{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9M1I7","uniProtkbId":"NPR6_ARATH","entryAudit":{"firstPublicDate":"2011-05-03","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-10-01","entryVersion":155,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15634206"}],"value":"Regulatory protein NPR6"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15634206"}],"value":"BTB/POZ domain-containing protein NPR6"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12441300"}],"value":"Protein BLADE-ON-PETIOLE 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15634206"}],"value":"NPR6"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12441300"}],"value":"BOP1"}],"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT3G57130"}],"value":"At3g57130"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"CAB72183.1"}],"value":"F24I3.210"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O22286"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12441300"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15564519"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15805484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17601823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18339677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118228"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20610407"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20626659"}],"value":"May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones (AZs) and suppression of bract formation, probably by regulating the cell wall disorganization"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O22286"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15805484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118228"}],"value":"Homodimer or heterodimer with BOP2. Interacts with PAN"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118228"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118228"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9M1I7-1"],"isoformSequenceStatus":"Displayed"}],"note":{"texts":[{"value":"A number of isoforms are produced. According to EST sequences."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15564519"}],"value":"Initially detectable in embryos with a localization to the base of the developing cotyledons near the SAM. Expressed during vegetative development in young leaf primordia and at the base of the rosette leaves on the adaxial side. Expressed during reproductive development in young floral buds, and at the base of the sepals and petals"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15749712"}],"value":"The BTB/POZ domain mediates the interaction with some component of ubiquitin ligase complexes"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15800002"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15805484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17601823"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18339677"}],"value":"Defects in rosette leaf development. bop1 and bop2 double mutant displays leafy petioles, loss of floral organ abscission, and asymmetric flowers subtended by a bract"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NOOT-BOP-COCH-like' (NBCL) subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Regulatory protein NPR6","featureId":"PRO_0000407995"},{"type":"Domain","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"BTB","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00037"}]},{"type":"Repeat","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"ANK 4","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Zinc finger","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"C2HC NPR-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01391"}]},{"type":"Region","location":{"start":{"value":434,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01391"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01391"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01391"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}},{"type":"Binding site","location":{"start":{"value":130,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01391"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105"}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"11130713","citationType":"journal article","authors":["Salanoubat M.","Lemcke K.","Rieger M.","Ansorge W.","Unseld M.","Fartmann B.","Valle G.","Bloecker H.","Perez-Alonso M.","Obermaier B.","Delseny M.","Boutry M.","Grivell L.A.","Mache R.","Puigdomenech P.","De Simone V.","Choisne N.","Artiguenave F.","Robert C.","Brottier P.","Wincker P.","Cattolico L.","Weissenbach J.","Saurin W.","Quetier F.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Benes V.","Wurmbach E.","Drzonek H.","Erfle H.","Jordan N.","Bangert S.","Wiedelmann R.","Kranz H.","Voss H.","Holland R.","Brandt P.","Nyakatura G.","Vezzi A.","D'Angelo M.","Pallavicini A.","Toppo S.","Simionati B.","Conrad A.","Hornischer K.","Kauer G.","Loehnert T.-H.","Nordsiek G.","Reichelt J.","Scharfe M.","Schoen O.","Bargues M.","Terol J.","Climent J.","Navarro P.","Collado C.","Perez-Perez A.","Ottenwaelder B.","Duchemin D.","Cooke R.","Laudie M.","Berger-Llauro C.","Purnelle B.","Masuy D.","de Haan M.","Maarse A.C.","Alcaraz J.-P.","Cottet A.","Casacuberta E.","Monfort A.","Argiriou A.","Flores M.","Liguori R.","Vitale D.","Mannhaupt G.","Haase D.","Schoof H.","Rudd S.","Zaccaria P.","Mewes H.-W.","Mayer K.F.X.","Kaul S.","Town C.D.","Koo H.L.","Tallon L.J.","Jenkins J.","Rooney T.","Rizzo M.","Walts A.","Utterback T.","Fujii C.Y.","Shea T.P.","Creasy T.H.","Haas B.","Maiti R.","Wu D.","Peterson J.","Van Aken S.","Pai G.","Militscher J.","Sellers P.","Gill J.E.","Feldblyum T.V.","Preuss D.","Lin X.","Nierman W.C.","Salzberg S.L.","White O.","Venter J.C.","Fraser C.M.","Kaneko T.","Nakamura Y.","Sato S.","Kato T.","Asamizu E.","Sasamoto S.","Kimura T.","Idesawa K.","Kawashima K.","Kishida Y.","Kiyokawa C.","Kohara M.","Matsumoto M.","Matsuno A.","Muraki A.","Nakayama S.","Nakazaki N.","Shinpo S.","Takeuchi C.","Wada T.","Watanabe A.","Yamada M.","Yasuda M.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"11130713"},{"database":"DOI","id":"10.1038/35048706"}],"title":"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"820","lastPage":"822","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-1799B0LS3140G","citationType":"submission","authors":["Underwood B.A.","Xiao Y.-L.","Moskal W.A. Jr.","Monaghan E.L.","Wang W.","Redman J.C.","Wu H.C.","Utterback T.","Town C.D."],"publicationDate":"MAY-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-BMBMTTFO9L1FD","citationType":"submission","authors":["Quinitio C.","Chen H.","Kim C.J.","Shinn P.","Ecker J.R."],"title":"Arabidopsis ORF Clones.","publicationDate":"AUG-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"CI-3F9411UNT5URU","citationType":"submission","authors":["Fujita M.","Mizukado S.","Seki M.","Shinozaki K.","Mitsuda N.","Takiguchi Y.","Takagi M."],"title":"ORF cloning and analysis of Arabidopsis transcription factor genes.","publicationDate":"MAR-2009","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":7,"citation":{"id":"12441300","citationType":"journal article","authors":["Ha C.M.","Kim G.T.","Kim B.C.","Jun J.H.","Soh M.S.","Ueno Y.","Machida Y.","Tsukaya H.","Nam H.G."],"citationCrossReferences":[{"database":"PubMed","id":"12441300"},{"database":"DOI","id":"10.1242/dev.00196"}],"title":"The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis.","publicationDate":"2003","journal":"Development","firstPage":"161","lastPage":"172","volume":"130"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"15564519","citationType":"journal article","authors":["Ha C.M.","Jun J.H.","Nam H.G.","Fletcher J.C."],"citationCrossReferences":[{"database":"PubMed","id":"15564519"},{"database":"DOI","id":"10.1093/pcp/pch201"}],"title":"BLADE-ON-PETIOLE1 encodes a BTB/POZ domain protein required for leaf morphogenesis in Arabidopsis thaliana.","publicationDate":"2004","journal":"Plant Cell Physiol.","firstPage":"1361","lastPage":"1370","volume":"45"},"referencePositions":["FUNCTION","DEVELOPMENTAL STAGE"]},{"referenceNumber":9,"citation":{"id":"15800002","citationType":"journal article","authors":["Norberg M.","Holmlund M.","Nilsson O."],"citationCrossReferences":[{"database":"PubMed","id":"15800002"},{"database":"DOI","id":"10.1242/dev.01815"}],"title":"The BLADE ON PETIOLE genes act redundantly to control the growth and development of lateral organs.","publicationDate":"2005","journal":"Development","firstPage":"2203","lastPage":"2213","volume":"132"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":10,"citation":{"id":"15749712","citationType":"journal article","authors":["Gingerich D.J.","Gagne J.M.","Salter D.W.","Hellmann H.","Estelle M.","Ma L.","Vierstra R.D."],"citationCrossReferences":[{"database":"PubMed","id":"15749712"},{"database":"DOI","id":"10.1074/jbc.m413247200"}],"title":"Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.","publicationDate":"2005","journal":"J. Biol. Chem.","firstPage":"18810","lastPage":"18821","volume":"280"},"referencePositions":["DOMAIN BTB"]},{"referenceNumber":11,"citation":{"id":"15805484","citationType":"journal article","authors":["Hepworth S.R.","Zhang Y.","McKim S.","Li X.","Haughn G.W."],"citationCrossReferences":[{"database":"PubMed","id":"15805484"},{"database":"DOI","id":"10.1105/tpc.104.030536"}],"title":"BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis.","publicationDate":"2005","journal":"Plant Cell","firstPage":"1434","lastPage":"1448","volume":"17"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","INTERACTION WITH PAN"]},{"referenceNumber":12,"citation":{"id":"15634206","citationType":"journal article","authors":["Liu G.","Holub E.B.","Alonso J.M.","Ecker J.R.","Fobert P.R."],"citationCrossReferences":[{"database":"PubMed","id":"15634206"},{"database":"DOI","id":"10.1111/j.1365-313x.2004.02296.x"}],"title":"An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance.","publicationDate":"2005","journal":"Plant J.","firstPage":"304","lastPage":"318","volume":"41"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]},{"referenceNumber":13,"citation":{"id":"17601823","citationType":"journal article","authors":["Ha C.M.","Jun J.H.","Nam H.G.","Fletcher J.C."],"citationCrossReferences":[{"database":"PubMed","id":"17601823"},{"database":"DOI","id":"10.1105/tpc.107.051938"}],"title":"BLADE-ON-PETIOLE 1 and 2 control Arabidopsis lateral organ fate through regulation of LOB domain and adaxial-abaxial polarity genes.","publicationDate":"2007","journal":"Plant Cell","firstPage":"1809","lastPage":"1825","volume":"19"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":14,"citation":{"id":"18339677","citationType":"journal article","authors":["McKim S.M.","Stenvik G.E.","Butenko M.A.","Kristiansen W.","Cho S.K.","Hepworth S.R.","Aalen R.B.","Haughn G.W."],"citationCrossReferences":[{"database":"PubMed","id":"18339677"},{"database":"DOI","id":"10.1242/dev.012807"}],"title":"The BLADE-ON-PETIOLE genes are essential for abscission zone formation in Arabidopsis.","publicationDate":"2008","journal":"Development","firstPage":"1537","lastPage":"1546","volume":"135"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":15,"citation":{"id":"20610407","citationType":"journal article","authors":["Ha C.M.","Jun J.H.","Fletcher J.C."],"citationCrossReferences":[{"database":"PubMed","id":"20610407"},{"database":"DOI","id":"10.1534/genetics.110.118703"}],"title":"Control of Arabidopsis leaf morphogenesis through regulation of the YABBY and KNOX families of transcription factors.","publicationDate":"2010","journal":"Genetics","firstPage":"197","lastPage":"206","volume":"186"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"20118228","citationType":"journal article","authors":["Jun J.H.","Ha C.M.","Fletcher J.C."],"citationCrossReferences":[{"database":"PubMed","id":"20118228"},{"database":"DOI","id":"10.1105/tpc.109.070763"}],"title":"BLADE-ON-PETIOLE1 coordinates organ determinacy and axial polarity in arabidopsis by directly activating ASYMMETRIC LEAVES2.","publicationDate":"2010","journal":"Plant Cell","firstPage":"62","lastPage":"76","volume":"22"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","SUBUNIT"]},{"referenceNumber":17,"citation":{"id":"20626659","citationType":"journal article","authors":["Xu M.","Hu T.","McKim S.M.","Murmu J.","Haughn G.W.","Hepworth S.R."],"citationCrossReferences":[{"database":"PubMed","id":"20626659"},{"database":"DOI","id":"10.1111/j.1365-313x.2010.04299.x"}],"title":"Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24.","publicationDate":"2010","journal":"Plant J.","firstPage":"974","lastPage":"989","volume":"63"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL138655","properties":[{"key":"ProteinId","value":"CAB72183.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE79617.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7044769.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"DQ056629","properties":[{"key":"ProteinId","value":"AAY78777.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT026363","properties":[{"key":"ProteinId","value":"ABH04470.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB493655","properties":[{"key":"ProteinId","value":"BAH30493.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"T47773","properties":[{"key":"EntryName","value":"T47773"}]},{"database":"RefSeq","id":"NP_191272.1","properties":[{"key":"NucleotideSequenceId","value":"NM_115572.2"}],"isoformId":"Q9M1I7-1"},{"database":"AlphaFoldDB","id":"Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"10196","properties":[{"key":"Interactions","value":"3"}]},{"database":"FunCoup","id":"Q9M1I7","properties":[{"key":"Number of interactors","value":"296"}]},{"database":"STRING","id":"3702.Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"250545","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9M1I7-1"},{"database":"GeneID","id":"824880","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G57130","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT3G57130","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT3G57130","properties":[{"key":"GeneName","value":"BOP1"}]},{"database":"eggNOG","id":"KOG0504","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_028148_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RMKDEHT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"45365at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:Q9M1I7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"ExpressionAtlas","id":"Q9M1I7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20118228"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20118228"}]},{"database":"GO","id":"GO:0010434","properties":[{"key":"GoTerm","value":"P:bract formation"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15800002"}]},{"database":"GO","id":"GO:0010582","properties":[{"key":"GoTerm","value":"P:floral meristem determinacy"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"20626659"}]},{"database":"GO","id":"GO:0010227","properties":[{"key":"GoTerm","value":"P:floral organ abscission"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15800002"}]},{"database":"GO","id":"GO:0048439","properties":[{"key":"GoTerm","value":"P:flower morphogenesis"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15805484"}]},{"database":"GO","id":"GO:0009864","properties":[{"key":"GoTerm","value":"P:induced systemic resistance, jasmonic acid mediated signaling pathway"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"23116333"}]},{"database":"GO","id":"GO:0009965","properties":[{"key":"GoTerm","value":"P:leaf morphogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15564519"}]},{"database":"GO","id":"GO:0010022","properties":[{"key":"GoTerm","value":"P:meristem determinacy"},{"key":"GoEvidenceType","value":"IMP:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12441300"}]},{"database":"GO","id":"GO:0010254","properties":[{"key":"GoTerm","value":"P:nectary development"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"18339677"}]},{"database":"GO","id":"GO:0009944","properties":[{"key":"GoTerm","value":"P:polarity specification of adaxial/abaxial axis"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17601823"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0009954","properties":[{"key":"GoTerm","value":"P:proximal/distal pattern formation"},{"key":"GoEvidenceType","value":"IGI:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"15805484"}]},{"database":"CDD","id":"cd18310","properties":[{"key":"EntryName","value":"BTB_POZ_NPR_plant"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.710.10:FF:000084","properties":[{"key":"EntryName","value":"regulatory protein NPR5 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000058","properties":[{"key":"EntryName","value":"regulatory protein NPR5 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.710.10","properties":[{"key":"EntryName","value":"Potassium Channel Kv1.1, Chain A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR000210","properties":[{"key":"EntryName","value":"BTB/POZ_dom"}]},{"database":"InterPro","id":"IPR044284","properties":[{"key":"EntryName","value":"NPR5/6"}]},{"database":"InterPro","id":"IPR024228","properties":[{"key":"EntryName","value":"NPR_central_dom"}]},{"database":"InterPro","id":"IPR011333","properties":[{"key":"EntryName","value":"SKP1/BTB/POZ_sf"}]},{"database":"InterPro","id":"IPR057250","properties":[{"key":"EntryName","value":"Znf_C2HC_NPR-type"}]},{"database":"PANTHER","id":"PTHR46668","properties":[{"key":"EntryName","value":"BTB/POZ DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN NH5.2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46668:SF5","properties":[{"key":"EntryName","value":"REGULATORY PROTEIN NPR6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00651","properties":[{"key":"EntryName","value":"BTB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11900","properties":[{"key":"EntryName","value":"DUF3420"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00225","properties":[{"key":"EntryName","value":"BTB"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54695","properties":[{"key":"EntryName","value":"POZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50097","properties":[{"key":"EntryName","value":"BTB"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS52046","properties":[{"key":"EntryName","value":"ZF_C2HC_NPR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSNTFEESLKSMSLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCESDPSQPGAEPANQTGSGARAAAVGGVIPVNSVGYEVFLLLLQFLYSGQVSIVPHKHEPRSNCGDRGCWHTHCTAAVDLSLDILAAARYFGVEQLALLTQKHLTSMVEKASIEDVMKVLIASRKQDMHQLWTTCSYLIAKSGLPQEILAKHLPIELVAKIEELRLKSSMPLRSLMPHHHDLTSTLDLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDESLALIYAVENCSREVVKALLELGAADVNYPAGPTGKTALHIAAEMVSPDMVAVLLDHHADPNVQTVDGITPLDILRTLTSDFLFKGAIPGLTHIEPNKLRLCLELVQSAALVISREEGNNNSNDNNTMIYPRMKDEHTSGSSLDSRLVYLNLGATNRDIGDDNSNQREGMNLHHHHHDPSTMYHHHHHHF","length":467,"molWeight":51785,"crc64":"1A063A205DF86A62","md5":"EEEF4D0BFEF974067AC567D6750F99AD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Repeat":4,"Zinc finger":1,"Region":1,"Compositional bias":1,"Binding site":4},"uniParcId":"UPI00000A5C2D"}}