{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9CRG1","secondaryAccessions":["Q3TBQ2","Q3U3Q6","Q4F873","Q6PES5"],"uniProtkbId":"TM7S3_MOUSE","entryAudit":{"firstPublicDate":"2002-06-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-12-20","entryVersion":127,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane 7 superfamily member 3"}},"alternativeNames":[{"fullName":{"value":"NARP1"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Tm7sf3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NS93"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21853325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27740623"}],"value":"Involved in the inhibition of cytokine-induced death of pancreatic beta cells (PubMed:21853325). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NS93"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"Transmembrane 7 superfamily member 3","featureId":"PRO_0000022538"},{"type":"Transmembrane","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":307,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":315,"modifier":"EXACT"},"end":{"value":335,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":447,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":478,"modifier":"EXACT"},"end":{"value":498,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Glycosylation","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in Ref. 1; AAZ14855 and 2; BAE42255","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"in Ref. 2; BAB27141/BAE32729","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":296,"modifier":"EXACT"},"end":{"value":296,"modifier":"EXACT"}},"description":"in Ref. 2; BAB27141/BAE32729","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"in Ref. 2; BAB27141/BAE32729","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in Ref. 2; BAE42255","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"in Ref. 2; BAB27141/BAE32729","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0346","category":"Biological process","name":"Stress response"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2QQN3N62QEIBJ","citationType":"submission","authors":["Chang N.-S."],"title":"Cloning and characterization of a 7-transmembrane protein NARP in the nucleus.","publicationDate":"JUN-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"C3H/An","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Embryonic stem cell","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 257-565"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21853325","citationType":"journal article","authors":["Beck A.","Isaac R.","Lavelin I.","Hart Y.","Volberg T.","Shatz-Azoulay H.","Geiger B.","Zick Y."],"citationCrossReferences":[{"database":"PubMed","id":"21853325"},{"database":"DOI","id":"10.1007/s00125-011-2277-3"}],"title":"An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.","publicationDate":"2011","journal":"Diabetologia","firstPage":"2845","lastPage":"2855","volume":"54"},"referencePositions":["FUNCTION"]},{"referenceNumber":5,"citation":{"id":"27740623","citationType":"journal article","authors":["Isaac R.","Goldstein I.","Furth N.","Zilber N.","Streim S.","Boura-Halfon S.","Elhanany E.","Rotter V.","Oren M.","Zick Y."],"citationCrossReferences":[{"database":"PubMed","id":"27740623"},{"database":"DOI","id":"10.1038/cdd.2016.108"}],"title":"TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.","publicationDate":"2017","journal":"Cell Death Differ.","firstPage":"132","lastPage":"143","volume":"24"},"referencePositions":["FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"DQ104329","properties":[{"key":"ProteinId","value":"AAZ14855.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK010720","properties":[{"key":"ProteinId","value":"BAB27141.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK154633","properties":[{"key":"ProteinId","value":"BAE32729.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK171111","properties":[{"key":"ProteinId","value":"BAE42255.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC057900","properties":[{"key":"ProteinId","value":"AAH57900.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS20699.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_080557.2","properties":[{"key":"NucleotideSequenceId","value":"NM_026281.2"}]},{"database":"AlphaFoldDB","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"212318","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q9CRG1","properties":[{"key":"Number of interactors","value":"774"}]},{"database":"IntAct","id":"Q9CRG1","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000045650","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q9CRG1","properties":[{"key":"glycosylation","value":"4 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q9CRG1","properties":[{"key":"glycosylation","value":"4 sites"}]},{"database":"iPTMnet","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000045650","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"259232","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"67623","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"67623","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:67623","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009ese.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1914873","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51768","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1914873","properties":[{"key":"GeneName","value":"Tm7sf3"}]},{"database":"eggNOG","id":"ENOG502QS07","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5967337at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"67623","properties":[{"key":"hits","value":"5 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q9CRG1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"RNAct","id":"Q9CRG1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0034620","properties":[{"key":"GoTerm","value":"P:cellular response to unfolded protein"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27740623"}]},{"database":"GO","id":"GO:0043069","properties":[{"key":"GoTerm","value":"P:negative regulation of programmed cell death"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21853325"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27740623"}]},{"database":"GO","id":"GO:0032024","properties":[{"key":"GoTerm","value":"P:positive regulation of insulin secretion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR060567","properties":[{"key":"EntryName","value":"Ig_TM7SF3_2nd"}]},{"database":"InterPro","id":"IPR059229","properties":[{"key":"EntryName","value":"Ig_TM7SF3_N"}]},{"database":"InterPro","id":"IPR025256","properties":[{"key":"EntryName","value":"TM7S3/TM198-like_dom"}]},{"database":"InterPro","id":"IPR042502","properties":[{"key":"EntryName","value":"TM7SF3"}]},{"database":"PANTHER","id":"PTHR15937","properties":[{"key":"EntryName","value":"TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15937:SF3","properties":[{"key":"EntryName","value":"TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF27919","properties":[{"key":"EntryName","value":"Ig_TM7SF3_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25992","properties":[{"key":"EntryName","value":"Ig_TM7SF3_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13886","properties":[{"key":"EntryName","value":"TM7S3_TM198"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSKSSPQEAVLRHISSNVTFLLFQIHSQYQNTTVSFTKTLLPSTSGTGNDRGLVFILRPEQAVCTWYLETGDTKPVQSVALTLSYSERDPIPGGCNLEFDLDIDPNLYLDYNFFETTIKFAPANIGYARATEPPPCDVSTSRESRWRLRYDVYQYFLPEGDLTEASLLHHLQRMAQVAQVKASAIKVATLTADDKTAVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFESVDGNCASPGRVSTKVFSTLFALLGLFVCFFGHRFWKTDLFFVGFIFLGFFFYILITRLTPLQYDVRLALTAVAGSFGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFMGCLRILNILACGVVGSYSVVLAVNSYMFTSLSYITLNVLRRALNTDFRGAFIRVPFQTNDYIILAVWGMLAVSGITLQIRRERGQPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGRVARIKELFQKEQPAGERTPLLL","length":565,"molWeight":63251,"crc64":"EBAD9EF756DF9C76","md5":"F1A60816A75FF5FCFC6B6A3C9D96355A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Transmembrane":7,"Glycosylation":4,"Sequence conflict":6},"uniParcId":"UPI000062764D"}}