{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96PS1","uniProtkbId":"FACOS_HUMAN","entryAudit":{"firstPublicDate":"2006-05-16","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2001-12-01","entryVersion":129,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"FANCD2 opposite strand protein"}},"alternativeNames":[{"fullName":{"value":"Fanconi anemia group D2 protein opposite strand transcript protein"}}]},"genes":[{"geneName":{"value":"FANCD2OS"},"synonyms":[{"value":"C3orf24"}],"orfNames":[{"value":"HSD19"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D4K4"}],"value":"Reduces testosterone levels by inhibiting steroidogenic enzymes and by promoting apoptosis in Leydig cells"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9D4K4"}],"value":"Cytoplasm","id":"SL-0086"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":177,"modifier":"EXACT"}},"description":"FANCD2 opposite strand protein","featureId":"PRO_0000235343"}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-CF0VJU9I01JGJ","citationType":"submission","authors":["Timmers C.D.","Hejna J.A.","Reifsteck C.","Lucas L.W.","Bruun D.A.","Thayer M.J.","Taniguchi T.","Olson S.B.","D'Andrea A.","Moses R.E.","Grompe M."],"publicationDate":"FEB-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5V4TO0MM60C1R","citationType":"submission","authors":["Yang C.B.","Miao S.Y.","Zhang X.D.","Qiao Y.","Liang G.","Wang L.F."],"title":"A new spermatogenesis-related gene.","publicationDate":"MAR-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16641997","citationType":"journal article","authors":["Muzny D.M.","Scherer S.E.","Kaul R.","Wang J.","Yu J.","Sudbrak R.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Wei S.","Wheeler D.A.","Wright M.W.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clendenning J.","Clerc-Blankenburg K.P.","Chen R.","Chen Z.","Davis C.","Delgado O.","Dinh H.H.","Dong W.","Draper H.","Ernst S.","Fu G.","Gonzalez-Garay M.L.","Garcia D.K.","Gillett W.","Gu J.","Hao B.","Haugen E.","Havlak P.","He X.","Hennig S.","Hu S.","Huang W.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Kube M.","Levy R.","Li Z.","Liu B.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Palmeiri A.","Pasternak S.","Perez L.M.","Phelps K.A.","Plopper F.J.","Qiang B.","Raymond C.","Rodriguez R.","Saenphimmachak C.","Santibanez J.","Shen H.","Shen Y.","Subramanian S.","Tabor P.E.","Verduzco D.","Waldron L.","Wang J.","Wang J.","Wang Q.","Williams G.A.","Wong G.K.-S.","Yao Z.","Zhang J.","Zhang X.","Zhao G.","Zhou J.","Zhou Y.","Nelson D.","Lehrach H.","Reinhardt R.","Naylor S.L.","Yang H.","Olson M.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16641997"},{"database":"DOI","id":"10.1038/nature04728"}],"title":"The DNA sequence, annotation and analysis of human chromosome 3.","publicationDate":"2006","journal":"Nature","firstPage":"1194","lastPage":"1198","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF230334","properties":[{"key":"ProteinId","value":"AAL05979.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY248899","properties":[{"key":"ProteinId","value":"AAP20050.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC034193","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC028122","properties":[{"key":"ProteinId","value":"AAH28122.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2596.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001158311.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001164839.2"}]},{"database":"RefSeq","id":"NP_775743.1","properties":[{"key":"NucleotideSequenceId","value":"NM_173472.2"}]},{"database":"AlphaFoldDB","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125455","properties":[{"key":"Interactions","value":"26"}]},{"database":"FunCoup","id":"Q96PS1","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"IntAct","id":"Q96PS1","properties":[{"key":"Interactions","value":"32"}]},{"database":"NDEx","id":"MUSIC2-C5196-FANCD2OS","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Cytoplasmic vescicle for mRNA regulation (43 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000429608","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96PS1","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"FANCD2OS","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000429608","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"77742","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"53127","properties":[{"key":"antibodies","value":"65 antibodies from 14 providers"}]},{"database":"DNASU","id":"115795","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000450660.3","properties":[{"key":"ProteinId","value":"ENSP00000429608.1"},{"key":"GeneId","value":"ENSG00000163705.13"}]},{"database":"Ensembl","id":"ENST00000524279.1","properties":[{"key":"ProteinId","value":"ENSP00000429663.1"},{"key":"GeneId","value":"ENSG00000163705.13"}]},{"database":"GeneID","id":"115795","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:115795","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000450660.3","properties":[{"key":"ProteinId","value":"ENSP00000429608.1"},{"key":"RefSeqNucleotideId","value":"NM_001164839.2"},{"key":"RefSeqProteinId","value":"NP_001158311.1"}]},{"database":"UCSC","id":"uc003buz.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:28623","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672385","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"115795","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"115795","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"FANCD2OS","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28623","properties":[{"key":"GeneName","value":"FANCD2OS"}]},{"database":"HPA","id":"ENSG00000163705","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (testis)"}]},{"database":"MalaCards","id":"FANCD2OS","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"621082","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000163705","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000163705","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S0QV","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000631","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1510145_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QPPHWTG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9433753at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96PS1","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"115795","properties":[{"key":"hits","value":"9 hits in 1136 CRISPR screens"}]},{"database":"ChiTaRS","id":"FANCD2OS","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"115795","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96PS1","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96PS1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q96PS1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000163705","properties":[{"key":"ExpressionPatterns","value":"Expressed in left testis and 100 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96PS1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000225","properties":[{"key":"GoTerm","value":"P:negative regulation of testosterone biosynthetic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR027966","properties":[{"key":"EntryName","value":"FANCD2OS"}]},{"database":"PANTHER","id":"PTHR31036","properties":[{"key":"EntryName","value":"FANCD2 OPPOSITE STRAND PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31036:SF0","properties":[{"key":"EntryName","value":"FANCD2 OPPOSITE STRAND PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15124","properties":[{"key":"EntryName","value":"FANCD2OS"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGYQLWSPWTPLDESFQWLRHTTPTPSSKHPFKASPCFPHTPSDLEVQLCFQEVTLVLDSPFLESGVSPKLPCHTSELRTMNNKGLVRKPQPIRLSGVDSVFGRVITAQPPKWTGTFRVSDKSAFCKIISREHQWPIGLKEPQIQMTVTMCKQMLRSILLLYATYKKCTFALQHSK","length":177,"molWeight":20188,"crc64":"4D193F8362CB6BEB","md5":"B02E47CCE9C1051CB2DB30CCC64995D0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI0000072955"}}