{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9CZJ9","secondaryAccessions":["Q8R371"],"uniProtkbId":"DJC18_MOUSE","entryAudit":{"firstPublicDate":"2006-06-27","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2001-06-01","entryVersion":149,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"DnaJ homolog subfamily C member 18"}}},"genes":[{"geneName":{"value":"Dnajc18"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H819"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H819"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"DnaJ homolog subfamily C member 18","featureId":"PRO_0000244087"},{"type":"Transmembrane","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"J","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00286"}]},{"type":"Sequence conflict","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"in Ref. 2; AAH26452","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Embryo","type":"TISSUE"},{"value":"Pituitary","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK012521","properties":[{"key":"ProteinId","value":"BAB28293.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK030483","properties":[{"key":"ProteinId","value":"BAC26985.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC026452","properties":[{"key":"ProteinId","value":"AAH26452.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS29148.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_083945.1","properties":[{"key":"NucleotideSequenceId","value":"NM_029669.4"}]},{"database":"RefSeq","id":"XP_006526406.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006526343.4"}]},{"database":"RefSeq","id":"XP_006526407.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006526344.4"}]},{"database":"RefSeq","id":"XP_006526408.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006526345.4"}]},{"database":"AlphaFoldDB","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9CZJ9","properties":[{"key":"Number of interactors","value":"672"}]},{"database":"STRING","id":"10090.ENSMUSP00000025208","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000025208","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"279778","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"26786","properties":[{"key":"antibodies","value":"26 antibodies from 13 providers"}]},{"database":"DNASU","id":"76594","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000025208.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000025208.6"},{"key":"GeneId","value":"ENSMUSG00000024350.7"}]},{"database":"GeneID","id":"76594","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:76594","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008emq.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1923844","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"202052","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1923844","properties":[{"key":"GeneName","value":"Dnajc18"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000024350","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0714","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160925","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_043579_3_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TGQARHY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"552049at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"76594","properties":[{"key":"hits","value":"3 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9CZJ9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 18"}]},{"database":"RNAct","id":"Q9CZJ9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000024350","properties":[{"key":"ExpressionPatterns","value":"Expressed in spermatid and 246 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9CZJ9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030544","properties":[{"key":"GoTerm","value":"F:Hsp70 protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0071218","properties":[{"key":"GoTerm","value":"P:cellular response to misfolded protein"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006457","properties":[{"key":"GoTerm","value":"P:protein folding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd06257","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.110:FF:000004","properties":[{"key":"EntryName","value":"DnaJ (Hsp40) homolog, subfamily B, member 14"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.110","properties":[{"key":"EntryName","value":"DnaJ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001623","properties":[{"key":"EntryName","value":"DnaJ_domain"}]},{"database":"InterPro","id":"IPR018253","properties":[{"key":"EntryName","value":"DnaJ_domain_CS"}]},{"database":"InterPro","id":"IPR051100","properties":[{"key":"EntryName","value":"DnaJ_subfamily_B/C"}]},{"database":"InterPro","id":"IPR015399","properties":[{"key":"EntryName","value":"DUF1977_DnaJ-like"}]},{"database":"InterPro","id":"IPR036869","properties":[{"key":"EntryName","value":"J_dom_sf"}]},{"database":"PANTHER","id":"PTHR43908","properties":[{"key":"EntryName","value":"AT29763P-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR43908:SF2","properties":[{"key":"EntryName","value":"DNAJ HOMOLOG SUBFAMILY C MEMBER 18"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00226","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09320","properties":[{"key":"EntryName","value":"DUF1977"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00625","properties":[{"key":"EntryName","value":"JDOMAIN"}]},{"database":"SMART","id":"SM00271","properties":[{"key":"EntryName","value":"DnaJ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46565","properties":[{"key":"EntryName","value":"Chaperone J-domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00636","properties":[{"key":"EntryName","value":"DNAJ_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50076","properties":[{"key":"EntryName","value":"DNAJ_2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MATTLGSGERWTQAYIDAIRRNKYPEDKRPDSHDPCGCCNCMKAQKEKKSENEWNQTRQGEGNATYTEEQLRGVQRIKKCRNYYDILGVSHNASDEELKKAYKKLALKFHPDKNCAPGATEAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTVPRARSYHYYKDFEADISPEELFNVFFGGHFPSGNIHMFSNVTDDSQYYRRRHRHERTQTHKREEDKSQTPYSAFVQLLPVLVIVTISVITQLLAANPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLRDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLRQKAESLKLENCAKLSKLIGLRRAG","length":357,"molWeight":41434,"crc64":"9798AF2559A6A215","md5":"D382F12ED6D7A7445F2B3AA2E4CAD546"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Domain":1,"Sequence conflict":1},"uniParcId":"UPI000002230F"}}