{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9DCB3","secondaryAccessions":["A0A140LI80","Q9JJ82"],"uniProtkbId":"RN227_MOUSE","entryAudit":{"firstPublicDate":"2008-04-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-07-18","entryVersion":94,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"RING finger protein 227"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NIN4"}],"value":"Rnf227"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915359"}],"value":"Chd3os"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAA95115.1"}],"value":"MNCb-2875"}]}],"comments":[{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA95115.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB22482.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"RING finger protein 227","featureId":"PRO_0000329084"},{"type":"Zinc finger","location":{"start":{"value":18,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"RING-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00175"}]},{"type":"Region","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"in Ref. 3; BAA95115","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"in Ref. 3; BAA95115","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-190"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-CJKQMKOGL9J01","citationType":"submission","authors":["Osada N.","Kusuda J.","Tanuma R.","Ito A.","Hirata M.","Sugano S.","Hashimoto K."],"title":"Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method.","publicationDate":"APR-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-190"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL645527","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK002962","properties":[{"key":"ProteinId","value":"BAB22482.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB041807","properties":[{"key":"ProteinId","value":"BAA95115.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001400402.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001413473.1"}]},{"database":"AlphaFoldDB","id":"Q9DCB3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9DCB3","properties":[{"key":"Number of interactors","value":"16"}]},{"database":"STRING","id":"10090.ENSMUSP00000146712","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9DCB3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000146712","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000129321.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000146712.2"},{"key":"GeneId","value":"ENSMUSG00000043419.12"}]},{"database":"GeneID","id":"80515","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:80515","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"MGI:1915359","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"284023","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915359","properties":[{"key":"GeneName","value":"Rnf227"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000043419","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002475","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9DCB3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"CPRELHC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"252722at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q9DCB3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q9DCB3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000043419","properties":[{"key":"ExpressionPatterns","value":"Expressed in superior colliculus and 210 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9DCB3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"3.30.40.10","properties":[{"key":"EntryName","value":"Zinc/RING finger domain, C3HC4 (zinc finger)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027952","properties":[{"key":"EntryName","value":"DUF4632"}]},{"database":"InterPro","id":"IPR051435","properties":[{"key":"EntryName","value":"RING_finger_E3_ubiq-ligases"}]},{"database":"InterPro","id":"IPR001841","properties":[{"key":"EntryName","value":"Znf_RING"}]},{"database":"InterPro","id":"IPR013083","properties":[{"key":"EntryName","value":"Znf_RING/FYVE/PHD"}]},{"database":"InterPro","id":"IPR017907","properties":[{"key":"EntryName","value":"Znf_RING_CS"}]},{"database":"PANTHER","id":"PTHR22791:SF14","properties":[{"key":"EntryName","value":"RING FINGER PROTEIN 227"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22791","properties":[{"key":"EntryName","value":"RING-TYPE DOMAIN-CONTAINING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15451","properties":[{"key":"EntryName","value":"DUF4632"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14634","properties":[{"key":"EntryName","value":"zf-RING_5"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00184","properties":[{"key":"EntryName","value":"RING"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF57850","properties":[{"key":"EntryName","value":"RING/U-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00518","properties":[{"key":"EntryName","value":"ZF_RING_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50089","properties":[{"key":"EntryName","value":"ZF_RING_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQLLMRVPSLPELGELDCNICFRPYNLGARAPRRLPGTARARCGHTLCTACLRELAARGDGSRTAARVVRLRRAVTCPFCRAPSPLPRGGVTEIALDPVLWSRLEEKARAEREGDPMGSPAKDSGEDGEDDDGEAESEKGAGPPSAGWRALRRILDRVLAPARRLRRPLPSNVLYCPEVKDIAHMTRCTL","length":190,"molWeight":20820,"crc64":"3B3EBFE3A1948FF3","md5":"FD9DF2C97B9E5D9862F027091F3D14DC"},"extraAttributes":{"countByCommentType":{"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Zinc finger":1,"Region":1,"Compositional bias":1,"Sequence conflict":2},"uniParcId":"UPI0007699F30"}}