{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96KV7","secondaryAccessions":["Q0VA87","Q0VA88","Q6P048","Q6ZMS1","Q6ZTH1","Q8N202","Q8N221","Q8NBB8","Q96PW4","Q96S18"],"uniProtkbId":"WDR90_HUMAN","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-06-10","entryVersion":179,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"WD repeat-containing protein 90"}}},"genes":[{"geneName":{"value":"WDR90"},"synonyms":[{"value":"C16orf15"},{"value":"C16orf16"},{"value":"C16orf17"},{"value":"C16orf18"},{"value":"C16orf19"},{"value":"KIAA1924"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28781053"}],"value":"Microtubule-binding protein that plays a crucial role in ensuring inner core protein localization within the centriole core, as well as in maintaining the microtubule wall integrity and the overall centriole roundness and stability (PubMed:32946374). Required for efficient primary cilium formation (PubMed:28781053)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96KV7","intActId":"EBI-9478492"},"interactantTwo":{"uniProtKBAccession":"Q93062","geneName":"RBPMS","intActId":"EBI-740322"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32946374"}],"value":"Localizes to the microtubule triplets in the central core region of centrioles and localizes to centriolar satellite in a PCM1-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28781053"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32946374"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole","id":"SL-0046"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32946374"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite","id":"SL-0485"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96KV7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q96KV7-10"],"sequenceIds":["VSP_034290","VSP_034303","VSP_041087","VSP_041088"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q96KV7-3"],"sequenceIds":["VSP_034298","VSP_034300"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q96KV7-7"],"sequenceIds":["VSP_034290","VSP_034303","VSP_034306"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q96KV7-5"],"sequenceIds":["VSP_034294","VSP_034298","VSP_034300"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the WD repeat WDR90/POC16 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAK61239.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAB67817.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAC03575.1","note":"Unlikely isoform. Aberrant splicing.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC04225.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAC04225.1","note":"Probable cloning artifact.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAD18654.1","note":"Probable cloning artifact.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EAW85775.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 2","sequenceCautionType":"Erroneous termination","sequence":"BAC04205.1","note":"Truncated C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 3","sequenceCautionType":"Frameshift","sequence":"AAI21187.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","molecule":"Isoform 5","sequenceCautionType":"Frameshift","sequence":"AAI21186.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"WD repeat-containing protein 90","featureId":"PRO_0000341412"},{"type":"Repeat","location":{"start":{"value":407,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"WD 1"},{"type":"Repeat","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"WD 2"},{"type":"Repeat","location":{"start":{"value":501,"modifier":"EXACT"},"end":{"value":541,"modifier":"EXACT"}},"description":"WD 3"},{"type":"Repeat","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"WD 4"},{"type":"Repeat","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":695,"modifier":"EXACT"}},"description":"WD 5"},{"type":"Repeat","location":{"start":{"value":698,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"WD 6"},{"type":"Repeat","location":{"start":{"value":740,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"WD 7"},{"type":"Repeat","location":{"start":{"value":782,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"WD 8"},{"type":"Repeat","location":{"start":{"value":882,"modifier":"EXACT"},"end":{"value":922,"modifier":"EXACT"}},"description":"WD 9"},{"type":"Repeat","location":{"start":{"value":926,"modifier":"EXACT"},"end":{"value":964,"modifier":"EXACT"}},"description":"WD 10"},{"type":"Repeat","location":{"start":{"value":969,"modifier":"EXACT"},"end":{"value":1009,"modifier":"EXACT"}},"description":"WD 11"},{"type":"Repeat","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":1201,"modifier":"EXACT"}},"description":"WD 12"},{"type":"Repeat","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1245,"modifier":"EXACT"}},"description":"WD 13"},{"type":"Repeat","location":{"start":{"value":1247,"modifier":"EXACT"},"end":{"value":1286,"modifier":"EXACT"}},"description":"WD 14"},{"type":"Repeat","location":{"start":{"value":1298,"modifier":"EXACT"},"end":{"value":1326,"modifier":"EXACT"}},"description":"WD 15"},{"type":"Repeat","location":{"start":{"value":1327,"modifier":"EXACT"},"end":{"value":1376,"modifier":"EXACT"}},"description":"WD 16"},{"type":"Repeat","location":{"start":{"value":1433,"modifier":"EXACT"},"end":{"value":1472,"modifier":"EXACT"}},"description":"WD 17"},{"type":"Repeat","location":{"start":{"value":1475,"modifier":"EXACT"},"end":{"value":1520,"modifier":"EXACT"}},"description":"WD 18"},{"type":"Repeat","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1562,"modifier":"EXACT"}},"description":"WD 19"},{"type":"Repeat","location":{"start":{"value":1568,"modifier":"EXACT"},"end":{"value":1614,"modifier":"EXACT"}},"description":"WD 20"},{"type":"Repeat","location":{"start":{"value":1715,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"WD 21"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":207,"modifier":"EXACT"}},"description":"Binds with microtubules","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32946374"}]},{"type":"Region","location":{"start":{"value":274,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1004,"modifier":"EXACT"},"end":{"value":1071,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPG2"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1401,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034290","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034294","alternativeSequence":{"originalSequence":"A","alternativeSequences":["AQ"]}},{"type":"Alternative sequence","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034298","alternativeSequence":{"originalSequence":"EHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAM","alternativeSequences":["GDAVGTLSQLPESLAWMLGRGRPSPRGSAVSRPGSWLHRVPRGQVAYPEPWGG"]}},{"type":"Alternative sequence","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034300","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1402,"modifier":"EXACT"},"end":{"value":1437,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034303","alternativeSequence":{"originalSequence":"DDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSK","alternativeSequences":["MLWFGQPGPGGWNRKCLRPFTLPRGQHPQPSYGFPQ"]}},{"type":"Alternative sequence","location":{"start":{"value":1580,"modifier":"EXACT"},"end":{"value":1627,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034306","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1629,"modifier":"EXACT"},"end":{"value":1672,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_041087","alternativeSequence":{"originalSequence":"TQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEK","alternativeSequences":["VNHAPGTVGGAGTHPPHRSMLRLCRLRATWHPPSLPSALGMGRS"]}},{"type":"Alternative sequence","location":{"start":{"value":1673,"modifier":"EXACT"},"end":{"value":1748,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_041088","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"in dbSNP:rs13337278","featureCrossReferences":[{"database":"dbSNP","id":"rs13337278"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11572484"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_044060","alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":250,"modifier":"EXACT"},"end":{"value":250,"modifier":"EXACT"}},"description":"in dbSNP:rs11642546","featureCrossReferences":[{"database":"dbSNP","id":"rs11642546"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_044061","alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":537,"modifier":"EXACT"},"end":{"value":537,"modifier":"EXACT"}},"description":"in dbSNP:rs3803697","featureCrossReferences":[{"database":"dbSNP","id":"rs3803697"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_044062","alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1001,"modifier":"EXACT"},"end":{"value":1001,"modifier":"EXACT"}},"description":"in dbSNP:rs4984906","featureCrossReferences":[{"database":"dbSNP","id":"rs4984906"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_044063","alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":1492,"modifier":"EXACT"},"end":{"value":1492,"modifier":"EXACT"}},"description":"in dbSNP:rs7190775","featureCrossReferences":[{"database":"dbSNP","id":"rs7190775"}],"featureId":"VAR_044064","alternativeSequence":{"originalSequence":"R","alternativeSequences":["H"]}},{"type":"Natural variant","location":{"start":{"value":1555,"modifier":"EXACT"},"end":{"value":1555,"modifier":"EXACT"}},"description":"in dbSNP:rs11866949","featureCrossReferences":[{"database":"dbSNP","id":"rs11866949"}],"featureId":"VAR_044065","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":899,"modifier":"EXACT"},"end":{"value":899,"modifier":"EXACT"}},"description":"in Ref. 1; BAD18654","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1085,"modifier":"EXACT"}},"description":"in Ref. 1; BAD18654","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":1245,"modifier":"EXACT"},"end":{"value":1245,"modifier":"EXACT"}},"description":"in Ref. 1; BAC04225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1302,"modifier":"EXACT"},"end":{"value":1302,"modifier":"EXACT"}},"description":"in Ref. 1; BAC04225","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0493","category":"Cellular component","name":"Microtubule"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0853","category":"Domain","name":"WD repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)","VARIANTS THR-165 AND THR-1001"],"referenceComments":[{"value":"Cerebellum","type":"TISSUE"},{"value":"Thymus","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"11157797","citationType":"journal article","authors":["Daniels R.J.","Peden J.F.","Lloyd C.","Horsley S.W.","Clark K.","Tufarelli C.","Kearney L.","Buckle V.J.","Doggett N.A.","Flint J.","Higgs D.R."],"citationCrossReferences":[{"database":"PubMed","id":"11157797"},{"database":"DOI","id":"10.1093/hmg/10.4.339"}],"title":"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.","publicationDate":"2001","journal":"Hum. Mol. Genet.","firstPage":"339","lastPage":"352","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.-C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.-R.","Wu K.","Yang J.","DeJong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5)","VARIANTS THR-165; LEU-250 AND ALA-537"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"11572484","citationType":"journal article","authors":["Nagase T.","Kikuno R.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"11572484"},{"database":"DOI","id":"10.1093/dnares/8.4.179"}],"title":"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.","publicationDate":"2001","journal":"DNA Res.","firstPage":"179","lastPage":"187","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1138 (ISOFORM 1)","VARIANT THR-165"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"28781053","citationType":"journal article","authors":["Hamel V.","Steib E.","Hamelin R.","Armand F.","Borgers S.","Flueckiger I.","Busso C.","Olieric N.","Sorzano C.O.S.","Steinmetz M.O.","Guichard P.","Goenczy P."],"citationCrossReferences":[{"database":"PubMed","id":"28781053"},{"database":"DOI","id":"10.1016/j.cub.2017.07.011"}],"title":"Identification of chlamydomonas central core centriolar proteins reveals a role for human WDR90 in ciliogenesis.","publicationDate":"2017","journal":"Curr. Biol.","firstPage":"2486","lastPage":"2498","volume":"27"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":8,"citation":{"id":"32946374","citationType":"journal article","authors":["Steib E.","Laporte M.H.","Gambarotto D.","Olieric N.","Zheng C.","Borgers S.","Olieric V.","Le Guennec M.","Koll F.","Tassin A.M.","Steinmetz M.O.","Guichard P.","Hamel V."],"citationCrossReferences":[{"database":"PubMed","id":"32946374"},{"database":"DOI","id":"10.7554/elife.57205"}],"title":"WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.","publicationDate":"2020","journal":"Elife","firstPage":"0","lastPage":"0","volume":"9"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","MICROTUBULES-BINDING REGION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK091062","properties":[{"key":"ProteinId","value":"BAC03575.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK093609","properties":[{"key":"ProteinId","value":"BAC04205.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK093802","properties":[{"key":"ProteinId","value":"BAC04225.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK131510","properties":[{"key":"ProteinId","value":"BAD18654.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AE006464","properties":[{"key":"ProteinId","value":"AAK61239.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL022341","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"Z92544","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471112","properties":[{"key":"ProteinId","value":"EAW85775.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC065836","properties":[{"key":"ProteinId","value":"AAH65836.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC121185","properties":[{"key":"ProteinId","value":"AAI21186.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC121186","properties":[{"key":"ProteinId","value":"AAI21187.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB067511","properties":[{"key":"ProteinId","value":"BAB67817.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS42092.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KV7-1"},{"database":"RefSeq","id":"NP_660337.3","properties":[{"key":"NucleotideSequenceId","value":"NM_145294.5"}],"isoformId":"Q96KV7-1"},{"database":"AlphaFoldDB","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"128250","properties":[{"key":"Interactions","value":"57"}]},{"database":"FunCoup","id":"Q96KV7","properties":[{"key":"Number of interactors","value":"504"}]},{"database":"IntAct","id":"Q96KV7","properties":[{"key":"Interactions","value":"42"}]},{"database":"MINT","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000293879","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96KV7","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"WDR90","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"190423649","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000293879","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"77120","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KV7-1"},{"database":"ProteomicsDB","id":"77122","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KV7-3"},{"database":"ProteomicsDB","id":"77123","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KV7-5"},{"database":"ProteomicsDB","id":"77124","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KV7-7"},{"database":"Antibodypedia","id":"70705","properties":[{"key":"antibodies","value":"23 antibodies from 8 providers"}]},{"database":"DNASU","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000293879.9","properties":[{"key":"ProteinId","value":"ENSP00000293879.4"},{"key":"GeneId","value":"ENSG00000161996.20"}],"isoformId":"Q96KV7-1"},{"database":"Ensembl","id":"ENST00000315764.8","properties":[{"key":"ProteinId","value":"ENSP00000322808.4"},{"key":"GeneId","value":"ENSG00000161996.20"}],"isoformId":"Q96KV7-7"},{"database":"GeneID","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:197335","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000293879.9","properties":[{"key":"ProteinId","value":"ENSP00000293879.4"},{"key":"RefSeqNucleotideId","value":"NM_145294.5"},{"key":"RefSeqProteinId","value":"NP_660337.3"}]},{"database":"UCSC","id":"uc002cii.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96KV7-1"},{"database":"AGR","id":"HGNC:26960","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA145147652","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"WDR90","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26960","properties":[{"key":"GeneName","value":"WDR90"}]},{"database":"HPA","id":"ENSG00000161996","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (testis)"}]},{"database":"MalaCards","id":"WDR90","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"618290","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000161996","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000161996","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0266","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG0318","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"eggNOG","id":"KOG3213","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000160173","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_081013_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"6252103at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96KV7","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000161996","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"197335","properties":[{"key":"hits","value":"16 hits in 1153 CRISPR screens"}]},{"database":"ChiTaRS","id":"WDR90","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"197335","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96KV7","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96KV7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q96KV7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000161996","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 147 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96KV7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0034451","properties":[{"key":"GoTerm","value":"C:centriolar satellite"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32946374"}]},{"database":"GO","id":"GO:0005814","properties":[{"key":"GoTerm","value":"C:centriole"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28781053"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32946374"}]},{"database":"GO","id":"GO:0005813","properties":[{"key":"GoTerm","value":"C:centrosome"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32946374"}]},{"database":"GO","id":"GO:0061511","properties":[{"key":"GoTerm","value":"P:centriole elongation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32946374"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28781053"}]},{"database":"FunFam","id":"2.130.10.10:FF:000522","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000590","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000742","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000772","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000865","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:000974","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.130.10.10:FF:001103","properties":[{"key":"EntryName","value":"WD repeat domain 90"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.130.10.10","properties":[{"key":"EntryName","value":"YVTN repeat-like/Quinoprotein amine dehydrogenase"},{"key":"MatchStatus","value":"7"}]},{"database":"InterPro","id":"IPR055440","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_4th"}]},{"database":"InterPro","id":"IPR055441","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_POC16_2nd"}]},{"database":"InterPro","id":"IPR007714","properties":[{"key":"EntryName","value":"CFA20_dom"}]},{"database":"InterPro","id":"IPR011047","properties":[{"key":"EntryName","value":"Quinoprotein_ADH-like_sf"}]},{"database":"InterPro","id":"IPR015943","properties":[{"key":"EntryName","value":"WD40/YVTN_repeat-like_dom_sf"}]},{"database":"InterPro","id":"IPR019775","properties":[{"key":"EntryName","value":"WD40_repeat_CS"}]},{"database":"InterPro","id":"IPR036322","properties":[{"key":"EntryName","value":"WD40_repeat_dom_sf"}]},{"database":"InterPro","id":"IPR001680","properties":[{"key":"EntryName","value":"WD40_rpt"}]},{"database":"InterPro","id":"IPR050630","properties":[{"key":"EntryName","value":"WD_repeat_EMAP"}]},{"database":"PANTHER","id":"PTHR13720:SF24","properties":[{"key":"EntryName","value":"WD REPEAT-CONTAINING PROTEIN 90"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13720","properties":[{"key":"EntryName","value":"WD-40 REPEAT PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23393","properties":[{"key":"EntryName","value":"Beta-prop_WDR90_POC16_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05018","properties":[{"key":"EntryName","value":"CFA20_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00400","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF23342","properties":[{"key":"EntryName","value":"WDR90_beta-prop_4th"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00320","properties":[{"key":"EntryName","value":"WD40"},{"key":"MatchStatus","value":"20"}]},{"database":"SUPFAM","id":"SSF50998","properties":[{"key":"EntryName","value":"Quinoprotein alcohol dehydrogenase-like"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF50978","properties":[{"key":"EntryName","value":"WD40 repeat-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00678","properties":[{"key":"EntryName","value":"WD_REPEATS_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50082","properties":[{"key":"EntryName","value":"WD_REPEATS_2"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS50294","properties":[{"key":"EntryName","value":"WD_REPEATS_REGION"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MARAWQHPFLNVFRHFRVDEWKRSAKQGDVAVVTDKTLKGAVYRIRGSVSAANYIQLPKSSTQSLGLTGRYLYVLFRPLPSKHFVIHLDVSSKDNQVIRVSFSNLFKEFKSTATWLQFPLVLEARTPQRDLVGLAPSGARWTCLQLDLQDVLLVYLNRCYGHLKSIRLCASLLVRNLYTSDLCFEPAISGAQWAKLPVTPMPREMAFPVPKGESWHDRYIHVRFPSESLKVPSKPIEKSCSPPEAVLLGPGPQPLPCPVASSKPVRFSVSPVVQTPSPTASGRAALAPRPFPEVSLSQERSDASNADGPGFHSLEPWAQLEASDIHTAAAGTHVLTHESAEVPVARTGSCEGFLPDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGEQRFFLGHTDKVSALALDGSSSLLASAQARAPSVMRLWDFQTGRCLCLFRSPMHVVCSLSFSDSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVTFFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDGCPEPSAAMLFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQKQTFSSGPGIAISSLSVSPAMCAVGSEDGFLRLWPLDFSSVLLEAEHEGPVSSVCVSPDGLRVLSATSSGHLGFLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSEDAPCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSCSQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGSASLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELPGVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQQVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQASPPRLGVCARPPEGGDGARDTRNSGAPRTTYLASCKAFTPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVVEDLHSGAQQHWSGHSAEISTLALSHSAQVLASASGRSSTTAHCQIRVWDVSGGLCQHLIFPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTATYDLVSSTRLPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSLCYGAPPLLYCGTSSGQVCVWDTRAGRCFLSWEADDGGIGLLLFSGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGAVVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSEDGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRTAMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAVSHPCTGTTFRVLSDHQGAPISTICVTCKECEDLGVEGTDLWLAASGDQRVSVWASDWLRNHCELVDWLSFPMPATTETQGHLPPSLAAFCPWDGALLMYVGPGVYKEVIIYNLCQKQVVEKIPLPFFAMSLSLSPGTHLLAVGFAECMLRLVDCAMGTAQDFAGHDNAVHLCRFTPSARLLFTAARNEILVWEVPGL","length":1748,"molWeight":187437,"crc64":"B9FC77D5F0FAAD9D","md5":"3BF63D642C0A5CB67B1AC5ADB638664A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":5,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":10},"countByFeatureType":{"Chain":1,"Repeat":21,"Region":3,"Modified residue":1,"Alternative sequence":8,"Natural variant":6,"Sequence conflict":4},"uniParcId":"UPI0000D67C48"}}