{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NUB4","uniProtkbId":"CT141_HUMAN","entryAudit":{"firstPublicDate":"2003-01-10","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2000-10-01","entryVersion":147,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C20orf141"}}},"genes":[{"geneName":{"value":"C20orf141"}}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9NUB4","intActId":"EBI-9088162"},"interactantTwo":{"uniProtKBAccession":"P02649","geneName":"APOE","intActId":"EBI-1222467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NUB4","intActId":"EBI-9088162"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NUB4","intActId":"EBI-9088162"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9NUB4","intActId":"EBI-9088162"},"interactantTwo":{"uniProtKBAccession":"Q8WXH2","geneName":"JPH3","intActId":"EBI-1055254"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Uncharacterized protein C20orf141","featureId":"PRO_0000079466"},{"type":"Transmembrane","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":155,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"11780052","citationType":"journal article","authors":["Deloukas P.","Matthews L.H.","Ashurst J.L.","Burton J.","Gilbert J.G.R.","Jones M.","Stavrides G.","Almeida J.P.","Babbage A.K.","Bagguley C.L.","Bailey J.","Barlow K.F.","Bates K.N.","Beard L.M.","Beare D.M.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Brown A.J.","Buck D.","Burrill W.D.","Butler A.P.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.","Clark G.","Clark L.N.","Clark S.Y.","Clee C.M.","Clegg S.","Cobley V.E.","Collier R.E.","Connor R.E.","Corby N.R.","Coulson A.","Coville G.J.","Deadman R.","Dhami P.D.","Dunn M.","Ellington A.G.","Frankland J.A.","Fraser A.","French L.","Garner P.","Grafham D.V.","Griffiths C.","Griffiths M.N.D.","Gwilliam R.","Hall R.E.","Hammond S.","Harley J.L.","Heath P.D.","Ho S.","Holden J.L.","Howden P.J.","Huckle E.","Hunt A.R.","Hunt S.E.","Jekosch K.","Johnson C.M.","Johnson D.","Kay M.P.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Lawlor S.","Lehvaeslaiho M.H.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Lovell J.D.","Marsh V.L.","Martin S.L.","McConnachie L.J.","McLay K.","McMurray A.A.","Milne S.A.","Mistry D.","Moore M.J.F.","Mullikin J.C.","Nickerson T.","Oliver K.","Parker A.","Patel R.","Pearce T.A.V.","Peck A.I.","Phillimore B.J.C.T.","Prathalingam S.R.","Plumb R.W.","Ramsay H.","Rice C.M.","Ross M.T.","Scott C.E.","Sehra H.K.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.L.","Soderlund C.","Steward C.A.","Sulston J.E.","Swann R.M.","Sycamore N.","Taylor R.","Tee L.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.C.","Vaudin M.","Wall M.","Wallis J.M.","Whitehead S.L.","Whittaker P.","Willey D.L.","Williams L.","Williams S.A.","Wilming L.","Wray P.W.","Hubbard T.","Durbin R.M.","Bentley D.R.","Beck S.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"11780052"},{"database":"DOI","id":"10.1038/414865a"}],"title":"The DNA sequence and comparative analysis of human chromosome 20.","publicationDate":"2001","journal":"Nature","firstPage":"865","lastPage":"871","volume":"414"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL713708","properties":[{"key":"ProteinId","value":"CAD28505.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL035460","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC014591","properties":[{"key":"ProteinId","value":"AAH14591.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS13034.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001243467.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001256538.2"}]},{"database":"RefSeq","id":"NP_542777.1","properties":[{"key":"NucleotideSequenceId","value":"NM_080739.2"}]},{"database":"AlphaFoldDB","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"126141","properties":[{"key":"Interactions","value":"19"}]},{"database":"FunCoup","id":"Q9NUB4","properties":[{"key":"Number of interactors","value":"3"}]},{"database":"IntAct","id":"Q9NUB4","properties":[{"key":"Interactions","value":"12"}]},{"database":"STRING","id":"9606.ENSP00000369963","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C20orf141","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"27734259","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000369963","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"54290","properties":[{"key":"antibodies","value":"72 antibodies from 13 providers"}]},{"database":"DNASU","id":"128653","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000380589.4","properties":[{"key":"ProteinId","value":"ENSP00000369963.3"},{"key":"GeneId","value":"ENSG00000258713.3"}]},{"database":"Ensembl","id":"ENST00000603872.2","properties":[{"key":"ProteinId","value":"ENSP00000473907.1"},{"key":"GeneId","value":"ENSG00000258713.3"}]},{"database":"GeneID","id":"128653","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:128653","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000603872.2","properties":[{"key":"ProteinId","value":"ENSP00000473907.1"},{"key":"RefSeqNucleotideId","value":"NM_001256538.2"},{"key":"RefSeqProteinId","value":"NP_001243467.1"}]},{"database":"UCSC","id":"uc002wgw.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:16134","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25684","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"128653","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C20orf141","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:16134","properties":[{"key":"GeneName","value":"C20orf141"}]},{"database":"HPA","id":"ENSG00000258713","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (testis)"}]},{"database":"OpenTargets","id":"ENSG00000258713","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000258713","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RU2X","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00910000144368","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_136858_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HTHLTRG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9539340at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9NUB4","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"128653","properties":[{"key":"hits","value":"6 hits in 1115 CRISPR screens"}]},{"database":"GenomeRNAi","id":"128653","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9NUB4","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9NUB4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 20"}]},{"database":"RNAct","id":"Q9NUB4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000258713","properties":[{"key":"ExpressionPatterns","value":"Expressed in left testis and 46 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR040425","properties":[{"key":"EntryName","value":"C20orf141-like"}]},{"database":"PANTHER","id":"PTHR39222","properties":[{"key":"EntryName","value":"MCG9903"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39222:SF1","properties":[{"key":"EntryName","value":"RIKEN CDNA 1700020A23 GENE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17717","properties":[{"key":"EntryName","value":"DUF5562"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTRLCLPRPEAREDPIPVPPRGLGAGEGSGSPVRPPVSTWGPSWAQLLDSVLWLGALGLTIQAVFSTTGPALLLLLVSFLTFDLLHRPAGHTLPQRKLLTRGQSQGAGEGPGQQEALLLQMGTVSGQLSLQDALLLLLMGLGPLLRACGMPLTLLGLAFCLHPWA","length":165,"molWeight":17394,"crc64":"B7F7FF37EEA6B361","md5":"CAA06307EE1D4A8BA3A9525A0F698D53"},"extraAttributes":{"countByCommentType":{"INTERACTION":4,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Region":1},"uniParcId":"UPI0000037B8A"}}