{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9HCQ7","secondaryAccessions":["A4D164","Q7LE27","Q96PI9"],"uniProtkbId":"NPVF_HUMAN","entryAudit":{"firstPublicDate":"2002-10-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-02-23","entryVersion":153,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Pro-FMRFamide-related neuropeptide VF"}},"contains":[{"recommendedName":{"fullName":{"value":"Neuropeptide NPSF"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11025660"}],"value":"Neuropeptide RFRP-1"}}},{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11025660"}],"value":"Neuropeptide RFRP-2"}}},{"recommendedName":{"fullName":{"value":"Neuropeptide NPVF"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11025660"}],"value":"Neuropeptide RFRP-3"}}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:13782"}],"value":"NPVF"},"synonyms":[{"value":"C7orf9"},{"value":"RFRP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9ESQ9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}],"value":"Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed:11025660, PubMed:20027225). Induces secretion of prolactin (By similarity)"}],"commentType":"FUNCTION","molecule":"Neuropeptide RFRP-1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}],"value":"Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia"}],"commentType":"FUNCTION","molecule":"Neuropeptide NPVF"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"}],"value":"Shows no inhibitory activity of forskolin-induced production of cAMP"}],"commentType":"FUNCTION","molecule":"Neuropeptide RFRP-2"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9HCQ7","intActId":"EBI-1753111"},"interactantTwo":{"uniProtKBAccession":"O43765","geneName":"SGTA","intActId":"EBI-347996"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9HCQ7","intActId":"EBI-1753111"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11025660"}],"value":"Secreted","id":"SL-0243"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9HCQ7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9HCQ7-2"],"sequenceIds":["VSP_039962"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11951088"}],"value":"Specifically expressed in the retina"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}],"value":"Detected in the hypothalamus"}],"commentType":"TISSUE SPECIFICITY","molecule":"Neuropeptide RFRP-1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}],"value":"Detected in the hypothalamus"}],"commentType":"TISSUE SPECIFICITY","molecule":"Neuropeptide NPVF"},{"commentType":"MASS SPECTROMETRY","molecule":"Neuropeptide RFRP-1","method":"MALDI","molWeight":1428.85,"molWeightError":0.0,"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}]},{"commentType":"MASS SPECTROMETRY","molecule":"Neuropeptide NPVF","method":"MALDI","molWeight":969.56,"molWeightError":0.0,"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FARP (FMRFamide related peptide) family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Propeptide","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000009920"},{"type":"Peptide","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Neuropeptide NPSF","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000009921"},{"type":"Peptide","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Neuropeptide RFRP-1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"}],"featureId":"PRO_0000401171"},{"type":"Propeptide","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000009922"},{"type":"Peptide","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"Neuropeptide RFRP-2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"}],"featureId":"PRO_0000009923"},{"type":"Propeptide","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000009924"},{"type":"Peptide","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Neuropeptide NPVF","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11025660"}],"featureId":"PRO_0000009925"},{"type":"Propeptide","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","featureId":"PRO_0000009926"},{"type":"Modified residue","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":92,"modifier":"EXACT"}},"description":"Phenylalanine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}]},{"type":"Modified residue","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Phenylalanine amide","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20027225"}]},{"type":"Alternative sequence","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11481330"}],"featureId":"VSP_039962","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"in dbSNP:rs886354","featureCrossReferences":[{"database":"dbSNP","id":"rs886354"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12853948"}],"featureId":"VAR_014073","alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in dbSNP:rs877834","featureCrossReferences":[{"database":"dbSNP","id":"rs877834"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11951088"}],"featureId":"VAR_014074","alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"}},"description":"in dbSNP:rs3213641","featureCrossReferences":[{"database":"dbSNP","id":"rs3213641"}],"featureId":"VAR_030644","alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0027","category":"PTM","name":"Amidation"},{"id":"KW-0165","category":"PTM","name":"Cleavage on pair of basic residues"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0527","category":"Molecular function","name":"Neuropeptide"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"11025660","citationType":"journal article","authors":["Hinuma S.","Shintani Y.","Fukusumi S.","Iijima N.","Matsumoto Y.","Hosoya M.","Fujii R.","Watanabe T.","Kikuchi K.","Terao Y.","Yano T.","Yamamoto T.","Kawamata Y.","Habata Y.","Asada M.","Kitada C.","Kurokawa T.","Onda H.","Nishimura O.","Tanaka M.","Ibata Y.","Fujino M."],"citationCrossReferences":[{"database":"PubMed","id":"11025660"},{"database":"DOI","id":"10.1038/35036326"}],"title":"New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.","publicationDate":"2000","journal":"Nat. Cell Biol.","firstPage":"703","lastPage":"708","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","SYNTHESIS OF RFRP-1; RFRP-2 AND NPVF","FUNCTION"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"11481330","citationType":"journal article","authors":["Liu Q.","Guan X.-M.","Martin W.J.","McDonald T.P.","Clements M.K.","Jiang Q.","Zeng Z.","Jacobson M.","Williams D.L. Jr.","Yu H.","Bomford D.","Figueroa D.","Mallee J.","Wang R.","Evans J.","Gould R.","Austin C.P."],"citationCrossReferences":[{"database":"PubMed","id":"11481330"},{"database":"DOI","id":"10.1074/jbc.m105308200"}],"title":"Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"36961","lastPage":"36969","volume":"276"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"]},{"referenceNumber":3,"citation":{"id":"11951088","citationType":"journal article","authors":["Schulz H.L.","Stoehr H.","White K.","van Driel M.A.","Hoyng C.B.","Cremers F.","Weber B.H.F."],"citationCrossReferences":[{"database":"PubMed","id":"11951088"}],"title":"Genomic structure and assessment of the retinally expressed RFamide-related peptide gene in dominant cystoid macular dystrophy.","publicationDate":"2002","journal":"Mol. Vis.","firstPage":"67","lastPage":"71","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)","TISSUE SPECIFICITY","VARIANT GLY-42"],"referenceComments":[{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"12853948","citationType":"journal article","authors":["Hillier L.W.","Fulton R.S.","Fulton L.A.","Graves T.A.","Pepin K.H.","Wagner-McPherson C.","Layman D.","Maas J.","Jaeger S.","Walker R.","Wylie K.","Sekhon M.","Becker M.C.","O'Laughlin M.D.","Schaller M.E.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Cordes M.","Du H.","Sun H.","Edwards J.","Bradshaw-Cordum H.","Ali J.","Andrews S.","Isak A.","Vanbrunt A.","Nguyen C.","Du F.","Lamar B.","Courtney L.","Kalicki J.","Ozersky P.","Bielicki L.","Scott K.","Holmes A.","Harkins R.","Harris A.","Strong C.M.","Hou S.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Leonard S.","Rohlfing T.","Rock S.M.","Tin-Wollam A.-M.","Abbott A.","Minx P.","Maupin R.","Strowmatt C.","Latreille P.","Miller N.","Johnson D.","Murray J.","Woessner J.P.","Wendl M.C.","Yang S.-P.","Schultz B.R.","Wallis J.W.","Spieth J.","Bieri T.A.","Nelson J.O.","Berkowicz N.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Bedell J.A.","Mardis E.R.","Clifton S.W.","Chissoe S.L.","Marra M.A.","Raymond C.","Haugen E.","Gillett W.","Zhou Y.","James R.","Phelps K.","Iadanoto S.","Bubb K.","Simms E.","Levy R.","Clendenning J.","Kaul R.","Kent W.J.","Furey T.S.","Baertsch R.A.","Brent M.R.","Keibler E.","Flicek P.","Bork P.","Suyama M.","Bailey J.A.","Portnoy M.E.","Torrents D.","Chinwalla A.T.","Gish W.R.","Eddy S.R.","McPherson J.D.","Olson M.V.","Eichler E.E.","Green E.D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"12853948"},{"database":"DOI","id":"10.1038/nature01782"}],"title":"The DNA sequence of human chromosome 7.","publicationDate":"2003","journal":"Nature","firstPage":"157","lastPage":"164","volume":"424"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT ILE-32"]},{"referenceNumber":5,"citation":{"id":"12690205","citationType":"journal article","authors":["Scherer S.W.","Cheung J.","MacDonald J.R.","Osborne L.R.","Nakabayashi K.","Herbrick J.-A.","Carson A.R.","Parker-Katiraee L.","Skaug J.","Khaja R.","Zhang J.","Hudek A.K.","Li M.","Haddad M.","Duggan G.E.","Fernandez B.A.","Kanematsu E.","Gentles S.","Christopoulos C.C.","Choufani S.","Kwasnicka D.","Zheng X.H.","Lai Z.","Nusskern D.R.","Zhang Q.","Gu Z.","Lu F.","Zeesman S.","Nowaczyk M.J.","Teshima I.","Chitayat D.","Shuman C.","Weksberg R.","Zackai E.H.","Grebe T.A.","Cox S.R.","Kirkpatrick S.J.","Rahman N.","Friedman J.M.","Heng H.H.Q.","Pelicci P.G.","Lo-Coco F.","Belloni E.","Shaffer L.G.","Pober B.","Morton C.C.","Gusella J.F.","Bruns G.A.P.","Korf B.R.","Quade B.J.","Ligon A.H.","Ferguson H.","Higgins A.W.","Leach N.T.","Herrick S.R.","Lemyre E.","Farra C.G.","Kim H.-G.","Summers A.M.","Gripp K.W.","Roberts W.","Szatmari P.","Winsor E.J.T.","Grzeschik K.-H.","Teebi A.","Minassian B.A.","Kere J.","Armengol L.","Pujana M.A.","Estivill X.","Wilson M.D.","Koop B.F.","Tosi S.","Moore G.E.","Boright A.P.","Zlotorynski E.","Kerem B.","Kroisel P.M.","Petek E.","Oscier D.G.","Mould S.J.","Doehner H.","Doehner K.","Rommens J.M.","Vincent J.B.","Venter J.C.","Li P.W.","Mural R.J.","Adams M.D.","Tsui L.-C."],"citationCrossReferences":[{"database":"PubMed","id":"12690205"},{"database":"DOI","id":"10.1126/science.1083423"}],"title":"Human chromosome 7: DNA sequence and biology.","publicationDate":"2003","journal":"Science","firstPage":"767","lastPage":"772","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"20027225","citationType":"journal article","authors":["Ubuka T.","Morgan K.","Pawson A.J.","Osugi T.","Chowdhury V.S.","Minakata H.","Tsutsui K.","Millar R.P.","Bentley G.E."],"citationCrossReferences":[{"database":"PubMed","id":"20027225"},{"database":"DOI","id":"10.1371/journal.pone.0008400"}],"title":"Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.","publicationDate":"2009","journal":"PLoS ONE","firstPage":"E8400","lastPage":"E8400","volume":"4"},"referencePositions":["PROTEIN SEQUENCE OF 81-92 AND 124-131","AMIDATION AT PHE-92 AND PHE-131","FUNCTION","TISSUE SPECIFICITY","MASS SPECTROMETRY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB040290","properties":[{"key":"ProteinId","value":"BAB17674.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF330057","properties":[{"key":"ProteinId","value":"AAK94201.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF440392","properties":[{"key":"ProteinId","value":"AAL90453.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF440395","properties":[{"key":"ProteinId","value":"AAL90458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF440393","properties":[{"key":"ProteinId","value":"AAL90458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF440394","properties":[{"key":"ProteinId","value":"AAL90458.1"},{"key":"Status","value":"JOINED"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC004129","properties":[{"key":"ProteinId","value":"AAP22339.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH236948","properties":[{"key":"ProteinId","value":"EAL24237.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471073","properties":[{"key":"ProteinId","value":"EAW93830.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS5395.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HCQ7-1"},{"database":"RefSeq","id":"NP_071433.3","properties":[{"key":"NucleotideSequenceId","value":"NM_022150.3"}],"isoformId":"Q9HCQ7-1"},{"database":"AlphaFoldDB","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122068","properties":[{"key":"Interactions","value":"17"}]},{"database":"FunCoup","id":"Q9HCQ7","properties":[{"key":"Number of interactors","value":"366"}]},{"database":"IntAct","id":"Q9HCQ7","properties":[{"key":"Interactions","value":"6"}]},{"database":"NDEx","id":"IQUERY-CP-NPVF","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000222674","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NPVF","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"311033508","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000222674","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"81787","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HCQ7-1"},{"database":"ProteomicsDB","id":"81788","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9HCQ7-2"},{"database":"Antibodypedia","id":"50012","properties":[{"key":"antibodies","value":"26 antibodies from 9 providers"}]},{"database":"DNASU","id":"64111","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000222674.2","properties":[{"key":"ProteinId","value":"ENSP00000222674.2"},{"key":"GeneId","value":"ENSG00000105954.2"}],"isoformId":"Q9HCQ7-1"},{"database":"GeneID","id":"64111","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:64111","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000222674.2","properties":[{"key":"ProteinId","value":"ENSP00000222674.2"},{"key":"RefSeqNucleotideId","value":"NM_022150.3"},{"key":"RefSeqProteinId","value":"NP_071433.3"}]},{"database":"UCSC","id":"uc003sxo.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9HCQ7-1"},{"database":"AGR","id":"HGNC:13782","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162398161","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"64111","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"64111","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NPVF","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:13782","properties":[{"key":"GeneName","value":"NPVF"}]},{"database":"HPA","id":"ENSG00000105954","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (retina)"}]},{"database":"MIM","id":"616984","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000105954","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000105954","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S5H9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000003271","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_120051_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KMPHSVA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8834619at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9HCQ7","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000105954","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"64111","properties":[{"key":"hits","value":"14 hits in 1129 CRISPR screens"}]},{"database":"GenomeRNAi","id":"64111","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9HCQ7","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9HCQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q9HCQ7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000105954","properties":[{"key":"ExpressionPatterns","value":"Expressed in hypothalamus and 11 other cell types or tissues"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11025660"}]},{"database":"GO","id":"GO:0160041","properties":[{"key":"GoTerm","value":"F:neuropeptide activity"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"11025660"}]},{"database":"GO","id":"GO:0005102","properties":[{"key":"GoTerm","value":"F:signaling receptor binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032277","properties":[{"key":"GoTerm","value":"P:negative regulation of gonadotropin secretion"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20027225"}]},{"database":"GO","id":"GO:0007218","properties":[{"key":"GoTerm","value":"P:neuropeptide signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR026297","properties":[{"key":"EntryName","value":"FMRFamide-related/fGRP"}]},{"database":"PANTHER","id":"PTHR14403:SF6","properties":[{"key":"EntryName","value":"PRO-FMRFAMIDE-RELATED NEUROPEPTIDE VF"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14403","properties":[{"key":"EntryName","value":"RFAMIDE PEPTIDE GONADOTROPIN INHIBITORY HORMONE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSLVRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSRRLLFKKIDDAELKQEK","length":196,"molWeight":22327,"crc64":"332248B927702198","md5":"8EF32DC9E5E2BC70B67562B3FE2D5B2A"},"extraAttributes":{"countByCommentType":{"FUNCTION":3,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":3,"MASS SPECTROMETRY":2,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Propeptide":4,"Peptide":4,"Modified residue":2,"Alternative sequence":1,"Natural variant":3},"uniParcId":"UPI000013380C"}}