{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9DC63","secondaryAccessions":["A2BHN5","A2BHN7","Q3TKB0","Q3U9C1","Q8C7I0","Q8CEJ0","Q91VI9","Q9D2J5","Q9JIE4"],"uniProtkbId":"FBX3_MOUSE","entryAudit":{"firstPublicDate":"2004-05-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":160,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"F-box only protein 3"}}},"genes":[{"geneName":{"value":"Fbxo3"},"synonyms":[{"value":"Fba"},{"value":"Fbx3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK99"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23542741"}],"value":"Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:23542741)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23542741"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK99"}],"value":"Part of a SCF (SKP1-cullin-F-box) protein ligase complex SCF(FBXO3) consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK99"}],"value":"Colocalizes with PML at the peripheries of nuclear bodies"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK99"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9DC63-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9DC63-2"],"sequenceIds":["VSP_039616","VSP_039617"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q9DC63-3"],"sequenceIds":["VSP_039615","VSP_039616","VSP_039617"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"F-box only protein 3","featureId":"PRO_0000119878"},{"type":"Domain","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"F-box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00080"}]},{"type":"Domain","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":408,"modifier":"EXACT"}},"description":"ApaG","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00412"}]},{"type":"Region","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":463,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_039615","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":414,"modifier":"EXACT"},"end":{"value":415,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10945468"}],"featureId":"VSP_039616","alternativeSequence":{"originalSequence":"EM","alternativeSequences":["VS"]}},{"type":"Alternative sequence","location":{"start":{"value":416,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10945468"}],"featureId":"VSP_039617","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":63,"modifier":"EXACT"}},"description":"in Ref. 2; BAB31793","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in Ref. 2; BAC34118","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["M"]}},{"type":"Sequence conflict","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"in Ref. 2; BAC25719","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"in Ref. 2; BAB31793","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":262,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"in Ref. 2; BAE30746/BAE30138","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"in Ref. 2; BAE30746/BAE30138","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"10945468","citationType":"journal article","authors":["Ilyin G.P.","Rialland M.","Pigeon C.","Guguen-Guillouzo C."],"citationCrossReferences":[{"database":"PubMed","id":"10945468"},{"database":"DOI","id":"10.1006/geno.2000.6211"}],"title":"cDNA cloning and expression analysis of new members of the mammalian F-box protein family.","publicationDate":"2000","journal":"Genomics","firstPage":"40","lastPage":"47","volume":"67"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"},{"value":"Hippocampus","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-70VOHH7BF94TO","citationType":"submission","authors":["Mural R.J.","Adams M.D.","Myers E.W.","Smith H.O.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Eye","type":"TISSUE"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"23542741","citationType":"journal article","authors":["Chen B.B.","Coon T.A.","Glasser J.R.","McVerry B.J.","Zhao J.","Zhao Y.","Zou C.","Ellis B.","Sciurba F.C.","Zhang Y.","Mallampalli R.K."],"citationCrossReferences":[{"database":"PubMed","id":"23542741"},{"database":"DOI","id":"10.1038/ni.2565"}],"title":"A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.","publicationDate":"2013","journal":"Nat. Immunol.","firstPage":"470","lastPage":"479","volume":"14"},"referencePositions":["FUNCTION","PATHWAY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF233226","properties":[{"key":"ProteinId","value":"AAF67156.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK004544","properties":[{"key":"ProteinId","value":"BAB23360.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK019550","properties":[{"key":"ProteinId","value":"BAB31793.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK028048","properties":[{"key":"ProteinId","value":"BAC25719.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK031428","properties":[{"key":"ProteinId","value":"BAC27398.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK049870","properties":[{"key":"ProteinId","value":"BAC33965.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK050195","properties":[{"key":"ProteinId","value":"BAC34118.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK151130","properties":[{"key":"ProteinId","value":"BAE30138.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK151857","properties":[{"key":"ProteinId","value":"BAE30746.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK152780","properties":[{"key":"ProteinId","value":"BAE31491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK167075","properties":[{"key":"ProteinId","value":"BAE39235.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX640578","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH466519","properties":[{"key":"ProteinId","value":"EDL27711.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH466519","properties":[{"key":"ProteinId","value":"EDL27712.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC010212","properties":[{"key":"ProteinId","value":"AAH10212.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058253","properties":[{"key":"ProteinId","value":"AAH58253.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS16484.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9DC63-1"},{"database":"CCDS","id":"CCDS16485.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9DC63-2"},{"database":"RefSeq","id":"NP_065618.1","properties":[{"key":"NucleotideSequenceId","value":"NM_020593.2"}],"isoformId":"Q9DC63-2"},{"database":"RefSeq","id":"NP_997598.1","properties":[{"key":"NucleotideSequenceId","value":"NM_212433.1"}],"isoformId":"Q9DC63-1"},{"database":"AlphaFoldDB","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"208300","properties":[{"key":"Interactions","value":"22"}]},{"database":"FunCoup","id":"Q9DC63","properties":[{"key":"Number of interactors","value":"2204"}]},{"database":"STRING","id":"10090.ENSMUSP00000028603","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000028603","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"267351","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9DC63-1"},{"database":"ProteomicsDB","id":"267352","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9DC63-2"},{"database":"ProteomicsDB","id":"267353","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9DC63-3"},{"database":"Pumba","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25751","properties":[{"key":"antibodies","value":"135 antibodies from 25 providers"}]},{"database":"DNASU","id":"57443","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000028603.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000028603.4"},{"key":"GeneId","value":"ENSMUSG00000027180.13"}],"isoformId":"Q9DC63-1"},{"database":"Ensembl","id":"ENSMUST00000102565.4","properties":[{"key":"ProteinId","value":"ENSMUSP00000099625.4"},{"key":"GeneId","value":"ENSMUSG00000027180.13"}],"isoformId":"Q9DC63-2"},{"database":"Ensembl","id":"ENSMUST00000111135.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000106765.2"},{"key":"GeneId","value":"ENSMUSG00000027180.13"}],"isoformId":"Q9DC63-3"},{"database":"GeneID","id":"57443","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:57443","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008lji.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q9DC63-2"},{"database":"UCSC","id":"uc008ljk.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q9DC63-1"},{"database":"AGR","id":"MGI:1929084","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26273","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1929084","properties":[{"key":"GeneName","value":"Fbxo3"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000027180","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4408","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000153571","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YVHDKDC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2305498at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"57443","properties":[{"key":"hits","value":"8 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9DC63","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q9DC63","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000027180","properties":[{"key":"ExpressionPatterns","value":"Expressed in sternocleidomastoid and 259 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9DC63","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0019005","properties":[{"key":"GoTerm","value":"C:SCF ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1990756","properties":[{"key":"GoTerm","value":"F:ubiquitin-like ligase-substrate adaptor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23542741"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"GO","id":"GO:0032496","properties":[{"key":"GoTerm","value":"P:response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031146","properties":[{"key":"GoTerm","value":"P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23542741"}]},{"database":"GO","id":"GO:0006366","properties":[{"key":"GoTerm","value":"P:transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd22084","properties":[{"key":"EntryName","value":"F-box_FBXO3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.1470:FF:000002","properties":[{"key":"EntryName","value":"F-box only protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.1280.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.1470","properties":[{"key":"EntryName","value":"ApaG domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1580.10","properties":[{"key":"EntryName","value":"SMI1/KNR4-like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007474","properties":[{"key":"EntryName","value":"ApaG_domain"}]},{"database":"InterPro","id":"IPR036767","properties":[{"key":"EntryName","value":"ApaG_sf"}]},{"database":"InterPro","id":"IPR036047","properties":[{"key":"EntryName","value":"F-box-like_dom_sf"}]},{"database":"InterPro","id":"IPR001810","properties":[{"key":"EntryName","value":"F-box_dom"}]},{"database":"InterPro","id":"IPR052121","properties":[{"key":"EntryName","value":"F-box_SCF_Substrate_Recog"}]},{"database":"InterPro","id":"IPR018958","properties":[{"key":"EntryName","value":"Knr4/Smi1-like_dom"}]},{"database":"InterPro","id":"IPR037883","properties":[{"key":"EntryName","value":"Knr4/Smi1-like_sf"}]},{"database":"NCBIfam","id":"NF003967","properties":[{"key":"EntryName","value":"PRK05461.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46550","properties":[{"key":"EntryName","value":"F-BOX ONLY PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46550:SF6","properties":[{"key":"EntryName","value":"F-BOX ONLY PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04379","properties":[{"key":"EntryName","value":"DUF525"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12937","properties":[{"key":"EntryName","value":"F-box-like"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09346","properties":[{"key":"EntryName","value":"SMI1_KNR4"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00256","properties":[{"key":"EntryName","value":"FBOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00860","properties":[{"key":"EntryName","value":"SMI1_KNR4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF110069","properties":[{"key":"EntryName","value":"ApaG-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81383","properties":[{"key":"EntryName","value":"F-box domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF160631","properties":[{"key":"EntryName","value":"SMI1/KNR4-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51087","properties":[{"key":"EntryName","value":"APAG"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50181","properties":[{"key":"EntryName","value":"FBOX"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDADENESDEGEGEARRRRVFDVPIRRRRCSRLF","length":480,"molWeight":55227,"crc64":"9AD9565076A67787","md5":"D889B8C5822E2270AAE4CDA050ECD697"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3},"countByFeatureType":{"Chain":1,"Domain":2,"Region":1,"Compositional bias":1,"Alternative sequence":3,"Sequence conflict":6},"uniParcId":"UPI0000022B01"}}