{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9FH50","secondaryAccessions":["Q94JX7"],"uniProtkbId":"APO3_ARATH","entryAudit":{"firstPublicDate":"2005-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-03-01","entryVersion":115,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"APO protein 3, mitochondrial"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"APO3"},"orderedLocusNames":[{"value":"At5g61930"}],"orfNames":[{"value":"K22G18.5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be involved in the stable assembly of several 4Fe-4S cluster-containing complexes of mitochondria"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The APO repeats may provide ligands for 4Fe-4S centers"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00832"}],"value":"Belongs to the APO family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAK48980.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"APO protein 3, mitochondrial","featureId":"PRO_0000001932"},{"type":"Domain","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"APO 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00832"}]},{"type":"Domain","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"APO 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00832"}]},{"type":"Region","location":{"start":{"value":37,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"in Ref. 4; AAK48980","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"10718197","citationType":"journal article","authors":["Sato S.","Nakamura Y.","Kaneko T.","Katoh T.","Asamizu E.","Kotani H.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10718197"},{"database":"DOI","id":"10.1093/dnares/7.1.31"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"31","lastPage":"63","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-402"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB022212","properties":[{"key":"ProteinId","value":"BAB08879.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED97538.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED97539.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF370553","properties":[{"key":"ProteinId","value":"AAK48980.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT002086","properties":[{"key":"ProteinId","value":"AAN72097.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001119475.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001126003.1"}]},{"database":"RefSeq","id":"NP_568945.2","properties":[{"key":"NucleotideSequenceId","value":"NM_125586.4"}]},{"database":"AlphaFoldDB","id":"Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9FH50","properties":[{"key":"Number of interactors","value":"722"}]},{"database":"STRING","id":"3702.Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9FH50","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"3702-Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"836314","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G61930","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G61930","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G61930","properties":[{"key":"GeneName","value":"APO3"}]},{"database":"eggNOG","id":"ENOG502QRU6","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_033199_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RNATHVW","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1926485at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9FH50","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q9FH50","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR023342","properties":[{"key":"EntryName","value":"APO_dom"}]},{"database":"PANTHER","id":"PTHR10388","properties":[{"key":"EntryName","value":"EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05634","properties":[{"key":"EntryName","value":"APO_RNA-bind"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51499","properties":[{"key":"EntryName","value":"APO"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MQRRKLVEISIFVIRKSNFSSSIKSLTNLDVDVSVDNDEDPLYADVPKPPKDKSERKPYPTPMKELIRRAKEEKQLRKLQPCRVLEDPPDNGLLVPELVDVAHCVHRCRNMLLSGLSKIIHHVPVHRCRLCAEVHIGKQGHEIRTCTGPGSGSRSATHVWKRGRVSDVVLFPKCFHLYDRAVKPRVIHDERFTVPKISAVLELCIQAGVDLEKFPSKRRSKPVYSIEGRIVDFEDVNDGNSELAVTSTTTLIQEDDRCKEEKKSLKELSFETMESWFEMVLGVRKLMERYRVWTCGYCPEIQVGPKGHKVRMCKATKHQMRDGMHAWQEATIDDVVGPTYVWHVRDPTDGSVLDNSLKRFYGKAPAVIEMCVQGGAPVPDQYNSMMRLDVVYPQRDEVDLVA","length":402,"molWeight":45912,"crc64":"42F8C6DC4D57F9F5","md5":"0FD2AE3A6CC5D3F3B44C1224696036AD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Domain":2,"Region":1,"Compositional bias":1,"Sequence conflict":1},"uniParcId":"UPI00000A02B8"}}