{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96MC5","secondaryAccessions":["O00223","O75769","Q8IZ36","Q96H25"],"uniProtkbId":"MERB1_HUMAN","entryAudit":{"firstPublicDate":"2005-07-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2001-12-01","entryVersion":164,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"bMERB domain-containing protein 1"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:19213"}],"value":"BMERB1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:19213"}],"value":"C16orf45"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96MC5","intActId":"EBI-718468"},"interactantTwo":{"uniProtKBAccession":"Q8WZA2","geneName":"RAPGEF4","intActId":"EBI-948476"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96MC5","intActId":"EBI-718468"},"interactantTwo":{"uniProtKBAccession":"Q99081","geneName":"TCF12","intActId":"EBI-722877"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96MC5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96MC5-2"],"sequenceIds":["VSP_047232"],"isoformSequenceStatus":"Described"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAC31663.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"bMERB domain-containing protein 1","featureId":"PRO_0000079281"},{"type":"Domain","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"bMERB","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01195"}]},{"type":"Region","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_047232","alternativeSequence":{"originalSequence":"MELKQSLSTHLEAEKPLRRYGAVEETAWKTERLGRN","alternativeSequences":["MWGDLTETGCMGRRSAKKD"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Stomach","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"10493829","citationType":"journal article","authors":["Loftus B.J.","Kim U.-J.","Sneddon V.P.","Kalush F.","Brandon R.","Fuhrmann J.","Mason T.","Crosby M.L.","Barnstead M.","Cronin L.","Mays A.D.","Cao Y.","Xu R.X.","Kang H.-L.","Mitchell S.","Eichler E.E.","Harris P.C.","Venter J.C.","Adams M.D."],"citationCrossReferences":[{"database":"PubMed","id":"10493829"},{"database":"DOI","id":"10.1006/geno.1999.5927"}],"title":"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.","publicationDate":"1999","journal":"Genomics","firstPage":"295","lastPage":"308","volume":"60"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Muscle","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK057180","properties":[{"key":"ProteinId","value":"BAB71376.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U95740","properties":[{"key":"ProteinId","value":"AAC31663.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC008967","properties":[{"key":"ProteinId","value":"AAH08967.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC023603","properties":[{"key":"ProteinId","value":"AAH23603.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10561.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96MC5-1"},{"database":"CCDS","id":"CCDS45422.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96MC5-2"},{"database":"RefSeq","id":"NP_001135941.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001142469.2"}],"isoformId":"Q96MC5-2"},{"database":"RefSeq","id":"NP_149978.1","properties":[{"key":"NucleotideSequenceId","value":"NM_033201.3"}],"isoformId":"Q96MC5-1"},{"database":"AlphaFoldDB","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"124644","properties":[{"key":"Interactions","value":"39"}]},{"database":"FunCoup","id":"Q96MC5","properties":[{"key":"Number of interactors","value":"157"}]},{"database":"IntAct","id":"Q96MC5","properties":[{"key":"Interactions","value":"25"}]},{"database":"NDEx","id":"IQUERY-CP-BMERB1","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000300006","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C16orf45","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"68565261","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000300006","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"77332","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96MC5-1"},{"database":"Antibodypedia","id":"51073","properties":[{"key":"antibodies","value":"73 antibodies from 20 providers"}]},{"database":"DNASU","id":"89927","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000300006.9","properties":[{"key":"ProteinId","value":"ENSP00000300006.4"},{"key":"GeneId","value":"ENSG00000166780.12"}],"isoformId":"Q96MC5-1"},{"database":"Ensembl","id":"ENST00000452191.6","properties":[{"key":"ProteinId","value":"ENSP00000408976.2"},{"key":"GeneId","value":"ENSG00000166780.12"}],"isoformId":"Q96MC5-2"},{"database":"Ensembl","id":"ENST00000610499.2","properties":[{"key":"ProteinId","value":"ENSP00000477880.1"},{"key":"GeneId","value":"ENSG00000278823.4"}],"isoformId":"Q96MC5-2"},{"database":"Ensembl","id":"ENST00000615273.4","properties":[{"key":"ProteinId","value":"ENSP00000483858.1"},{"key":"GeneId","value":"ENSG00000278823.4"}],"isoformId":"Q96MC5-1"},{"database":"GeneID","id":"89927","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:89927","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000300006.9","properties":[{"key":"ProteinId","value":"ENSP00000300006.4"},{"key":"RefSeqNucleotideId","value":"NM_033201.3"},{"key":"RefSeqProteinId","value":"NP_149978.1"}]},{"database":"UCSC","id":"uc002ddo.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96MC5-1"},{"database":"AGR","id":"HGNC:19213","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134973206","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"89927","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"89927","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"BMERB1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:19213","properties":[{"key":"GeneName","value":"BMERB1"}]},{"database":"HPA","id":"ENSG00000166780","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (brain)"}]},{"database":"OpenTargets","id":"ENSG00000166780","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000166780","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RC9C","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00440000038745","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_123952_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ATQCSIM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10048027at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96MC5","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000166780","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"89927","properties":[{"key":"hits","value":"15 hits in 1117 CRISPR screens"}]},{"database":"ChiTaRS","id":"C16orf45","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"89927","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96MC5","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q96MC5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q96MC5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000166780","properties":[{"key":"ExpressionPatterns","value":"Expressed in superior frontal gyrus and 104 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96MC5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0015630","properties":[{"key":"GoTerm","value":"C:microtubule cytoskeleton"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007026","properties":[{"key":"GoTerm","value":"P:negative regulation of microtubule depolymerization"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR040127","properties":[{"key":"EntryName","value":"BMERB"}]},{"database":"InterPro","id":"IPR022735","properties":[{"key":"EntryName","value":"bMERB_dom"}]},{"database":"PANTHER","id":"PTHR22704:SF1","properties":[{"key":"EntryName","value":"BMERB DOMAIN-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22704","properties":[{"key":"EntryName","value":"BMERB DOMAIN-CONTAINING PROTEIN 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12130","properties":[{"key":"EntryName","value":"bMERB_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01203","properties":[{"key":"EntryName","value":"DUF3585"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51848","properties":[{"key":"EntryName","value":"BMERB"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELKQSLSTHLEAEKPLRRYGAVEETAWKTERLGRNQLDIISMAETTMMPEEIELEMAKIQRLREVLVRRESELRFMMDDIQLCKDIMDLKQELQNLVAIPEKEKTKLQKQREDELIQKIHKLVQKRDFLVDDAEVERLREQEEDKEMADFLRIKLKPLDKVTKSPASSRAEKKAEPPPSKPTVAKTGLALIKDCCGATQCNIM","length":204,"molWeight":23732,"crc64":"5D702950A7744A5F","md5":"3FFB76B59216D44B93E305EEC7107E40"},"extraAttributes":{"countByCommentType":{"INTERACTION":2,"ALTERNATIVE PRODUCTS":2,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":1,"Alternative sequence":1},"uniParcId":"UPI000006CFC7"}}