{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q99459","secondaryAccessions":["Q76N46","Q99974"],"uniProtkbId":"CDC5L_HUMAN","entryAudit":{"firstPublicDate":"2005-08-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-16","entryVersion":228,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cell division cycle 5-like protein"},"shortNames":[{"value":"Cdc5-like protein"}]},"alternativeNames":[{"fullName":{"value":"Pombe cdc5-related protein"}}]},"genes":[{"geneName":{"value":"CDC5L"},"synonyms":[{"value":"KIAA0432"},{"value":"PCDC5RP"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10570151"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11082045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11101529"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11544257"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11991638"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12927788"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18583928"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20176811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24332808"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28076346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28502770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29301961"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29360106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29361316"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30705154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30728453"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9038199"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9468527"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"9632794"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"33509932"}],"value":"DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O08837"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10827081"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11082045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11544257"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11991638"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12927788"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18583928"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18722174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20176811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21385873"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23022480"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28076346"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28502770"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29301961"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29360106"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29361316"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30705154"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30728453"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32484799"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33509932"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36229594"}],"value":"Homodimer. Interacts with DAPK3 (By similarity). Component of the precatalytic, catalytic and postcatalytic spliceosome complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with SCNM1 (PubMed:33509932). Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. The interaction with CTNNBL1 is direct (PubMed:18722174, PubMed:20176811, PubMed:21385873, PubMed:32484799). Interacts (via its C-terminus) directly in the complex with PRPF19 and BCAS2. Interacts (via its C-terminus) directly with PRGL1 (via its WD40 repeat domain); the interaction is required for mRNA splicing but not for spliceosome assembly. Interacts with PRPF19 (via N-terminus) (By similarity). Interacts with USB1 (PubMed:23022480). Interacts with DDX41 (PubMed:36229594)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q13535","geneName":"ATR","intActId":"EBI-968983"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"O75934","geneName":"BCAS2","intActId":"EBI-1050106"},"numberOfExperiments":16,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q99459","geneName":"CDC5L","intActId":"EBI-374880"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q8WYA6","geneName":"CTNNBL1","intActId":"EBI-748128"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q0D2H9","geneName":"GOLGA8DP","intActId":"EBI-10181276"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q08AF8","geneName":"GOLGA8G","intActId":"EBI-10181260"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"P07910","geneName":"HNRNPC","intActId":"EBI-357966"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"P52272","geneName":"HNRNPM","intActId":"EBI-486809"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q9UJC3","geneName":"HOOK1","intActId":"EBI-746704"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"P42858","geneName":"HTT","intActId":"EBI-466029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q63ZY3","geneName":"KANK2","intActId":"EBI-2556193"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q7Z3B3","geneName":"KANSL1","intActId":"EBI-740244"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"O60341","geneName":"KDM1A","intActId":"EBI-710124"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"O95751","geneName":"LDOC1","intActId":"EBI-740738"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q5JR59-3","geneName":"MTUS2","intActId":"EBI-11522433"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q13416","geneName":"ORC2","intActId":"EBI-374957"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"O43660","geneName":"PLRG1","intActId":"EBI-1051504"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"P62136","geneName":"PPP1CA","intActId":"EBI-357253"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q96KQ4","geneName":"PPP1R13B","intActId":"EBI-1105153"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q9UMS4","geneName":"PRPF19","intActId":"EBI-395746"},"numberOfExperiments":14,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q15428","geneName":"SF3A2","intActId":"EBI-2462271"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q99459","intActId":"EBI-374880"},"interactantTwo":{"uniProtKBAccession":"Q01082","geneName":"SPTBN1","intActId":"EBI-351561"},"number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Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8"}],"commentType":"PTM"},{"commentType":"DISEASE","note":{"texts":[{"value":"A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. 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