{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BSJ6","secondaryAccessions":["Q96CT4","Q9NVV1","Q9NWB5"],"uniProtkbId":"PIMRE_HUMAN","entryAudit":{"firstPublicDate":"2007-03-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":157,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein PIMREG"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19383357"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23419774"}],"value":"CALM-interactor expressed in thymus and spleen"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25483"}],"value":"PICALM-interacting mitotic regulator"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18757745"}],"value":"Regulator of chromosome segregation protein 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25483"}],"value":"PIMREG"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19383357"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23419774"}],"value":"CATS"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25483"}],"value":"FAM64A"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18757745"}],"value":"RCS1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"value":"During mitosis, may play a role in the control of metaphase-to-anaphase transition"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"value":"Isoform 1 and isoform 2 interact with PICALM; this interaction may target PICALM to the nucleus (PubMed:16491119). During mitosis, associates with HDAC2 and MTA2 subunits of the chromatin-remodeling NuRD complex; this association is strongest at prometaphase and decreases as the cell progresses through metaphase and anaphase (PubMed:18757745)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q6RW13","geneName":"AGTRAP","intActId":"EBI-741181"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q6RW13-2","geneName":"AGTRAP","intActId":"EBI-11522760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q9H6L4","geneName":"ARMC7","intActId":"EBI-742909"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q7L4P6","geneName":"BEND5","intActId":"EBI-724373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"O95273","geneName":"CCNDBP1","intActId":"EBI-748961"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q8NHQ1","geneName":"CEP70","intActId":"EBI-739624"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q96DZ9-2","geneName":"CMTM5","intActId":"EBI-11522780"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"P67870","geneName":"CSNK2B","intActId":"EBI-348169"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q8NF50","geneName":"DOCK8","intActId":"EBI-2548605"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"P50402","geneName":"EMD","intActId":"EBI-489887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q96ED9-2","geneName":"HOOK2","intActId":"EBI-10961706"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q6A162","geneName":"KRT40","intActId":"EBI-10171697"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q969L2","geneName":"MAL2","intActId":"EBI-944295"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"P04156","geneName":"PRNP","intActId":"EBI-977302"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q6NUQ1","geneName":"RINT1","intActId":"EBI-726876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q8IUQ4-2","geneName":"SIAH1","intActId":"EBI-11522811"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q96R06","geneName":"SPAG5","intActId":"EBI-413317"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q9Y2D8","geneName":"SSX2IP","intActId":"EBI-2212028"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q12800","geneName":"TFCP2","intActId":"EBI-717422"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"P14373","geneName":"TRIM27","intActId":"EBI-719493"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BSJ6","intActId":"EBI-2568609"},"interactantTwo":{"uniProtKBAccession":"Q8N1B4","geneName":"VPS52","intActId":"EBI-2799833"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19383357"}],"value":"Partially localizes to the nucleolus"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19383357"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19383357"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9BSJ6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9BSJ6-2"],"sequenceIds":["VSP_023997"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19383357"}],"value":"Expressed in thymus (at protein level). Detected in spleen, colon, ovary and small intestines"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"value":"Regulated in a cell-cycle dependent manner, with lowest levels in quiescent cells or at G1 phase. Progressive up-regulation starting at S phase and peaking at G2 and G2/M phases, followed by a drastic drop as cells exit mitosis (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"value":"The N-terminal destruction box 2 (D-box 2) is required for APC/C ubiquitination and proteasomal degradation"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"value":"Ubiquitinated by the anaphase-promoting complex/cyclosome (APC/C) complex in the presence of FZR1, leading to its degradation by the proteasome during mitotic exit. However, degradation is not essential for normal mitotic progression within a single cell cycle"}],"commentType":"PTM"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Protein PIMREG","featureId":"PRO_0000281159"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"D-box 1"},{"type":"Motif","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"D-box 2"},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":11,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Phosphoserine; by UHMK1; in vitro","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23419774"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":201,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Alternative sequence","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_023997","alternativeSequence":{"originalSequence":"RKQALSDRQGFILKDVYASP","alternativeSequences":["SGDIVSLIHD"]}},{"type":"Natural variant","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"in dbSNP:rs16955870","featureCrossReferences":[{"database":"dbSNP","id":"rs16955870"}],"featureId":"VAR_056873","alternativeSequence":{"originalSequence":"S","alternativeSequences":["C"]}},{"type":"Mutagenesis","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"Weak reduction in ubiquitination. Complete loss of ubiquitination; when associated with 53-A--A-56.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"alternativeSequence":{"originalSequence":"RRSL","alternativeSequences":["ARSA"]}},{"type":"Mutagenesis","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":56,"modifier":"EXACT"}},"description":"Great reduction in ubiquitination. Complete loss of ubiquitination; when associated with 14-A--A-17.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757745"}],"alternativeSequence":{"originalSequence":"RLPL","alternativeSequences":["ALPA"]}},{"type":"Mutagenesis","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"No effect on phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23419774"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Reduced phosphorylation.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23419774"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in Ref. 1; BAA91468","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"in Ref. 1; BAA91644","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-0132","category":"Biological process","name":"Cell division"},{"id":"KW-0498","category":"Biological process","name":"Mitosis"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"]},{"referenceNumber":2,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Colon","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16491119","citationType":"journal article","authors":["Archangelo L.F.","Glaesner J.","Krause A.","Bohlander S.K."],"citationCrossReferences":[{"database":"PubMed","id":"16491119"},{"database":"DOI","id":"10.1038/sj.onc.1209438"}],"title":"The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.","publicationDate":"2006","journal":"Oncogene","firstPage":"4099","lastPage":"4109","volume":"25"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH PICALM","TISSUE SPECIFICITY","IDENTIFICATION OF ISOFORMS 1 AND 2"]},{"referenceNumber":5,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"19383357","citationType":"journal article","authors":["Archangelo L.F.","Greif P.A.","Hoelzel M.","Harasim T.","Kremmer E.","Przemeck G.K.","Eick D.","Deshpande A.J.","Buske C.","de Angelis M.H.","Saad S.T.","Bohlander S.K."],"citationCrossReferences":[{"database":"PubMed","id":"19383357"},{"database":"DOI","id":"10.1016/j.molonc.2008.08.001"}],"title":"The CALM and CALM/AF10 interactor CATS is a marker for proliferation.","publicationDate":"2008","journal":"Mol. Oncol.","firstPage":"356","lastPage":"367","volume":"2"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION","INDUCTION"]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-199 AND SER-201","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"18757745","citationType":"journal article","authors":["Zhao W.M.","Coppinger J.A.","Seki A.","Cheng X.L.","Yates J.R. III","Fang G."],"citationCrossReferences":[{"database":"PubMed","id":"18757745"},{"database":"DOI","id":"10.1073/pnas.0709227105"}],"title":"RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"13415","lastPage":"13420","volume":"105"},"referencePositions":["FUNCTION IN MITOSIS PROGRESSION","INTERACTION WITH NURD COMPLEX","DEVELOPMENTAL STAGE","D-BOX MOTIF","MUTAGENESIS OF 14-ARG--LEU-17 AND 53-ARG--LEU-56","UBIQUITINATION"]},{"referenceNumber":9,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-129 AND SER-131","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"23419774","citationType":"journal article","authors":["Archangelo L.F.","Greif P.A.","Maucuer A.","Manceau V.","Koneru N.","Bigarella C.L.","Niemann F.","Dos Santos M.T.","Kobarg J.","Bohlander S.K.","Saad S.T."],"citationCrossReferences":[{"database":"PubMed","id":"23419774"},{"database":"DOI","id":"10.1016/j.bbamcr.2013.02.004"}],"title":"The CATS (FAM64A) protein is a substrate of the kinase interacting stathmin (KIS).","publicationDate":"2013","journal":"Biochim. Biophys. Acta","firstPage":"1269","lastPage":"1279","volume":"1833"},"referencePositions":["SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-131","MUTAGENESIS OF SER-129 AND SER-131"]},{"referenceNumber":12,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-16","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK001018","properties":[{"key":"ProteinId","value":"BAA91468.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK001353","properties":[{"key":"ProteinId","value":"BAA91644.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC055872","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC005004","properties":[{"key":"ProteinId","value":"AAH05004.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC013966","properties":[{"key":"ProteinId","value":"AAH13966.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32541.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BSJ6-2"},{"database":"CCDS","id":"CCDS56016.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BSJ6-1"},{"database":"RefSeq","id":"NP_001182157.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001195228.2"}],"isoformId":"Q9BSJ6-1"},{"database":"RefSeq","id":"NP_061886.2","properties":[{"key":"NucleotideSequenceId","value":"NM_019013.3"}],"isoformId":"Q9BSJ6-2"},{"database":"RefSeq","id":"XP_047292267.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436311.1"}],"isoformId":"Q9BSJ6-2"},{"database":"RefSeq","id":"XP_054172506.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054316531.1"}],"isoformId":"Q9BSJ6-2"},{"database":"AlphaFoldDB","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119983","properties":[{"key":"Interactions","value":"48"}]},{"database":"DIP","id":"DIP-56370N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q9BSJ6","properties":[{"key":"Number of interactors","value":"784"}]},{"database":"IntAct","id":"Q9BSJ6","properties":[{"key":"Interactions","value":"38"}]},{"database":"MINT","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000250056","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q9BSJ6","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"PIMREG","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74733018","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000250056","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"78904","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BSJ6-1"},{"database":"ProteomicsDB","id":"78905","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BSJ6-2"},{"database":"Pumba","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"42756","properties":[{"key":"antibodies","value":"74 antibodies from 17 providers"}]},{"database":"DNASU","id":"54478","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000250056.12","properties":[{"key":"ProteinId","value":"ENSP00000250056.8"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-1"},{"database":"Ensembl","id":"ENST00000572447.6","properties":[{"key":"ProteinId","value":"ENSP00000459235.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000576056.5","properties":[{"key":"ProteinId","value":"ENSP00000458534.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000851328.1","properties":[{"key":"ProteinId","value":"ENSP00000521387.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924241.1","properties":[{"key":"ProteinId","value":"ENSP00000594300.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924242.1","properties":[{"key":"ProteinId","value":"ENSP00000594301.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924244.1","properties":[{"key":"ProteinId","value":"ENSP00000594303.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924245.1","properties":[{"key":"ProteinId","value":"ENSP00000594304.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924247.1","properties":[{"key":"ProteinId","value":"ENSP00000594306.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924250.1","properties":[{"key":"ProteinId","value":"ENSP00000594309.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"Ensembl","id":"ENST00000924251.1","properties":[{"key":"ProteinId","value":"ENSP00000594310.1"},{"key":"GeneId","value":"ENSG00000129195.17"}],"isoformId":"Q9BSJ6-2"},{"database":"GeneID","id":"54478","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:54478","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000572447.6","properties":[{"key":"ProteinId","value":"ENSP00000459235.1"},{"key":"RefSeqNucleotideId","value":"NM_019013.3"},{"key":"RefSeqProteinId","value":"NP_061886.2"}],"isoformId":"Q9BSJ6-2"},{"database":"UCSC","id":"uc002gcu.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9BSJ6-1"},{"database":"AGR","id":"HGNC:25483","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142671874","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"54478","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"54478","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"PIMREG","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25483","properties":[{"key":"GeneName","value":"PIMREG"}]},{"database":"HPA","id":"ENSG00000129195","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid)"}]},{"database":"MIM","id":"617611","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000129195","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000129195","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S0SN","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008128","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1209428_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"SNYYYLM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9898669at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BSJ6","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000129195","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"54478","properties":[{"key":"hits","value":"11 hits in 1155 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"FAM64A","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"54478","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BSJ6","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q9BSJ6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q9BSJ6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000129195","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 109 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9BSJ6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"IDA:BHF-UCL"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16491119"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16491119"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19383357"}]},{"database":"InterPro","id":"IPR009932","properties":[{"key":"EntryName","value":"RCS1"}]},{"database":"PANTHER","id":"PTHR35819","properties":[{"key":"EntryName","value":"PICALM INTERACTING MITOTIC REGULATOR PIMREG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35819:SF1","properties":[{"key":"EntryName","value":"PROTEIN PIMREG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07326","properties":[{"key":"EntryName","value":"RCS1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQGLQAAARSAKSALGAVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGSGSPTHSLSQKSTRLSGAAPAHSAADPWEKEHHRLSVRMGSHAHPLRRSRREAAFRSPYSSTEPLCSPSESDSDLEPVGAGIQHLQKLSQELDEAIMAEERKQALSDRQGFILKDVYASP","length":248,"molWeight":27480,"crc64":"E981F1AF64375D5A","md5":"0105329B659FC63994AB99013B9694C5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":22,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"PTM":1},"countByFeatureType":{"Chain":1,"Region":2,"Motif":2,"Compositional bias":3,"Modified residue":6,"Alternative sequence":1,"Natural variant":1,"Mutagenesis":4,"Sequence conflict":2},"uniParcId":"UPI000006F065"}}