{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9D5W4","secondaryAccessions":["A1L0U4"],"uniProtkbId":"CCD81_MOUSE","entryAudit":{"firstPublicDate":"2007-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":133,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Coiled-coil domain-containing protein 81"}}},"genes":[{"geneName":{"value":"Ccdc81"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZN84"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome","id":"SL-0048"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Coiled-coil domain-containing protein 81","featureId":"PRO_0000288878"},{"type":"Region","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":431,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":293,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":206,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5XIN9"}]},{"type":"Modified residue","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":273,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5XIN9"}]},{"type":"Modified residue","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":275,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5XIN9"}]},{"type":"Modified residue","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5XIN9"}]},{"type":"Modified residue","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":419,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5XIN9"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-613"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK014876","properties":[{"key":"ProteinId","value":"BAB29597.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC127049","properties":[{"key":"ProteinId","value":"AAI27050.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS52306.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001156451.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001162979.1"}]},{"database":"AlphaFoldDB","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"214318","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q9D5W4","properties":[{"key":"Number of interactors","value":"104"}]},{"database":"STRING","id":"10090.ENSMUSP00000044087","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9D5W4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000044087","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"265599","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"50011","properties":[{"key":"antibodies","value":"101 antibodies from 19 providers"}]},{"database":"Ensembl","id":"ENSMUST00000041195.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000044087.6"},{"key":"GeneId","value":"ENSMUSG00000039391.12"}]},{"database":"GeneID","id":"70884","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:70884","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009igf.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1918134","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"60494","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1918134","properties":[{"key":"GeneName","value":"Ccdc81"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000039391","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QT76","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000011985","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_020603_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QCEKYPR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"125906at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"70884","properties":[{"key":"hits","value":"4 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9D5W4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q9D5W4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000039391","properties":[{"key":"ExpressionPatterns","value":"Expressed in spermatid and 45 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9D5W4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005815","properties":[{"key":"GoTerm","value":"C:microtubule organizing center"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR026295","properties":[{"key":"EntryName","value":"CCD81"}]},{"database":"InterPro","id":"IPR040673","properties":[{"key":"EntryName","value":"CCDC81_HU_dom_2"}]},{"database":"InterPro","id":"IPR028034","properties":[{"key":"EntryName","value":"HU-CCDC81"}]},{"database":"PANTHER","id":"PTHR14362","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 81"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14362:SF2","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 81"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14908","properties":[{"key":"EntryName","value":"HU-CCDC81_euk_1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18289","properties":[{"key":"EntryName","value":"HU-CCDC81_euk_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLDRVGPGFQDLCRQVLPTLPTLSQEEVSTIWANVSDFVERQLTMHKGVQISGLGTFTFSRQQLEVGNKKFVLVQRPVFIMAEKLVQTHGLKQNKVFSPGDIPVVPLNFVMISLEGPFNRDTIEGCVKETLLFLSRSISVKQKVEFTFKGIGVLSIRDSKVKMRFYKDFLCSMDGSGILTKALANRPGTMDSVLSSRESYRKRPNSAMAFPRIEHKETENKTPVEVVGEEGGENRPRKIKLKDQSDKEGGAREISSPKKHRERQSISPAKVTSVSLLDKFERSGNGGKITACENLSSPGCQRNDNERPRTSPAPACQDHNKAGQEMCYVCLQRAQRNFALHYGDERRRREIEDERLMQQYQILKDQEAFFKNQVKGMAAREQNQKNAAYNLGVAEAIRNHKNEKPEFYKSFLFDKRPLSPEINAFKQEEYSQSLLKQMESKREKEIKQRQNRELMDRLEQVQLTEELAAQRAQYLKEKMEETQHYKRALDAQVKNKPPQLPMFEPDSAEPIFGKNDGEREMEKRKREQSCMKHQMEAAASHKRNTILNQLVDQRRDLQMLQRTQREHMADRAAEMDRVNRLNQCLQEDWDRSLAMKKQRDVEEKAFERASDKLFLLDQCEKYRRCRQCQRRTCNTGESNLWPMNKFLQGSRLLV","length":654,"molWeight":75826,"crc64":"8161BB8965EFA835","md5":"87531A894B76A2081E3F72F0318204C4"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Region":2,"Coiled coil":1,"Compositional bias":3,"Modified residue":5},"uniParcId":"UPI0000025106"}}