{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9H714","secondaryAccessions":["A8KAG9","A8XR19","B3KS87","Q5W051","Q5W053","Q6PJ74","Q6PK94","Q86XH7","Q8N5J6"],"uniProtkbId":"PACER_HUMAN","entryAudit":{"firstPublicDate":"2005-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-09-23","entryVersion":158,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28306502"}],"value":"Protein associated with UVRAG as autophagy enhancer"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28306502"}],"value":"Pacer"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein Rubicon-like"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:20420"}],"value":"RUBCNL"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:20420"}],"value":"C13orf18"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:20420"}],"value":"KIAA0226L"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TD16"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28306502"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30704899"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23522960"}],"value":"Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). 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Interacts with STX17 (PubMed:28306502, PubMed:30704899)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9H714-3","intActId":"EBI-9088146"},"interactantTwo":{"uniProtKBAccession":"Q14457","geneName":"BECN1","intActId":"EBI-949378"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9H714-3","intActId":"EBI-9088146"},"interactantTwo":{"uniProtKBAccession":"Q96T51-2","geneName":"RUFY1","intActId":"EBI-12192715"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28306502"}],"value":"Associates with late autophagic structure (PubMed:28306502). 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