ID FGFP2_HUMAN Reviewed; 223 AA. AC Q9BYJ0; DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 1. DT 27-NOV-2024, entry version 138. DE RecName: Full=Fibroblast growth factor-binding protein 2; DE Short=FGF-BP2; DE Short=FGF-binding protein 2; DE Short=FGFBP-2; DE AltName: Full=37 kDa killer-specific secretory protein; DE Short=Ksp37; DE AltName: Full=HBp17-related protein; DE Short=HBp17-RP; DE Flags: Precursor; GN Name=FGFBP2; Synonyms=KSP37; ORFNames=UNQ425/PRO1065; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION. RC TISSUE=Cytotoxic T-cell; RX PubMed=11342666; DOI=10.4049/jimmunol.166.10.6404; RA Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K., RA Takano S., Nakamura M., Nagata K.; RT "A novel serum protein that is selectively produced by cytotoxic RT lymphocytes."; RL J. Immunol. 166:6404-6412(2001). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Epidermal carcinoma; RA Sato J.D., Chapline M.C.; RT "cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17- RT RP)."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q9BYJ0; P55061: TMBIM6; NbExp=3; IntAct=EBI-12911356, EBI-1045825; CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space CC {ECO:0000269|PubMed:11342666}. CC -!- TISSUE SPECIFICITY: Expressed in serum, peripheral leukocytes and CC cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at CC protein level). {ECO:0000269|PubMed:11342666}. CC -!- SIMILARITY: Belongs to the fibroblast growth factor-binding protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB021123; BAB39770.1; -; mRNA. DR EMBL; AF361936; AAK51503.1; -; mRNA. DR EMBL; AY358978; AAQ89337.1; -; mRNA. DR EMBL; BC025720; AAH25720.1; -; mRNA. DR CCDS; CCDS3419.1; -. DR RefSeq; NP_114156.1; NM_031950.3. DR AlphaFoldDB; Q9BYJ0; -. DR BioGRID; 123799; 5. DR IntAct; Q9BYJ0; 4. DR STRING; 9606.ENSP00000259989; -. DR GlyCosmos; Q9BYJ0; 2 sites, 2 glycans. DR GlyGen; Q9BYJ0; 8 sites, 3 O-linked glycans (8 sites). DR iPTMnet; Q9BYJ0; -. DR PhosphoSitePlus; Q9BYJ0; -. DR BioMuta; FGFBP2; -. DR DMDM; 74733476; -. DR jPOST; Q9BYJ0; -. DR MassIVE; Q9BYJ0; -. DR PaxDb; 9606-ENSP00000259989; -. DR PeptideAtlas; Q9BYJ0; -. DR ProteomicsDB; 79654; -. DR Antibodypedia; 43624; 108 antibodies from 24 providers. DR DNASU; 83888; -. DR Ensembl; ENST00000259989.7; ENSP00000259989.6; ENSG00000137441.8. DR GeneID; 83888; -. DR KEGG; hsa:83888; -. DR MANE-Select; ENST00000259989.7; ENSP00000259989.6; NM_031950.4; NP_114156.1. DR UCSC; uc003gon.4; human. DR AGR; HGNC:29451; -. DR CTD; 83888; -. DR DisGeNET; 83888; -. DR GeneCards; FGFBP2; -. DR HGNC; HGNC:29451; FGFBP2. DR HPA; ENSG00000137441; Tissue enhanced (adipose tissue, bone marrow). DR MIM; 607713; gene. DR neXtProt; NX_Q9BYJ0; -. DR OpenTargets; ENSG00000137441; -. DR PharmGKB; PA162388435; -. DR VEuPathDB; HostDB:ENSG00000137441; -. DR eggNOG; ENOG502S0EZ; Eukaryota. DR GeneTree; ENSGT00940000154372; -. DR HOGENOM; CLU_086542_0_0_1; -. DR InParanoid; Q9BYJ0; -. DR OMA; KSYWCEY; -. DR OrthoDB; 5316124at2759; -. DR PhylomeDB; Q9BYJ0; -. DR TreeFam; TF335877; -. DR PathwayCommons; Q9BYJ0; -. DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation. DR SignaLink; Q9BYJ0; -. DR BioGRID-ORCS; 83888; 14 hits in 1142 CRISPR screens. DR GenomeRNAi; 83888; -. DR Pharos; Q9BYJ0; Tbio. DR PRO; PR:Q9BYJ0; -. DR Proteomes; UP000005640; Chromosome 4. DR RNAct; Q9BYJ0; protein. DR Bgee; ENSG00000137441; Expressed in tibia and 115 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central. DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central. DR InterPro; IPR010510; FGF1-bd. DR PANTHER; PTHR15258; FGF BINDING PROTEIN-RELATED; 1. DR PANTHER; PTHR15258:SF1; FIBROBLAST GROWTH FACTOR-BINDING PROTEIN 2; 1. DR Pfam; PF06473; FGF-BP1; 1. PE 1: Evidence at protein level; KW Disulfide bond; Growth factor binding; Proteomics identification; KW Reference proteome; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT CHAIN 20..223 FT /note="Fibroblast growth factor-binding protein 2" FT /id="PRO_0000245860" FT REGION 23..45 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 120..201 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 124..148 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 43..63 FT /evidence="ECO:0000250" FT DISULFID 72..106 FT /evidence="ECO:0000250" FT DISULFID 81..117 FT /evidence="ECO:0000250" FT DISULFID 206..214 FT /evidence="ECO:0000250" FT VARIANT 28 FT /note="S -> N (in dbSNP:rs35496730)" FT /id="VAR_061171" FT VARIANT 84 FT /note="F -> L (in dbSNP:rs2286459)" FT /id="VAR_059287" FT VARIANT 90 FT /note="P -> S (in dbSNP:rs758329)" FT /id="VAR_049065" SQ SEQUENCE 223 AA; 24581 MW; 792E68933E7929D9 CRC64; MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG //