{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BRQ5","secondaryAccessions":["Q96BI8"],"uniProtkbId":"ORAI3_HUMAN","entryAudit":{"firstPublicDate":"2006-05-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-06-01","entryVersion":154,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein orai-3"}},"alternativeNames":[{"fullName":{"value":"Transmembrane protein 142C"}}]},"genes":[{"geneName":{"value":"ORAI3"},"synonyms":[{"value":"TMEM142C"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17442569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19182790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19622606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19706554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20354224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415068"}],"value":"Pore-forming subunit of two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:16807233, PubMed:17442569, PubMed:19182790, PubMed:19622606, PubMed:19706554, PubMed:20354224, PubMed:32415068). Assembles with ORAI1 and ORAI2 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription (PubMed:16807233, PubMed:17442569, PubMed:19182790, PubMed:19706554, PubMed:20354224, PubMed:32415068). Assembles with ORAI1 to form channels that mediate store-independent Ca(2+) influx in response to inflammatory metabolites arachidonate or its derivative leukotriene C4, termed ARC and LRC channels respectively (PubMed:19622606, PubMed:32415068)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17442569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19182790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19622606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20354224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415068"}]},"physiologicalReactions":[{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:29673"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17442569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19182790"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19622606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20354224"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415068"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19706554"}],"value":"CRAC channels are regulated by fast Ca(2+)-dependent inactivation (FCDI), a mechanism that limits Ca(2+) influx and cell toxicity. ORAI3 subunit displays prominent FCDI (PubMed:19706554). Inhibited by lanthanides such as Gd(3+) ions (PubMed:16807233)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17442569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19622606"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19706554"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20418871"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415068"}],"value":"Oligomerizes in homomeric and heteromeric ORAI complexes. Native CRAC channels most likely consist of hexameric ORAI heteromers, implying that diverse ORAI1, ORAI2 and ORAI3 subunit combinations with distinct biophysical properties can operate in a cell-type specific way (PubMed:17442569, PubMed:32415068). ARC channels are heteropentamers consisting of three ORAI1 and two ORAI3 subunits (PubMed:19622606). Interacts with STIM1; this regulates channel activity (PubMed:19706554, PubMed:32415068). Interacts with CRACR2A/EFCAB4B"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BRQ5","intActId":"EBI-4279484"},"interactantTwo":{"uniProtKBAccession":"Q96D31","geneName":"ORAI1","intActId":"EBI-2291476"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19706554"}],"value":"Colocalizes with STIM1 upon store depletion"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16807233"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20354224"}],"value":"Expressed in both naive and effector T helper cells with higher levels in effector cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the Orai family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"Protein orai-3","featureId":"PRO_0000234395"},{"type":"Transmembrane","location":{"start":{"value":63,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":244,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Confers selective permeability to Ca(2+) ions","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415068"}]},{"type":"Modified residue","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P8G8"}]},{"type":"Modified residue","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P8G8"}]},{"type":"Mutagenesis","location":{"start":{"value":81,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"Dominant-negative. 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