{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96M63","secondaryAccessions":["Q6ZRL4","Q96M06","Q9UFG8"],"uniProtkbId":"ODAD1_HUMAN","entryAudit":{"firstPublicDate":"2007-05-29","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2009-01-20","entryVersion":150,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Outer dynein arm-docking complex subunit 1"}},"alternativeNames":[{"fullName":{"value":"Coiled-coil domain-containing protein 114"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:26560"}],"value":"ODAD1"},"synonyms":[{"value":"CCDC114"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F1N2N9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27486780"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23261302"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"23261303"}],"value":"Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Involved in mediating assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"F1N2N9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25192045"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27486780"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30148830"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30471718"}],"value":"Component of the outer dynein arm-docking complex along with ODAD2, ODAD3, ODAD4 and CLXN (PubMed:25192045, PubMed:27486780). Interacts with ODAD3 (PubMed:25192045). Interacts with ODAD4; this interaction may facilitate the recruitment and/or attachment of outer dynein arm docking complex proteins, including ODAD1, ODAD3, and ODAD4 to ciliary axonemes (PubMed:27486780). Interacts with DNAH9 (PubMed:25192045, PubMed:27486780, PubMed:30471718). Interacts with MNS1 (PubMed:30148830). Interacts with PIERCE1 and PIERCE2; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q8TAB5","geneName":"C1orf216","intActId":"EBI-747505"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q9NYC9","geneName":"DNAH9","intActId":"EBI-766388"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q96CS2","geneName":"HAUS1","intActId":"EBI-2514791"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z4Q4","geneName":"HGS","intActId":"EBI-16429135"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"O14964","geneName":"HGS","intActId":"EBI-740220"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q07866","geneName":"KLC1","intActId":"EBI-721019"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q8TBB1","geneName":"LNX1","intActId":"EBI-739832"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"A5D8V7","geneName":"ODAD3","intActId":"EBI-8466445"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"A5D8V7-2","geneName":"ODAD3","intActId":"EBI-10173824"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q5VU62","geneName":"TPM3","intActId":"EBI-10184033"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96M63","intActId":"EBI-10173858"},"interactantTwo":{"uniProtKBAccession":"Q99757","geneName":"TXN2","intActId":"EBI-2932492"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25192045"}],"value":"Cytoplasm, cytoskeleton, cilium axoneme","id":"SL-0304"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96M63-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96M63-4"],"sequenceIds":["VSP_036212"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q96M63-5"],"sequenceIds":["VSP_036213","VSP_036214"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261303"}],"value":"Expressed in nasal epithelial cells (PubMed:23261302, PubMed:23261303). 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Unlike other forms of CILD characterized by reduced fertility, patients with CILD20 do not appear to be infertile.","diseaseCrossReference":{"database":"MIM","id":"615067"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261303"}]},"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261302"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23261303"}],"value":"The disease is caused by variants affecting the gene represented in this entry. The genetic variation producing the missense variant p.A248T, associated with CILD20, has been shown to predominantly affect splicing, yielding aberrant transcripts carrying premature translation termination signals. Only very low expression levels of the transcript carrying the missense could be detected in patients' nasal epithelial cells"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ODA1/DCC2 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB71448.1","note":"Unlikely isoform. Aberrant splice sites.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAC87296.1","note":"Unlikely isoform. 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