2004","journal":"Biophys. J.","firstPage":"2380","lastPage":"2396","volume":"87"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","INTERACTION WITH DPP10 AND DPP6","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"15358149","citationType":"journal article","authors":["Lin Y.-L.","Chen C.Y.","Cheng C.P.","Chang L.S."],"citationCrossReferences":[{"database":"PubMed","id":"15358149"},{"database":"DOI","id":"10.1016/j.bbrc.2004.07.006"}],"title":"Protein-protein interactions of KChIP proteins and Kv4.2.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"606","lastPage":"610","volume":"321"},"referencePositions":["INTERACTION WITH KCNIP1 AND KCNIP2","SUBUNIT","DOMAIN"]},{"referenceNumber":17,"citation":{"id":"16934482","citationType":"journal article","authors":["Singh B.","Ogiwara I.","Kaneda M.","Tokonami N.","Mazaki E.","Baba K.","Matsuda K.","Inoue Y.","Yamakawa K."],"citationCrossReferences":[{"database":"PubMed","id":"16934482"},{"database":"DOI","id":"10.1016/j.nbd.2006.07.001"}],"title":"A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy.","publicationDate":"2006","journal":"Neurobiol. Dis.","firstPage":"245","lastPage":"253","volume":"24"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","SUBUNIT","DOMAIN","ROLE IN DISEASE"]},{"referenceNumber":18,"citation":{"id":"17917103","citationType":"journal article","authors":["Baranauskas G."],"citationCrossReferences":[{"database":"PubMed","id":"17917103"},{"database":"DOI","id":"10.1007/s12035-007-8001-0"}],"title":"Ionic channel function in action potential generation: current perspective.","publicationDate":"2007","journal":"Mol. Neurobiol.","firstPage":"129","lastPage":"150","volume":"35"},"referencePositions":["REVIEW"]},{"referenceNumber":19,"citation":{"id":"18357523","citationType":"journal article","authors":["Covarrubias M.","Bhattacharji A.","De Santiago-Castillo J.A.","Dougherty K.","Kaulin Y.A.","Na-Phuket T.R.","Wang G."],"citationCrossReferences":[{"database":"PubMed","id":"18357523"},{"database":"DOI","id":"10.1007/s11064-008-9650-8"}],"title":"The neuronal Kv4 channel complex.","publicationDate":"2008","journal":"Neurochem. Res.","firstPage":"1558","lastPage":"1567","volume":"33"},"referencePositions":["REVIEW"]},{"referenceNumber":20,"citation":{"id":"19171772","citationType":"journal article","authors":["Barghaan J.","Baehring R."],"citationCrossReferences":[{"database":"PubMed","id":"19171772"},{"database":"DOI","id":"10.1085/jgp.200810073"}],"title":"Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of Kv4.2 channels.","publicationDate":"2009","journal":"J. Gen. Physiol.","firstPage":"205","lastPage":"224","volume":"133"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","SUBUNIT","MUTAGENESIS OF GLY-309; ARG-311; ILE-312; LEU-313; GLY-314; TYR-315; THR-316; LEU-317; LYS-318; SER-319; CYS-320; SER-322; GLU-323; LEU-324; LEU-327; LEU-328; PHE-329; VAL-397; ILE-398; ALA-399; PRO-401; 402-VAL--VAL-404; PRO-403; ILE-405; VAL-406; SER-407; ASN-408 AND PHE-409"]},{"referenceNumber":21,"citation":{"id":"24811166","citationType":"journal article","authors":["Kitazawa M.","Kubo Y.","Nakajo K."],"citationCrossReferences":[{"database":"PubMed","id":"24811166"},{"database":"DOI","id":"10.1074/jbc.m114.563452"}],"title":"The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"17597","lastPage":"17609","volume":"289"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION","SUBUNIT","INTERACTION WITH KCNIP4"]},{"referenceNumber":22,"citation":{"id":"14980201","citationType":"journal article","authors":["Kim L.A.","Furst J.","Gutierrez D.","Butler M.H.","Xu S.","Goldstein S.A.","Grigorieff N."],"citationCrossReferences":[{"database":"PubMed","id":"14980201"},{"database":"DOI","id":"10.1016/s0896-6273(04)00050-9"}],"title":"Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.","publicationDate":"2004","journal":"Neuron","firstPage":"513","lastPage":"519","volume":"41"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","STRUCTURE BY ELECTRON MICROSCOPY (21 ANGSTROMS) OF THE KCND2-KCNIP2 COMPLEX","SUBCELLULAR LOCATION","SUBUNIT"]},{"referenceNumber":23,"citation":{"id":"14623880","citationType":"journal article","authors":["Kim L.A.","Furst J.","Butler M.H.","Xu S.","Grigorieff N.","Goldstein S.A."],"citationCrossReferences":[{"database":"PubMed","id":"14623880"},{"database":"DOI","id":"10.1074/jbc.m311332200"}],"title":"Ito channels are octameric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"5549","lastPage":"5554","volume":"279"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","INTERACTION WITH KCNIP2","SUBCELLULAR LOCATION","SUBUNIT"]},{"referenceNumber":24,"citation":{"id":"15991246","citationType":"journal article","authors":["Kunz L.","Ramsch R.","Krieger A.","Young K.A.","Dissen G.A.","Stouffer R.L.","Ojeda S.R.","Mayerhofer A."],"citationCrossReferences":[{"database":"PubMed","id":"15991246"},{"database":"DOI","id":"10.1002/jcp.20453"}],"title":"Voltage-dependent K+ channel acts as sex steroid sensor in endocrine cells of the human ovary.","publicationDate":"2006","journal":"J. Cell. Physiol.","firstPage":"167","lastPage":"174","volume":"206"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":25,"citation":{"id":"14980207","citationType":"journal article","authors":["Scannevin R.H.","Wang K.","Jow F.","Megules J.","Kopsco D.C.","Edris W.","Carroll K.C.","Lu Q.","Xu W.","Xu Z.","Katz A.H.","Olland S.","Lin L.","Taylor M.","Stahl M.","Malakian K.","Somers W.","Mosyak L.","Bowlby M.R.","Chanda P.","Rhodes K.J."],"citationCrossReferences":[{"database":"PubMed","id":"14980207"},{"database":"DOI","id":"10.1016/s0896-6273(04)00049-2"}],"title":"Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.","publicationDate":"2004","journal":"Neuron","firstPage":"587","lastPage":"598","volume":"41"},"referencePositions":["INTERACTION WITH KCNIP1"]},{"referenceNumber":26,"citation":{"id":"19213956","citationType":"journal article","authors":["El-Haou S.","Balse E.","Neyroud N.","Dilanian G.","Gavillet B.","Abriel H.","Coulombe A.","Jeromin A.","Hatem S.N."],"citationCrossReferences":[{"database":"PubMed","id":"19213956"},{"database":"DOI","id":"10.1161/circresaha.108.191007"}],"title":"Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.","publicationDate":"2009","journal":"Circ. Res.","firstPage":"758","lastPage":"769","volume":"104"},"referencePositions":["INTERACTION WITH DLG1"]},{"referenceNumber":27,"citation":{"id":"34552243","citationType":"journal article","authors":["Kise Y.","Kasuya G.","Okamoto H.H.","Yamanouchi D.","Kobayashi K.","Kusakizako T.","Nishizawa T.","Nakajo K.","Nureki O."],"citationCrossReferences":[{"database":"PubMed","id":"34552243"},{"database":"DOI","id":"10.1038/s41586-021-03935-z"}],"title":"Structural basis of gating modulation of Kv4 channel complexes.","publicationDate":"2021","journal":"Nature","firstPage":"158","lastPage":"164","volume":"599"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.90 ANGSTROMS) IN COMPLEX WITH ZINC; KCNIP1; DPP6","SUBUNIT","FUNCTION","TRANSPORTER ACTIVITY","TOPOLOGY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E7Z"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E83"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E84"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E87"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E8B"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E8E"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7E8H"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F0J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7F3F"}]},{"referenceNumber":28,"citation":{"id":"35597238","citationType":"journal article","authors":["Ye W.","Zhao H.","Dai Y.","Wang Y.","Lo Y.H.","Jan L.Y.","Lee C.H."],"citationCrossReferences":[{"database":"PubMed","id":"35597238"},{"database":"DOI","id":"10.1016/j.molcel.2022.04.032"}],"title":"Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes.","publicationDate":"2022","journal":"Mol. Cell","firstPage":"2427","lastPage":"2442","volume":"82"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (2.24 ANGSTROMS) OF 1-524 IN COMPLEX WITH KCNIP2; DPP6; POTASSIUM AND ZINC","FUNCTION","TRANSPORTER ACTIVITY","SUBUNIT","DOMAIN"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UK5"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKC"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKD"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKE"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKF"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKG"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7UKH"}]},{"referenceNumber":29,"citation":{"id":"24501278","citationType":"journal article","authors":["Lee H.","Lin M.C.","Kornblum H.I.","Papazian D.M.","Nelson S.F."],"citationCrossReferences":[{"database":"PubMed","id":"24501278"},{"database":"DOI","id":"10.1093/hmg/ddu056"}],"title":"Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.","publicationDate":"2014","journal":"Hum. Mol. Genet.","firstPage":"3481","lastPage":"3489","volume":"23"},"referencePositions":["VARIANT MET-404","CHARACTERIZATION OF VARIANT MET-404","FUNCTION","TRANSPORTER ACTIVITY","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF121104","properties":[{"key":"ProteinId","value":"AAD22053.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB028967","properties":[{"key":"ProteinId","value":"BAA82996.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AJ010969","properties":[{"key":"ProteinId","value":"CAB56841.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF166008","properties":[{"key":"ProteinId","value":"AAF65618.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF166007","properties":[{"key":"ProteinId","value":"AAF65618.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC004888","properties":[{"key":"ProteinId","value":"AAC83405.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC004946","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF142568","properties":[{"key":"ProteinId","value":"AAD52159.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC110449","properties":[{"key":"ProteinId","value":"AAI10450.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC110450","properties":[{"key":"ProteinId","value":"AAI10451.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS5776.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_036413.1","properties":[{"key":"NucleotideSequenceId","value":"NM_012281.3"}]},{"database":"RefSeq","id":"XP_047276302.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047420346.1"}]},{"database":"RefSeq","id":"XP_054214141.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054358166.1"}]},{"database":"PDB","id":"7E7Z","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.20 A"},{"key":"Chains","value":"A/B/C/D=163-417"}]},{"database":"PDB","id":"7E83","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/C/D/G=2-495"}]},{"database":"PDB","id":"7E84","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/D/G=2-495"}]},{"database":"PDB","id":"7E87","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.40 A"},{"key":"Chains","value":"A/D=40-436, B/C=40-437"}]},{"database":"PDB","id":"7E8B","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.20 A"},{"key":"Chains","value":"A/C=40-436, B/D=40-437"}]},{"database":"PDB","id":"7E8E","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.90 A"},{"key":"Chains","value":"A/B/C/D=2-495"}]},{"database":"PDB","id":"7E8H","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"A/B/C/D=2-495"}]},{"database":"PDB","id":"7F0J","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"B/C/F/H=1-630"}]},{"database":"PDB","id":"7F3F","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"A/B/D/G=1-630"}]},{"database":"PDB","id":"7UK5","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.76 A"},{"key":"Chains","value":"A/B/C/D=1-630"}]},{"database":"PDB","id":"7UKC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDB","id":"7UKD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.88 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDB","id":"7UKE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.01 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDB","id":"7UKF","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.02 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDB","id":"7UKG","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.24 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDB","id":"7UKH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.33 A"},{"key":"Chains","value":"A/B/C/D=1-524"}]},{"database":"PDBsum","id":"7E7Z","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E83","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E84","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E87","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E8B","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E8E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7E8H","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F0J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7F3F","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UK5","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKG","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UKH","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26575","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26576","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26577","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26578","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26579","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26580","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26581","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31005","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31009","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31011","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31013","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31016","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31019","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31399","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-31433","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"109953","properties":[{"key":"Interactions","value":"21"}]},{"database":"ComplexPortal","id":"CPX-3239","properties":[{"key":"EntryName","value":"Kv4.2-KChIP2 channel complex"}]},{"database":"CORUM","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9NZV8","properties":[{"key":"Number of interactors","value":"340"}]},{"database":"IntAct","id":"Q9NZV8","properties":[{"key":"Interactions","value":"11"}]},{"database":"NDEx","id":"IQUERY-CP-KCND2","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000333496","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5885","properties":[{"key":"Description","value":"-"}]},{"database":"DrugBank","id":"DB06637","properties":[{"key":"GenericName","value":"Dalfampridine"}]},{"database":"DrugBank","id":"DB00280","properties":[{"key":"GenericName","value":"Disopyramide"}]},{"database":"DrugBank","id":"DB00228","properties":[{"key":"GenericName","value":"Enflurane"}]},{"database":"DrugBank","id":"DB00458","properties":[{"key":"GenericName","value":"Imipramine"}]},{"database":"DrugBank","id":"DB01110","properties":[{"key":"GenericName","value":"Miconazole"}]},{"database":"DrugBank","id":"DB01069","properties":[{"key":"GenericName","value":"Promethazine"}]},{"database":"DrugCentral","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.1.2.5","properties":[{"key":"FamilyName","value":"the voltage-gated ion channel (vic) superfamily"}]},{"database":"iPTMnet","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"KCND2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"38258257","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000333496","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"83521","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q9NZV8","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"31683","properties":[{"key":"antibodies","value":"432 antibodies from 41 providers"}]},{"database":"DNASU","id":"3751","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000331113.9","properties":[{"key":"ProteinId","value":"ENSP00000333496.4"},{"key":"GeneId","value":"ENSG00000184408.10"}]},{"database":"GeneID","id":"3751","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:3751","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000331113.9","properties":[{"key":"ProteinId","value":"ENSP00000333496.4"},{"key":"RefSeqNucleotideId","value":"NM_012281.3"},{"key":"RefSeqProteinId","value":"NP_036413.1"}]},{"database":"UCSC","id":"uc003vjj.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:6238","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30030","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"3751","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"3751","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"KCND2","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"KCND2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:6238","properties":[{"key":"GeneName","value":"KCND2"}]},{"database":"HPA","id":"ENSG00000184408","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (brain)"}]},{"database":"MalaCards","id":"KCND2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"605410","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000184408","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000184408","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4390","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155472","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_011722_9_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SCMEVTT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"433309at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NZV8","properties":[{"key":"Number of GO annotations","value":"8 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1296072","properties":[{"key":"PathwayName","value":"Voltage gated Potassium channels"}]},{"database":"Reactome","id":"R-HSA-5576894","properties":[{"key":"PathwayName","value":"Phase 1 - inactivation of fast Na+ channels"}]},{"database":"SignaLink","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000184408","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"3751","properties":[{"key":"hits","value":"14 hits in 1162 CRISPR screens"}]},{"database":"ChiTaRS","id":"KCND2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"KCND2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"3751","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NZV8","properties":[{"key":"DevelopmentLevel","value":"Tclin"}]},{"database":"PRO","id":"PR:Q9NZV8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q9NZV8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000184408","properties":[{"key":"ExpressionPatterns","value":"Expressed in cerebellar vermis and 134 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9NZV8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0070161","properties":[{"key":"GoTerm","value":"C:anchoring junction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098982","properties":[{"key":"GoTerm","value":"C:GABA-ergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071193","properties":[{"key":"GoTerm","value":"C:Kv4.2-KChIP2 channel complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"14980201"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032809","properties":[{"key":"GoTerm","value":"C:neuronal cell body membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043204","properties":[{"key":"GoTerm","value":"C:perikaryon"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24811166"}]},{"database":"GO","id":"GO:0044853","properties":[{"key":"GoTerm","value":"C:plasma membrane raft"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0099634","properties":[{"key":"GoTerm","value":"C:postsynaptic specialization membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0008076","properties":[{"key":"GoTerm","value":"C:voltage-gated potassium channel complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24811166"}]},{"database":"GO","id":"GO:0005250","properties":[{"key":"GoTerm","value":"F:A-type (transient outward) potassium channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24811166"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35597238"}]},{"database":"GO","id":"GO:1905030","properties":[{"key":"GoTerm","value":"F:voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005249","properties":[{"key":"GoTerm","value":"F:voltage-gated potassium channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24811166"}]},{"database":"GO","id":"GO:0001508","properties":[{"key":"GoTerm","value":"P:action potential"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14980201"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007268","properties":[{"key":"GoTerm","value":"P:chemical synaptic transmission"},{"key":"GoEvidenceType","value":"TAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"11102480"}]},{"database":"GO","id":"GO:0045475","properties":[{"key":"GoTerm","value":"P:locomotor rhythm"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0086009","properties":[{"key":"GoTerm","value":"P:membrane repolarization"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14980201"}]},{"database":"GO","id":"GO:0006936","properties":[{"key":"GoTerm","value":"P:muscle contraction"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11287421"}]},{"database":"GO","id":"GO:0019228","properties":[{"key":"GoTerm","value":"P:neuronal action potential"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0071805","properties":[{"key":"GoTerm","value":"P:potassium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"10551270"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11507158"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14623880"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14695263"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14980201"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15454437"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16934482"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19171772"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24501278"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24811166"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34552243"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35597238"}]},{"database":"GO","id":"GO:0051260","properties":[{"key":"GoTerm","value":"P:protein homooligomerization"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0008016","properties":[{"key":"GoTerm","value":"P:regulation of heart contraction"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11747815"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"FunFam","id":"1.10.287.70:FF:000073","properties":[{"key":"EntryName","value":"Potassium voltage-gated channel subfamily D member 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000111","properties":[{"key":"EntryName","value":"Potassium voltage-gated channel subfamily D member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000016","properties":[{"key":"EntryName","value":"Potassium voltage-gated channel subfamily D member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.710.10:FF:000004","properties":[{"key":"EntryName","value":"Potassium voltage-gated channel subfamily D member 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.710.10","properties":[{"key":"EntryName","value":"Potassium Channel Kv1.1, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.350","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels. Chain C"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000210","properties":[{"key":"EntryName","value":"BTB/POZ_dom"}]},{"database":"InterPro","id":"IPR005821","properties":[{"key":"EntryName","value":"Ion_trans_dom"}]},{"database":"InterPro","id":"IPR003968","properties":[{"key":"EntryName","value":"K_chnl_volt-dep_Kv"}]},{"database":"InterPro","id":"IPR003975","properties":[{"key":"EntryName","value":"K_chnl_volt-dep_Kv4"}]},{"database":"InterPro","id":"IPR004055","properties":[{"key":"EntryName","value":"K_chnl_volt-dep_Kv4.2"}]},{"database":"InterPro","id":"IPR024587","properties":[{"key":"EntryName","value":"K_chnl_volt-dep_Kv4_C"}]},{"database":"InterPro","id":"IPR021645","properties":[{"key":"EntryName","value":"Shal-type_N"}]},{"database":"InterPro","id":"IPR011333","properties":[{"key":"EntryName","value":"SKP1/BTB/POZ_sf"}]},{"database":"InterPro","id":"IPR003131","properties":[{"key":"EntryName","value":"T1-type_BTB"}]},{"database":"InterPro","id":"IPR028325","properties":[{"key":"EntryName","value":"VG_K_chnl"}]},{"database":"InterPro","id":"IPR027359","properties":[{"key":"EntryName","value":"Volt_channel_dom_sf"}]},{"database":"PANTHER","id":"PTHR11537:SF265","properties":[{"key":"EntryName","value":"POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11537","properties":[{"key":"EntryName","value":"VOLTAGE-GATED POTASSIUM CHANNEL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02214","properties":[{"key":"EntryName","value":"BTB_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11879","properties":[{"key":"EntryName","value":"DUF3399"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00520","properties":[{"key":"EntryName","value":"Ion_trans"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11601","properties":[{"key":"EntryName","value":"Shal-type"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00169","properties":[{"key":"EntryName","value":"KCHANNEL"}]},{"database":"PRINTS","id":"PR01517","properties":[{"key":"EntryName","value":"KV42CHANNEL"}]},{"database":"PRINTS","id":"PR01491","properties":[{"key":"EntryName","value":"KVCHANNEL"}]},{"database":"PRINTS","id":"PR01497","properties":[{"key":"EntryName","value":"SHALCHANNEL"}]},{"database":"SMART","id":"SM00225","properties":[{"key":"EntryName","value":"BTB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54695","properties":[{"key":"EntryName","value":"POZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81324","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL","length":630,"molWeight":70537,"crc64":"0C11E62FFA220421","md5":"97CBE414D98E9F8DB5E6341695945CFE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":3,"PTM":1,"DISEASE":2,"MISCELLANEOUS":2,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":8,"Transmembrane":6,"Intramembrane":2,"Region":6,"Motif":2,"Binding site":8,"Modified residue":9,"Natural variant":1,"Mutagenesis":30,"Sequence conflict":4,"Helix":27,"Turn":4,"Beta strand":9},"uniParcId":"UPI0000073D37"}}