{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9DAG5","uniProtkbId":"STPG4_MOUSE","entryAudit":{"firstPublicDate":"2007-11-13","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2001-06-01","entryVersion":121,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein STPG4"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16571911"}],"value":"Gonad-specific expression gene protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16571911"}],"value":"GSE"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1922717"}],"value":"Sperm-tail PG-rich repeat-containing protein 4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1922717"}],"value":"Stpg4"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23560077"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28930672"}],"value":"Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote (PubMed:23560077, PubMed:28930672). Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:23560077, PubMed:28930672)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23560077"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28930672"}],"value":"Interacts with histone H3 (PubMed:23560077). Interacts with histone H4 (PubMed:23560077). Interacts with METTL23 (PubMed:28930672)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23560077"}],"value":"Localizes in female and male zygote pronucleus (PubMed:16571911, PubMed:23560077). Associates preferentially with the paternal chromatin during zygote development (PubMed:23560077)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16571911"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16571911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23560077"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16571911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23560077"}],"value":"Expressed in ovary and testis (PubMed:16571911). Expressed in spermatocytes I in the pachytene stage, round spermatids, and elongated spermatids (PubMed:16571911). Expressed in the germinal vesicle (GV) stage and stage 2 meiosis (MII) oocytes and pre-implantation embryos until blastocyst stage (at protein level) (PubMed:16571911, PubMed:23560077)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28930672"}],"value":"No visible phenotype (PubMed:28930672). Mice were born at the expected Mendelian ratio and show no overt phenotype (PubMed:28930672). 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