{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q9BQA9","secondaryAccessions":["E1B6X3","Q96NR1"],"uniProtkbId":"CYBC1_HUMAN","entryAudit":{"firstPublicDate":"2007-03-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-06-01","entryVersion":153,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cytochrome b-245 chaperone 1"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TYS2"}],"value":"Essential for reactive oxygen species protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TYS2"}],"value":"Eros"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:28672"}],"value":"CYBC1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:28672"}],"value":"C17orf62"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TYS2"}],"value":"EROS"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TYS2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30361506"}],"value":"Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28351984"}],"value":"Interacts with CYBB; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q15848","geneName":"ADIPOQ","intActId":"EBI-10827839"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q6RW13-2","geneName":"AGTRAP","intActId":"EBI-11522760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8IVF2-3","geneName":"AHNAK2","intActId":"EBI-12078468"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9NVV5-2","geneName":"AIG1","intActId":"EBI-11957045"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8NCL9","geneName":"APCDD1L","intActId":"EBI-12904424"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P02652","geneName":"APOA2","intActId":"EBI-1171525"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9BQE5","geneName":"APOL2","intActId":"EBI-4290634"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q96PS8","geneName":"AQP10","intActId":"EBI-12820279"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q13520","geneName":"AQP6","intActId":"EBI-13059134"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O94778","geneName":"AQP8","intActId":"EBI-19124986"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8WVX3-2","geneName":"ARLN","intActId":"EBI-12003442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O15155","geneName":"BET1","intActId":"EBI-749204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P19397","geneName":"CD53","intActId":"EBI-6657396"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8N5K1","geneName":"CISD2","intActId":"EBI-1045797"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O95471","geneName":"CLDN7","intActId":"EBI-740744"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9NWW5","geneName":"CLN6","intActId":"EBI-6165897"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O75208","geneName":"COQ9","intActId":"EBI-724524"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q7Z7G2","geneName":"CPLX4","intActId":"EBI-18013275"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P04839","geneName":"CYBB","intActId":"EBI-6253630"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9Y282","geneName":"ERGIC3","intActId":"EBI-781551"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P14921","geneName":"ETS1","intActId":"EBI-913209"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q5JX71","geneName":"FAM209A","intActId":"EBI-18304435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P48165","geneName":"GJA8","intActId":"EBI-17458373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8TDV0","geneName":"GPR151","intActId":"EBI-11955647"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8TDT2","geneName":"GPR152","intActId":"EBI-13345167"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8NBQ5","geneName":"HSD17B11","intActId":"EBI-1052304"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q7Z5P4","geneName":"HSD17B13","intActId":"EBI-18053395"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9Y5U4","geneName":"INSIG2","intActId":"EBI-8503746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8N5M9","geneName":"JAGN1","intActId":"EBI-10266796"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8N6L0","geneName":"KASH5","intActId":"EBI-749265"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P43628","geneName":"KIR2DL3","intActId":"EBI-8632435"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O43561-2","geneName":"LAT","intActId":"EBI-8070286"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9BS40","geneName":"LXN","intActId":"EBI-1044504"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9GZY8-5","geneName":"MFF","intActId":"EBI-11956541"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q5SR56","geneName":"MFSD14B","intActId":"EBI-373355"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O14880","geneName":"MGST3","intActId":"EBI-724754"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9H2K0","geneName":"MTIF3","intActId":"EBI-3923617"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9NZG7","geneName":"NINJ2","intActId":"EBI-10317425"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9HBY0","geneName":"NOX3","intActId":"EBI-13069010"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8N912","geneName":"NRAC","intActId":"EBI-12051377"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8IXM6","geneName":"NRM","intActId":"EBI-10262547"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P51575","geneName":"P2RX1","intActId":"EBI-11599725"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q13113","geneName":"PDZK1IP1","intActId":"EBI-716063"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O00623","geneName":"PEX12","intActId":"EBI-594836"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O60664","geneName":"PLIN3","intActId":"EBI-725795"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P60201-2","geneName":"PLP1","intActId":"EBI-12188331"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q04941","geneName":"PLP2","intActId":"EBI-608347"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O00767","geneName":"SCD","intActId":"EBI-2684237"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q96DD7","geneName":"SHISA4","intActId":"EBI-18035902"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9NQQ7-3","geneName":"SLC35C2","intActId":"EBI-17295964"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P16150","geneName":"SPN","intActId":"EBI-10049055"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8WWF3","geneName":"SSMEM1","intActId":"EBI-17280858"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P32856-2","geneName":"STX2","intActId":"EBI-11956649"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"P07204","geneName":"THBD","intActId":"EBI-941422"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q96DZ7","geneName":"TM4SF19","intActId":"EBI-6448756"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q5BJH2-2","geneName":"TMEM128","intActId":"EBI-10694905"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q96HE8","geneName":"TMEM80","intActId":"EBI-11742770"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O15393-2","geneName":"TMPRSS2","intActId":"EBI-12345267"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q9Y320","geneName":"TMX2","intActId":"EBI-6447886"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"Q8N609","geneName":"TRAM1L1","intActId":"EBI-11996766"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q9BQA9","intActId":"EBI-2680384"},"interactantTwo":{"uniProtKBAccession":"O95859","geneName":"TSPAN12","intActId":"EBI-2466403"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28351984"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q9BQA9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q9BQA9-2"],"sequenceIds":["VSP_046335"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28351984"}],"value":"Highly expressed in macrophages, neutrophils and monocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28351984"}],"value":"In macrophages, expression is induced after treatment with IFNG or a combination of IFNG and Salmonella Tiphimurium"}],"commentType":"INDUCTION"},{"commentType":"DISEASE","disease":{"diseaseId":"Granulomatous disease, chronic, autosomal recessive, 5","diseaseAccession":"DI-05870","acronym":"CGD5","description":"A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens. CGD5 is an autosomal recessive form characterized by onset of recurrent infections and severe colitis in the first decade of life. Clinical manifestations include increased susceptibility to catalase-positive organisms, features of inflammatory bowel disease, lymphopenia, lymphadenitis, and autoinflammatory symptoms in some patients.","diseaseCrossReference":{"database":"MIM","id":"618935"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28600779"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30361506"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"value":"Belongs to the CYBC1 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB70818.1","note":"Wrong choice of frame.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Cytochrome b-245 chaperone 1","featureId":"PRO_0000281418"},{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Modified residue","location":{"start":{"value":168,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6AYA6"}]},{"type":"Alternative sequence","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_046335","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"in CGD5; loss of protein expression; decreased PMA-induced oxidative burst in neutrophils","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30361506"}],"featureId":"VAR_084696","alternativeSequence":{}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0143","category":"Molecular function","name":"Chaperone"},{"id":"KW-0161","category":"Disease","name":"Chronic granulomatous disease"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-0399","category":"Biological process","name":"Innate immunity"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-56FT96O07V0QG","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lung carcinoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":6,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":7,"citation":{"id":"28600779","citationType":"journal article","authors":["Monies D.","Abouelhoda M.","AlSayed M.","Alhassnan Z.","Alotaibi M.","Kayyali H.","Al-Owain M.","Shah A.","Rahbeeni Z.","Al-Muhaizea M.A.","Alzaidan H.I.","Cupler E.","Bohlega S.","Faqeih E.","Faden M.","Alyounes B.","Jaroudi D.","Goljan E.","Elbardisy H.","Akilan A.","Albar R.","Aldhalaan H.","Gulab S.","Chedrawi A.","Al Saud B.K.","Kurdi W.","Makhseed N.","Alqasim T.","El Khashab H.Y.","Al-Mousa H.","Alhashem A.","Kanaan I.","Algoufi T.","Alsaleem K.","Basha T.A.","Al-Murshedi F.","Khan S.","Al-Kindy A.","Alnemer M.","Al-Hajjar S.","Alyamani S.","Aldhekri H.","Al-Mehaidib A.","Arnaout R.","Dabbagh O.","Shagrani M.","Broering D.","Tulbah M.","Alqassmi A.","Almugbel M.","AlQuaiz M.","Alsaman A.","Al-Thihli K.","Sulaiman R.A.","Al-Dekhail W.","Alsaegh A.","Bashiri F.A.","Qari A.","Alhomadi S.","Alkuraya H.","Alsebayel M.","Hamad M.H.","Szonyi L.","Abaalkhail F.","Al-Mayouf S.M.","Almojalli H.","Alqadi K.S.","Elsiesy H.","Shuaib T.M.","Seidahmed M.Z.","Abosoudah I.","Akleh H.","AlGhonaium A.","Alkharfy T.M.","Al Mutairi F.","Eyaid W.","Alshanbary A.","Sheikh F.R.","Alsohaibani F.I.","Alsonbul A.","Al Tala S.","Balkhy S.","Bassiouni R.","Alenizi A.S.","Hussein M.H.","Hassan S.","Khalil M.","Tabarki B.","Alshahwan S.","Oshi A.","Sabr Y.","Alsaadoun S.","Salih M.A.","Mohamed S.","Sultana H.","Tamim A.","El-Haj M.","Alshahrani S.","Bubshait D.K.","Alfadhel M.","Faquih T.","El-Kalioby M.","Subhani S.","Shah Z.","Moghrabi N.","Meyer B.F.","Alkuraya F.S."],"citationCrossReferences":[{"database":"PubMed","id":"28600779"},{"database":"DOI","id":"10.1007/s00439-017-1821-8"}],"title":"The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.","publicationDate":"2017","journal":"Hum. Genet.","firstPage":"921","lastPage":"939","volume":"136"},"referencePositions":["INVOLVEMENT IN CGD5"]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"28351984","citationType":"journal article","authors":["Thomas D.C.","Clare S.","Sowerby J.M.","Pardo M.","Juss J.K.","Goulding D.A.","van der Weyden L.","Storisteanu D.","Prakash A.","Espeli M.","Flint S.","Lee J.C.","Hoenderdos K.","Kane L.","Harcourt K.","Mukhopadhyay S.","Umrania Y.","Antrobus R.","Nathan J.A.","Adams D.J.","Bateman A.","Choudhary J.S.","Lyons P.A.","Condliffe A.M.","Chilvers E.R.","Dougan G.","Smith K.G."],"citationCrossReferences":[{"database":"PubMed","id":"28351984"},{"database":"DOI","id":"10.1084/jem.20161382"}],"title":"Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.","publicationDate":"2017","journal":"J. Exp. Med.","firstPage":"1111","lastPage":"1128","volume":"214"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","INDUCTION BY IFNG"]},{"referenceNumber":10,"citation":{"id":"30361506","citationType":"journal article","authors":["Arnadottir G.A.","Norddahl G.L.","Gudmundsdottir S.","Agustsdottir A.B.","Sigurdsson S.","Jensson B.O.","Bjarnadottir K.","Theodors F.","Benonisdottir S.","Ivarsdottir E.V.","Oddsson A.","Kristjansson R.P.","Sulem G.","Alexandersson K.F.","Juliusdottir T.","Gudmundsson K.R.","Saemundsdottir J.","Jonasdottir A.","Jonasdottir A.","Sigurdsson A.","Manzanillo P.","Gudjonsson S.A.","Thorisson G.A.","Magnusson O.T.","Masson G.","Orvar K.B.","Holm H.","Bjornsson S.","Arngrimsson R.","Gudbjartsson D.F.","Thorsteinsdottir U.","Jonsdottir I.","Haraldsson A.","Sulem P.","Stefansson K."],"citationCrossReferences":[{"database":"PubMed","id":"30361506"},{"database":"DOI","id":"10.1038/s41467-018-06964-x"}],"title":"A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease.","publicationDate":"2018","journal":"Nat. Commun.","firstPage":"4447","lastPage":"4447","volume":"9"},"referencePositions":["VARIANT CGD5 2-TYR--SER-187 DEL","CHARACTERIZATION OF VARIANT CGD5 2-TYR--SER-187 DEL","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK054876","properties":[{"key":"ProteinId","value":"BAB70818.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC132938","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471099","properties":[{"key":"ProteinId","value":"EAW89786.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC004171","properties":[{"key":"ProteinId","value":"AAH04171.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC003595","properties":[{"key":"ProteinId","value":"AAH03595.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS32776.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA9-1"},{"database":"CCDS","id":"CCDS45817.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA9-2"},{"database":"RefSeq","id":"NP_001028218.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001033046.4"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"NP_001093877.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001100407.3"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"NP_001093878.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001100408.3"}],"isoformId":"Q9BQA9-2"},{"database":"RefSeq","id":"NP_001180582.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001193653.2"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"NP_001180583.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001193654.2"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"NP_001180584.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001193655.2"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"NP_001180586.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001193657.2"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"XP_011521908.2","properties":[{"key":"NucleotideSequenceId","value":"XM_011523606.4"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"XP_047292697.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436741.1"}],"isoformId":"Q9BQA9-2"},{"database":"RefSeq","id":"XP_047292698.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047436742.1"}],"isoformId":"Q9BQA9-2"},{"database":"RefSeq","id":"XP_054173180.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054317205.1"}],"isoformId":"Q9BQA9-1"},{"database":"RefSeq","id":"XP_054173181.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054317206.1"}],"isoformId":"Q9BQA9-2"},{"database":"RefSeq","id":"XP_054173182.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054317207.1"}],"isoformId":"Q9BQA9-2"},{"database":"PDB","id":"8KEI","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.56 A"},{"key":"Chains","value":"D=1-164"}]},{"database":"PDBsum","id":"8KEI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-37159","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"122665","properties":[{"key":"Interactions","value":"91"}]},{"database":"FunCoup","id":"Q9BQA9","properties":[{"key":"Number of interactors","value":"1048"}]},{"database":"IntAct","id":"Q9BQA9","properties":[{"key":"Interactions","value":"88"}]},{"database":"MINT","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CYBC1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000388909","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C17orf62","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74732825","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000388909","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"15206","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"78649","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA9-1"},{"database":"Pumba","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q9BQA9-1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q9BQA9-1"},{"database":"Antibodypedia","id":"53358","properties":[{"key":"antibodies","value":"139 antibodies from 13 providers"}]},{"database":"DNASU","id":"79415","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000306645.10","properties":[{"key":"ProteinId","value":"ENSP00000307765.5"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000434650.6","properties":[{"key":"ProteinId","value":"ENSP00000401626.2"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000437807.6","properties":[{"key":"ProteinId","value":"ENSP00000388909.2"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000577436.5","properties":[{"key":"ProteinId","value":"ENSP00000464633.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000577696.6","properties":[{"key":"ProteinId","value":"ENSP00000463215.2"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000577732.5","properties":[{"key":"ProteinId","value":"ENSP00000463228.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000578919.6","properties":[{"key":"ProteinId","value":"ENSP00000464080.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000585064.5","properties":[{"key":"ProteinId","value":"ENSP00000463846.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000585080.5","properties":[{"key":"ProteinId","value":"ENSP00000462529.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000585115.2","properties":[{"key":"ProteinId","value":"ENSP00000513957.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000698819.1","properties":[{"key":"ProteinId","value":"ENSP00000513955.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000698820.1","properties":[{"key":"ProteinId","value":"ENSP00000513956.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000852066.1","properties":[{"key":"ProteinId","value":"ENSP00000522125.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000852067.1","properties":[{"key":"ProteinId","value":"ENSP00000522126.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000852068.1","properties":[{"key":"ProteinId","value":"ENSP00000522127.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000852069.1","properties":[{"key":"ProteinId","value":"ENSP00000522128.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000852070.1","properties":[{"key":"ProteinId","value":"ENSP00000522129.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000852071.1","properties":[{"key":"ProteinId","value":"ENSP00000522130.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000852072.1","properties":[{"key":"ProteinId","value":"ENSP00000522131.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000852073.1","properties":[{"key":"ProteinId","value":"ENSP00000522132.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000928818.1","properties":[{"key":"ProteinId","value":"ENSP00000598877.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000928819.1","properties":[{"key":"ProteinId","value":"ENSP00000598878.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000928820.1","properties":[{"key":"ProteinId","value":"ENSP00000598879.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000928821.1","properties":[{"key":"ProteinId","value":"ENSP00000598880.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000928822.1","properties":[{"key":"ProteinId","value":"ENSP00000598881.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950064.1","properties":[{"key":"ProteinId","value":"ENSP00000620123.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950065.1","properties":[{"key":"ProteinId","value":"ENSP00000620124.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950066.1","properties":[{"key":"ProteinId","value":"ENSP00000620125.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000950067.1","properties":[{"key":"ProteinId","value":"ENSP00000620126.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950068.1","properties":[{"key":"ProteinId","value":"ENSP00000620127.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950069.1","properties":[{"key":"ProteinId","value":"ENSP00000620128.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"Ensembl","id":"ENST00000950070.1","properties":[{"key":"ProteinId","value":"ENSP00000620129.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-1"},{"database":"Ensembl","id":"ENST00000950071.1","properties":[{"key":"ProteinId","value":"ENSP00000620130.1"},{"key":"GeneId","value":"ENSG00000178927.20"}],"isoformId":"Q9BQA9-2"},{"database":"GeneID","id":"79415","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:79415","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000306645.10","properties":[{"key":"ProteinId","value":"ENSP00000307765.5"},{"key":"RefSeqNucleotideId","value":"NM_001033046.4"},{"key":"RefSeqProteinId","value":"NP_001028218.1"}]},{"database":"UCSC","id":"uc002kfa.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q9BQA9-1"},{"database":"AGR","id":"HGNC:28672","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672245","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79415","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"79415","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CYBC1","properties":[{"key":"Description","value":"-"}]},{"database":"GeneReviews","id":"CYBC1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28672","properties":[{"key":"GeneName","value":"CYBC1"}]},{"database":"HPA","id":"ENSG00000178927","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"CYBC1","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"618334","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"618935","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000178927","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"379","properties":[{"key":"Disease","value":"Chronic granulomatous disease"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000178927","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S06T","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000004691","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_100734_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"WKLFYIT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10022724at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q9BQA9","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000178927","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"79415","properties":[{"key":"hits","value":"16 hits in 1146 CRISPR screens"}]},{"database":"ChiTaRS","id":"C17orf62","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"79415","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q9BQA9","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q9BQA9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q9BQA9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000178927","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 176 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q9BQA9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28351984"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28351984"}]},{"database":"GO","id":"GO:0045087","properties":[{"key":"GoTerm","value":"P:innate immune response"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30361506"}]},{"database":"GO","id":"GO:0045728","properties":[{"key":"GoTerm","value":"P:respiratory burst after phagocytosis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30361506"}]},{"database":"InterPro","id":"IPR027846","properties":[{"key":"EntryName","value":"Cybc1"}]},{"database":"PANTHER","id":"PTHR31837","properties":[{"key":"EntryName","value":"CYTOCHROME B-245 CHAPERONE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31837:SF3","properties":[{"key":"EntryName","value":"CYTOCHROME B-245 CHAPERONE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15169","properties":[{"key":"EntryName","value":"Cybc1_Eros"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAVQNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYFGKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEAGDPASQS","length":187,"molWeight":20774,"crc64":"363321B2FC5D36A7","md5":"D409CF8DBB7ED6BA3D51D88090AFFCC9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":61,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Modified residue":1,"Alternative sequence":1,"Natural variant":1},"uniParcId":"UPI000006FDD3"}}