ID   FGFP2_HUMAN             Reviewed;         223 AA.
AC   Q9BYJ0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 134.
DE   RecName: Full=Fibroblast growth factor-binding protein 2;
DE            Short=FGF-BP2;
DE            Short=FGF-binding protein 2;
DE            Short=FGFBP-2;
DE   AltName: Full=37 kDa killer-specific secretory protein;
DE            Short=Ksp37;
DE   AltName: Full=HBp17-related protein;
DE            Short=HBp17-RP;
DE   Flags: Precursor;
GN   Name=FGFBP2; Synonyms=KSP37; ORFNames=UNQ425/PRO1065;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Cytotoxic T-cell;
RX   PubMed=11342666; DOI=10.4049/jimmunol.166.10.6404;
RA   Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K.,
RA   Takano S., Nakamura M., Nagata K.;
RT   "A novel serum protein that is selectively produced by cytotoxic
RT   lymphocytes.";
RL   J. Immunol. 166:6404-6412(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epidermal carcinoma;
RA   Sato J.D., Chapline M.C.;
RT   "cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-
RT   RP).";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q9BYJ0; P55061: TMBIM6; NbExp=3; IntAct=EBI-12911356, EBI-1045825;
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000269|PubMed:11342666}.
CC   -!- TISSUE SPECIFICITY: Expressed in serum, peripheral leukocytes and
CC       cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at
CC       protein level). {ECO:0000269|PubMed:11342666}.
CC   -!- SIMILARITY: Belongs to the fibroblast growth factor-binding protein
CC       family. {ECO:0000305}.
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DR   EMBL; AB021123; BAB39770.1; -; mRNA.
DR   EMBL; AF361936; AAK51503.1; -; mRNA.
DR   EMBL; AY358978; AAQ89337.1; -; mRNA.
DR   EMBL; BC025720; AAH25720.1; -; mRNA.
DR   CCDS; CCDS3419.1; -.
DR   RefSeq; NP_114156.1; NM_031950.3.
DR   AlphaFoldDB; Q9BYJ0; -.
DR   BioGRID; 123799; 5.
DR   IntAct; Q9BYJ0; 2.
DR   STRING; 9606.ENSP00000259989; -.
DR   GlyCosmos; Q9BYJ0; 2 sites, 2 glycans.
DR   GlyGen; Q9BYJ0; 8 sites, 3 O-linked glycans (8 sites).
DR   iPTMnet; Q9BYJ0; -.
DR   PhosphoSitePlus; Q9BYJ0; -.
DR   BioMuta; FGFBP2; -.
DR   DMDM; 74733476; -.
DR   jPOST; Q9BYJ0; -.
DR   MassIVE; Q9BYJ0; -.
DR   PaxDb; 9606-ENSP00000259989; -.
DR   PeptideAtlas; Q9BYJ0; -.
DR   ProteomicsDB; 79654; -.
DR   Antibodypedia; 43624; 136 antibodies from 25 providers.
DR   DNASU; 83888; -.
DR   Ensembl; ENST00000259989.7; ENSP00000259989.6; ENSG00000137441.8.
DR   GeneID; 83888; -.
DR   KEGG; hsa:83888; -.
DR   MANE-Select; ENST00000259989.7; ENSP00000259989.6; NM_031950.4; NP_114156.1.
DR   UCSC; uc003gon.4; human.
DR   AGR; HGNC:29451; -.
DR   CTD; 83888; -.
DR   DisGeNET; 83888; -.
DR   GeneCards; FGFBP2; -.
DR   HGNC; HGNC:29451; FGFBP2.
DR   HPA; ENSG00000137441; Tissue enhanced (adipose tissue, bone marrow).
DR   MIM; 607713; gene.
DR   neXtProt; NX_Q9BYJ0; -.
DR   OpenTargets; ENSG00000137441; -.
DR   PharmGKB; PA162388435; -.
DR   VEuPathDB; HostDB:ENSG00000137441; -.
DR   eggNOG; ENOG502S0EZ; Eukaryota.
DR   GeneTree; ENSGT00940000154372; -.
DR   HOGENOM; CLU_086542_0_0_1; -.
DR   InParanoid; Q9BYJ0; -.
DR   OMA; KSYWCEY; -.
DR   OrthoDB; 5316124at2759; -.
DR   PhylomeDB; Q9BYJ0; -.
DR   TreeFam; TF335877; -.
DR   PathwayCommons; Q9BYJ0; -.
DR   Reactome; R-HSA-190377; FGFR2b ligand binding and activation.
DR   SignaLink; Q9BYJ0; -.
DR   BioGRID-ORCS; 83888; 14 hits in 1142 CRISPR screens.
DR   GenomeRNAi; 83888; -.
DR   Pharos; Q9BYJ0; Tbio.
DR   PRO; PR:Q9BYJ0; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q9BYJ0; Protein.
DR   Bgee; ENSG00000137441; Expressed in tibia and 115 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   InterPro; IPR010510; FGF1-bd.
DR   PANTHER; PTHR15258; FGF BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR15258:SF1; FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR   Pfam; PF06473; FGF-BP1; 1.
DR   Genevisible; Q9BYJ0; HS.
PE   1: Evidence at protein level;
KW   Disulfide bond; Growth factor binding; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..223
FT                   /note="Fibroblast growth factor-binding protein 2"
FT                   /id="PRO_0000245860"
FT   REGION          23..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        43..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..214
FT                   /evidence="ECO:0000250"
FT   VARIANT         28
FT                   /note="S -> N (in dbSNP:rs35496730)"
FT                   /id="VAR_061171"
FT   VARIANT         84
FT                   /note="F -> L (in dbSNP:rs2286459)"
FT                   /id="VAR_059287"
FT   VARIANT         90
FT                   /note="P -> S (in dbSNP:rs758329)"
FT                   /id="VAR_049065"
SQ   SEQUENCE   223 AA;  24581 MW;  792E68933E7929D9 CRC64;
     MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR
     VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA
     GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR
     PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG
//