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Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts) (PubMed:29466386). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1 and facilitating MCD1 positioning to membrane tethered FtsZ filaments to form the chloroplast Z-Ring; inhibits GDP-induced disassembly of FTSZ2 but enables ARC3 binding to FTSZ2-1 (PubMed:29138260, PubMed:29466386, PubMed:29769312, PubMed:29967285). Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring (PubMed:28248291). Required for plastid equatorial positioning of PDV2 and ARC5. May contribute to gravitropism in stems and hypocotyls. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15928083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16146521"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18284374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18812496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19995726"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22028775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22823492"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26527658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29138260"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29769312"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29967285"}],"value":"Self-interacts (PubMed:28248291, PubMed:29769312). Part of a complex made of ARC3, ARC6, FTSZ1 and FTSZ2 (PubMed:22823492). Interacts with FTSZ2-1 and FTSZ2-2 (via C-terminus), but not with FTSZ1; this interaction enables ARC3 binding to FTSZ2 (PubMed:26527658, PubMed:29138260, PubMed:29769312, PubMed:29967285). Binds to CDT1A. Interacts (via C-terminus) with PDV2 (via C-terminus) in the chloroplast intermembrane space; this interaction induces homodimerization and leads to the formation of a heterotetramer containing two ARC6 and two PDV2 subunits (PubMed:28248291). Interacts with MCD1 in the chloroplast stroma and facilitates its subsequent binding to FtsZ2-1 (PubMed:29967285). Interacts (via J domain) with CJD1 (via J-like domain) (PubMed:22028775)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9FIG9","intActId":"EBI-2000800"},"interactantTwo":{"uniProtKBAccession":"Q42545","geneName":"FTSZ1","intActId":"EBI-2131124"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9FIG9","intActId":"EBI-2000800"},"interactantTwo":{"uniProtKBAccession":"Q9XII1","geneName":"PDV2","intActId":"EBI-2000823"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18812496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"}],"value":"Localized to a ring at the center of the chloroplasts (equatorial positioning) prior to and during constriction"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12897262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15928083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18812496"}],"value":"Plastid, chloroplast inner membrane","id":"SL-0051"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12897262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15928083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18812496"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27988788"}],"value":"Mostly expressed in young leaves"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27988788"}],"value":"Levels decrease slightly from young developing leaves to mature ones (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23020316"}],"value":"Slightly induced by gibberellic acid (GA)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10417716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11975738"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12232400"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12897262"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18764889"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19318374"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22028775"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29466386"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29967285"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30252596"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8537433"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9489024"}],"value":"Defective in proplastid and plastid division, with only one or two grossly enlarged plastids per cell, sometimes exhibiting alteration in stromule length and frequency in non-green tissues (e.g. increase in the frequency of stromules in nearly all cells) and in stomatal guard cells (GCs) (PubMed:29466386). Heterogeneous chloroplasts sizes and shapes such as giant and mini-plastids in leaf epidermal pavement cells (PCs) (PubMed:29466386). Abnormal subplastidial localization of the key plastid division proteins FTSZ1 and FTSZ2 (numerous short and disorganized FtsZ filament fragments) (PubMed:29967285). Root cells statoliths, chloroplasts, and other plastids are also abnormally large. Impaired gravitropism of inflorescence stems and hypocotyls, but not of roots. Several mesophyll and stomatal guard cells contain chlorophyll-free plastids, probably missing chloroplastic DNA. Misexpression and mislocalization of ADT2 (PubMed:30252596). The double mutant mcd1 arc6 exhibits similar chloroplast defect than the single mutant arc6, including the abnormal localization of FTSZ1 to short filaments and dots within chloroplasts (PubMed:29967285). The double mutant arc6 cjd1 exhibits both phenotypes of single mutants cjd1 and arc6 including altered fatty acid profiles and heterogeneous chloroplasts sizes and shapes, respectively (PubMed:22028775)"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Chloroplast","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic","featureId":"PRO_0000406333"},{"type":"Topological domain","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":618,"modifier":"EXACT"}},"description":"Stromal","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":619,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Chloroplast intermembrane","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00286"}]},{"type":"Region","location":{"start":{"value":639,"modifier":"EXACT"},"end":{"value":801,"modifier":"EXACT"}},"description":"Interaction with PDV2","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18812496"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5GTB"}]},{"type":"Mutagenesis","location":{"start":{"value":686,"modifier":"EXACT"},"end":{"value":686,"modifier":"EXACT"}},"description":"Reduced interaction with PDV2 leading to altered chloroplast division and formation of dumbbell-shaped plastids.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":776,"modifier":"EXACT"}},"description":"Reduced interaction with PDV2 leading to altered chloroplast division and formation of dumbbell-shaped plastids.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A","D"]}},{"type":"Mutagenesis","location":{"start":{"value":778,"modifier":"EXACT"},"end":{"value":778,"modifier":"EXACT"}},"description":"Reduced interaction with PDV2 leading to altered chloroplast division and formation of dumbbell-shaped plastids.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28248291"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in Ref. 1; 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