{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NVK5","secondaryAccessions":["Q6R955","Q8N5L7","Q9P034","Q9UFK8"],"uniProtkbId":"FGOP2_HUMAN","entryAudit":{"firstPublicDate":"2007-08-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-10-01","entryVersion":158,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"FGFR1 oncogene partner 2"}}},"genes":[{"geneName":{"value":"FGFR1OP2"},"orfNames":[{"value":"HSPC123"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"May be involved in wound healing pathway"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NVK5","intActId":"EBI-1104764"},"interactantTwo":{"uniProtKBAccession":"Q96CS2","geneName":"HAUS1","intActId":"EBI-2514791"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NVK5-3","intActId":"EBI-12377025"},"interactantTwo":{"uniProtKBAccession":"P57075-2","geneName":"UBASH3A","intActId":"EBI-7353612"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NVK5-3","intActId":"EBI-12377025"},"interactantTwo":{"uniProtKBAccession":"Q53FD0-2","geneName":"ZC2HC1C","intActId":"EBI-14104088"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9NVK5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9NVK5-2"],"sequenceIds":["VSP_027538"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9NVK5-3"],"sequenceIds":["VSP_027539","VSP_027540"],"isoformSequenceStatus":"Described"}]},{"texts":[{"value":"Expressed in bone marrow, spleen and thymus"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SIKE family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAF29087.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAB56012.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"FGFR1 oncogene partner 2","featureId":"PRO_0000299041"},{"type":"Region","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Breakpoint for translocation to form FGFR1OP2-FGFR1"},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11042152"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_027538","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":171,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_027539","alternativeSequence":{"originalSequence":"EL","alternativeSequences":["VH"]}},{"type":"Alternative sequence","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_027540","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"in Ref. 5; CAB56012","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"in Ref. 3; AAR91611","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["T"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0160","category":"Coding sequence diversity","name":"Chromosomal rearrangement"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11042152","citationType":"journal article","authors":["Zhang Q.-H.","Ye M.","Wu X.-Y.","Ren S.-X.","Zhao M.","Zhao C.-J.","Fu G.","Shen Y.","Fan H.-Y.","Lu G.","Zhong M.","Xu X.-R.","Han Z.-G.","Zhang J.-W.","Tao J.","Huang Q.-H.","Zhou J.","Hu G.-X.","Gu J.","Chen S.-J.","Chen Z."],"citationCrossReferences":[{"database":"PubMed","id":"11042152"},{"database":"DOI","id":"10.1101/gr.140200"}],"title":"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.","publicationDate":"2000","journal":"Genome Res.","firstPage":"1546","lastPage":"1560","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Blood","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"CI-CMMP2TJIAJPVM","citationType":"submission","authors":["Lin L.","Zhong G.","Ke R.","Li H.","Zhou G.","Shen C.","Yang S."],"publicationDate":"DEC-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-253 (ISOFORM 2)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15034873","citationType":"journal article","authors":["Grand E.K.","Grand F.H.","Chase A.J.","Ross F.M.","Corcoran M.M.","Oscier D.G.","Cross N.C.P."],"citationCrossReferences":[{"database":"PubMed","id":"15034873"},{"database":"DOI","id":"10.1002/gcc.20023"}],"title":"Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome.","publicationDate":"2004","journal":"Genes Chromosomes Cancer","firstPage":"78","lastPage":"83","volume":"40"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH FGFR1"]},{"referenceNumber":7,"citation":{"id":"16946300","citationType":"journal article","authors":["Gu T.-L.","Goss V.L.","Reeves C.","Popova L.","Nardone J.","Macneill J.","Walters D.K.","Wang Y.","Rush J.","Comb M.J.","Druker B.J.","Polakiewicz R.D."],"citationCrossReferences":[{"database":"PubMed","id":"16946300"},{"database":"DOI","id":"10.1182/blood-2006-06-026666"}],"title":"Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia.","publicationDate":"2006","journal":"Blood","firstPage":"4202","lastPage":"4204","volume":"108"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH FGFR1"]},{"referenceNumber":8,"citation":{"id":"17389761","citationType":"journal article","authors":["Dong S.","Kang S.","Gu T.","Kardar S.","Fu H.","Lonial S.","Khoury H.J.","Khuri F.","Chen J."],"citationCrossReferences":[{"database":"PubMed","id":"17389761"},{"database":"DOI","id":"10.1182/blood-2006-12-065615"}],"title":"14-3-3 integrates pro-survival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1 transformed hematopoietic cells.","publicationDate":"2007","journal":"Blood","firstPage":"360","lastPage":"369","volume":"110"},"referencePositions":["CHROMOSOMAL TRANSLOCATION WITH FGFR1"]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF161472","properties":[{"key":"ProteinId","value":"AAF29087.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK001534","properties":[{"key":"ProteinId","value":"BAA91745.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY506561","properties":[{"key":"ProteinId","value":"AAR91611.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032143","properties":[{"key":"ProteinId","value":"AAH32143.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL117608","properties":[{"key":"ProteinId","value":"CAB56012.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS53766.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-3"},{"database":"CCDS","id":"CCDS53767.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-2"},{"database":"CCDS","id":"CCDS8709.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-1"},{"database":"PIR","id":"T17322","properties":[{"key":"EntryName","value":"T17322"}]},{"database":"RefSeq","id":"NP_001165358.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171887.2"}],"isoformId":"Q9NVK5-2"},{"database":"RefSeq","id":"NP_001165359.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001171888.2"}],"isoformId":"Q9NVK5-3"},{"database":"RefSeq","id":"NP_056448.1","properties":[{"key":"NucleotideSequenceId","value":"NM_015633.3"}],"isoformId":"Q9NVK5-1"},{"database":"AlphaFoldDB","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"117566","properties":[{"key":"Interactions","value":"101"}]},{"database":"FunCoup","id":"Q9NVK5","properties":[{"key":"Number of interactors","value":"2024"}]},{"database":"IntAct","id":"Q9NVK5","properties":[{"key":"Interactions","value":"94"}]},{"database":"STRING","id":"9606.ENSP00000229395","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9NVK5","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FGFR1OP2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74734519","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000229395","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"82818","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-1"},{"database":"ProteomicsDB","id":"82819","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-2"},{"database":"ProteomicsDB","id":"82820","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9NVK5-3"},{"database":"Pumba","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24359","properties":[{"key":"antibodies","value":"216 antibodies from 26 providers"}]},{"database":"DNASU","id":"26127","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000229395.8","properties":[{"key":"ProteinId","value":"ENSP00000229395.3"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000327214.5","properties":[{"key":"ProteinId","value":"ENSP00000323763.5"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000546072.5","properties":[{"key":"ProteinId","value":"ENSP00000437556.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-3"},{"database":"Ensembl","id":"ENST00000887799.1","properties":[{"key":"ProteinId","value":"ENSP00000557858.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000887800.1","properties":[{"key":"ProteinId","value":"ENSP00000557859.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000887801.1","properties":[{"key":"ProteinId","value":"ENSP00000557860.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000887802.1","properties":[{"key":"ProteinId","value":"ENSP00000557861.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000887803.1","properties":[{"key":"ProteinId","value":"ENSP00000557862.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000887804.1","properties":[{"key":"ProteinId","value":"ENSP00000557863.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000972030.1","properties":[{"key":"ProteinId","value":"ENSP00000642089.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000972031.1","properties":[{"key":"ProteinId","value":"ENSP00000642090.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"Ensembl","id":"ENST00000972032.1","properties":[{"key":"ProteinId","value":"ENSP00000642091.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000972033.1","properties":[{"key":"ProteinId","value":"ENSP00000642092.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-1"},{"database":"Ensembl","id":"ENST00000972034.1","properties":[{"key":"ProteinId","value":"ENSP00000642093.1"},{"key":"GeneId","value":"ENSG00000111790.15"}],"isoformId":"Q9NVK5-2"},{"database":"GeneID","id":"26127","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:26127","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000229395.8","properties":[{"key":"ProteinId","value":"ENSP00000229395.3"},{"key":"RefSeqNucleotideId","value":"NM_015633.3"},{"key":"RefSeqProteinId","value":"NP_056448.1"}]},{"database":"UCSC","id":"uc001rhl.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9NVK5-1"},{"database":"AGR","id":"HGNC:23098","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134972108","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26127","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"26127","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FGFR1OP2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:23098","properties":[{"key":"GeneName","value":"FGFR1OP2"}]},{"database":"HPA","id":"ENSG00000111790","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"608858","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000111790","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000111790","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSAD","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000018003","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_073167_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KYRQHTE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"21214at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NVK5","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-1839117","properties":[{"key":"PathwayName","value":"Signaling by cytosolic FGFR1 fusion mutants"}]},{"database":"Reactome","id":"R-HSA-5655302","properties":[{"key":"PathwayName","value":"Signaling by FGFR1 in disease"}]},{"database":"SignaLink","id":"Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000111790","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"26127","properties":[{"key":"hits","value":"86 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"FGFR1OP2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"26127","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NVK5","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9NVK5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q9NVK5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000111790","properties":[{"key":"ExpressionPatterns","value":"Expressed in calcaneal tendon and 186 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9NVK5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0009611","properties":[{"key":"GoTerm","value":"P:response to wounding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR008555","properties":[{"key":"EntryName","value":"SIKE"}]},{"database":"PANTHER","id":"PTHR12186:SF3","properties":[{"key":"EntryName","value":"FGFR1 ONCOGENE PARTNER 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12186","properties":[{"key":"EntryName","value":"SIKE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05769","properties":[{"key":"EntryName","value":"SIKE"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MSCTIEKALADAKALVERLRDHDDAAESLIEQTTALNKRVEAMKQYQEEIQELNEVARHRPRSTLVMGIQQENRQIRELQQENKELRTSLEEHQSALELIMSKYREQMFRLLMASKKDDPGIIMKLKEQHSKIDMVHRNKSEGFFLDASRHILEAPQHGLERRHLEANQNELQAHVDQITEMAAVMRKAIEIDEQQGCKEQERIFQLEQENKGLREILQITRESFLNLRKDDASESTSLSALVTNSDLSLRKS","length":253,"molWeight":29426,"crc64":"89F60BF3F96C3436","md5":"15E991F7512D328CD26FAB97CF7056C3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":2,"Compositional bias":1,"Site":1,"Modified residue":1,"Alternative sequence":3,"Sequence conflict":2},"uniParcId":"UPI000006F604"}}