{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9FL87","secondaryAccessions":["Q8LDX8"],"uniProtkbId":"CRR7_ARATH","entryAudit":{"firstPublicDate":"2015-06-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-03-01","entryVersion":124,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein CHLORORESPIRATORY REDUCTION 7, chloroplastic"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16359395"}],"value":"CRR7"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Araport","id":"AT5G39210"}],"value":"At5g39210"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAB09375.1"}],"value":"K3K3.10"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16359395"}],"value":"Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex of the photosynthetic electron transport chain. May function in assembly or stabilization of the NDH complex (PubMed:16359395)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16359395"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16359395"}],"value":"Impaired chloroplastic NAD(P)H dehydrogenase (NDH) activity, probably due to a reduced stability of the NDH complex"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20444231"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"36951245"}],"value":"Was shown to be a chloroplast stromal protein that may be required for post-translational steps of NDH subcomplex A biogenesis essential for its accumulation. However, The corresponding paper has been retracted due to evidence of digital manipulation of some of the data, making the conclusions unreliable"}],"commentType":"CAUTION"}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Chloroplast","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"Protein CHLORORESPIRATORY REDUCTION 7, chloroplastic","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000433244"},{"type":"Sequence conflict","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"in Ref. 5; AAM62952","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"VHVTDSLSV","alternativeSequences":["FHVIDSLPA"]}},{"type":"Sequence conflict","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"in Ref. 5; AAM62952","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"ICY","alternativeSequences":["VCS"]}},{"type":"Sequence conflict","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in Ref. 5; AAM62952","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"9679202","citationType":"journal article","authors":["Kaneko T.","Kotani H.","Nakamura Y.","Sato S.","Asamizu E.","Miyajima N.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"9679202"},{"database":"DOI","id":"10.1093/dnares/5.2.131"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence features of the regions of 1,381,565 bp covered by twenty one physically assigned P1 and TAC clones.","publicationDate":"1998","journal":"DNA Res.","firstPage":"131","lastPage":"145","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"16359395","citationType":"journal article","authors":["Kamruzzaman Munshi M.","Kobayashi Y.","Shikanai T."],"citationCrossReferences":[{"database":"PubMed","id":"16359395"},{"database":"DOI","id":"10.1111/j.1365-313x.2005.02604.x"}],"title":"Identification of a novel protein, CRR7, required for the stabilization of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis.","publicationDate":"2005","journal":"Plant J.","firstPage":"1036","lastPage":"1044","volume":"44"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"]},{"referenceNumber":7,"citation":{"id":"20444231","citationType":"journal article","authors":["Peng L.","Cai W.","Shikanai T."],"citationCrossReferences":[{"database":"PubMed","id":"20444231"},{"database":"DOI","id":"10.1111/j.1365-313x.2010.04240.x"}],"title":"Chloroplast stromal proteins, CRR6 and CRR7, are required for assembly of the NAD(P)H dehydrogenase subcomplex A in Arabidopsis.","publicationDate":"2010","journal":"Plant J.","firstPage":"203","lastPage":"211","volume":"63"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":8,"citation":{"id":"36951245","citationType":"journal article","authors":["Peng L.","Cai W.","Shikanai T."],"citationCrossReferences":[{"database":"PubMed","id":"36951245"},{"database":"DOI","id":"10.1111/tpj.16170"}],"publicationDate":"2023","journal":"Plant J.","firstPage":"455","lastPage":"455","volume":"114"},"referencePositions":["RETRACTION NOTICE OF PUBMED:20444231"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB010694","properties":[{"key":"ProteinId","value":"BAB09375.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED94408.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7054486.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY065367","properties":[{"key":"ProteinId","value":"AAL38808.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY114028","properties":[{"key":"ProteinId","value":"AAM45076.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY085734","properties":[{"key":"ProteinId","value":"AAM62952.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_568563.1","properties":[{"key":"NucleotideSequenceId","value":"NM_123283.5"}]},{"database":"AlphaFoldDB","id":"Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9FL87","properties":[{"key":"Number of interactors","value":"488"}]},{"database":"STRING","id":"3702.Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"224545","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"833917","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G39210","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G39210","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G39210","properties":[{"key":"GeneName","value":"CRR7"}]},{"database":"eggNOG","id":"ENOG502S4HW","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_135253_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LENWPVN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9FL87","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q9FL87","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16359395"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16359395"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"FunFam","id":"3.90.940.40:FF:000001","properties":[{"key":"EntryName","value":"Protein CHLORORESPIRATORY REDUCTION 7 chloroplastic"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.90.940.40","properties":[{"key":"EntryName","value":"Protein CHLORORESPIRATORY REDUCTION 7"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR021954","properties":[{"key":"EntryName","value":"CRR7"}]},{"database":"InterPro","id":"IPR038150","properties":[{"key":"EntryName","value":"CRR7-like_sf"}]},{"database":"PANTHER","id":"PTHR36803","properties":[{"key":"EntryName","value":"PROTEIN CHLORORESPIRATORY REDUCTION 7, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36803:SF1","properties":[{"key":"EntryName","value":"PROTEIN CHLORORESPIRATORY REDUCTION 7, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12095","properties":[{"key":"EntryName","value":"CRR7"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MECSLQKQLFNNGDKLFSSRHNRRVSIEQVHVTDSLSVNSINLFHKPICYPISSIITSRKSKSHFSVCATRRRRVHSNSDTYVLLEAGQDEQFVTEDELKAKLRGWLENWPVNSLPPDLARFDDLDEAVDFLVKAVCELEIDGEVGSVQWYQVRLE","length":156,"molWeight":17967,"crc64":"EB65F51D3B62D354","md5":"F1C89CA887F01B096DA6195AD6832247"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DISRUPTION PHENOTYPE":1,"CAUTION":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Sequence conflict":3},"uniParcId":"UPI00000A1FBB"}}