{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NWR8","secondaryAccessions":["A8K4Y3","Q6IAC1"],"uniProtkbId":"MCUB_HUMAN","entryAudit":{"firstPublicDate":"2007-04-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-04-03","entryVersion":151,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Calcium uniporter regulatory subunit MCUb, mitochondrial"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q810S1"}],"value":"MCUb"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Coiled-coil domain-containing protein 109B"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24231807"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:26076"}],"value":"MCUB"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:26076"}],"value":"CCDC109B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q810S1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31533452"}],"value":"Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:31533452). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452). Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q810S1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24231807"}],"value":"Homooligomer (By similarity). Associates with the uniplex complex, composed of MCU, MICU1, MICU2 and EMRE/SMDT1, inhibiting its activity (PubMed:24231807)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NWR8","intActId":"EBI-719989"},"interactantTwo":{"uniProtKBAccession":"Q15047","geneName":"SETDB1","intActId":"EBI-79691"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24231807"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MCU (TC 1.A.77) family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH02633.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA91309.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"Calcium uniporter regulatory subunit MCUb, mitochondrial","featureId":"PRO_0000282980"},{"type":"Transmembrane","location":{"start":{"value":220,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":297,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Natural variant","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in dbSNP:rs4698744","featureCrossReferences":[{"database":"dbSNP","id":"rs4698744"}],"featureId":"VAR_060149","alternativeSequence":{"originalSequence":"I","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in dbSNP:rs13846","featureCrossReferences":[{"database":"dbSNP","id":"rs13846"}],"featureId":"VAR_031443","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Natural variant","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"in dbSNP:rs1053680","featureCrossReferences":[{"database":"dbSNP","id":"rs1053680"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_031444","alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"in Ref. 4; CAG33515","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in Ref. 4; CAG33515","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0109","category":"Biological process","name":"Calcium transport"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0999","category":"Cellular component","name":"Mitochondrion inner membrane"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-D49P6QQO8F5LU","citationType":"submission","authors":["Ebert L.","Schick M.","Neubert P.","Schatten R.","Henze S.","Korn B."],"title":"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).","publicationDate":"JUN-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-336","VARIANT VAL-255"]},{"referenceNumber":5,"citation":{"id":"24231807","citationType":"journal article","authors":["Sancak Y.","Markhard A.L.","Kitami T.","Kovacs-Bogdan E.","Kamer K.J.","Udeshi N.D.","Carr S.A.","Chaudhuri D.","Clapham D.E.","Li A.A.","Calvo S.E.","Goldberger O.","Mootha V.K."],"citationCrossReferences":[{"database":"PubMed","id":"24231807"},{"database":"DOI","id":"10.1126/science.1242993"}],"title":"EMRE is an essential component of the mitochondrial calcium uniporter complex.","publicationDate":"2013","journal":"Science","firstPage":"1379","lastPage":"1382","volume":"342"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH THE UNIPLEX COMPLEX"]},{"referenceNumber":6,"citation":{"id":"31533452","citationType":"journal article","authors":["Lambert J.P.","Luongo T.S.","Tomar D.","Jadiya P.","Gao E.","Zhang X.","Lucchese A.M.","Kolmetzky D.W.","Shah N.S.","Elrod J.W."],"citationCrossReferences":[{"database":"PubMed","id":"31533452"},{"database":"DOI","id":"10.1161/circulationaha.118.037968"}],"title":"MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress.","publicationDate":"2019","journal":"Circulation","firstPage":"1720","lastPage":"1733","volume":"140"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK000654","properties":[{"key":"ProteinId","value":"BAA91309.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK291098","properties":[{"key":"ProteinId","value":"BAF83787.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471057","properties":[{"key":"ProteinId","value":"EAX06242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002633","properties":[{"key":"ProteinId","value":"AAH02633.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR457234","properties":[{"key":"ProteinId","value":"CAG33515.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3683.2","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_060388.2","properties":[{"key":"NucleotideSequenceId","value":"NM_017918.5"}]},{"database":"AlphaFoldDB","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120345","properties":[{"key":"Interactions","value":"182"}]},{"database":"ComplexPortal","id":"CPX-5966","properties":[{"key":"EntryName","value":"Mitochondrial calcium uniporter complex, MICUB variant"}]},{"database":"CORUM","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9NWR8","properties":[{"key":"Number of interactors","value":"418"}]},{"database":"IntAct","id":"Q9NWR8","properties":[{"key":"Interactions","value":"22"}]},{"database":"NDEx","id":"IQUERY-CP-MCUB","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000378145","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.77.1.12","properties":[{"key":"FamilyName","value":"the mg(2+)/ca(2+) uniporter (mcu) family"}]},{"database":"GlyGen","id":"Q9NWR8","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MCUB","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"143955289","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000378145","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"82963","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"62656","properties":[{"key":"antibodies","value":"80 antibodies from 18 providers"}]},{"database":"DNASU","id":"55013","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000394650.7","properties":[{"key":"ProteinId","value":"ENSP00000378145.4"},{"key":"GeneId","value":"ENSG00000005059.17"}]},{"database":"GeneID","id":"55013","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55013","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000394650.7","properties":[{"key":"ProteinId","value":"ENSP00000378145.4"},{"key":"RefSeqNucleotideId","value":"NM_017918.5"},{"key":"RefSeqProteinId","value":"NP_060388.2"}]},{"database":"UCSC","id":"uc011cfs.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:26076","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA145008731","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55013","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55013","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MCUB","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26076","properties":[{"key":"GeneName","value":"MCUB"}]},{"database":"HPA","id":"ENSG00000005059","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid)"}]},{"database":"MIM","id":"620702","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000005059","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000005059","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2966","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158059","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_056554_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TINYKHG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"278338at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NWR8","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8949215","properties":[{"key":"PathwayName","value":"Mitochondrial calcium ion transport"}]},{"database":"Reactome","id":"R-HSA-8949664","properties":[{"key":"PathwayName","value":"Processing of SMDT1"}]},{"database":"SignaLink","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000005059","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"55013","properties":[{"key":"hits","value":"13 hits in 1156 CRISPR screens"}]},{"database":"ChiTaRS","id":"MCUB","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"55013","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NWR8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9NWR8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"Q9NWR8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000005059","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 177 other cell types or tissues"}]},{"database":"GO","id":"GO:0034704","properties":[{"key":"GoTerm","value":"C:calcium channel complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005743","properties":[{"key":"GoTerm","value":"C:mitochondrial inner membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24231807"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:1990246","properties":[{"key":"GoTerm","value":"C:uniplex complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24231807"}]},{"database":"GO","id":"GO:0019855","properties":[{"key":"GoTerm","value":"F:calcium channel inhibitor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31533452"}]},{"database":"GO","id":"GO:0036444","properties":[{"key":"GoTerm","value":"P:calcium import into the mitochondrion"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"31533452"}]},{"database":"GO","id":"GO:0051560","properties":[{"key":"GoTerm","value":"P:mitochondrial calcium ion homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006851","properties":[{"key":"GoTerm","value":"P:mitochondrial calcium ion transmembrane transport"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0110099","properties":[{"key":"GoTerm","value":"P:negative regulation of calcium import into the mitochondrion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31533452"}]},{"database":"GO","id":"GO:1902726","properties":[{"key":"GoTerm","value":"P:positive regulation of skeletal muscle satellite cell differentiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043030","properties":[{"key":"GoTerm","value":"P:regulation of macrophage activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043403","properties":[{"key":"GoTerm","value":"P:skeletal muscle tissue regeneration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR006769","properties":[{"key":"EntryName","value":"MCU_C"}]},{"database":"InterPro","id":"IPR039055","properties":[{"key":"EntryName","value":"MCU_fam"}]},{"database":"PANTHER","id":"PTHR13462","properties":[{"key":"EntryName","value":"CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13462:SF6","properties":[{"key":"EntryName","value":"CALCIUM UNIPORTER REGULATORY SUBUNIT MCUB, MITOCHONDRIAL"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04678","properties":[{"key":"EntryName","value":"MCU"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLQRGLWPWRTRLLPTPGTWRPARPWPLPPPPQVLRVKLCGNVKYYQSHHYSTVVPPDEITVIYRHGLPLVTLTLPSRKERCQFVVKPMLSTVGSFLQDLQNEDKGIKTAAIFTADGNMISASTLMDILLMNDFKLVINKIAYDVQCPKREKPSNEHTAEMEHMKSLVHRLFTILHLEESQKKREHHLLEKIDHLKEQLQPLEQVKAGIEAHSEAKTSGLLWAGLALLSIQGGALAWLTWWVYSWDIMEPVTYFITFANSMVFFAYFIVTRQDYTYSAVKSRQFLQFFHKKSKQQHFDVQQYNKLKEDLAKAKESLKQARHSLCLQMQVEELNEKN","length":336,"molWeight":39082,"crc64":"90C4BEBD5B1EFFD9","md5":"5E8D4C5C39BF570ACDF00221ED7F8A81"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Transmembrane":2,"Coiled coil":2,"Natural variant":3,"Sequence conflict":2},"uniParcId":"UPI000037446B"}}