{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9LUQ3","secondaryAccessions":["Q9M7X0"],"uniProtkbId":"SDE5_ARATH","entryAudit":{"firstPublicDate":"2015-10-14","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-10-01","entryVersion":125,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Putative nuclear RNA export factor SDE5"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17397509"}],"value":"Protein SILENCING DEFECTIVE 5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17397509"}],"value":"SDE5"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT3G15390"}],"value":"At3g15390"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAF35405.1"}],"value":"MJK13.5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17397509"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20798330"}],"value":"Involved in sense transgene post-transcriptional gene silencing (S-PTGS). Not involved in repeat-induced transgene silencing (IR-PTGS). Essential component of the trans-acting short interfering RNA (tasiRNA) pathway. Required for the production of tasiRNAs (PubMed:17397509, PubMed:20798330). Acts together with RDR6 in generating double-stranded RNA from specific single-stranded RNAs. May be involved in the transport of RNA molecules that are converted into a double-stranded form by RDR6. Involved in virus-induced silencing. Not involved in the biogenesis of microRNAs and 24 nt siRNAs produced by DCL3 (PubMed:17397509)"}],"commentType":"FUNCTION"},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9LUQ3-1"],"isoformSequenceStatus":"Displayed"}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"A number of isoforms are produced. According to EST data."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17397509"}],"value":"Elongated and curled downward leaves. Upon infection, over-accumulation of cucumber mosaic virus (CMV) RNA and enhanced susceptibility to CMV"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAF35405.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"Putative nuclear RNA export factor SDE5","featureId":"PRO_0000434564"}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0611","category":"Biological process","name":"Plant defense"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"}],"references":[{"referenceNumber":1,"citation":{"id":"10819329","citationType":"journal article","authors":["Sato S.","Nakamura Y.","Kaneko T.","Katoh T.","Asamizu E.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10819329"},{"database":"DOI","id":"10.1093/dnares/7.2.131"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"131","lastPage":"135","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"11130713","citationType":"journal article","authors":["Salanoubat M.","Lemcke K.","Rieger M.","Ansorge W.","Unseld M.","Fartmann B.","Valle G.","Bloecker H.","Perez-Alonso M.","Obermaier B.","Delseny M.","Boutry M.","Grivell L.A.","Mache R.","Puigdomenech P.","De Simone V.","Choisne N.","Artiguenave F.","Robert C.","Brottier P.","Wincker P.","Cattolico L.","Weissenbach J.","Saurin W.","Quetier F.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Benes V.","Wurmbach E.","Drzonek H.","Erfle H.","Jordan N.","Bangert S.","Wiedelmann R.","Kranz H.","Voss H.","Holland R.","Brandt P.","Nyakatura G.","Vezzi A.","D'Angelo M.","Pallavicini A.","Toppo S.","Simionati B.","Conrad A.","Hornischer K.","Kauer G.","Loehnert T.-H.","Nordsiek G.","Reichelt J.","Scharfe M.","Schoen O.","Bargues M.","Terol J.","Climent J.","Navarro P.","Collado C.","Perez-Perez A.","Ottenwaelder B.","Duchemin D.","Cooke R.","Laudie M.","Berger-Llauro C.","Purnelle B.","Masuy D.","de Haan M.","Maarse A.C.","Alcaraz J.-P.","Cottet A.","Casacuberta E.","Monfort A.","Argiriou A.","Flores M.","Liguori R.","Vitale D.","Mannhaupt G.","Haase D.","Schoof H.","Rudd S.","Zaccaria P.","Mewes H.-W.","Mayer K.F.X.","Kaul S.","Town C.D.","Koo H.L.","Tallon L.J.","Jenkins J.","Rooney T.","Rizzo M.","Walts A.","Utterback T.","Fujii C.Y.","Shea T.P.","Creasy T.H.","Haas B.","Maiti R.","Wu D.","Peterson J.","Van Aken S.","Pai G.","Militscher J.","Sellers P.","Gill J.E.","Feldblyum T.V.","Preuss D.","Lin X.","Nierman W.C.","Salzberg S.L.","White O.","Venter J.C.","Fraser C.M.","Kaneko T.","Nakamura Y.","Sato S.","Kato T.","Asamizu E.","Sasamoto S.","Kimura T.","Idesawa K.","Kawashima K.","Kishida Y.","Kiyokawa C.","Kohara M.","Matsumoto M.","Matsuno A.","Muraki A.","Nakayama S.","Nakazaki N.","Shinpo S.","Takeuchi C.","Wada T.","Watanabe A.","Yamada M.","Yasuda M.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"11130713"},{"database":"DOI","id":"10.1038/35048706"}],"title":"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"820","lastPage":"822","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"17397509","citationType":"journal article","authors":["Hernandez-Pinzon I.","Yelina N.E.","Schwach F.","Studholme D.J.","Baulcombe D.","Dalmay T."],"citationCrossReferences":[{"database":"PubMed","id":"17397509"},{"database":"DOI","id":"10.1111/j.1365-313x.2007.03043.x"}],"title":"SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA.","publicationDate":"2007","journal":"Plant J.","firstPage":"140","lastPage":"148","volume":"50"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":6,"citation":{"id":"20798330","citationType":"journal article","authors":["Jauvion V.","Elmayan T.","Vaucheret H."],"citationCrossReferences":[{"database":"PubMed","id":"20798330"},{"database":"DOI","id":"10.1105/tpc.110.076638"}],"title":"The conserved RNA trafficking proteins HPR1 and TEX1 are involved in the production of endogenous and exogenous small interfering RNA in Arabidopsis.","publicationDate":"2010","journal":"Plant Cell","firstPage":"2697","lastPage":"2709","volume":"22"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB022218","properties":[{"key":"ProteinId","value":"BAB02368.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC024081","properties":[{"key":"ProteinId","value":"AAF35405.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE75662.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7041023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"NP_188158.4","properties":[{"key":"NucleotideSequenceId","value":"NM_112407.5"}],"isoformId":"Q9LUQ3-1"},{"database":"AlphaFoldDB","id":"Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9LUQ3","properties":[{"key":"Number of interactors","value":"353"}]},{"database":"STRING","id":"3702.Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"232889","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9LUQ3-1"},{"database":"GeneID","id":"820778","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G15390","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT3G15390","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT3G15390","properties":[{"key":"GeneName","value":"SDE5"}]},{"database":"eggNOG","id":"KOG2401","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_024477_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ITMKEYY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9LUQ3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"ExpressionAtlas","id":"Q9LUQ3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0036464","properties":[{"key":"GoTerm","value":"C:cytoplasmic ribonucleoprotein granule"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36640363"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"25293756"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0010267","properties":[{"key":"GoTerm","value":"P:ta-siRNA processing"},{"key":"GoEvidenceType","value":"TAS:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"17397509"}]},{"database":"InterPro","id":"IPR060512","properties":[{"key":"EntryName","value":"At5g58720/SDE5-like_middle"}]},{"database":"InterPro","id":"IPR056254","properties":[{"key":"EntryName","value":"At5g58720/SDE5-like_UBA-like"}]},{"database":"InterPro","id":"IPR013899","properties":[{"key":"EntryName","value":"DUF1771"}]},{"database":"PANTHER","id":"PTHR47872","properties":[{"key":"EntryName","value":"NUCLEAR RNA EXPORT FACTOR SDE5-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47872:SF1","properties":[{"key":"EntryName","value":"NUCLEAR RNA EXPORT FACTOR SDE5-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08590","properties":[{"key":"EntryName","value":"DUF1771"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24767","properties":[{"key":"EntryName","value":"UBA_At5g58720"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF28508","properties":[{"key":"EntryName","value":"UBA_SDE5"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01162","properties":[{"key":"EntryName","value":"DUF1771"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKIASSSNSDPDSRSLQVLLDTFGSRFSLDDIAAAYCQASQNVDVAGEILSAMAEKTPQCDQVEMKTATSKPTQVYVPKEVPRQEDSKAKVWRPKRNSISNGTVSSVIGKEYARTRPISNAPKEATKPLKINSRDIPETEIWSEEMRKSNEGKISRAPTDVEEFIVKMLGEGFQASQEVIHQVLGVCGYDVKKSTEKLLDFSDTKKYADVGISNEVMSKVDPQRQSTSCNQMELQKISQSVGARTFTGSQEGRNAKNGLEKEVLEALFSGAERYVDKPKVTRHFGERRPGVAGRPVFKPLEDPFQERVVAVKQSSNTSKEDDDENEFKAHRKAVREHLNQMKEYYGAAAEAFSKGETERAHRLVEKGHFFGQKAREADDKSVAKMIDVNQEDDSTYEEDEVVTVNMNEHEAKEALRLLKRQLIYFSGISSFKYLRVQLGEKKEDFKSKRKHIVKLLEGESIPWTEEDGGLVIMIRVDEIDPKKLSFAKK","length":490,"molWeight":55162,"crc64":"942CFB3FB27712DD","md5":"391FA287BEFB634F52D57ADEC8F74FA9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ALTERNATIVE PRODUCTS":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI00000A3882"}}