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Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877). Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877). Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037). Also acts as a negative regulator of basal autophagy (PubMed:26812014). Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014). May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21329877"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26812014"}],"value":"Interacts (via coiled coil domain) with RNF20, RNF40 and UBE2A (PubMed:21329877). Interacts (via WW domain) with RNA polymerase II (PubMed:21329877). Interacts with MTOR and other components of the MTOR pathway including RPTOR, RUVBL1, RUVBL2, TTI1 and TTI2 (PubMed:26812014)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q99996-2","geneName":"AKAP9","intActId":"EBI-9641546"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q8WWB3","geneName":"DYDC1","intActId":"EBI-740680"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q6P597","geneName":"KLC3","intActId":"EBI-1643885"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"P19012","geneName":"KRT15","intActId":"EBI-739566"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q5JR59","geneName":"MTUS2","intActId":"EBI-742948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q16236","geneName":"NFE2L2","intActId":"EBI-2007911"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q8TDW5","geneName":"SYTL5","intActId":"EBI-2939487"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q13077","geneName":"TRAF1","intActId":"EBI-359224"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9","intActId":"EBI-749118"},"interactantTwo":{"uniProtKBAccession":"Q9Y228","geneName":"TRAF3IP3","intActId":"EBI-765817"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9-2","intActId":"EBI-10298216"},"interactantTwo":{"uniProtKBAccession":"P19012","geneName":"KRT15","intActId":"EBI-739566"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9-2","intActId":"EBI-10298216"},"interactantTwo":{"uniProtKBAccession":"Q5JR59","geneName":"MTUS2","intActId":"EBI-742948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BTA9-5","intActId":"EBI-25956668"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q924H7"}],"value":"In distinct nuclear speckles. 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