{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9LJU6","uniProtkbId":"FAX6_ARATH","entryAudit":{"firstPublicDate":"2015-04-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2000-10-01","entryVersion":139,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000006548"}],"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25646734"}],"value":"Protein FATTY ACID EXPORT 6"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25646734"}],"value":"At-FAX6"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25646734"}],"value":"FAX6"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT3G20510"}],"value":"At3g20510"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAB01160.1"}],"value":"K10D20.5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q93V66"}],"value":"May be involved in free fatty acids export"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"25646734"}],"value":"For all TMEM14 proteins, 4 hydrophobic alpha-helical domains are predicted. However, NMR structure determination of the human TMEM14A showed that only 3 of these helices are membrane-spaning while the amphiphilic N-terminal helix is probably located at the lipid micelle-water interface"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM14 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Protein FATTY ACID EXPORT 6","featureId":"PRO_0000432806"},{"type":"Transmembrane","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10907853","citationType":"journal article","authors":["Kaneko T.","Katoh T.","Sato S.","Nakamura Y.","Asamizu E.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10907853"},{"database":"DOI","id":"10.1093/dnares/7.3.217"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"217","lastPage":"221","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-43D7862RKG1IA","citationType":"submission","authors":["Totoki Y.","Seki M.","Ishida J.","Nakajima M.","Enju A.","Kamiya A.","Narusaka M.","Shin-i T.","Nakagawa M.","Sakamoto N.","Oishi K.","Kohara Y.","Kobayashi M.","Toyoda A.","Sakaki Y.","Sakurai T.","Iida K.","Akiyama K.","Satou M.","Toyoda T.","Konagaya A.","Carninci P.","Kawai J.","Hayashizaki Y.","Shinozaki K."],"title":"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.","publicationDate":"SEP-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":6,"citation":{"id":"25646734","citationType":"journal article","authors":["Li N.","Guegel I.L.","Giavalisco P.","Zeisler V.","Schreiber L.","Soll J.","Philippar K."],"citationCrossReferences":[{"database":"PubMed","id":"25646734"},{"database":"DOI","id":"10.1371/journal.pbio.1002053"}],"title":"FAX1, a novel membrane protein mediating plastid fatty acid export.","publicationDate":"2015","journal":"PLoS Biol.","firstPage":"E1002053","lastPage":"E1002053","volume":"13"},"referencePositions":["GENE FAMILY","NOMENCLATURE","3D-STRUCTURE MODELING"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AP000410","properties":[{"key":"ProteinId","value":"BAB01160.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE76389.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7041687.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT010505","properties":[{"key":"ProteinId","value":"AAQ65128.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK176567","properties":[{"key":"ProteinId","value":"BAD44330.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK176851","properties":[{"key":"ProteinId","value":"BAD44614.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_188687.1","properties":[{"key":"NucleotideSequenceId","value":"NM_112943.5"}]},{"database":"AlphaFoldDB","id":"Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9LJU6","properties":[{"key":"Number of interactors","value":"1879"}]},{"database":"IntAct","id":"Q9LJU6","properties":[{"key":"Interactions","value":"9"}]},{"database":"STRING","id":"3702.Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"231011","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"821597","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G20510","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT3G20510","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT3G20510","properties":[{"key":"GeneName","value":"FAX6"}]},{"database":"eggNOG","id":"KOG4267","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_096652_5_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GRINECM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5620at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9LJU6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"ExpressionAtlas","id":"Q9LJU6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"15610358"}]},{"database":"GO","id":"GO:0012505","properties":[{"key":"GoTerm","value":"C:endomembrane system"},{"key":"GoEvidenceType","value":"TAS:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"25646734"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"15610358"}]},{"database":"FunFam","id":"1.10.10.1740:FF:000005","properties":[{"key":"EntryName","value":"BnaCnng46150D protein"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.1740","properties":[{"key":"EntryName","value":"Transmembrane protein 14-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005349","properties":[{"key":"EntryName","value":"TMEM14"}]},{"database":"InterPro","id":"IPR044890","properties":[{"key":"EntryName","value":"TMEM14_sf"}]},{"database":"PANTHER","id":"PTHR12668:SF5","properties":[{"key":"EntryName","value":"PROTEIN FATTY ACID EXPORT 5-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12668","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 14, 15"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03647","properties":[{"key":"EntryName","value":"Tmemb_14"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MHDFCFTIPYGMLLIGGGFIGYMKKGSITSFAGGAGTGLLLILAGYISLKAFEKKKNSTIAMVLQTVIAAALTLVMGQRYLLTGKIMPAGLVAGISALMTCFYVYKIATGGNKFPAKAE","length":119,"molWeight":12511,"crc64":"68B1F641BC424EAC","md5":"2D0FA314B193C6376F1B9F9986AD530F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":3},"uniParcId":"UPI00000AB2FF"}}