{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NZN3","secondaryAccessions":["B4DFR5","D6W574","Q8N514","Q9NZB3"],"uniProtkbId":"EHD3_HUMAN","entryAudit":{"firstPublicDate":"2001-09-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2010-07-13","entryVersion":190,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"EH domain-containing protein 3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"PAST homolog 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3244"}],"value":"EHD3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10673336"}],"value":"EHD2"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:3244"}],"value":"PAST3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QXY6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16251358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17233914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19139087"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21791287"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23781025"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24019528"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25686250"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20489164"}],"value":"ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QXY6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16251358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17233914"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18331452"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19864458"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20489164"}],"value":"Homooligomer, and heterooligomer with EHD1, EHD2 and EHD4, ATP-binding is required for heterooligomerization (PubMed:16251358, PubMed:17233914). Interacts with PACSIN1 (By similarity). Interacts with PACSIN2 (By similarity). Interacts (via EH domain) with MICALL1 (PubMed:19864458). Interacts (via EH domain) with RAB11FIP2 (PubMed:16251358). Interacts with ANK2 (PubMed:20489164)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q01484","geneName":"ANK2","intActId":"EBI-941975"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q9P2R3","geneName":"ANKFY1","intActId":"EBI-2513908"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q15041","geneName":"ARL6IP1","intActId":"EBI-714543"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q9H4M9","geneName":"EHD1","intActId":"EBI-490691"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q8N3F8","geneName":"MICALL1","intActId":"EBI-1056885"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q9H1K0","geneName":"RBSN","intActId":"EBI-1105310"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZN3","intActId":"EBI-2870749"},"interactantTwo":{"uniProtKBAccession":"Q9QXY6","geneName":"Ehd3","intActId":"EBI-775304"},"numberOfExperiments":5,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9QXY6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20489164"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25686250"}],"value":"Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with RAB8A and MYO5B to a cytoplasmic tubular network devoid of RAB11A (By similarity). Colocalizes with ANK2 in myocyte perinuclear region (PubMed:20489164). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. 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