{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q99NH2","secondaryAccessions":["Q58T10","Q58T11","Q8CB21"],"uniProtkbId":"PARD3_MOUSE","entryAudit":{"firstPublicDate":"2003-05-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-25","entryVersion":197,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Partitioning defective 3 homolog"},"shortNames":[{"value":"PAR-3"},{"value":"PARD-3"}]},"alternativeNames":[{"fullName":{"value":"Atypical PKC isotype-specific-interacting protein"},"shortNames":[{"value":"ASIP"}]},{"fullName":{"value":"Ephrin-interacting protein"},"shortNames":[{"value":"PHIP"}]}]},"genes":[{"geneName":{"value":"Pard3"},"synonyms":[{"value":"Par3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEW0"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z340"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11839275"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21949390"}],"value":"Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). 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Involved in Schwann cell peripheral myelination (PubMed:21949390)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TEW0"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10934474"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10934475"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11447115"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11839275"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19893486"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20047332"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080746"}],"value":"Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus). Component of a complex whose core is composed of ARHGAP17, AMOT, PALS1, PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB. Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with ECT2 and FBF1 (By similarity). Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Directly interacts with TIAM1 and TIAM2. Interacts with SIRT2. Interacts (via coiled-coil domain) with FRMD4A (PubMed:20080746). Found in a complex with PARD3, CYTH1 and FRMD4A (PubMed:20080746). Interacts with SAPCD2 (By similarity). 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