{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BUL9","secondaryAccessions":["D3DW70","Q9NX88"],"uniProtkbId":"RPP25_HUMAN","entryAudit":{"firstPublicDate":"2006-05-30","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":164,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Ribonuclease P protein subunit p25"},"shortNames":[{"value":"RNase P protein subunit p25"}]}},"genes":[{"geneName":{"value":"RPP25"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12003489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16723659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28115465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30454648"}],"value":"Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12003489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15096576"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16723659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20215441"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28115465"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29625199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30454648"}],"value":"Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:12003489, PubMed:15096576, PubMed:16723659, PubMed:20215441, PubMed:28115465, PubMed:30454648). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:12003489, PubMed:16723659, PubMed:20215441, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:15096576, PubMed:16723659, PubMed:28115465). POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA (PubMed:20215441, PubMed:29625199)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9NYB9-2","geneName":"ABI2","intActId":"EBI-11096309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9BYV9","geneName":"BACH2","intActId":"EBI-1642333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5-2","geneName":"BANP","intActId":"EBI-11524452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q8WTU0","geneName":"DDI1","intActId":"EBI-748248"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"O75190","geneName":"DNAJB6","intActId":"EBI-1053164"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q01658","geneName":"DR1","intActId":"EBI-750300"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"P35637","geneName":"FUS","intActId":"EBI-400434"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q00403","geneName":"GTF2B","intActId":"EBI-389564"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9Y5Q9","geneName":"GTF3C3","intActId":"EBI-1054873"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"P19012","geneName":"KRT15","intActId":"EBI-739566"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"O95751","geneName":"LDOC1","intActId":"EBI-740738"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q5JTD7","geneName":"LRRC73","intActId":"EBI-12003882"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q5S007","geneName":"LRRK2","intActId":"EBI-5323863"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q96CV9","geneName":"OPTN","intActId":"EBI-748974"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9NR12","geneName":"PDLIM7","intActId":"EBI-350517"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q8ND90","geneName":"PNMA1","intActId":"EBI-302345"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q99575","geneName":"POP1","intActId":"EBI-366741"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"O95707","geneName":"POP4","intActId":"EBI-366477"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q969H6","geneName":"POP5","intActId":"EBI-366525"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"O75817","geneName":"POP7","intActId":"EBI-366574"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q93062-3","geneName":"RBPMS","intActId":"EBI-740343"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"O95059","geneName":"RPP14","intActId":"EBI-366542"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"P21673","geneName":"SAT1","intActId":"EBI-711613"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q15427","geneName":"SF3B4","intActId":"EBI-348469"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"P00441","geneName":"SOD1","intActId":"EBI-990792"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q9NYB0","geneName":"TERF2IP","intActId":"EBI-750109"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BUL9","intActId":"EBI-366570"},"interactantTwo":{"uniProtKBAccession":"Q7Z4V0","geneName":"ZNF438","intActId":"EBI-11962468"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12003489"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20215441"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the histone-like Alba family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Ribonuclease P protein subunit p25","featureId":"PRO_0000237582"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Sequence conflict","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in Ref. 2; BAA91128","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Beta strand","location":{"start":{"value":10,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6LT7"}]},{"type":"Turn","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":31,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Beta strand","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Helix","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Beta strand","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Beta strand","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Helix","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Helix","location":{"start":{"value":74,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Beta strand","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Beta strand","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]},{"type":"Helix","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":156,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6CWX"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0698","category":"Biological process","name":"rRNA processing"},{"id":"KW-0819","category":"Biological process","name":"tRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"12003489","citationType":"journal article","authors":["Guerrier-Takada C.","Eder P.S.","Gopalan V.","Altman S."],"citationCrossReferences":[{"database":"PubMed","id":"12003489"},{"database":"DOI","id":"10.1017/s1355838202027954"}],"title":"Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P.","publicationDate":"2002","journal":"RNA","firstPage":"290","lastPage":"295","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","SUBUNIT","RNA-BINDING","SUBCELLULAR LOCATION"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15096576","citationType":"journal article","authors":["Welting T.J.","van Venrooij W.J.","Pruijn G.J."],"citationCrossReferences":[{"database":"PubMed","id":"15096576"},{"database":"DOI","id":"10.1093/nar/gkh539"}],"title":"Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.","publicationDate":"2004","journal":"Nucleic Acids Res.","firstPage":"2138","lastPage":"2146","volume":"32"},"referencePositions":["IDENTIFICATION IN THE RNASE P AND RNASE MRP COMPLEXES","SUBUNIT"]},{"referenceNumber":6,"citation":{"id":"16723659","citationType":"journal article","authors":["Welting T.J.","Kikkert B.J.","van Venrooij W.J.","Pruijn G.J."],"citationCrossReferences":[{"database":"PubMed","id":"16723659"},{"database":"DOI","id":"10.1261/rna.2293906"}],"title":"Differential association of protein subunits with the human RNase MRP and RNase P complexes.","publicationDate":"2006","journal":"RNA","firstPage":"1373","lastPage":"1382","volume":"12"},"referencePositions":["IDENTIFICATION IN RNASE P COMPLEX","SUBUNIT"]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"20215441","citationType":"journal article","authors":["Hands-Taylor K.L.","Martino L.","Tata R.","Babon J.J.","Bui T.T.","Drake A.F.","Beavil R.L.","Pruijn G.J.","Brown P.R.","Conte M.R."],"citationCrossReferences":[{"database":"PubMed","id":"20215441"},{"database":"DOI","id":"10.1093/nar/gkq141"}],"title":"Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.","publicationDate":"2010","journal":"Nucleic Acids Res.","firstPage":"4052","lastPage":"4066","volume":"38"},"referencePositions":["SUBCELLULAR LOCATION","SUBUNIT"]},{"referenceNumber":9,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172 AND SER-182","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"28115465","citationType":"journal article","authors":["Goldfarb K.C.","Cech T.R."],"citationCrossReferences":[{"database":"PubMed","id":"28115465"},{"database":"DOI","id":"10.1101/gad.286963.116"}],"title":"Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.","publicationDate":"2017","journal":"Genes Dev.","firstPage":"59","lastPage":"71","volume":"31"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":12,"citation":{"id":"30454648","citationType":"journal article","authors":["Wu J.","Niu S.","Tan M.","Huang C.","Li M.","Song Y.","Wang Q.","Chen J.","Shi S.","Lan P.","Lei M."],"citationCrossReferences":[{"database":"PubMed","id":"30454648"},{"database":"DOI","id":"10.1016/j.cell.2018.10.003"}],"title":"Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.","publicationDate":"2018","journal":"Cell","firstPage":"1393","lastPage":"1404.e11","volume":"175"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (3.66 ANGSTROMS) OF RNASE P HOLOENZYME IN COMPLEX WITH TRNA","FUNCTION","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6AHR"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6AHU"}]},{"referenceNumber":13,"citation":{"id":"29625199","citationType":"journal article","authors":["Chan C.W.","Kiesel B.R.","Mondragon A."],"citationCrossReferences":[{"database":"PubMed","id":"29625199"},{"database":"DOI","id":"10.1016/j.jmb.2018.03.029"}],"title":"Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.","publicationDate":"2018","journal":"J. Mol. Biol.","firstPage":"1403","lastPage":"1416","volume":"430"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH POP7","SUBUNIT","RNA-BINDING"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6CWX"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY034074","properties":[{"key":"ProteinId","value":"AAK54443.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK000381","properties":[{"key":"ProteinId","value":"BAA91128.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471136","properties":[{"key":"ProteinId","value":"EAW99285.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471136","properties":[{"key":"ProteinId","value":"EAW99286.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002497","properties":[{"key":"ProteinId","value":"AAH02497.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC007270","properties":[{"key":"ProteinId","value":"AAH07270.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10274.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_060263.2","properties":[{"key":"NucleotideSequenceId","value":"NM_017793.3"}]},{"database":"PDB","id":"6AHR","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.92 A"},{"key":"Chains","value":"F=1-199"}]},{"database":"PDB","id":"6AHU","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.66 A"},{"key":"Chains","value":"F=1-199"}]},{"database":"PDB","id":"6CWX","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.25 A"},{"key":"Chains","value":"B=1-199"}]},{"database":"PDB","id":"6LT7","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"B/E=2-199"}]},{"database":"PDBsum","id":"6AHR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6AHU","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6CWX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6LT7","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64157","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64159","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-64160","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9626","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-9627","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120255","properties":[{"key":"Interactions","value":"60"}]},{"database":"ComplexPortal","id":"CPX-2876","properties":[{"key":"EntryName","value":"Ribonuclease MRP complex"}]},{"database":"ComplexPortal","id":"CPX-2877","properties":[{"key":"EntryName","value":"Nucleolar ribonuclease P complex"}]},{"database":"CORUM","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9BUL9","properties":[{"key":"Number of interactors","value":"209"}]},{"database":"IntAct","id":"Q9BUL9","properties":[{"key":"Interactions","value":"54"}]},{"database":"STRING","id":"9606.ENSP00000317691","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9BUL9","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RPP25","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74733233","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000317691","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"79109","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"50450","properties":[{"key":"antibodies","value":"93 antibodies from 24 providers"}]},{"database":"DNASU","id":"54913","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000322177.6","properties":[{"key":"ProteinId","value":"ENSP00000317691.6"},{"key":"GeneId","value":"ENSG00000178718.7"}]},{"database":"GeneID","id":"54913","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:54913","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000322177.6","properties":[{"key":"ProteinId","value":"ENSP00000317691.6"},{"key":"RefSeqNucleotideId","value":"NM_017793.3"},{"key":"RefSeqProteinId","value":"NP_060263.2"}]},{"database":"UCSC","id":"uc002azj.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:30361","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134990737","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"54913","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"54913","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RPP25","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30361","properties":[{"key":"GeneName","value":"RPP25"}]},{"database":"HPA","id":"ENSG00000178718","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"619235","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000178718","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000178718","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2567","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002564","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_096311_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WENKDPQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"424402at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BUL9","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"3.1.26.5","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-6784531","properties":[{"key":"PathwayName","value":"tRNA processing in the nucleus"}]},{"database":"Reactome","id":"R-HSA-6791226","properties":[{"key":"PathwayName","value":"Major pathway of rRNA processing in the nucleolus and cytosol"}]},{"database":"SignaLink","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000178718","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"54913","properties":[{"key":"hits","value":"22 hits in 1156 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"GenomeRNAi","id":"54913","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BUL9","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9BUL9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q9BUL9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000178718","properties":[{"key":"ExpressionPatterns","value":"Expressed in vena cava and 179 other cell types or tissues"}]},{"database":"GO","id":"GO:0030681","properties":[{"key":"GoTerm","value":"C:multimeric ribonuclease P complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30454648"}]},{"database":"GO","id":"GO:0005655","properties":[{"key":"GoTerm","value":"C:nucleolar ribonuclease P complex"},{"key":"GoEvidenceType","value":"IPI:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"30454648"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"30454648"}]},{"database":"GO","id":"GO:0000172","properties":[{"key":"GoTerm","value":"C:ribonuclease MRP complex"},{"key":"GoEvidenceType","value":"IDA:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16723659"}]},{"database":"GO","id":"GO:0033204","properties":[{"key":"GoTerm","value":"F:ribonuclease P RNA binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30454648"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"22658674"}]},{"database":"GO","id":"GO:0006396","properties":[{"key":"GoTerm","value":"P:RNA processing"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16723659"}]},{"database":"GO","id":"GO:0001682","properties":[{"key":"GoTerm","value":"P:tRNA 5'-leader removal"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"30454648"}]},{"database":"DisProt","id":"DP02616","properties":[{"key":"Description","value":"-"}]},{"database":"FunFam","id":"3.30.110.20:FF:000006","properties":[{"key":"EntryName","value":"Ribonuclease P protein subunit p25"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.110.20","properties":[{"key":"EntryName","value":"Alba-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036882","properties":[{"key":"EntryName","value":"Alba-like_dom_sf"}]},{"database":"InterPro","id":"IPR051958","properties":[{"key":"EntryName","value":"Alba-like_NAB"}]},{"database":"InterPro","id":"IPR002775","properties":[{"key":"EntryName","value":"DNA/RNA-bd_Alba-like"}]},{"database":"PANTHER","id":"PTHR13516:SF5","properties":[{"key":"EntryName","value":"RIBONUCLEASE P PROTEIN SUBUNIT P25"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13516","properties":[{"key":"EntryName","value":"RIBONUCLEASE P SUBUNIT P25"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01918","properties":[{"key":"EntryName","value":"Alba"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82704","properties":[{"key":"EntryName","value":"AlbA-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MENFRKVRSEEAPAGCGAEGGGPGSGPFADLAPGAVHMRVKEGSKIRNLMAFATASMAQPATRAIVFSGCGRATTKTVTCAEILKRRLAGLHQVTRLRYRSVREVWQSLPPGPTQGQTPGEPAASLSVLKNVPGLAILLSKDALDPRQPGYQPPNPHPGPSSPPAAPASKRSLGEPAAGEGSAKRSQPEPGVADEDQTA","length":199,"molWeight":20632,"crc64":"9A4494F0297B2A81","md5":"1A9F496E00E2A35CC8D726BA2B66766A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":28,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":2,"Modified residue":2,"Sequence conflict":1,"Beta strand":6,"Turn":1,"Helix":4},"uniParcId":"UPI0000072730"}}