{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9CX63","secondaryAccessions":["B1ATC1"],"uniProtkbId":"IL40_MOUSE","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":142,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein IL-40"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28978694"}],"value":"Interleukin-40"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28978694"}],"value":"IL-40"}]}],"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses (PubMed:28978694). Involved in lymphocyte B cell development and immunoglobulin/IgA production (PubMed:28978694)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6UX52"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Expressed in bone marrow, spleen and lymph node (PubMed:28978694)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Up-regulated in the mammary gland upon the onset of lactation (PubMed:28978694). Up-regulated in peripheral blood lymphocyte B cells upon activation (PubMed:28978694)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Mice are viable and reproduce normally (PubMed:28978694). Show reduced number of both peripheral lymphocyte B cells in the spleen and precursor and mature lymphocyte B cells in the bone marrow (PubMed:28978694). Show smaller and fewer Peyer's patches, lower numbers of immunoglobulin/IgA-secreting B cells and an altered gut microbiome (PubMed:28978694). Exhibit reduced levels of immunoglobulin/IgA in the serum, gut, feces, and lactating mammary gland (PubMed:28978694)"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":18,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"Protein IL-40","featureId":"PRO_0000272655"},{"type":"Glycosylation","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":177,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""}],"keywords":[{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"28978694","citationType":"journal article","authors":["Catalan-Dibene J.","Vazquez M.I.","Luu V.P.","Nuccio S.P.","Karimzadeh A.","Kastenschmidt J.M.","Villalta S.A.","Ushach I.","Pone E.J.","Casali P.","Raffatellu M.","Burkhardt A.M.","Hernandez-Ruiz M.","Heller G.","Hevezi P.A.","Zlotnik A."],"citationCrossReferences":[{"database":"PubMed","id":"28978694"},{"database":"DOI","id":"10.4049/jimmunol.1700534"}],"title":"Identification of IL-40, a novel B cell-associated cytokine.","publicationDate":"2017","journal":"J. Immunol.","firstPage":"3326","lastPage":"3335","volume":"199"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE","INDUCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK020081","properties":[{"key":"ProteinId","value":"BAB31985.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL645856","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS48992.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_084240.1","properties":[{"key":"NucleotideSequenceId","value":"NM_029964.1"}]},{"database":"AlphaFoldDB","id":"Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9CX63","properties":[{"key":"Number of interactors","value":"257"}]},{"database":"GlyGen","id":"Q9CX63","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"iPTMnet","id":"Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000101938","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32542","properties":[{"key":"antibodies","value":"25 antibodies from 12 providers"}]},{"database":"Ensembl","id":"ENSMUST00000106331.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000101938.2"},{"key":"GeneId","value":"ENSMUSG00000025573.5"}]},{"database":"GeneID","id":"77727","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:77727","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007mnv.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1924977","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1924977","properties":[{"key":"GeneName","value":"6030468B19Rik"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000025573","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SPUE","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244808","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_096525_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AEMSCWA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9524734at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"77727","properties":[{"key":"hits","value":"2 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9CX63","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q9CX63","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000025573","properties":[{"key":"ExpressionPatterns","value":"Expressed in mesodermal cell in embryo and 20 other cell types or tissues"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002313","properties":[{"key":"GoTerm","value":"P:mature B cell differentiation involved in immune response"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28978694"}]},{"database":"GO","id":"GO:2000558","properties":[{"key":"GoTerm","value":"P:positive regulation of immunoglobulin production in mucosal tissue"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28978694"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR040878","properties":[{"key":"EntryName","value":"IL-40-like_Ig"}]},{"database":"Pfam","id":"PF17736","properties":[{"key":"EntryName","value":"Ig_C17orf99"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MALLQLLLFAMLAACGFSEEQTEGITIAYKVLEVYPQSRRVLITCDAPEASQPITYSLLASRGILVAKKVVHDSVPASFNINITIKSSPDLLTYSCQATSNSGTYGPSSRLQMYQELWAKPVSQLQADFVLRHGDSGPTVELSCLASSGSPPITYRLVGNGGRVLAQQRPLHGKPANFSLPLSQTTGWFQCEAENDVGVDSSARIPLPRAEARAKLVTTLAGELPLTPTCILAGSLVSIAVIASRMLSSTGL","length":252,"molWeight":26851,"crc64":"3F5F6339341F206B","md5":"61F1C2373893D1F24D8CF6412FFC838B"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1},"countByFeatureType":{"Signal":1,"Chain":1,"Glycosylation":2},"uniParcId":"UPI0000027282"}}