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Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21391237"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27991920"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32614325"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34050020"}],"value":"Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2 (By similarity). Interacts with SUN2. Interacts with RNF26; this interaction is important to modulate innate immune signaling through the cGAS-STING pathway (PubMed:32614325). Interacts with CARD10 (PubMed:27991920). Interacts with gap junctions proteins GJB2/Cx26 and GJB4/Cx30 (PubMed:34050020)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q6Q788","geneName":"APOA5","intActId":"EBI-3936819"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q3SXY8","geneName":"ARL13B","intActId":"EBI-11343438"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q8N5K1","geneName":"CISD2","intActId":"EBI-1045797"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"P50402","geneName":"EMD","intActId":"EBI-489887"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"P02671-2","geneName":"FGA","intActId":"EBI-9640259"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q14318","geneName":"FKBP8","intActId":"EBI-724839"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q96HH9","geneName":"GRAMD2B","intActId":"EBI-2832937"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q9Y5K3-3","geneName":"PCYT1B","intActId":"EBI-12280028"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"P11684","geneName":"SCGB1A1","intActId":"EBI-7797649"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q8IUQ4","geneName":"SIAH1","intActId":"EBI-747107"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q8IUQ4-2","geneName":"SIAH1","intActId":"EBI-11522811"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q9H7V2","geneName":"SYNDIG1","intActId":"EBI-726331"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q9BTV4","geneName":"TMEM43","intActId":"EBI-721293"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q9UHP3","geneName":"USP25","intActId":"EBI-2513462"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTV4","intActId":"EBI-721293"},"interactantTwo":{"uniProtKBAccession":"Q6PEW1","geneName":"ZCCHC12","intActId":"EBI-748373"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. 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