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Required for retaining emerin at the inner nuclear membrane (PubMed:18230648). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (PubMed:34050020)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9BTV4"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16141072"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18230648"}],"value":"Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane (PubMed:18230648). Interacts with LMNA and LMNB2 (PubMed:18230648). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway. Interacts with CARD10. Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18230648"}],"value":"Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9BTV4"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18230648"}],"value":"Nucleus inner membrane","id":"SL-0179"},"topology":{"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9BTV4"}],"value":"Cell membrane","id":"SL-0039"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34050020"}],"value":"Widely expressed, including in the cochlea, heart, eye, brain and kidney"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34050020"}],"value":"In the cochlea, mainly expressed in the organ of Corti, along the entire cochlear length, at postnatal day 4 (P4) through P20. At P20, the expression becomes more restricted to the apical membrane of the inner border cells and the cell junctions of the inner sulcus cells. Throughout the early developmental period, up to P20, expression is mainly found at inner glia-like supporting cells of Kolliker's organ, while hair cell expression is comparably sparse. 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