{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9JLV2","secondaryAccessions":["Q920J6","Q99L03"],"uniProtkbId":"TP4AP_MOUSE","entryAudit":{"firstPublicDate":"2002-11-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-11-15","entryVersion":165,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Short transient receptor potential channel 4-associated protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Trp4-associated protein"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Trpc4-associated protein"}]},"alternativeNames":[{"fullName":{"value":"Protein TAP1"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"Rabex-5/Rin2-interacting protein"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14585990"}],"value":"TNF-receptor ubiquitous scaffolding/signaling protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14585990"}],"value":"Protein TRUSS"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1930751"}],"value":"Trpc4ap"},"synonyms":[{"value":"Trrp4ap"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16876162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20458742"}],"value":"Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. 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Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (PubMed:20458742)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585990"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16876162"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20458742"}],"value":"Component of the DCX(TRPC4AP) E3 ubiquitin ligase complex, at least composed of CUL4A, DDB1, TRPC4AP/TRUSS and RBX1 (By similarity). Interacts with MYC (By similarity). Constitutively associated with TNFRSF1A (PubMed:14585990). Directly interacts with TRADD, TRAF2, CHUK, IKBKB and IKBKG (PubMed:14585990, PubMed:16876162). Interacts with TRPC1, TRPC4 and TRPC5 (PubMed:20458742)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9JLV2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9JLV2-2"],"sequenceIds":["VSP_003983"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585990"}],"value":"Widely expressed, with high levels in heart, liver and testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Phosphorylated by GSK3B; phosphorylation is required for ubiquitination"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEL6"}],"value":"Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation. 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