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The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA (PubMed:19589784). Participates in S phase and G2 phase checkpoint activation upon DNA damage (PubMed:25862789)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17412408"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17460694"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19995904"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20603015"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21775430"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25862789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36385258"}],"value":"Homodimer (PubMed:25862789). Part of a FANCI-FANCD2 heterodimeric complex that binds and scans dsDNA for DNA damage (PubMed:17412408, PubMed:17460694, PubMed:36385258). Interacts with FANCL (PubMed:21775430). Interacts with MTMR15/FAN1 (PubMed:20603015). Interacts with POLN (PubMed:19995904). Interacts with UBL5; the interaction promotes FANCI homodimerization (PubMed:25862789)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NVI1","intActId":"EBI-1013291"},"interactantTwo":{"uniProtKBAccession":"Q9Y5B0","geneName":"CTDP1","intActId":"EBI-2807555"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NVI1","intActId":"EBI-1013291"},"interactantTwo":{"uniProtKBAccession":"Q9BXW9","geneName":"FANCD2","intActId":"EBI-359343"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. 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