{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9DCQ2","secondaryAccessions":["Q8VCQ0"],"uniProtkbId":"ASPDH_MOUSE","entryAudit":{"firstPublicDate":"2005-08-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":156,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Aspartate dehydrogenase domain-containing protein"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915602"}],"value":"Aspdh"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the L-aspartate dehydrogenase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":287,"modifier":"EXACT"}},"description":"Aspartate dehydrogenase domain-containing protein","featureId":"PRO_0000144901"},{"type":"Modified residue","location":{"start":{"value":24,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6ND91"}]},{"type":"Modified residue","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6ND91"}]},{"type":"Sequence conflict","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"in Ref. 2; AAH19451","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in Ref. 2; AAH19451","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-DHLEILD3HP6AK","citationType":"submission","authors":["Lubec G.","Sunyer B.","Chen W.-Q."],"publicationDate":"JAN-2009","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 13-20","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"OF1","type":"STRAIN"},{"value":"Hippocampus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK002587","properties":[{"key":"ProteinId","value":"BAB22209.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC019451","properties":[{"key":"ProteinId","value":"AAH19451.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS21207.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_080966.1","properties":[{"key":"NucleotideSequenceId","value":"NM_026690.1"}]},{"database":"AlphaFoldDB","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9DCQ2","properties":[{"key":"Number of interactors","value":"177"}]},{"database":"STRING","id":"10090.ENSMUSP00000039202","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9DCQ2","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000039202","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"277046","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"46022","properties":[{"key":"antibodies","value":"76 antibodies from 11 providers"}]},{"database":"Ensembl","id":"ENSMUST00000035929.11","properties":[{"key":"ProteinId","value":"ENSMUSP00000039202.5"},{"key":"GeneId","value":"ENSMUSG00000038704.13"}]},{"database":"GeneID","id":"68352","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:68352","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009gpk.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1915602","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"554235","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915602","properties":[{"key":"GeneName","value":"Aspdh"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000038704","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVGC","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004452","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KHPTSFK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4310724at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"68352","properties":[{"key":"hits","value":"5 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9DCQ2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q9DCQ2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000038704","properties":[{"key":"ExpressionPatterns","value":"Expressed in right kidney and 35 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9DCQ2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0033735","properties":[{"key":"GoTerm","value":"F:L-aspartate dehydrogenase [NAD(P)+] activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0050661","properties":[{"key":"GoTerm","value":"F:NADP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009435","properties":[{"key":"GoTerm","value":"P:NAD+ biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.360.10","properties":[{"key":"EntryName","value":"Dihydrodipicolinate Reductase, domain 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR005106","properties":[{"key":"EntryName","value":"Asp/hSer_DH_NAD-bd"}]},{"database":"InterPro","id":"IPR002811","properties":[{"key":"EntryName","value":"Asp_DH"}]},{"database":"InterPro","id":"IPR011182","properties":[{"key":"EntryName","value":"L-Asp_DH"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"PANTHER","id":"PTHR31873:SF6","properties":[{"key":"EntryName","value":"ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31873","properties":[{"key":"EntryName","value":"L-ASPARTATE DEHYDROGENASE-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01958","properties":[{"key":"EntryName","value":"Asp_DH_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03447","properties":[{"key":"EntryName","value":"NAD_binding_3"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF005227","properties":[{"key":"EntryName","value":"Asp_dh_NAD_syn"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55347","properties":[{"key":"EntryName","value":"Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATSTLPQVPYKVGVVGYGRLGQSLVSRLLAQGSELGLELVFVWNRDPGRMAGSVPPALQLQDLTALEERHPDLVVEVAHPKIIHESGAQILRHANLLVGSPSALADQTTEQQLLEASKRWGHTVFVARGALWGSEDISRLDAAGGLQSLRVTMATHPDGFRLEGPLAAAHSSGPRTVLYEGPVRGLCPLAPRNSNTMAAAALAAPSLGFDRVIGVLVADLSLTDMHVVDVELLGPPGPSGRSFAVHTHRENPAQPGAVTGSATVTAFWHSLLGCCQLTSRPGIHLC","length":287,"molWeight":30270,"crc64":"889D164D943B88DD","md5":"5A7E07CBCC5979FF38AF442C9D9A293B"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Modified residue":2,"Sequence conflict":2},"uniParcId":"UPI0000023DC0"}}