{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9NQB0","secondaryAccessions":["B4DRJ8","B9X074","C6ZRJ8","C6ZRK0","E2GH14","E2GH19","E2GH20","E2GH24","E2GH25","E9PFH9","F8W742","F8W7T5","O00185","Q9NQB1","Q9NQB2","Q9NQB3","Q9NQB4","Q9NQB5","Q9NQB6","Q9NQB7","Q9ULC2"],"uniProtkbId":"TF7L2_HUMAN","entryAudit":{"firstPublicDate":"2003-03-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-25","entryVersion":233,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcription factor 7-like 2"}},"alternativeNames":[{"fullName":{"value":"HMG box transcription factor 4"}},{"fullName":{"value":"T-cell-specific transcription factor 4"},"shortNames":[{"value":"T-cell factor 4"},{"value":"TCF-4"},{"value":"hTCF-4"}]}]},"genes":[{"geneName":{"value":"TCF7L2"},"synonyms":[{"value":"TCF4"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12408868"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19443654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22699938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9727977"}],"value":"Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. 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Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q924A0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10080941"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11266540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12446687"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12556497"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12727872"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16434966"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16714285"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17052462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17873903"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19304756"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19443654"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19816403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21454679"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22155184"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22258766"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22304967"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22699938"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24589551"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28829046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29061846"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29739711"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9065401"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9916915"}],"value":"Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex (PubMed:10080941, PubMed:17052462, PubMed:19816403, PubMed:28829046, PubMed:29739711, PubMed:9065401, PubMed:9916915). Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Interacts with DDIT3/CHOP. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Identified in a complex with CTNNB1 and FERMT2. Interacts with SPIN1 (PubMed:22258766, PubMed:24589551, PubMed:29061846). Interacts with C11orf84/SPINDOC in a SPIN1-dependent manner (PubMed:29061846). Interacts with DAZAP2; the interaction results in localization of DAZAP2 to the nucleus 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