ID   PG12B_HUMAN             Reviewed;         195 AA.
AC   Q9BX93; B7ZL23; Q52LB2; Q96Q99;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   24-JAN-2024, entry version 169.
DE   RecName: Full=Group XIIB secretory phospholipase A2-like protein;
DE   AltName: Full=Group XIII secretory phospholipase A2-like protein;
DE            Short=GXIII sPLA2-like;
DE   AltName: Full=sPLA2-GXIIB;
DE            Short=GXIIB;
DE   Flags: Precursor;
GN   Name=PLA2G12B; Synonyms=PLA2G13; ORFNames=FKSG71;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Takahashi K.;
RT   "Cloning of human group XIII secreted phospholipase A2.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Wang Y.-G., Gong L.;
RT   "Cloning and characterization of FKSG71, a novel gene encoding group XIII
RT   secreted phospholipase A2.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LACK OF ENZYME ACTIVITY, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=14516201; DOI=10.1021/bi0349930;
RA   Rouault M., Bollinger J.G., Lazdunski M., Gelb M.H., Lambeau G.;
RT   "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic
RT   activity.";
RL   Biochemistry 42:11494-11503(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 20-34.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally verified
RT   cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Not known; does not seem to have catalytic activity.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BX93-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BX93-2; Sequence=VSP_054398;
CC   -!- TISSUE SPECIFICITY: Strong expression in liver, small intestine and
CC       kidney. {ECO:0000269|PubMed:14516201}.
CC   -!- SIMILARITY: Belongs to the phospholipase A2 family. {ECO:0000305}.
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DR   EMBL; AF349540; AAK30168.1; -; mRNA.
DR   EMBL; AF339053; AAL09472.1; -; mRNA.
DR   EMBL; AY358032; AAQ92918.1; -; mRNA.
DR   EMBL; CH471083; EAW54466.1; -; Genomic_DNA.
DR   EMBL; BC093996; AAH93996.1; -; mRNA.
DR   EMBL; BC111946; AAI11947.1; -; mRNA.
DR   EMBL; BC143532; AAI43533.1; -; mRNA.
DR   CCDS; CCDS7319.1; -. [Q9BX93-1]
DR   RefSeq; NP_001305053.1; NM_001318124.1. [Q9BX93-2]
DR   RefSeq; NP_115951.2; NM_032562.4. [Q9BX93-1]
DR   AlphaFoldDB; Q9BX93; -.
DR   BioGRID; 124170; 4.
DR   IntAct; Q9BX93; 1.
DR   STRING; 9606.ENSP00000362123; -.
DR   BindingDB; Q9BX93; -.
DR   ChEMBL; CHEMBL4524005; -.
DR   BioMuta; PLA2G12B; -.
DR   DMDM; 20178010; -.
DR   jPOST; Q9BX93; -.
DR   MassIVE; Q9BX93; -.
DR   MaxQB; Q9BX93; -.
DR   PaxDb; 9606-ENSP00000362123; -.
DR   PeptideAtlas; Q9BX93; -.
DR   ProteomicsDB; 79387; -. [Q9BX93-1]
DR   Antibodypedia; 45352; 43 antibodies from 15 providers.
DR   DNASU; 84647; -.
DR   Ensembl; ENST00000373032.4; ENSP00000362123.3; ENSG00000138308.6. [Q9BX93-1]
DR   GeneID; 84647; -.
DR   KEGG; hsa:84647; -.
DR   MANE-Select; ENST00000373032.4; ENSP00000362123.3; NM_032562.5; NP_115951.2.
DR   UCSC; uc001jtf.2; human. [Q9BX93-1]
DR   AGR; HGNC:18555; -.
DR   CTD; 84647; -.
DR   DisGeNET; 84647; -.
DR   GeneCards; PLA2G12B; -.
DR   HGNC; HGNC:18555; PLA2G12B.
DR   HPA; ENSG00000138308; Tissue enhanced (intestine, kidney, liver).
DR   MIM; 611653; gene.
DR   neXtProt; NX_Q9BX93; -.
DR   OpenTargets; ENSG00000138308; -.
DR   PharmGKB; PA38573; -.
DR   VEuPathDB; HostDB:ENSG00000138308; -.
DR   eggNOG; ENOG502QQU1; Eukaryota.
DR   GeneTree; ENSGT00390000008798; -.
DR   HOGENOM; CLU_093969_1_1_1; -.
DR   InParanoid; Q9BX93; -.
DR   OMA; ICQYRCR; -.
DR   OrthoDB; 50205at2759; -.
DR   PhylomeDB; Q9BX93; -.
DR   TreeFam; TF323302; -.
DR   PathwayCommons; Q9BX93; -.
DR   SignaLink; Q9BX93; -.
DR   BioGRID-ORCS; 84647; 7 hits in 1144 CRISPR screens.
DR   GenomeRNAi; 84647; -.
DR   Pharos; Q9BX93; Tdark.
DR   PRO; PR:Q9BX93; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9BX93; Protein.
DR   Bgee; ENSG00000138308; Expressed in jejunal mucosa and 41 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004623; F:phospholipase A2 activity; IEA:InterPro.
DR   GO; GO:0050482; P:arachidonic acid secretion; IEA:InterPro.
DR   GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   GO; GO:0006644; P:phospholipid metabolic process; IEA:InterPro.
DR   GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR   Gene3D; 1.20.90.10; Phospholipase A2 domain; 1.
DR   InterPro; IPR010711; PLA2G12.
DR   InterPro; IPR036444; PLipase_A2_dom_sf.
DR   PANTHER; PTHR12824; GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR12824:SF2; GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN; 1.
DR   Pfam; PF06951; PLA2G12; 1.
DR   SUPFAM; SSF48619; Phospholipase A2, PLA2; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   Genevisible; Q9BX93; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calcium; Direct protein sequencing; Metal-binding;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:15340161"
FT   CHAIN           20..195
FT                   /note="Group XIIB secretory phospholipase A2-like protein"
FT                   /id="PRO_0000022772"
FT   BINDING         89
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         93
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         116
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         157
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_054398"
SQ   SEQUENCE   195 AA;  21659 MW;  C00C817F81D68A70 CRC64;
     MKLASGFLVL WLSLGGGLAQ SDTSPDTEES YSDWGLRHLR GSFESVNSYF DSFLELLGGK
     NGVCQYRCRY GKAPMPRPGY KPQEPNGCGS YFLGLKVPES MDLGIPAMTK CCNQLDVCYD
     TCGANKYRCD AKFRWCLHSI CSDLKRSLGF VSKVEAACDS LVDTVFNTVW TLGCRPFMNS
     QRAACICAEE EKEEL
//