ID MUC5B_HUMAN Reviewed; 5762 AA. AC Q9HC84; O00447; O00573; O14985; O15494; O95291; O95451; Q14881; Q7M4S5; AC Q99552; Q9UE28; DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot. DT 05-OCT-2010, sequence version 3. DT 02-OCT-2024, entry version 193. DE RecName: Full=Mucin-5B; DE Short=MUC-5B; DE AltName: Full=Cervical mucin; DE AltName: Full=High molecular weight salivary mucin MG1; DE AltName: Full=Mucin-5 subtype B, tracheobronchial; DE AltName: Full=Sublingual gland mucin; DE Flags: Precursor; GN Name=MUC5B; Synonyms=MUC5; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-1593, INDUCTION, TISSUE SPECIFICITY, RP AND VARIANT GLY-34. RX PubMed=11713095; DOI=10.1165/ajrcmb.25.5.4298; RA Chen Y., Zhao Y.H., Di Y.P., Wu R.; RT "Characterization of human mucin 5B gene expression in airway epithelium RT and the genomic clone of the amino-terminal and 5'-flanking region."; RL Am. J. Respir. Cell Mol. Biol. 25:542-553(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-1324. RX PubMed=9790959; DOI=10.1006/bbrc.1998.9469; RA Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F.; RT "The amino-terminal sequence of MUC5B contains conserved multifunctional D RT domains: implications for tissue-specific mucin functions."; RL Biochem. Biophys. Res. Commun. 251:350-355(1998). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-1323, AND VARIANT GLY-34. RX PubMed=9804771; DOI=10.1074/jbc.273.46.30157; RA Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A.; RT "Genomic organization of the human mucin gene MUC5B: cDNA and genomic RT sequences upstream of the large central exon."; RL J. Biol. Chem. 273:30157-30164(1998). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1325-4954, NUCLEOTIDE SEQUENCE [MRNA] RP OF 4170-4791, AND VARIANTS SER-1805; LEU-1889; THR-2025; THR-2194; RP PRO-2238; THR-2425; SER-3072; ALA-3284; PRO-3468; MET-3816; GLY-4404; RP LEU-4440; PRO-4706; MET-4712; THR-4867 AND ALA-4882. RC TISSUE=Placenta, and Tracheobronchial mucosa; RX PubMed=9013550; DOI=10.1074/jbc.272.6.3168; RA Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A.; RT "Human mucin gene MUC5B, the 10.7 kb large central exon encodes various RT alternate subdomains resulting in a super-repeat. Structural evidence for a RT 11p15.5 gene family."; RL J. Biol. Chem. 272:3168-3178(1997). RN [5] RP PROTEIN SEQUENCE OF 2346-2358; 2903-2915; 3603-3615 AND 4160-4172. RC TISSUE=Tracheobronchial mucosa; RX PubMed=2656675; DOI=10.1016/s0021-9258(18)83168-4; RA Rose M.C., Kaufman B., Martin B.M.; RT "Proteolytic fragmentation and peptide mapping of human RT carboxyamidomethylated tracheobronchial mucin."; RL J. Biol. Chem. 264:8193-8199(1989). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] OF 2301-3811, AND TISSUE SPECIFICITY. RC TISSUE=Salivary gland; RX PubMed=9147051; DOI=10.1093/glycob/7.3.413; RA Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., RA Clausen H.; RT "Identification of a major human high molecular weight salivary mucin (MG1) RT as tracheobronchial mucin MUC5B."; RL Glycobiology 7:413-419(1997). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4780-5423, NUCLEOTIDE SEQUENCE [MRNA] RP OF 5373-5762, AND TISSUE SPECIFICITY. RC TISSUE=Gall bladder; RX PubMed=9164870; DOI=10.1042/bj3240295; RA Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D.; RT "Molecular cloning of a major human gall bladder mucin: complete C-terminal RT sequence and genomic organization of MUC5B."; RL Biochem. J. 324:295-303(1997). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 4868-5746, AND TISSUE SPECIFICITY. RC TISSUE=Sublingual gland; RX PubMed=8554565; DOI=10.1006/bbrc.1995.2884; RA Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G.; RT "Molecular cloning of a novel high molecular weight mucin (MG1) from human RT sublingual gland."; RL Biochem. Biophys. Res. Commun. 217:1112-1119(1995). RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4918-5762, AND VARIANT THR-5196. RC TISSUE=Placenta; RX PubMed=9201995; DOI=10.1074/jbc.272.27.16873; RA Desseyn J.-L., Aubert J.-P., Porchet N., Laine A.; RT "Genomic organization of the 3 region of the human MUC5B mucin."; RL J. Biol. Chem. 272:16873-16883(1997). RN [10] RP STRUCTURE OF O-LINKED CARBOHYDRATES, AND IDENTIFICATION BY MASS RP SPECTROMETRY. RX PubMed=11445551; DOI=10.1093/glycob/11.6.459; RA Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K., RA Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A.; RT "In vivo glycosylation of mucin tandem repeats."; RL Glycobiology 11:459-471(2001). RN [11] RP GLYCOSYLATION, AND MUTAGENESIS OF TRP-1790. RX PubMed=14718370; DOI=10.1093/glycob/cwh041; RA Perez-Vilar J., Randell S.H., Boucher R.C.; RT "C-Mannosylation of MUC5AC and MUC5B Cys subdomains."; RL Glycobiology 14:325-337(2004). RN [12] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145; ASN-254; ASN-1556; RP ASN-4960; ASN-5017; ASN-5024; ASN-5046; ASN-5096; ASN-5111 AND ASN-5215. RC TISSUE=Saliva; RX PubMed=16740002; DOI=10.1021/pr050492k; RA Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.; RT "Identification of N-linked glycoproteins in human saliva by glycoprotein RT capture and mass spectrometry."; RL J. Proteome Res. 5:1493-1503(2006). RN [13] RP INVOLVEMENT IN ILD2. RX PubMed=21506741; DOI=10.1056/nejmoa1013660; RA Seibold M.A., Wise A.L., Speer M.C., Steele M.P., Brown K.K., Loyd J.E., RA Fingerlin T.E., Zhang W., Gudmundsson G., Groshong S.D., Evans C.M., RA Garantziotis S., Adler K.B., Dickey B.F., du Bois R.M., Yang I.V., RA Herron A., Kervitsky D., Talbert J.L., Markin C., Park J., Crews A.L., RA Slifer S.H., Auerbach S., Roy M.G., Lin J., Hennessy C.E., Schwarz M.I., RA Schwartz D.A.; RT "A common MUC5B promoter polymorphism and pulmonary fibrosis."; RL N. Engl. J. Med. 364:1503-1512(2011). RN [14] RP INVOLVEMENT IN ILD2. RX PubMed=21506748; DOI=10.1056/nejmc1013504; RA Zhang Y., Noth I., Garcia J.G., Kaminski N.; RT "A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis."; RL N. Engl. J. Med. 364:1576-1577(2011). RN [15] RP DISULFIDE BOND. RX PubMed=31570524; DOI=10.1074/jbc.ra119.010771; RA Ridley C., Lockhart-Cairns M.P., Collins R.F., Jowitt T.A., Subramani D.B., RA Kesimer M., Baldock C., Thornton D.J.; RT "The C-terminal dimerization domain of the respiratory mucin MUC5B RT functions in mucin stability and intracellular packaging before RT secretion."; RL J. Biol. Chem. 294:17105-17116(2019). CC -!- FUNCTION: Gel-forming mucin that is thought to contribute to the CC lubricating and viscoelastic properties of whole saliva and cervical CC mucus. CC -!- SUBUNIT: Homomultimer; disulfide-linked (PubMed:31570524). The N- and CC C-terminus mediate their assembly into higher order structures to form CC filaments (By similarity). The CTCK domains of two polypeptides CC associate in the endoplasmic reticulum to generate intermolecularly CC disulfide-bonded dimers (PubMed:31570524). These dimers progress to the CC Golgi apparatus, which is a more acidic environment than the CC endoplasmic reticulum (By similarity). Under acidic conditions, the N- CC termini form non-covalent intermolecular interactions that juxtapose CC assemblies from different CTCK-linked dimers to produce long, CC disulfide-linked polymers that remain highly compact until secretion CC (By similarity). {ECO:0000250|UniProtKB:Q02817, CC ECO:0000269|PubMed:31570524}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Expressed on surface airway epithelia. Expressed CC mainly in mucous cells of submucosal glands of airway tissues. Highly CC expressed in the sublingual gland. Also found in submaxillary glands, CC endocervix, gall bladder, and pancreas. {ECO:0000269|PubMed:11713095, CC ECO:0000269|PubMed:8554565, ECO:0000269|PubMed:9147051, CC ECO:0000269|PubMed:9164870}. CC -!- INDUCTION: Regulated by all-trans-retinoic acid (ATRA) in a cell-type CC specific manner. {ECO:0000269|PubMed:11713095}. CC -!- DOMAIN: The CTCK domain mediates interchain disulfide bonds with CC another molecule of MUC5B. {ECO:0000269|PubMed:31570524}. CC -!- DOMAIN: The cysteine residues in the Cys-rich subdomain repeats are not CC involved in disulfide bonding. CC -!- PTM: Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in CC the Cys-rich subdomains probably on the first Trp residue of the WXXW CC motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) CC region. The repeat region is about 59% O-glycosylated with a high CC abundance of NeuAc(2)Hex(1)HexNac1-ol. {ECO:0000269|PubMed:14718370, CC ECO:0000269|PubMed:16740002}. CC -!- DISEASE: Interstitial lung disease 2 (ILD2) [MIM:178500]: A form of CC interstitial lung disease, a heterogeneous group of diseases affecting CC the distal part of the lung and characterized by a progressive CC remodeling of the alveolar interstitium. The disease spectrum ranges CC from idiopathic interstitial pneumonia or pneumonitis to idiopathic CC pulmonary fibrosis, that is associated with an increased risk of CC developing lung cancer. Clinical features of interstitial lung disease CC include dyspnea, clubbing of the fingers, and restrictive lung CC capacity. ILD2 inheritance is autosomal dominant. CC {ECO:0000269|PubMed:21506741, ECO:0000269|PubMed:21506748}. CC Note=Disease susceptibility is associated with variants affecting the CC gene represented in this entry. A common polymorphism in the promoter CC of MUC5B is associated with familial interstitial pneumonia and CC idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B CC expression in the lung may be involved in the pathogenesis of pulmonary CC fibrosis (PubMed:21506741). {ECO:0000269|PubMed:21506741}. CC -!- SEQUENCE CAUTION: CC Sequence=CAA06167.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Mucin database; CC URL="http://www.medkem.gu.se/mucinbiology/databases/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF107890; AAG33673.1; -; Genomic_DNA. DR EMBL; AF086604; AAC67545.1; -; mRNA. DR EMBL; AJ004862; CAA06167.1; ALT_INIT; Genomic_DNA. DR EMBL; X74955; CAA52910.1; -; mRNA. DR EMBL; Z72496; CAA96577.1; -; Genomic_DNA. DR EMBL; U63836; AAB61398.1; -; mRNA. DR EMBL; U78551; AAC51343.1; -; mRNA. DR EMBL; AH006676; AAC51344.1; -; Genomic_DNA. DR EMBL; U95031; AAB65151.1; -; mRNA. DR EMBL; Y09788; CAA70926.1; -; Genomic_DNA. DR CCDS; CCDS44515.2; -. DR PIR; A33811; A33811. DR PIR; T45025; T45025. DR RefSeq; NP_002449.2; NM_002458.2. DR PDB; 8OES; EM; 3.00 A; A/B/C/D/E/F/G/H=26-1252, I/J/K/L/M/N=1333-1432. DR PDBsum; 8OES; -. DR EMDB; EMD-10264; -. DR EMDB; EMD-10336; -. DR EMDB; EMD-10339; -. DR EMDB; EMD-16808; -. DR SMR; Q9HC84; -. DR BioGRID; 608337; 53. DR IntAct; Q9HC84; 28. DR MINT; Q9HC84; -. DR STRING; 9606.ENSP00000436812; -. DR MEROPS; I08.953; -. DR GlyConnect; 1520; 15 N-Linked glycans (10 sites), 6 O-Linked glycans. DR GlyConnect; 376; 10 O-Linked glycans. DR GlyCosmos; Q9HC84; 38 sites, 41 glycans. DR GlyGen; Q9HC84; 39 sites, 18 N-linked glycans (9 sites), 28 O-linked glycans (1 site). DR iPTMnet; Q9HC84; -. DR PhosphoSitePlus; Q9HC84; -. DR SwissPalm; Q9HC84; -. DR BioMuta; MUC5B; -. DR DMDM; 308153579; -. DR jPOST; Q9HC84; -. DR MassIVE; Q9HC84; -. DR PaxDb; 9606-ENSP00000436812; -. DR PeptideAtlas; Q9HC84; -. DR PRIDE; Q9HC84; -. DR Antibodypedia; 1456; 359 antibodies from 34 providers. DR DNASU; 727897; -. DR Ensembl; ENST00000529681.5; ENSP00000436812.1; ENSG00000117983.17. DR GeneID; 727897; -. DR KEGG; hsa:727897; -. DR MANE-Select; ENST00000529681.5; ENSP00000436812.1; NM_002458.3; NP_002449.2. DR UCSC; uc001lta.4; human. DR AGR; HGNC:7516; -. DR CTD; 727897; -. DR DisGeNET; 727897; -. DR GeneCards; MUC5B; -. DR HGNC; HGNC:7516; MUC5B. DR HPA; ENSG00000117983; Tissue enriched (salivary). DR MalaCards; MUC5B; -. DR MIM; 178500; phenotype. DR MIM; 600770; gene. DR neXtProt; NX_Q9HC84; -. DR OpenTargets; ENSG00000117983; -. DR Orphanet; 171700; Diffuse panbronchiolitis. DR Orphanet; 31740; Hypersensitivity pneumonitis. DR Orphanet; 2032; Idiopathic pulmonary fibrosis. DR PharmGKB; PA31321; -. DR VEuPathDB; HostDB:ENSG00000117983; -. DR eggNOG; KOG1216; Eukaryota. DR GeneTree; ENSGT00940000162219; -. DR HOGENOM; CLU_000076_3_1_1; -. DR InParanoid; Q9HC84; -. DR OMA; STWILTE; -. DR OrthoDB; 2872912at2759; -. DR TreeFam; TF300299; -. DR PathwayCommons; Q9HC84; -. DR Reactome; R-HSA-5083625; Defective GALNT3 causes HFTC. DR Reactome; R-HSA-5083632; Defective C1GALT1C1 causes TNPS. DR Reactome; R-HSA-5083636; Defective GALNT12 causes CRCS1. DR Reactome; R-HSA-5621480; Dectin-2 family. DR Reactome; R-HSA-913709; O-linked glycosylation of mucins. DR Reactome; R-HSA-977068; Termination of O-glycan biosynthesis. DR SignaLink; Q9HC84; -. DR BioGRID-ORCS; 727897; 14 hits in 1145 CRISPR screens. DR ChiTaRS; MUC5B; human. DR GeneWiki; MUC5B; -. DR GenomeRNAi; 727897; -. DR Pharos; Q9HC84; Tbio. DR PRO; PR:Q9HC84; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q9HC84; protein. DR Bgee; ENSG00000117983; Expressed in trachea and 121 other cell types or tissues. DR ExpressionAtlas; Q9HC84; baseline and differential. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB. DR GO; GO:0005796; C:Golgi lumen; TAS:Reactome. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd19941; TIL; 4. DR Gene3D; 2.10.25.10; Laminin; 4. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR050780; Mucin_vWF_Thrombospondin_sf. DR InterPro; IPR036084; Ser_inhib-like_sf. DR InterPro; IPR002919; TIL_dom. DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom. DR InterPro; IPR001007; VWF_dom. DR InterPro; IPR001846; VWF_type-D. DR InterPro; IPR025155; WxxW_domain. DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1. DR PANTHER; PTHR11339:SF371; MUCIN-5B; 1. DR Pfam; PF08742; C8; 4. DR Pfam; PF13330; Mucin2_WxxW; 7. DR Pfam; PF01826; TIL; 2. DR Pfam; PF00094; VWD; 4. DR SMART; SM00832; C8; 4. DR SMART; SM00041; CT; 1. DR SMART; SM00214; VWC; 5. DR SMART; SM00215; VWC_out; 3. DR SMART; SM00216; VWD; 4. DR SUPFAM; SSF57603; FnI-like domain; 2. DR SUPFAM; SSF57567; Serine protease inhibitors; 4. DR PROSITE; PS01185; CTCK_1; 1. DR PROSITE; PS01225; CTCK_2; 1. DR PROSITE; PS01208; VWFC_1; 2. DR PROSITE; PS50184; VWFC_2; 2. DR PROSITE; PS51233; VWFD; 4. PE 1: Evidence at protein level; KW 3D-structure; Copper; Direct protein sequencing; Disulfide bond; KW Glycoprotein; Metal-binding; Proteomics identification; Reference proteome; KW Repeat; Secreted; Signal. FT SIGNAL 1..25 FT /evidence="ECO:0000255" FT CHAIN 26..5762 FT /note="Mucin-5B" FT /id="PRO_0000019283" FT DOMAIN 75..245 FT /note="VWFD 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 329..385 FT /note="TIL 1" FT DOMAIN 423..598 FT /note="VWFD 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 695..752 FT /note="TIL 2" FT DOMAIN 805..855 FT /note="TIL 3" FT DOMAIN 855..927 FT /note="VWFC 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 893..1062 FT /note="VWFD 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT REPEAT 1333..1432 FT /note="Cys-rich subdomain 1" FT REPEAT 1503..1604 FT /note="Cys-rich subdomain 2" FT REPEAT 1784..1885 FT /note="Cys-rich subdomain 3" FT REPEAT 2313..2414 FT /note="Cys-rich subdomain 4" FT REPEAT 2854..2886 FT /note="HAT 1" FT REPEAT 2871..2971 FT /note="Cys-rich subdomain 5" FT REPEAT 3554..3586 FT /note="HAT 2" FT REPEAT 3571..3671 FT /note="Cys-rich subdomain 6" FT REPEAT 4111..4143 FT /note="HAT 3" FT REPEAT 4128..4228 FT /note="Cys-rich subdomain 7" FT DOMAIN 5073..5261 FT /note="VWFD 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 5412..5484 FT /note="VWFC 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 5521..5587 FT /note="VWFC 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 5653..5742 FT /note="CTCK" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT REGION 27..50 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1333..4228 FT /note="7 X Cys-rich subdomain repeats" FT REGION 1437..1462 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1480..1502 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1607..1783 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1890..2199 FT /note="11 X approximate tandem repeats, Ser/Thr-rich" FT REGION 1890..2019 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2031..2100 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2114..2211 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2242..2302 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2419..2756 FT /note="11 X approximate tandem repeats, Ser/Thr-rich" FT REGION 2443..2462 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2473..2522 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2556..2861 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2976..3456 FT /note="17 X approximate tandem repeats, Ser/Thr-rich" FT REGION 3001..3049 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3256..3357 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3371..3469 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3481..3561 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3676..4013 FT /note="11 X approximate tandem repeats, Ser/Thr-rich" FT REGION 3699..3779 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3813..3917 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 3956..4118 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4233..4879 FT /note="23 X approximate tandem repeats, Ser/Thr-rich" FT REGION 4259..4389 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4428..4447 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4458..4527 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 4541..4750 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1442..1462 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1611..1783 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 4285..4389 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 194 FT /ligand="Cu(2+)" FT /ligand_id="ChEBI:CHEBI:29036" FT /evidence="ECO:0000250|UniProtKB:Q02817" FT BINDING 311 FT /ligand="Cu(2+)" FT /ligand_id="ChEBI:CHEBI:29036" FT /evidence="ECO:0000250|UniProtKB:Q02817" FT BINDING 358 FT /ligand="Cu(2+)" FT /ligand_id="ChEBI:CHEBI:29036" FT /evidence="ECO:0000250|UniProtKB:Q02817" FT CARBOHYD 145 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 201 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 254 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 401 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 515 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 805 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 929 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1276 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1292 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1340 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 1509 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 1556 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 1774 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1790 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 2320 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 2749 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2877 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 3449 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3577 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 4006 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4134 FT /note="C-linked (Man) tryptophan" FT /evidence="ECO:0000305" FT CARBOHYD 4804 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4960 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5017 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5024 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5046 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5096 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5111 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5215 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000269|PubMed:16740002" FT CARBOHYD 5486 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5526 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5565 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5566 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5602 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5612 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5663 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5677 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5721 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 77..207 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 99..244 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 425..562 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 447..597 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 469..477 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 895..1026 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 917..1061 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 926..1023 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 944..951 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 5075..5221 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 5097..5260 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 5121..5132 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 5653..5705 FT /evidence="ECO:0000250" FT DISULFID 5672..5719 FT /evidence="ECO:0000250" FT DISULFID 5681..5735 FT /evidence="ECO:0000250" FT DISULFID 5685..5737 FT /evidence="ECO:0000250" FT DISULFID ?..5741 FT /evidence="ECO:0000250" FT VARIANT 34 FT /note="E -> G (in dbSNP:rs2672785)" FT /evidence="ECO:0000269|PubMed:11713095, FT ECO:0000269|PubMed:9804771" FT /id="VAR_063616" FT VARIANT 51 FT /note="R -> W (in dbSNP:rs2075853)" FT /id="VAR_056588" FT VARIANT 1360 FT /note="T -> M (in dbSNP:rs12363494)" FT /id="VAR_059538" FT VARIANT 1401 FT /note="R -> H (in dbSNP:rs10835639)" FT /id="VAR_059539" FT VARIANT 1805 FT /note="G -> S (in dbSNP:rs1541314)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063617" FT VARIANT 1889 FT /note="P -> L (in dbSNP:rs2943510)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063618" FT VARIANT 2025 FT /note="A -> T (in dbSNP:rs34739266)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063619" FT VARIANT 2027 FT /note="A -> T (in dbSNP:rs1554937069)" FT /id="VAR_059540" FT VARIANT 2194 FT /note="M -> T (in dbSNP:rs2943502)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063620" FT VARIANT 2238 FT /note="L -> P (in dbSNP:rs4963031)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063621" FT VARIANT 2425 FT /note="M -> T (in dbSNP:rs3965632)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063622" FT VARIANT 2559 FT /note="T -> M (in dbSNP:rs60787297)" FT /id="VAR_059541" FT VARIANT 3072 FT /note="F -> S (in dbSNP:rs55813014)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063623" FT VARIANT 3284 FT /note="T -> A (in dbSNP:rs2943531)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063624" FT VARIANT 3468 FT /note="R -> P (in dbSNP:rs2943529)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063625" FT VARIANT 3816 FT /note="T -> M (in dbSNP:rs201948297)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063626" FT VARIANT 4404 FT /note="A -> G (in dbSNP:rs2943517)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063627" FT VARIANT 4440 FT /note="P -> L (in dbSNP:rs2943516)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063628" FT VARIANT 4706 FT /note="T -> P (in dbSNP:rs2943512)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063629" FT VARIANT 4712 FT /note="T -> M (in dbSNP:rs2943511)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063630" FT VARIANT 4867 FT /note="A -> T (in dbSNP:rs3021155)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063631" FT VARIANT 4882 FT /note="T -> A (in dbSNP:rs3021156)" FT /evidence="ECO:0000269|PubMed:9013550" FT /id="VAR_063632" FT VARIANT 5196 FT /note="S -> T (in dbSNP:rs2672788)" FT /evidence="ECO:0000269|PubMed:9201995" FT /id="VAR_014123" FT MUTAGEN 1790 FT /note="W->A: Poorly secreted." FT /evidence="ECO:0000269|PubMed:14718370" FT CONFLICT 95..100 FT /note="FPGLCN -> LPCLCK (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 104 FT /note="S -> C (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 142 FT /note="E -> K (in Ref. 1; AAG33673)" FT /evidence="ECO:0000305" FT CONFLICT 225 FT /note="R -> S (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 330..331 FT /note="PL -> T (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 337 FT /note="E -> N (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 356 FT /note="E -> K (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 362 FT /note="G -> R (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 368 FT /note="G -> GS (in Ref. 1; AAG33673)" FT /evidence="ECO:0000305" FT CONFLICT 373 FT /note="D -> N (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 392..393 FT /note="RT -> TR (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 467..468 FT /note="RK -> GR (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 511 FT /note="L -> P (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 584..586 FT /note="GAA -> AH (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 600 FT /note="A -> S (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 627..628 FT /note="DP -> RS (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 632 FT /note="F -> L (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 675 FT /note="A -> P (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 700 FT /note="R -> P (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 751 FT /note="E -> K (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 811 FT /note="P -> L (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 816..817 FT /note="LR -> DG (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 859..860 FT /note="HN -> NK (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 866 FT /note="P -> L (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 872 FT /note="V -> F (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 883 FT /note="R -> T (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 889 FT /note="R -> G (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 1020 FT /note="G -> A (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 1082 FT /note="Q -> E (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 1144 FT /note="S -> C (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 1195 FT /note="G -> R (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 1207 FT /note="Missing (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 1291 FT /note="S -> T (in Ref. 3; CAA06167)" FT /evidence="ECO:0000305" FT CONFLICT 1317 FT /note="Missing (in Ref. 2; AAC67545)" FT /evidence="ECO:0000305" FT CONFLICT 1675..1677 FT /note="TTP -> RQS (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 1926..1927 FT /note="PT -> AS (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 1930..1931 FT /note="LR -> QA (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 1934..1940 FT /note="PPPKVLT -> GTPHVS (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 1956 FT /note="S -> F (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 1980..1982 FT /note="VTP -> FTA (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2002 FT /note="T -> M (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2017 FT /note="A -> V (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2052 FT /note="P -> L (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2069..2073 FT /note="TALTP -> RARTL (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2102 FT /note="A -> P (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2174 FT /note="N -> S (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2203 FT /note="P -> S (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2211 FT /note="R -> C (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2233 FT /note="V -> G (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2300 FT /note="S -> Q (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2333 FT /note="P -> S (in Ref. 6; AAB61398)" FT /evidence="ECO:0000305" FT CONFLICT 2456..2497 FT /note="SSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVS -> TSTLRT FT APPPKVLT (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2461..2462 FT /note="TT -> DD (in Ref. 6; AAB61398)" FT /evidence="ECO:0000305" FT CONFLICT 2468..3695 FT /note="Missing (in Ref. 6; AAB61398)" FT /evidence="ECO:0000305" FT CONFLICT 2513 FT /note="F -> S (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2537..2539 FT /note="FTA -> VTP (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2574 FT /note="V -> A (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2582 FT /note="T -> A (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2609 FT /note="L -> P (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2628..2630 FT /note="RTL -> LTP (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2659 FT /note="P -> A (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2713 FT /note="T -> R (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 2834 FT /note="R -> T (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3028 FT /note="T -> Q (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3080..3086 FT /note="LPEQTTT -> SQNRPPH (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3148..3152 FT /note="TGPTA -> LPHG (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3289 FT /note="Missing (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3490 FT /note="V -> G (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3500 FT /note="S -> G (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3504 FT /note="H -> P (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3716..3747 FT /note="PGTTWILTEPSTTATVTVPTGSTATASSTQAT -> QGPP (in Ref. 4; FT CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3811 FT /note="Q -> P (in Ref. 6; AAB61398)" FT /evidence="ECO:0000305" FT CONFLICT 3831 FT /note="A -> V (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3845 FT /note="R -> G (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3909 FT /note="V -> I (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3924..3925 FT /note="TT -> QP (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 3975 FT /note="V -> E (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4060..4061 FT /note="QH -> TT (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4114 FT /note="S -> Q (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4177 FT /note="Q -> T (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4313 FT /note="S -> T (in Ref. 4; CAA52910)" FT /evidence="ECO:0000305" FT CONFLICT 4373 FT /note="Missing (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4461..4463 FT /note="VPT -> APP (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4567 FT /note="A -> T (in Ref. 4; CAA96577)" FT /evidence="ECO:0000305" FT CONFLICT 4780 FT /note="T -> P (in Ref. 7; AAC51344)" FT /evidence="ECO:0000305" FT CONFLICT 5134 FT /note="R -> A (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5164 FT /note="Q -> P (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5187 FT /note="R -> A (in Ref. 7; AAC51344 and 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5289 FT /note="P -> L (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5304..5306 FT /note="NLV -> TLL (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5333 FT /note="A -> R (in Ref. 7; AAC51344)" FT /evidence="ECO:0000305" FT CONFLICT 5397 FT /note="D -> N (in Ref. 7; AAC51343/AAC51344)" FT /evidence="ECO:0000305" FT CONFLICT 5474 FT /note="E -> R (in Ref. 9; CAA70926)" FT /evidence="ECO:0000305" FT CONFLICT 5475 FT /note="N -> T (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5620 FT /note="A -> S (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" FT CONFLICT 5632 FT /note="A -> D (in Ref. 7; AAC51343)" FT /evidence="ECO:0000305" FT CONFLICT 5660 FT /note="V -> C (in Ref. 8; AAB65151)" FT /evidence="ECO:0000305" SQ SEQUENCE 5762 AA; 596340 MW; 1FEC7CDCD0ADA81C CRC64; MGAPSACRTL VLALAAMLVV PQAETQGPVE PSWENAGHTM DGGAPTSSPT RRVSFVPPVT VFPSLSPLNP AHNGRVCSTW GDFHYKTFDG DVFRFPGLCN YVFSEHCRAA YEDFNVQLRR GLVGSRPVVT RVVIKAQGLV LEASNGSVLI NGQREELPYS RTGLLVEQSG DYIKVSIRLV LTFLWNGEDS ALLELDPKYA NQTCGLCGDF NGLPAFNEFY AHNARLTPLQ FGNLQKLDGP TEQCPDPLPL PAGNCTDEEG ICHRTLLGPA FAECHALVDS TAYLAACAQD LCRCPTCPCA TFVEYSRQCA HAGGQPRNWR CPELCPRTCP LNMQHQECGS PCTDTCSNPQ RAQLCEDHCV DGCFCPPGTV LDDITHSGCL PLGQCPCTHG GRTYSPGTSF NTTCSSCTCS GGLWQCQDLP CPGTCSVQGG AHISTYDEKL YDLHGDCSYV LSKKCADSSF TVLAELRKCG LTDNENCLKA VTLSLDGGDT AIRVQADGGV FLNSIYTQLP LSAANITLFT PSSFFIVVQT GLGLQLLVQL VPLMQVFVRL DPAHQGQMCG LCGNFNQNQA DDFTALSGVV EATGAAFANT WKAQAACANA RNSFEDPCSL SVENENYARH WCSRLTDPNS AFSRCHSIIN PKPFHSNCMF DTCNCERSED CLCAALSSYV HACAAKGVQL SDWRDGVCTK YMQNCPKSQR YAYVVDACQP TCRGLSEADV TCSVSFVPVD GCTCPAGTFL NDAGACVPAQ ECPCYAHGTV LAPGEVVHDE GAVCSCTGGK LSCLGASLQK STGCAAPMVY LDCSNSSAGT PGAECLRSCH TLDVGCFSTH CVSGCVCPPG LVSDGSGGCI AEEDCPCVHN EATYKPGETI RVDCNTCTCR NRRWECSHRL CLGTCVAYGD GHFITFDGDR YSFEGSCEYI LAQDYCGDNT THGTFRIVTE NIPCGTTGTT CSKAIKLFVE SYELILQEGT FKAVARGPGG DPPYKIRYMG IFLVIETHGM AVSWDRKTSV FIRLHQDYKG RVCGLCGNFD DNAINDFATR SRSVVGDALE FGNSWKLSPS CPDALAPKDP CTANPFRKSW AQKQCSILHG PTFAACRSQV DSTKYYEACV NDACACDSGG DCECFCTAVA AYAQACHDAG LCVSWRTPDT CPLFCDFYNP HGGCEWHYQP CGAPCLKTCR NPSGHCLVDL PGLEGCYPKC PPSQPFFNED QMKCVAQCGC YDKDGNYYDV GARVPTAENC QSCNCTPSGI QCAHSLEACT CTYEDRTYSY QDVIYNTTDG LGACLIAICG SNGTIIRKAV ACPGTPATTP FTFTTAWVPH STTSPALPVS TVCVREVCRW SSWYNGHRPE PGLGGGDFET FENLRQRGYQ VCPVLADIEC RAAQLPDMPL EELGQQVDCD RMRGLMCANS QQSPPLCHDY ELRVLCCEYV PCGPSPAPGT SPQPSLSAST EPAVPTPTQT TATEKTTLWV TPSIRSTAAL TSQTGSSSGP VTVTPSAPGT TTCQPRCQWT EWFDEDYPKS EQLGGDVESY DKIRAAGGHL CQQPKDIECQ AESFPNWTLA QVGQKVHCDV HFGLVCRNWE QEGVFKMCYN YRIRVLCCSD DHCRGRATTP PPTTELETAT TTTTQALFST PQPTSSPGLT RAPPASTTAV PTLSEGLTSP RYTSTLGTAT TGGPTTPAGS TEPTVPGVAT STLPTRSALP GTTGSLGTWR PSQPPTLAPT TMATSRARPT GTASTASKEP LTTSLAPTLT SELSTSQAET STPRTETTMS PLTNTTTSQG TTRCQPKCEW TEWFDVDFPT SGVAGGDMET FENIRAAGGK MCWAPKSIEC RAENYPEVSI DQVGQVLTCS LETGLTCKNE DQTGRFNMCF NYNVRVLCCD DYSHCPSTPA TSSTATPSST PGTTWILTKP TTTATTTAST GSTATPTSTL RTAPPPKVLT TTATTPTVTS SKATPSSSPG TATALPALRS TATTPTATSV TPIPSSSLGT TWTRLSQTTT PTATMSTATP SSTPETAHTS TVLTATATTT GATGSVATPS STPGTAHTTK VPTTTTTGFT ATPSSSPGTA LTPPVWISTT TTPTTRGSTV TPSSIPGTTH TATVLTTTTT TVATGSMATP SSSTQTSGTP PSLTTTATTI TATGSTTNPS STPGTTPIPP VLTTTATTPA ATSNTVTPSS ALGTTHTPPV PNTMATTHGR SLPPSSPHTV RTAWTSATSG ILGTTHITEP STVTSHTLAA TTGTTQHSTP ALSSPHPSSR TTESPPSPGT TTPGHTTATS RTTATATPSK TRTSTLLPSS PTSAPITTVV TMGCEPQCAW SEWLDYSYPM PGPSGGDFDT YSNIRAAGGA VCEQPLGLEC RAQAQPGVPL RELGQVVECS LDFGLVCRNR EQVGKFKMCF NYEIRVFCCN YGHCPSTPAT SSTAMPSSTP GTTWILTELT TTATTTESTG STATPSSTPG TTWILTEPST TATVTVPTGS TATASSTQAT AGTPHVSTTA TTPTVTSSKA TPFSSPGTAT ALPALRSTAT TPTATSFTAI PSSSLGTTWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTATTTGAT GSVATPSSTP GTAHTTKVLT TTTTGFTATP SSSPGTARTL PVWISTTTTP TTRGSTVTPS SIPGTTHTPT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLS PSSPHTVRTA WTSATSGTLG TTHITEPSTG TSHTPAATTG TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRATSRTT ATATPSKTRT STLLPSSPTS APITTVVTMG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTEQTTAA TTTATTGSTA IPSSTPGTAP PPKVLTSTAT TPTATSSKAT SSSSPRTATT LPVLTSTATK STATSFTPIP SFTLGTTGTL PEQTTTPMAT MSTIHPSSTP ETTHTSTVLT TKATTTRATS SMSTPSSTPG TTWILTELTT AATTTAATGP TATPSSTPGT TWILTEPSTT ATVTVPTGST ATASSTRATA GTLKVLTSTA TTPTVISSRA TPSSSPGTAT ALPALRSTAT TPTATSVTAI PSSSLGTAWT RLSQTTTPTA TMSTATPSST PETVHTSTVL TTTTTTTRAT GSVATPSSTP GTAHTTKVPT TTTTGFTATP SSSPGTALTP PVWISTTTTP TTRGSTVTPS SIPGTTHTAT VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPIPPVLT TTATTPAATS STVTPSSALG TTHTPPVPNT TATTHGRSLP PSSPHTVRTA WTSATSGILG TTHITEPSTV TSHTPAATTS TTQHSTPALS SPHPSSRTTE SPPSPGTTTP GHTRGTSRTT ATATPSKTRT STLLPSSPTS APITTVVTTG CEPQCAWSEW LDYSYPMPGP SGGDFDTYSN IRAAGGAVCE QPLGLECRAQ AQPGVPLREL GQVVECSLDF GLVCRNREQV GKFKMCFNYE IRVFCCNYGH CPSTPATSST ATPSSTPGTT WILTKLTTTA TTTESTGSTA TPSSTPGTTW ILTEPSTTAT VTVPTGSTAT ASSTQATAGT PHVSTTATTP TVTSSKATPF SSPGTATALP ALRSTATTPT ATSFTAIPSS SLGTTWTRLS QTTTPTATMS TATPSSTPET AHTSTVLTTT ATTTRATGSV ATPSSTPGTA HTTKVPTTTT TGFTVTPSSS PGTARTPPVW ISTTTTPTTS GSTVTPSSVP GTTHTPTVLT TTTTTVATGS MATPSSSTQT SGTPPSLITT ATTITATGST TNPSSTPGTT PIPPVLTTTA TTPAATSSTV TPSSALGTTH TPPVPNTTAT THGRSLSPSS PHTVRTAWTS ATSGTLGTTH ITEPSTGTSH TPAATTGTTQ HSTPALSSPH PSSRTTESPP SPGTTTPGHT TATSRTTATA TPSKTRTSTL LPSSPTSAPI TTVVTTGCEP QCAWSEWLDY SYPMPGPSGG DFDTYSNIRA AGGAVCEQPL GLECRAQAQP GVPLGELGQV VECSLDFGLV CRNREQVGKF KMCFNYEIRV FCCNYGHCPS TPATSSTAMP SSTPGTTWIL TELTTTATTT ASTGSTATPS STPGTAPPPK VLTSPATTPT ATSSKATSSS SPRTATTLPV LTSTATKSTA TSVTPIPSST LGTTGTLPEQ TTTPVATMST IHPSSTPETT HTSTVLTTKA TTTRATSSTS TPSSTPGTTW ILTELTTAAT TTAATGPTAT PSSTPGTTWI LTELTTTATT TASTGSTATP SSTPGTTWIL TEPSTTATVT VPTGSTATAS STQATAGTPH VSTTATTPTV TSSKATPSSS PGTATALPAL RSTATTPTAT SFTAIPSSSL GTTWTRLSQT TTPTATMSTA TPSSTPETVH TSTVLTATAT TTGATGSVAT PSSTPGTAHT TKVPTTTTTG FTATPSSSPG TALTPPVWIS TTTTPTTTTP TTSGSTVTPS SIPGTTHTAR VLTTTTTTVA TGSMATPSSS TQTSGTPPSL TTTATTITAT GSTTNPSSTP GTTPITPVLT STATTPAATS SKATSSSSPR TATTLPVLTS TATKSTATSF TPIPSSTLWT TWTVPAQTTT PMSTMSTIHT SSTPETTHTS TVLTTTATMT RATNSTATPS STLGTTRILT ELTTTATTTA ATGSTATLSS TPGTTWILTE PSTIATVMVP TGSTATASST LGTAHTPKVV TTMATMPTAT ASTVPSSSTV GTTRTPAVLP SSLPTFSVST VSSSVLTTLR PTGFPSSHFS TPCFCRAFGQ FFSPGEVIYN KTDRAGCHFY AVCNQHCDID RFQGACPTSP PPVSSAPLSS PSPAPGCDNA IPLRQVNETW TLENCTVARC VGDNRVVLLD PKPVANVTCV NKHLPIKVSD PSQPCDFHYE CECICSMWGG SHYSTFDGTS YTFRGNCTYV LMREIHARFG NLSLYLDNHY CTASATAAAA RCPRALSIHY KSMDIVLTVT MVHGKEEGLI LFDQIPVSSG FSKNGVLVSV LGTTTMRVDI PALGVSVTFN GQVFQARLPY SLFHNNTEGQ CGTCTNNQRD DCLQRDGTTA ASCKDMAKTW LVPDSRKDGC WAPTGTPPTA SPAAPVSSTP TPTPCPPQPL CDLMLSQVFA ECHNLVPPGP FFNACISDHC RGRLEVPCQS LEAYAELCRA RGVCSDWRGA TGGLCDLTCP PTKVYKPCGP IQPATCNSRN QSPQLEGMAE GCFCPEDQIL FNAHMGICVQ ACPCVGPDGF PKFPGERWVS NCQSCVCDEG SVSVQCKPLP CDAQGQPPPC NRPGFVTVTR PRAENPCCPE TVCVCNTTTC PQSLPVCPPG QESICTQEEG DCCPTFRCRP QLCSYNGTFY GVGATFPGAL PCHMCTCLSG DTQDPTVQCQ EDACNNTTCP QGFEYKRVAG QCCGECVQTA CLTPDGQPVQ LNETWVNSHV DNCTVYLCEA EGGVHLLTPQ PASCPDVSSC RGSLRKTGCC YSCEEDSCQV RINTTILWHQ GCETEVNITF CEGSCPGASK YSAEAQAMQH QCTCCQERRV HEETVPLHCP NGSAILHTYT HVDECGCTPF CVPAPMAPPH TRGFPAQEAT AV //