{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96MH7","uniProtkbId":"CE034_HUMAN","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-02-23","entryVersion":140,"sequenceVersion":3},"annotationScore":1.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C5orf34"}}},"genes":[{"geneName":{"value":"C5orf34"}}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":638,"modifier":"EXACT"}},"description":"Uncharacterized protein C5orf34","featureId":"PRO_0000295897"},{"type":"Natural variant","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in a breast cancer sample; somatic mutation","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16959974"}],"featureId":"VAR_035618","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Pulmonary artery","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"16959974","citationType":"journal article","authors":["Sjoeblom T.","Jones S.","Wood L.D.","Parsons D.W.","Lin J.","Barber T.D.","Mandelker D.","Leary R.J.","Ptak J.","Silliman N.","Szabo S.","Buckhaults P.","Farrell C.","Meeh P.","Markowitz S.D.","Willis J.","Dawson D.","Willson J.K.V.","Gazdar A.F.","Hartigan J.","Wu L.","Liu C.","Parmigiani G.","Park B.H.","Bachman K.E.","Papadopoulos N.","Vogelstein B.","Kinzler K.W.","Velculescu V.E."],"citationCrossReferences":[{"database":"PubMed","id":"16959974"},{"database":"DOI","id":"10.1126/science.1133427"}],"title":"The consensus coding sequences of human breast and colorectal cancers.","publicationDate":"2006","journal":"Science","firstPage":"268","lastPage":"274","volume":"314"},"referencePositions":["VARIANT [LARGE SCALE ANALYSIS] ARG-266"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK056925","properties":[{"key":"ProteinId","value":"BAB71311.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC025457","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC114956","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF457895","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF459895","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"KF459900","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC036867","properties":[{"key":"ProteinId","value":"AAH36867.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS3946.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_940968.1","properties":[{"key":"NucleotideSequenceId","value":"NM_198566.4"}]},{"database":"RefSeq","id":"XP_054208508.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054352533.1"}]},{"database":"AlphaFoldDB","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"131979","properties":[{"key":"Interactions","value":"36"}]},{"database":"FunCoup","id":"Q96MH7","properties":[{"key":"Number of interactors","value":"1209"}]},{"database":"IntAct","id":"Q96MH7","properties":[{"key":"Interactions","value":"26"}]},{"database":"STRING","id":"9606.ENSP00000303490","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96MH7","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C5orf34","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"338817858","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000303490","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"77360","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"50296","properties":[{"key":"antibodies","value":"22 antibodies from 6 providers"}]},{"database":"DNASU","id":"375444","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000306862.7","properties":[{"key":"ProteinId","value":"ENSP00000303490.2"},{"key":"GeneId","value":"ENSG00000172244.10"}]},{"database":"Ensembl","id":"ENST00000951952.1","properties":[{"key":"ProteinId","value":"ENSP00000622011.1"},{"key":"GeneId","value":"ENSG00000172244.10"}]},{"database":"GeneID","id":"375444","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:375444","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000306862.7","properties":[{"key":"ProteinId","value":"ENSP00000303490.2"},{"key":"RefSeqNucleotideId","value":"NM_198566.4"},{"key":"RefSeqProteinId","value":"NP_940968.1"}]},{"database":"UCSC","id":"uc003jnz.3","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:24738","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162380068","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"375444","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"375444","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C5orf34","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:24738","properties":[{"key":"GeneName","value":"C5orf34"}]},{"database":"HPA","id":"ENSG00000172244","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000172244","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000172244","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSYT","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00500000044987","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_029198_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TAVISWC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"75908at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96MH7","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000172244","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"375444","properties":[{"key":"hits","value":"16 hits in 1126 CRISPR screens"}]},{"database":"ChiTaRS","id":"C5orf34","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"375444","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96MH7","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96MH7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q96MH7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000172244","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 125 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96MH7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR053901","properties":[{"key":"EntryName","value":"C5orf34-like"}]},{"database":"InterPro","id":"IPR053899","properties":[{"key":"EntryName","value":"C5orf34-like_2nd"}]},{"database":"InterPro","id":"IPR027865","properties":[{"key":"EntryName","value":"C5orf34-like_C"}]},{"database":"InterPro","id":"IPR053900","properties":[{"key":"EntryName","value":"C5orf34-like_dom"}]},{"database":"InterPro","id":"IPR027830","properties":[{"key":"EntryName","value":"C5orf34-like_N"}]},{"database":"PANTHER","id":"PTHR34531:SF1","properties":[{"key":"EntryName","value":"CHROMOSOME 5 OPEN READING FRAME 34"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34531","properties":[{"key":"EntryName","value":"ZGC:153352"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15025","properties":[{"key":"EntryName","value":"C5orf34-like_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22833","properties":[{"key":"EntryName","value":"C5orf34_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15016","properties":[{"key":"EntryName","value":"C5orf34_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22834","properties":[{"key":"EntryName","value":"Polo_box_4"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAELRMILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSAHPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSETIIPSERKKHIFIDITEVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVSQKSDSSAVLSETNNKAPKDKLVEKTGKICIRGNLPGQRLKNKENEFHCQIMKSKETLKKMSCVNGTEGREELPSPGTKHTCVYTWVKQCWSVAACPEEWKYPLSLALHFHNKISNMSKIDAHITQSRFLTSDISEERGKVVSVLPRALSLSCPVPHLHRWNFCDSLLQRQSDEYSYPELVKMVWYKGVTYRLTHQNMNSIEIYSGDGSVFKSEGAYFGNYFTYYSIQEGSGKREEKTYSVNNLPPDRPGSPFTVGSLIKQATRILQHCVKMRLSLSHNYRICCWKMVPGINDSNILPLVLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSPIEKRQVNQGLNLGWCKLTFPDGQEQLIQIEHPEPYERYVTTVTSWCRRLTQTSPREMPTHSSSSVLQENWSVASELEKIQKFNLLLENSGILNQISNKKNEQQSFDHYKPGSSETLLGEVNENRVSIALKKTSEILHDIDCLLSNSKK","length":638,"molWeight":72884,"crc64":"65ABB9EEDB786362","md5":"F16BE3279A55B66406CB0905113973B0"},"extraAttributes":{"countByFeatureType":{"Chain":1,"Natural variant":1},"uniParcId":"UPI0000073C8B"}}