{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9D1F5","secondaryAccessions":["Q9CX85"],"uniProtkbId":"MRNIP_MOUSE","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":132,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915317"}],"value":"MRN complex-interacting protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"MRN-interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915317"}],"value":"Mrnip"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive. Interacts with MRE11. Interacts with NBN. Interacts with RAD50"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Recruited to sites of DNA damage. Phosphorylation induces its nuclear localization and promotes genome stability"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Nucleus, nucleoplasm","id":"SL-0190"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}],"value":"Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation is necessary for its nuclear retention"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MRNIP family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"MRN complex-interacting protein","featureId":"PRO_0000326120"},{"type":"Region","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Necessary for the association with the MRN complex","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}]},{"type":"Region","location":{"start":{"value":273,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"Nuclear localization signal (NLS)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}]},{"type":"Compositional bias","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6NTE8"}]},{"type":"Sequence conflict","location":{"start":{"value":294,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in Ref. 2; BAB31698","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"},{"value":"Head","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK003636","properties":[{"key":"ProteinId","value":"BAB22904.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK019392","properties":[{"key":"ProteinId","value":"BAB31698.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL627187","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC028428","properties":[{"key":"ProteinId","value":"AAH28428.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS48784.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_080819.2","properties":[{"key":"NucleotideSequenceId","value":"NM_026543.3"}]},{"database":"AlphaFoldDB","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9D1F5","properties":[{"key":"Number of interactors","value":"1320"}]},{"database":"STRING","id":"10090.ENSMUSP00000020647","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9D1F5","properties":[{"key":"glycosylation","value":"1 site, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000020647","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"290319","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"62814","properties":[{"key":"antibodies","value":"105 antibodies from 13 providers"}]},{"database":"Ensembl","id":"ENSMUST00000020647.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000020647.4"},{"key":"GeneId","value":"ENSMUSG00000020381.11"}]},{"database":"GeneID","id":"68067","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:68067","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007irv.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1915317","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915317","properties":[{"key":"GeneName","value":"Mrnip"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000020381","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S8YD","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006124","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_068693_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GHQQAEN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"79217at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"68067","properties":[{"key":"hits","value":"5 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9D1F5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q9D1F5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000020381","properties":[{"key":"ExpressionPatterns","value":"Expressed in animal zygote and 145 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9D1F5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030870","properties":[{"key":"GoTerm","value":"C:Mre11 complex"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007095","properties":[{"key":"GoTerm","value":"P:mitotic G2 DNA damage checkpoint signaling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1905168","properties":[{"key":"GoTerm","value":"P:positive regulation of double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045860","properties":[{"key":"GoTerm","value":"P:positive regulation of protein kinase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071168","properties":[{"key":"GoTerm","value":"P:protein localization to chromatin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2001032","properties":[{"key":"GoTerm","value":"P:regulation of double-strand break repair via nonhomologous end joining"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010212","properties":[{"key":"GoTerm","value":"P:response to ionizing radiation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR032739","properties":[{"key":"EntryName","value":"MRNIP"}]},{"database":"InterPro","id":"IPR049472","properties":[{"key":"EntryName","value":"MRNIP_N"}]},{"database":"PANTHER","id":"PTHR15863","properties":[{"key":"EntryName","value":"MRN COMPLEX-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15863:SF2","properties":[{"key":"EntryName","value":"MRN COMPLEX-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15749","properties":[{"key":"EntryName","value":"MRNIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAPAQQSRVLRCCSCHIFQAHQVKKSLKWTCKACGEKQSFVRAYGEGSGADCRRHVQKLNLLQGQVSELSLRSVEEAVNGSEEENAGPLQAEAGSQQAPSKPLESRWLKYLDKGCEDQELDRGRPALKTQLSTSAERPSSPAQPRKRKWNQRTGQPAHSLHGQGVDSVEDNFEHQDSTGLFGTEQQGTSPALSTANHTRELGFPRWKLPSPVTQVNAPSSKWARFLLAPGNSPQVDEKPSPLQEATMLADLAQGTVENKTPVEGHFSRAPAIRPPQAIHTTTPQLDRPDRKTREQPRDMGTPRADGRPLAQGTQKAPPLQLHNLFTTGEDFDDDL","length":335,"molWeight":36897,"crc64":"4F24FDA35BEB6070","md5":"B731697BED353361A9F7945D60EDFFFE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":4,"Motif":1,"Compositional bias":3,"Modified residue":1,"Sequence conflict":1},"uniParcId":"UPI00000218EA"}}