{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BVG4","uniProtkbId":"PBDC1_HUMAN","entryAudit":{"firstPublicDate":"2006-10-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":163,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein PBDC1"}},"alternativeNames":[{"fullName":{"value":"Polysaccharide biosynthesis domain-containing protein 1"}}]},"genes":[{"geneName":{"value":"PBDC1"},"synonyms":[{"value":"CXorf26"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BVG4","intActId":"EBI-722092"},"interactantTwo":{"uniProtKBAccession":"P13569","geneName":"CFTR","intActId":"EBI-349854"},"numberOfExperiments":3,"organismDiffer":false}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PBDC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Protein PBDC1","featureId":"PRO_0000254105"},{"type":"Region","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":233,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"}]},{"type":"Modified residue","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":197,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18318008"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]}],"keywords":[{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Leiomyosarcoma","type":"TISSUE"},{"value":"Rhabdomyosarcoma","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"18318008","citationType":"journal article","authors":["Han G.","Ye M.","Zhou H.","Jiang X.","Feng S.","Jiang X.","Tian R.","Wan D.","Zou H.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"18318008"},{"database":"DOI","id":"10.1002/pmic.200700884"}],"title":"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.","publicationDate":"2008","journal":"Proteomics","firstPage":"1346","lastPage":"1361","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-197","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":7,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-197","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC001220","properties":[{"key":"ProteinId","value":"AAH01220.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC051894","properties":[{"key":"ProteinId","value":"AAH51894.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14432.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001287817.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001300888.2"}]},{"database":"RefSeq","id":"NP_057584.2","properties":[{"key":"NucleotideSequenceId","value":"NM_016500.5"}]},{"database":"AlphaFoldDB","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119416","properties":[{"key":"Interactions","value":"51"}]},{"database":"FunCoup","id":"Q9BVG4","properties":[{"key":"Number of interactors","value":"234"}]},{"database":"IntAct","id":"Q9BVG4","properties":[{"key":"Interactions","value":"19"}]},{"database":"MINT","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000362456","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5725172","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9BVG4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PBDC1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74733325","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000362456","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"79200","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"507","properties":[{"key":"antibodies","value":"197 antibodies from 18 providers"}]},{"database":"DNASU","id":"51260","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000373358.8","properties":[{"key":"ProteinId","value":"ENSP00000362456.3"},{"key":"GeneId","value":"ENSG00000102390.13"}]},{"database":"GeneID","id":"51260","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:51260","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000373358.8","properties":[{"key":"ProteinId","value":"ENSP00000362456.3"},{"key":"RefSeqNucleotideId","value":"NM_016500.5"},{"key":"RefSeqProteinId","value":"NP_057584.2"}]},{"database":"UCSC","id":"uc004ecl.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:28790","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA128394657","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51260","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PBDC1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28790","properties":[{"key":"GeneName","value":"PBDC1"}]},{"database":"HPA","id":"ENSG00000102390","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000102390","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000102390","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4093","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000016333","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_103791_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MELMHGA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10248897at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BVG4","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000102390","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"51260","properties":[{"key":"hits","value":"7 hits in 774 CRISPR screens"}]},{"database":"ChiTaRS","id":"PBDC1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"51260","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BVG4","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9BVG4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q9BVG4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000102390","properties":[{"key":"ExpressionPatterns","value":"Expressed in epithelial cell of pancreas and 184 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9BVG4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0044183","properties":[{"key":"GoTerm","value":"F:protein folding chaperone"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0051083","properties":[{"key":"GoTerm","value":"P:'de novo' cotranslational protein folding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"1.10.3560.10","properties":[{"key":"EntryName","value":"yst0336 like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR023139","properties":[{"key":"EntryName","value":"PBDC1-like_dom_sf"}]},{"database":"InterPro","id":"IPR008476","properties":[{"key":"EntryName","value":"PBDC1_metazoa/fungi"}]},{"database":"InterPro","id":"IPR021148","properties":[{"key":"EntryName","value":"Polysacc_synth_dom"}]},{"database":"PANTHER","id":"PTHR13410","properties":[{"key":"EntryName","value":"PROTEIN PBDC1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13410:SF9","properties":[{"key":"EntryName","value":"PROTEIN PBDC1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04669","properties":[{"key":"EntryName","value":"PBDC1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAATSGTDEPVSGELVSVAHALSLPAESYGNDPDIEMAWAMRAMQHAEVYYKLISSVDPQFLKLTKVDDQIYSEFRKNFETLRIDVLDPEELKSESAKEKWRPFCLKFNGIVEDFNYGTLLRLDCSQGYTEENTIFAPRIQFFAIEIARNREGYNKAVYISVQDKEGEKGVNNGGEKRADSGEEENTKNGGEKGADSGEEKEEGINREDKTDKGGEKGKEADKEINKSGEKAM","length":233,"molWeight":26057,"crc64":"31FD39EC70B9A9C7","md5":"B2344B588632970796A5AE7318F7AC54"},"extraAttributes":{"countByCommentType":{"INTERACTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Modified residue":3},"uniParcId":"UPI0000072009"}}