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Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25092918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26203195"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413131"}],"value":"Interacts with PRMT5; this interaction is direct (PubMed:25092918). Interacts with GNL2 and RPL23A (PubMed:26203195). Interacts with nucleolin/NCL; this interaction is direct (By similarity). Interacts with phosphorylated IRF3; this interaction impairs IRF3 DNA-binding activity (PubMed:31413131)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"Q8N7W2-2","geneName":"BEND7","intActId":"EBI-10181188"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"Q9NX58","geneName":"LYAR","intActId":"EBI-713507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"O75569","geneName":"PRKRA","intActId":"EBI-713955"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"Q9H190","geneName":"SDCBP2","intActId":"EBI-742426"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"Q8N9Q2","geneName":"SREK1IP1","intActId":"EBI-10268630"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"P0DTC9","geneName":"N","intActId":"EBI-25475856"},"numberOfExperiments":6,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q9NX58","intActId":"EBI-713507"},"interactantTwo":{"uniProtKBAccession":"A0A142I5B9","intActId":"EBI-20625235"},"numberOfExperiments":2,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08288"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24495227"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990247"}],"value":"Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227). 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In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25092918"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31413131"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12429849"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24495227"}],"value":"Nucleus, nucleolus","id":"SL-0188"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990247"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q08288"}],"value":"Cell projection, cilium, photoreceptor outer segment","id":"SL-0458"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24990247"}],"value":"Predominantly expressed in testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25092918"}],"value":"In an ex vivo erythroid culture system, highly expressed from early (preproerythroblasts) to mid (basophilic normoblasts) maturation. 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