{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NZM4","secondaryAccessions":["A8MW01"],"uniProtkbId":"BICRA_HUMAN","entryAudit":{"firstPublicDate":"2001-09-26","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-25","entryVersion":158,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"BRD4-interacting chromatin-remodeling complex-associated protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4332"}],"value":"Glioma tumor suppressor candidate region gene 1 protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4332"}],"value":"BICRA"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:4332"}],"value":"GLTSCR1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29374058"}],"value":"Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555454"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29374058"}],"value":"Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Interacts with BRD4; the interaction bridges BRD4 to the GBAF complex (PubMed:21555454, PubMed:29374058)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NZM4","intActId":"EBI-1754943"},"interactantTwo":{"uniProtKBAccession":"P46108","geneName":"CRK","intActId":"EBI-886"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NZM4","intActId":"EBI-1754943"},"interactantTwo":{"uniProtKBAccession":"P16333","geneName":"NCK1","intActId":"EBI-389883"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21555454"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9NZM4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9NZM4-2"],"sequenceIds":["VSP_035776"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10708517"}],"value":"Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Coffin-Siris syndrome 12","diseaseAccession":"DI-06109","acronym":"CSS12","description":"A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. CSS12 is an autosomal dominant form characterized by global developmental delay with variably impaired intellectual development, speech and language delay, and behavioral abnormalities, such as autism or hyperactivity. Most CSS12 patients do not have the classic hypoplastic fifth digit/nail abnormalities that are often observed in other forms the disease.","diseaseCrossReference":{"database":"MIM","id":"619325"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33232675"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAF62874.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"BRD4-interacting chromatin-remodeling complex-associated protein","featureId":"PRO_0000083864"},{"type":"Region","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":688,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":949,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":1028,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1049,"modifier":"EXACT"},"end":{"value":1075,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1215,"modifier":"EXACT"},"end":{"value":1300,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1324,"modifier":"EXACT"},"end":{"value":1424,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1440,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":624,"modifier":"EXACT"},"end":{"value":664,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":726,"modifier":"EXACT"},"end":{"value":736,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":747,"modifier":"EXACT"},"end":{"value":780,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":831,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":880,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":881,"modifier":"EXACT"},"end":{"value":896,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":941,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1005,"modifier":"EXACT"},"end":{"value":1028,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1227,"modifier":"EXACT"},"end":{"value":1236,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1264,"modifier":"EXACT"},"end":{"value":1281,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1331,"modifier":"EXACT"},"end":{"value":1356,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1401,"modifier":"EXACT"},"end":{"value":1412,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1485,"modifier":"EXACT"},"end":{"value":1515,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":919,"modifier":"EXACT"},"end":{"value":919,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1057,"modifier":"EXACT"},"end":{"value":1057,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Modified residue","location":{"start":{"value":1413,"modifier":"EXACT"},"end":{"value":1413,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":1313,"modifier":"EXACT"},"end":{"value":1313,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10708517"}],"featureId":"VSP_035776","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in CSS12; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33232675"}],"featureId":"VAR_085989","alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Natural variant","location":{"start":{"value":665,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"in CSS12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33232675"}],"featureId":"VAR_085990","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"in dbSNP:rs3745762","featureCrossReferences":[{"database":"dbSNP","id":"rs3745762"}],"featureId":"VAR_061663","alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":1044,"modifier":"EXACT"},"end":{"value":1044,"modifier":"EXACT"}},"description":"in dbSNP:rs13346368","featureCrossReferences":[{"database":"dbSNP","id":"rs13346368"}],"featureId":"VAR_059665","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1423,"modifier":"EXACT"},"end":{"value":1423,"modifier":"EXACT"}},"description":"in CSS12; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33232675"}],"featureId":"VAR_085991","alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":1457,"modifier":"EXACT"},"end":{"value":1560,"modifier":"EXACT"}},"description":"in CSS12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33232675"}],"featureId":"VAR_085992","alternativeSequence":{}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0991","category":"Disease","name":"Intellectual disability"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"10708517","citationType":"journal article","authors":["Smith J.S.","Tachibana I.","Pohl U.","Lee H.K.","Thanarajasingam U.","Portier B.P.","Ueki K.","Billings S.","Ramaswamy S.","Mohrenweiser H.W.","Scheithauer B.W.","Louis D.N.","Jenkins R.B."],"citationCrossReferences":[{"database":"PubMed","id":"10708517"},{"database":"DOI","id":"10.1006/geno.1999.6101"}],"title":"A transcript map of the chromosome 19q-Arm glioma tumor suppressor region.","publicationDate":"2000","journal":"Genomics","firstPage":"44","lastPage":"50","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","TISSUE SPECIFICITY"]},{"referenceNumber":2,"citation":{"id":"15057824","citationType":"journal article","authors":["Grimwood J.","Gordon L.A.","Olsen A.S.","Terry A.","Schmutz J.","Lamerdin J.E.","Hellsten U.","Goodstein D.","Couronne O.","Tran-Gyamfi M.","Aerts A.","Altherr M.","Ashworth L.","Bajorek E.","Black S.","Branscomb E.","Caenepeel S.","Carrano A.V.","Caoile C.","Chan Y.M.","Christensen M.","Cleland C.A.","Copeland A.","Dalin E.","Dehal P.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Garcia C.","Georgescu A.M.","Glavina T.","Gomez M.","Gonzales E.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Ho I.","Huang W.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Larionov V.","Leem S.-H.","Lopez F.","Lou Y.","Lowry S.","Malfatti S.","Martinez D.","McCready P.M.","Medina C.","Morgan J.","Nelson K.","Nolan M.","Ovcharenko I.","Pitluck S.","Pollard M.","Popkie A.P.","Predki P.","Quan G.","Ramirez L.","Rash S.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","She X.","Smith D.","Slezak T.","Solovyev V.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wagner M.","Wheeler J.","Wu K.","Xie G.","Yang J.","Dubchak I.","Furey T.S.","DeJong P.","Dickson M.","Gordon D.","Eichler E.E.","Pennacchio L.A.","Richardson P.","Stubbs L.","Rokhsar D.S.","Myers R.M.","Rubin E.M.","Lucas S.M."],"citationCrossReferences":[{"database":"PubMed","id":"15057824"},{"database":"DOI","id":"10.1038/nature02399"}],"title":"The DNA sequence and biology of human chromosome 19.","publicationDate":"2004","journal":"Nature","firstPage":"529","lastPage":"535","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-500 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"19608861","citationType":"journal article","authors":["Choudhary C.","Kumar C.","Gnad F.","Nielsen M.L.","Rehman M.","Walther T.C.","Olsen J.V.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"19608861"},{"database":"DOI","id":"10.1126/science.1175371"}],"title":"Lysine acetylation targets protein complexes and co-regulates major cellular functions.","publicationDate":"2009","journal":"Science","firstPage":"834","lastPage":"840","volume":"325"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1057","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"21555454","citationType":"journal article","authors":["Rahman S.","Sowa M.E.","Ottinger M.","Smith J.A.","Shi Y.","Harper J.W.","Howley P.M."],"citationCrossReferences":[{"database":"PubMed","id":"21555454"},{"database":"DOI","id":"10.1128/mcb.01341-10"}],"title":"The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.","publicationDate":"2011","journal":"Mol. Cell. Biol.","firstPage":"2641","lastPage":"2652","volume":"31"},"referencePositions":["FUNCTION","INTERACTION WITH BRD4","SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-921 AND SER-1413","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-919","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1313","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":10,"citation":{"id":"29374058","citationType":"journal article","authors":["Alpsoy A.","Dykhuizen E.C."],"citationCrossReferences":[{"database":"PubMed","id":"29374058"},{"database":"DOI","id":"10.1074/jbc.ra117.001065"}],"title":"Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.","publicationDate":"2018","journal":"J. Biol. Chem.","firstPage":"3892","lastPage":"3903","volume":"293"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE GBAF COMPLEX","INTERACTION WITH BRD4"]},{"referenceNumber":11,"citation":{"id":"33232675","citationType":"journal article","authoringGroup":["Undiagnosed Diseases Network"],"authors":["Barish S.","Barakat T.S.","Michel B.C.","Mashtalir N.","Phillips J.B.","Valencia A.M.","Ugur B.","Wegner J.","Scott T.M.","Bostwick B.","Murdock D.R.","Dai H.","Perenthaler E.","Nikoncuk A.","van Slegtenhorst M.","Brooks A.S.","Keren B.","Nava C.","Mignot C.","Douglas J.","Rodan L.","Nowak C.","Ellard S.","Stals K.","Lynch S.A.","Faoucher M.","Lesca G.","Edery P.","Engleman K.L.","Zhou D.","Thiffault I.","Herriges J.","Gass J.","Louie R.J.","Stolerman E.","Washington C.","Vetrini F.","Otsubo A.","Pratt V.M.","Conboy E.","Treat K.","Shannon N.","Camacho J.","Wakeling E.","Yuan B.","Chen C.A.","Rosenfeld J.A.","Westerfield M.","Wangler M.","Yamamoto S.","Kadoch C.","Scott D.A.","Bellen H.J."],"citationCrossReferences":[{"database":"PubMed","id":"33232675"},{"database":"DOI","id":"10.1016/j.ajhg.2020.11.003"}],"title":"BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.","publicationDate":"2020","journal":"Am. J. Hum. Genet.","firstPage":"1096","lastPage":"1112","volume":"107"},"referencePositions":["INVOLVEMENT IN CSS12","VARIANTS CSS12 ASP-64; 665-GLN--ARG-1560 DEL; LYS-1423 AND 1457-GLN--ARG-1560 DEL"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF182077","properties":[{"key":"ProteinId","value":"AAF62874.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008985","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC010519","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471126","properties":[{"key":"ProteinId","value":"EAW57504.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC032065","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS46134.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NZM4-1"},{"database":"RefSeq","id":"NP_001381301.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001394372.1"}],"isoformId":"Q9NZM4-1"},{"database":"RefSeq","id":"NP_056526.3","properties":[{"key":"NucleotideSequenceId","value":"NM_015711.3"}],"isoformId":"Q9NZM4-1"},{"database":"AlphaFoldDB","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119022","properties":[{"key":"Interactions","value":"74"}]},{"database":"ComplexPortal","id":"CPX-4084","properties":[{"key":"EntryName","value":"GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant"}]},{"database":"ComplexPortal","id":"CPX-4206","properties":[{"key":"EntryName","value":"GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant"}]},{"database":"ComplexPortal","id":"CPX-4223","properties":[{"key":"EntryName","value":"GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant"}]},{"database":"ComplexPortal","id":"CPX-4225","properties":[{"key":"EntryName","value":"GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant"}]},{"database":"FunCoup","id":"Q9NZM4","properties":[{"key":"Number of interactors","value":"1259"}]},{"database":"IntAct","id":"Q9NZM4","properties":[{"key":"Interactions","value":"41"}]},{"database":"MINT","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5220-BICRA","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - SWI/SNF complex (26 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000379946","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724771","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9NZM4","properties":[{"key":"glycosylation","value":"3 sites, 2 glycans"}]},{"database":"GlyGen","id":"Q9NZM4","properties":[{"key":"glycosylation","value":"19 sites, 2 O-linked glycans (10 sites)"}]},{"database":"iPTMnet","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"BICRA","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"215273990","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379946","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"83449","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NZM4-1"},{"database":"ProteomicsDB","id":"83450","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NZM4-2"},{"database":"Pumba","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"65070","properties":[{"key":"antibodies","value":"80 antibodies from 18 providers"}]},{"database":"DNASU","id":"29998","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000396720.7","properties":[{"key":"ProteinId","value":"ENSP00000379946.2"},{"key":"GeneId","value":"ENSG00000063169.13"}],"isoformId":"Q9NZM4-1"},{"database":"Ensembl","id":"ENST00000594866.3","properties":[{"key":"ProteinId","value":"ENSP00000469738.2"},{"key":"GeneId","value":"ENSG00000063169.13"}],"isoformId":"Q9NZM4-1"},{"database":"Ensembl","id":"ENST00000614245.2","properties":[{"key":"ProteinId","value":"ENSP00000480219.2"},{"key":"GeneId","value":"ENSG00000063169.13"}],"isoformId":"Q9NZM4-2"},{"database":"GeneID","id":"29998","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:29998","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000594866.3","properties":[{"key":"ProteinId","value":"ENSP00000469738.2"},{"key":"RefSeqNucleotideId","value":"NM_001394372.1"},{"key":"RefSeqProteinId","value":"NP_001381301.1"}]},{"database":"UCSC","id":"uc002phh.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9NZM4-1"},{"database":"AGR","id":"HGNC:4332","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA28735","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"29998","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"29998","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"BICRA","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"BICRA","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:4332","properties":[{"key":"GeneName","value":"BICRA"}]},{"database":"HPA","id":"ENSG00000063169","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"BICRA","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"605690","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"619325","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000063169","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000063169","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QU2K","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159112","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_002283_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FERVSCQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2556847at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NZM4","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-9933947","properties":[{"key":"PathwayName","value":"Formation of the non-canonical BAF (ncBAF) complex"}]},{"database":"SignaLink","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000063169","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"29998","properties":[{"key":"hits","value":"31 hits in 1166 CRISPR screens"}]},{"database":"ChiTaRS","id":"BICRA","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"29998","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NZM4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9NZM4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q9NZM4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000063169","properties":[{"key":"ExpressionPatterns","value":"Expressed in oocyte and 198 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9NZM4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29374058"}]},{"database":"GO","id":"GO:0140288","properties":[{"key":"GoTerm","value":"C:GBAF complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29374058"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555454"}]},{"database":"GO","id":"GO:0016514","properties":[{"key":"GoTerm","value":"C:SWI/SNF complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"29374058"}]},{"database":"GO","id":"GO:0140537","properties":[{"key":"GoTerm","value":"F:transcription regulator activator activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555454"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29374058"}]},{"database":"GO","id":"GO:0045596","properties":[{"key":"GoTerm","value":"P:negative regulation of cell differentiation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30510198"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29374058"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21555454"}]},{"database":"GO","id":"GO:1902459","properties":[{"key":"GoTerm","value":"P:positive regulation of stem cell population maintenance"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30510198"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29374058"}]},{"database":"InterPro","id":"IPR052438","properties":[{"key":"EntryName","value":"Chromatin_remod/trans_coact"}]},{"database":"InterPro","id":"IPR015671","properties":[{"key":"EntryName","value":"GSCR1_dom"}]},{"database":"PANTHER","id":"PTHR15572:SF1","properties":[{"key":"EntryName","value":"BRD4-INTERACTING CHROMATIN-REMODELING COMPLEX-ASSOCIATED PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15572","properties":[{"key":"EntryName","value":"GLIOMA TUMOR SUPPRESSOR CANDIDATE REGION GENE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15249","properties":[{"key":"EntryName","value":"GLTSCR1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDNPGEAQSAFYEGPGLHVQEASGNHLNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEAELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQPVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAHILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETVSTQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKEKPDEYVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVTWARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAPHCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELYQRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEHLQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHNGGLGARTLTR","length":1560,"molWeight":158490,"crc64":"32453B35C9219462","md5":"E09A0B243869CF0254AC1F3CCE034529"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DISEASE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":8,"Compositional bias":15,"Modified residue":4,"Cross-link":1,"Alternative sequence":1,"Natural variant":6},"uniParcId":"UPI00016278EE"}}