{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96KQ7","secondaryAccessions":["B0UZY2","Q14349","Q5JP83","Q5JQ92","Q5JQA1","Q5JQG3","Q6PK06","Q96MH5","Q96QD0","Q9UQL8","Q9Y331"],"uniProtkbId":"EHMT2_HUMAN","entryAudit":{"firstPublicDate":"2002-11-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":235,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Histone-lysine N-methyltransferase EHMT2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22387026"}],"value":"2.1.1.-"},{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"}],"value":"2.1.1.367"}]},"alternativeNames":[{"fullName":{"value":"Euchromatic histone-lysine N-methyltransferase 2"}},{"fullName":{"value":"HLA-B-associated transcript 8"}},{"fullName":{"value":"Histone H3-K9 methyltransferase 3"},"shortNames":[{"value":"H3-K9-HMTase 3"}]},{"fullName":{"value":"Lysine N-methyltransferase 1C"}},{"fullName":{"value":"Protein G9a"}}]},"genes":[{"geneName":{"value":"EHMT2"},"synonyms":[{"value":"BAT8"},{"value":"C6orf30"},{"value":"G9A"},{"value":"KMT1C"},{"value":"NG36"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12004135"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19144645"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20118233"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22387026"}],"value":"Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:11316813, PubMed:20084102). Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication (PubMed:22387026). Also weakly methylates 'Lys-27' of histone H3 (H3K27me) (PubMed:11316813). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. Also able to mono- and dimethylate histone H1-4 at 'Lys-26' (H1.4K26me1 and H1.4K26me2, respectively) (PubMed:19144645). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53 (PubMed:20118233). Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself (PubMed:18438403)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60284"},{"database":"Rhea","id":"RHEA-COMP:15541"},{"database":"Rhea","id":"RHEA-COMP:15542"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60285"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11316813"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60280"},{"database":"Rhea","id":"RHEA-COMP:15542"},{"database":"Rhea","id":"RHEA-COMP:15546"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"}],"ecNumber":"2.1.1.367","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60281"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11316813"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-lysyl(56)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(56)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85519"},{"database":"Rhea","id":"RHEA-COMP:20681"},{"database":"Rhea","id":"RHEA-COMP:20682"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29969"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22387026"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85520"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22387026"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(6)-methyl-L-lysyl(56)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(56)-[histone H3] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:85919"},{"database":"Rhea","id":"RHEA-COMP:20682"},{"database":"Rhea","id":"RHEA-COMP:20684"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:61929"},{"database":"ChEBI","id":"CHEBI:61976"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22387026"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:85920"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22387026"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z148"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12004135"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16688220"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16702210"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19056828"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19061646"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21549307"}],"value":"Heterodimer; heterodimerizes with EHMT1/GLP (PubMed:16702210). Interacts with GFI1B and WIZ (PubMed:16688220, PubMed:16702210). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EHMT1, RING1, RNF2, MBLR, L3MBTL2 and YAF2 (PubMed:12004135). Part of a complex composed of TRIM28, HDAC1, HDAC2 and EHMT2 (PubMed:21549307). Interacts with UHRF1 (PubMed:19056828). Interacts with CDYL (PubMed:19061646). Interacts with REST only in the presence of CDYL (PubMed:19061646). Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2 (PubMed:19061646). Interacts with PRDM9 and CDYL; interaction only takes place when PRDM9 is bound to hotspot DNA (By similarity). Interacts with SMYD5 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q6VMQ6-2","geneName":"ATF7IP","intActId":"EBI-12070560"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q6P1J9","geneName":"CDC73","intActId":"EBI-930143"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9UBC3","geneName":"DNMT3B","intActId":"EBI-80125"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"P38919","geneName":"EIF4A3","intActId":"EBI-299104"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9UM22","geneName":"EPDR1","intActId":"EBI-946972"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"P23771","geneName":"GATA3","intActId":"EBI-6664760"},"numberOfExperiments":20,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q99684","geneName":"GFI1","intActId":"EBI-949368"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q13547","geneName":"HDAC1","intActId":"EBI-301834"},"numberOfExperiments":10,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q96JB3","geneName":"HIC2","intActId":"EBI-726282"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q92831","geneName":"KAT2B","intActId":"EBI-477430"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"O60341-1","geneName":"KDM1A","intActId":"EBI-15599570"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9Y4X4","geneName":"KLF12","intActId":"EBI-750750"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"P57682","geneName":"KLF3","intActId":"EBI-8472267"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q13330","geneName":"MTA1","intActId":"EBI-714236"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"O94776","geneName":"MTA2","intActId":"EBI-1783035"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9BTC8","geneName":"MTA3","intActId":"EBI-2461787"},"numberOfExperiments":18,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"P20592","geneName":"MX2","intActId":"EBI-10200618"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9BSU3","geneName":"NAA11","intActId":"EBI-2585120"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q99801-1","geneName":"NKX3-1","intActId":"EBI-16208773"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"O60568","geneName":"PLOD3","intActId":"EBI-741582"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9NQX1","geneName":"PRDM5","intActId":"EBI-4292031"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q5JSZ5","geneName":"PRRC2B","intActId":"EBI-744891"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q7Z3Z2","geneName":"RD3","intActId":"EBI-10257497"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9P2R6","geneName":"RERE","intActId":"EBI-948076"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q14119","geneName":"VEZF1","intActId":"EBI-11980193"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q96GT9","geneName":"XAGE2","intActId":"EBI-750167"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"O60315","geneName":"ZEB2","intActId":"EBI-717614"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q9NWS9-2","geneName":"ZNF446","intActId":"EBI-740232"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q96JM2","geneName":"ZNF462","intActId":"EBI-1210359"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"A0A0S2Z5X4","geneName":"ZNF688","intActId":"EBI-16429014"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q96BV0","geneName":"ZNF775","intActId":"EBI-7149881"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q96EG3","geneName":"ZNF837","intActId":"EBI-11962574"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96KQ7","intActId":"EBI-744366"},"interactantTwo":{"uniProtKBAccession":"Q07120","geneName":"Gfi1","intActId":"EBI-4289236"},"numberOfExperiments":3,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q96KQ7-1","intActId":"EBI-15737402"},"interactantTwo":{"uniProtKBAccession":"O60341-1","geneName":"KDM1A","intActId":"EBI-15599570"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"}],"value":"Associates with euchromatic regions (PubMed:11316813). Does not associate with heterochromatin (PubMed:11316813)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q96KQ7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"NG36G9a-SPI"}],"isoformIds":["Q96KQ7-2"],"sequenceIds":["VSP_002211"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"NG36"}],"isoformIds":["Q96KQ7-3"],"sequenceIds":["VSP_002212","VSP_002213"],"isoformSequenceStatus":"Described"}],"note":{"texts":[{"value":"Additional isoforms seem to exist."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707778"}],"value":"Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"value":"The SET domain mediates interaction with WIZ"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"value":"The ANK repeats bind H3K9me1 and H3K9me2"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"value":"In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"}],"value":"Methylated at Lys-185; automethylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00190"}],"value":"Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"11707778"}],"value":"While NG36 and G9a were originally thought to derive from 2 separate genes, all G9A transcripts also contain the in frame coding sequence of NG36"}],"commentType":"CAUTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"It is uncertain whether Met-1 or Met-21 is the initiator methionine"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAD21811.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAD21812.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH02686.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH09351.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH18718.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH20970.2","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB63294.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAB63295.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAA49491.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"Histone-lysine N-methyltransferase EHMT2","featureId":"PRO_0000186068"},{"type":"Repeat","location":{"start":{"value":649,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"ANK 1"},{"type":"Repeat","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":713,"modifier":"EXACT"}},"description":"ANK 2"},{"type":"Repeat","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"ANK 3"},{"type":"Repeat","location":{"start":{"value":750,"modifier":"EXACT"},"end":{"value":780,"modifier":"EXACT"}},"description":"ANK 4"},{"type":"Repeat","location":{"start":{"value":784,"modifier":"EXACT"},"end":{"value":813,"modifier":"EXACT"}},"description":"ANK 5"},{"type":"Repeat","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"ANK 6"},{"type":"Repeat","location":{"start":{"value":850,"modifier":"EXACT"},"end":{"value":879,"modifier":"EXACT"}},"description":"ANK 7"},{"type":"Domain","location":{"start":{"value":972,"modifier":"EXACT"},"end":{"value":1035,"modifier":"EXACT"}},"description":"Pre-SET","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00157"}]},{"type":"Domain","location":{"start":{"value":1038,"modifier":"EXACT"},"end":{"value":1155,"modifier":"EXACT"}},"description":"SET","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00190"}]},{"type":"Domain","location":{"start":{"value":1164,"modifier":"EXACT"},"end":{"value":1180,"modifier":"EXACT"}},"description":"Post-SET"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":608,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":819,"modifier":"EXACT"}},"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1074,"modifier":"EXACT"},"end":{"value":1093,"modifier":"EXACT"}},"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1154,"modifier":"EXACT"},"end":{"value":1157,"modifier":"EXACT"}},"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":216,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":291,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":347,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":426,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":428,"modifier":"EXACT"},"end":{"value":428,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":446,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":459,"modifier":"EXACT"},"end":{"value":459,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":491,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":494,"modifier":"EXACT"},"end":{"value":494,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":509,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":517,"modifier":"EXACT"},"end":{"value":517,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":533,"modifier":"EXACT"},"end":{"value":533,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":535,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":536,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34278292"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":974,"modifier":"EXACT"},"end":{"value":974,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":976,"modifier":"EXACT"},"end":{"value":976,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":980,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":980,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"7"}},{"type":"Binding site","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":987,"modifier":"EXACT"},"end":{"value":987,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":1017,"modifier":"EXACT"},"end":{"value":1017,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":1017,"modifier":"EXACT"},"end":{"value":1017,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"7"}},{"type":"Binding site","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"6"}},{"type":"Binding site","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"7"}},{"type":"Binding site","location":{"start":{"value":1027,"modifier":"EXACT"},"end":{"value":1027,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"7"}},{"type":"Binding site","location":{"start":{"value":1050,"modifier":"EXACT"},"end":{"value":1050,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1084,"modifier":"EXACT"},"end":{"value":1084,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27648579"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5T0M"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1085,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1112,"modifier":"EXACT"},"end":{"value":1112,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1113,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1115,"modifier":"EXACT"},"end":{"value":1115,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"8"}},{"type":"Binding site","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1168,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1168,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"8"}},{"type":"Binding site","location":{"start":{"value":1169,"modifier":"EXACT"},"end":{"value":1169,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:57856"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"S-adenosyl-L-homocysteine","id":"ChEBI:CHEBI:57856"}},{"type":"Binding site","location":{"start":{"value":1170,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"8"}},{"type":"Binding site","location":{"start":{"value":1175,"modifier":"EXACT"},"end":{"value":1175,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24900801"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"8"}},{"type":"Site","location":{"start":{"value":1067,"modifier":"EXACT"},"end":{"value":1067,"modifier":"EXACT"}},"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"N6,N6,N6-trimethyllysine; by EHMT2; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"}]},{"type":"Modified residue","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"N6,N6-dimethyllysine; by EHMT2; alternate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18438403"}]},{"type":"Modified residue","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":350,"modifier":"EXACT"},"end":{"value":350,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9Z148"}]},{"type":"Modified residue","location":{"start":{"value":413,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":555,"modifier":"EXACT"},"end":{"value":555,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":569,"modifier":"EXACT"},"end":{"value":569,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"}]},{"type":"Modified residue","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1204,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1210,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Cross-link","location":{"start":{"value":219,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":229,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_002212","alternativeSequence":{"originalSequence":"PPVPEKRP","alternativeSequences":["VSGMGEMG"]}},{"type":"Alternative sequence","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_002213","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":373,"modifier":"EXACT"},"end":{"value":406,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_002211","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":55,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"in dbSNP:rs7887","featureCrossReferences":[{"database":"dbSNP","id":"rs7887"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11707778"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14574404"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.5"}],"featureId":"VAR_027973","alternativeSequence":{"originalSequence":"T","alternativeSequences":["N"]}},{"type":"Natural variant","location":{"start":{"value":1165,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"in dbSNP:rs13919","featureCrossReferences":[{"database":"dbSNP","id":"rs13919"}],"featureId":"VAR_027974","alternativeSequence":{"originalSequence":"Y","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":786,"modifier":"EXACT"},"end":{"value":786,"modifier":"EXACT"}},"description":"Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":794,"modifier":"EXACT"},"end":{"value":794,"modifier":"EXACT"}},"description":"Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":817,"modifier":"EXACT"}},"description":"Impairs binding to histone H3K9me.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":824,"modifier":"EXACT"},"end":{"value":824,"modifier":"EXACT"}},"description":"Abolishes binding to histone H3K9me without affecting the histone methyltransferase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":852,"modifier":"EXACT"},"end":{"value":852,"modifier":"EXACT"}},"description":"Impairs binding to histone H3K9me.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18264113"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in Ref. 2; CAC86666","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":985,"modifier":"EXACT"},"end":{"value":985,"modifier":"EXACT"}},"description":"in Ref. 2; CAC86666","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":994,"modifier":"EXACT"},"end":{"value":994,"modifier":"EXACT"}},"description":"in Ref. 8; CAA49491","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Helix","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Helix","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Turn","location":{"start":{"value":442,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":455,"modifier":"EXACT"},"end":{"value":458,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Helix","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Turn","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":497,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":512,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":515,"modifier":"EXACT"},"end":{"value":519,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Helix","location":{"start":{"value":521,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":525,"modifier":"EXACT"},"end":{"value":527,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":532,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Turn","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":536,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Helix","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":542,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Beta strand","location":{"start":{"value":544,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6MM1"}]},{"type":"Helix","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":919,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5JIY"}]},{"type":"Beta strand","location":{"start":{"value":920,"modifier":"EXACT"},"end":{"value":924,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Turn","location":{"start":{"value":926,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":931,"modifier":"EXACT"},"end":{"value":933,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":937,"modifier":"EXACT"},"end":{"value":943,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":944,"modifier":"EXACT"},"end":{"value":947,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":949,"modifier":"EXACT"},"end":{"value":952,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":957,"modifier":"EXACT"},"end":{"value":960,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":968,"modifier":"EXACT"},"end":{"value":970,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":977,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"3K5K"}]},{"type":"Helix","location":{"start":{"value":986,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":991,"modifier":"EXACT"},"end":{"value":993,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"8Z7C"}]},{"type":"Beta strand","location":{"start":{"value":1004,"modifier":"EXACT"},"end":{"value":1006,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7X73"}]},{"type":"Beta strand","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1010,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1011,"modifier":"EXACT"},"end":{"value":1013,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1023,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1027,"modifier":"EXACT"},"end":{"value":1029,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1032,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1040,"modifier":"EXACT"},"end":{"value":1044,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1046,"modifier":"EXACT"},"end":{"value":1056,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1063,"modifier":"EXACT"},"end":{"value":1067,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1069,"modifier":"EXACT"},"end":{"value":1073,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1074,"modifier":"EXACT"},"end":{"value":1077,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1086,"modifier":"EXACT"},"end":{"value":1089,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1092,"modifier":"EXACT"},"end":{"value":1094,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7XUD"}]},{"type":"Beta strand","location":{"start":{"value":1097,"modifier":"EXACT"},"end":{"value":1105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1107,"modifier":"EXACT"},"end":{"value":1110,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1118,"modifier":"EXACT"},"end":{"value":1127,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1135,"modifier":"EXACT"},"end":{"value":1142,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1156,"modifier":"EXACT"},"end":{"value":1162,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Turn","location":{"start":{"value":1163,"modifier":"EXACT"},"end":{"value":1165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Beta strand","location":{"start":{"value":1176,"modifier":"EXACT"},"end":{"value":1178,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]},{"type":"Helix","location":{"start":{"value":1179,"modifier":"EXACT"},"end":{"value":1189,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"5VSC"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0040","category":"Domain","name":"ANK repeat"},{"id":"KW-0156","category":"Molecular function","name":"Chromatin regulator"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0862","category":"Ligand","name":"Zinc"}],"references":[{"referenceNumber":1,"citation":{"id":"11707778","citationType":"journal article","authors":["Brown S.E.","Campbell R.D.","Sanderson C.M."],"citationCrossReferences":[{"database":"PubMed","id":"11707778"},{"database":"DOI","id":"10.1007/s00335-001-3029-3"}],"title":"Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions.","publicationDate":"2001","journal":"Mamm. Genome","firstPage":"916","lastPage":"924","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","ALTERNATIVE SPLICING (ISOFORM 2)","TISSUE SPECIFICITY","VARIANT ASN-55"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14656967","citationType":"journal article","authors":["Xie T.","Rowen L.","Aguado B.","Ahearn M.E.","Madan A.","Qin S.","Campbell R.D.","Hood L."],"citationCrossReferences":[{"database":"PubMed","id":"14656967"},{"database":"DOI","id":"10.1101/gr.1736803"}],"title":"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2621","lastPage":"2636","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"CI-2PUV94I6VH99V","citationType":"submission","authors":["Hirakawa M.","Yamaguchi H.","Imai K.","Shimada J.","Shiina S.","Tamiya G.","Oka A.","Inoko H."],"title":"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.","publicationDate":"SEP-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT ASN-55"]},{"referenceNumber":6,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT ASN-55"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1210 (ISOFORM 1)","VARIANT ASN-55"],"referenceComments":[{"value":"Muscle","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"8457211","citationType":"journal article","authors":["Milner C.M.","Campbell R.D."],"citationCrossReferences":[{"database":"PubMed","id":"8457211"},{"database":"DOI","id":"10.1042/bj2900811"}],"title":"The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats.","publicationDate":"1993","journal":"Biochem. J.","firstPage":"811","lastPage":"818","volume":"290"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 195-1210"],"referenceComments":[{"value":"Histiocytic lymphoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"11316813","citationType":"journal article","authors":["Tachibana M.","Sugimoto K.","Fukushima T.","Shinkai Y."],"citationCrossReferences":[{"database":"PubMed","id":"11316813"},{"database":"DOI","id":"10.1074/jbc.m101914200"}],"title":"Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.","publicationDate":"2001","journal":"J. Biol. Chem.","firstPage":"25309","lastPage":"25317","volume":"276"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"12004135","citationType":"journal article","authors":["Ogawa H.","Ishiguro K.","Gaubatz S.","Livingston D.M.","Nakatani Y."],"citationCrossReferences":[{"database":"PubMed","id":"12004135"},{"database":"DOI","id":"10.1126/science.1069861"}],"title":"A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.","publicationDate":"2002","journal":"Science","firstPage":"1132","lastPage":"1136","volume":"296"},"referencePositions":["IDENTIFICATION IN COMPLEX WITH E2F6; TFDP1; MAX; MGA; EHMT1; CBX3; RING1; RNF2; MBLR; L3MBTL2 AND YAF2"]},{"referenceNumber":11,"citation":{"id":"16688220","citationType":"journal article","authors":["Vassen L.","Fiolka K.","Moeroey T."],"citationCrossReferences":[{"database":"PubMed","id":"16688220"},{"database":"DOI","id":"10.1038/sj.emboj.7601124"}],"title":"Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin.","publicationDate":"2006","journal":"EMBO J.","firstPage":"2409","lastPage":"2419","volume":"25"},"referencePositions":["INTERACTION WITH GFI1B"]},{"referenceNumber":12,"citation":{"id":"16702210","citationType":"journal article","authors":["Ueda J.","Tachibana M.","Ikura T.","Shinkai Y."],"citationCrossReferences":[{"database":"PubMed","id":"16702210"},{"database":"DOI","id":"10.1074/jbc.m603087200"}],"title":"Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"20120","lastPage":"20128","volume":"281"},"referencePositions":["INTERACTION WITH WIZ AND EHMT1"]},{"referenceNumber":13,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-569","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"19061646","citationType":"journal article","authors":["Mulligan P.","Westbrook T.F.","Ottinger M.","Pavlova N.","Chang B.","Macia E.","Shi Y.J.","Barretina J.","Liu J.","Howley P.M.","Elledge S.J.","Shi Y."],"citationCrossReferences":[{"database":"PubMed","id":"19061646"},{"database":"DOI","id":"10.1016/j.molcel.2008.10.025"}],"title":"CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"718","lastPage":"726","volume":"32"},"referencePositions":["INTERACTION WITH CDYL AND REST","IDENTIFICATION IN A COMPLEX WITH REST; CDYL; SETB1; EHMT1 AND WIZ"]},{"referenceNumber":16,"citation":{"id":"18438403","citationType":"journal article","authors":["Rathert P.","Dhayalan A.","Murakami M.","Zhang X.","Tamas R.","Jurkowska R.","Komatsu Y.","Shinkai Y.","Cheng X.","Jeltsch A."],"citationCrossReferences":[{"database":"PubMed","id":"18438403"},{"database":"DOI","id":"10.1038/nchembio.88"}],"title":"Protein lysine methyltransferase G9a acts on non-histone targets.","publicationDate":"2008","journal":"Nat. Chem. Biol.","firstPage":"344","lastPage":"346","volume":"4"},"referencePositions":["FUNCTION","METHYLATION AT LYS-185","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":17,"citation":{"id":"18264113","citationType":"journal article","authors":["Collins R.E.","Northrop J.P.","Horton J.R.","Lee D.Y.","Zhang X.","Stallcup M.R.","Cheng X."],"citationCrossReferences":[{"database":"PubMed","id":"18264113"},{"database":"DOI","id":"10.1038/nsmb.1384"}],"title":"The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.","publicationDate":"2008","journal":"Nat. Struct. Mol. Biol.","firstPage":"245","lastPage":"250","volume":"15"},"referencePositions":["DOMAIN ANK REPEATS","MUTAGENESIS OF TRP-786; TRP-791; GLU-794; GLU-817; TRP-824 AND ASP-852"]},{"referenceNumber":18,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-173; SER-232; SER-246 AND THR-1210","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"19144645","citationType":"journal article","authors":["Trojer P.","Zhang J.","Yonezawa M.","Schmidt A.","Zheng H.","Jenuwein T.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"19144645"},{"database":"DOI","id":"10.1074/jbc.m807818200"}],"title":"Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"8395","lastPage":"8405","volume":"284"},"referencePositions":["FUNCTION"]},{"referenceNumber":21,"citation":{"id":"19056828","citationType":"journal article","authors":["Kim J.K.","Esteve P.O.","Jacobsen S.E.","Pradhan S."],"citationCrossReferences":[{"database":"PubMed","id":"19056828"},{"database":"DOI","id":"10.1093/nar/gkn961"}],"title":"UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.","publicationDate":"2009","journal":"Nucleic Acids Res.","firstPage":"493","lastPage":"505","volume":"37"},"referencePositions":["INTERACTION WITH UHRF1"]},{"referenceNumber":22,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"20118233","citationType":"journal article","authors":["Huang J.","Dorsey J.","Chuikov S.","Perez-Burgos L.","Zhang X.","Jenuwein T.","Reinberg D.","Berger S.L."],"citationCrossReferences":[{"database":"PubMed","id":"20118233"},{"database":"DOI","id":"10.1074/jbc.m109.062588"}],"title":"G9a and Glp methylate lysine 373 in the tumor suppressor p53.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"9636","lastPage":"9641","volume":"285"},"referencePositions":["FUNCTION"]},{"referenceNumber":24,"citation":{"id":"CI-FP6KI8V4R50TD","citationType":"journal article","authors":["Huang J.","Dorsey J.","Chuikov S.","Perez-Burgos L.","Zhang X.","Jenuwein T.","Reinberg D.","Berger S.L."],"publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"18122","lastPage":"18122","volume":"285"},"referencePositions":["ERRATUM OF PUBMED:20118233"]},{"referenceNumber":25,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-232 AND SER-246","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":26,"citation":{"id":"21549307","citationType":"journal article","authors":["Rowbotham S.P.","Barki L.","Neves-Costa A.","Santos F.","Dean W.","Hawkes N.","Choudhary P.","Will W.R.","Webster J.","Oxley D.","Green C.M.","Varga-Weisz P.","Mermoud J.E."],"citationCrossReferences":[{"database":"PubMed","id":"21549307"},{"database":"DOI","id":"10.1016/j.molcel.2011.02.036"}],"title":"Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"285","lastPage":"296","volume":"42"},"referencePositions":["IDENTIFICATION IN A COMPLEX WITH TRIM28; HDAC1 AND HDAC2"]},{"referenceNumber":27,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-232; SER-246; SER-413 AND SER-1204","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":28,"citation":{"id":"22387026","citationType":"journal article","authors":["Yu Y.","Song C.","Zhang Q.","Dimaggio P.A.","Garcia B.A.","York A.","Carey M.F.","Grunstein M."],"citationCrossReferences":[{"database":"PubMed","id":"22387026"},{"database":"DOI","id":"10.1016/j.molcel.2012.01.019"}],"title":"Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.","publicationDate":"2012","journal":"Mol. Cell","firstPage":"7","lastPage":"17","volume":"46"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY"]},{"referenceNumber":29,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":30,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44; SER-47; SER-140; SER-232; SER-242; SER-350 AND THR-555","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":31,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":32,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-219; LYS-229 AND LYS-634","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":33,"citation":{"id":"20084102","citationType":"journal article","authors":["Wu H.","Min J.","Lunin V.V.","Antoshenko T.","Dombrovski L.","Zeng H.","Allali-Hassani A.","Campagna-Slater V.","Vedadi M.","Arrowsmith C.H.","Plotnikov A.N.","Schapira M."],"citationCrossReferences":[{"database":"PubMed","id":"20084102"},{"database":"DOI","id":"10.1371/journal.pone.0008570"}],"title":"Structural biology of human H3K9 methyltransferases.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"E8570","lastPage":"E8570","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 913-1193 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND ZINC IONS","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"2O8J"}]},{"referenceNumber":34,"citation":{"id":"24900801","citationType":"journal article","authors":["Sweis R.F.","Pliushchev M.","Brown P.J.","Guo J.","Li F.","Maag D.","Petros A.M.","Soni N.B.","Tse C.","Vedadi M.","Michaelides M.R.","Chiang G.G.","Pappano W.N."],"citationCrossReferences":[{"database":"PubMed","id":"24900801"},{"database":"DOI","id":"10.1021/ml400496h"}],"title":"Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.","publicationDate":"2014","journal":"ACS Med. Chem. Lett.","firstPage":"205","lastPage":"209","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 913-1193 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE AND ZN(2+)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"4NVQ"}]},{"referenceNumber":35,"citation":{"id":"27648579","citationType":"journal article","authors":["Shan C.M.","Wang J.","Xu K.","Chen H.","Yue J.X.","Andrews S.","Moresco J.J.","Yates J.R.","Nagy P.L.","Tong L.","Jia S."],"citationCrossReferences":[{"database":"PubMed","id":"27648579"},{"database":"DOI","id":"10.7554/elife.17903"}],"title":"A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading.","publicationDate":"2016","journal":"Elife","firstPage":"e17903","lastPage":"e17903","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 913-1193 IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE; S-ADENOSYL-L-METHIONINE AND ZN(2+)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5T0K"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5T0M"}]},{"referenceNumber":36,"citation":{"id":"34278292","citationType":"journal article","authors":["Kerchner K.M.","Mou T.C.","Sun Y.","Rusnac D.V.","Sprang S.R.","Briknarova K."],"citationCrossReferences":[{"database":"PubMed","id":"34278292"},{"database":"DOI","id":"10.1016/j.yjsbx.2021.100050"}],"title":"The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).","publicationDate":"2021","journal":"J. Struct. Biol. X","firstPage":"100050","lastPage":"100050","volume":"5"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 419-552 IN COMPLEX WITH ZN(2+)"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6MM1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ315532","properties":[{"key":"ProteinId","value":"CAC86666.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK056936","properties":[{"key":"ProteinId","value":"BAB71314.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF134726","properties":[{"key":"ProteinId","value":"AAD21811.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AF134726","properties":[{"key":"ProteinId","value":"AAD21812.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BA000025","properties":[{"key":"ProteinId","value":"BAB63294.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BA000025","properties":[{"key":"ProteinId","value":"BAB63295.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL662834","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL671762","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL844853","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR388202","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR388219","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR759784","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CR936237","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471081","properties":[{"key":"ProteinId","value":"EAX03542.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002686","properties":[{"key":"ProteinId","value":"AAH02686.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009351","properties":[{"key":"ProteinId","value":"AAH09351.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC018718","properties":[{"key":"ProteinId","value":"AAH18718.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC020970","properties":[{"key":"ProteinId","value":"AAH20970.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"X69838","properties":[{"key":"ProteinId","value":"CAA49491.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS4725.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KQ7-1"},{"database":"CCDS","id":"CCDS4726.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KQ7-2"},{"database":"RefSeq","id":"NP_001276342.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289413.2"}]},{"database":"RefSeq","id":"NP_001305762.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001318833.2"}]},{"database":"RefSeq","id":"NP_006700.3","properties":[{"key":"NucleotideSequenceId","value":"NM_006709.5"}],"isoformId":"Q96KQ7-1"},{"database":"RefSeq","id":"NP_079532.5","properties":[{"key":"NucleotideSequenceId","value":"NM_025256.7"}],"isoformId":"Q96KQ7-2"},{"database":"PDB","id":"2O8J","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B/C/D=913-1193"}]},{"database":"PDB","id":"3DM1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"B/D/F/H=179-190"}]},{"database":"PDB","id":"3K5K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"3RJW","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.56 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"4NVQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.03 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"5JHN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A/B=916-1189"}]},{"database":"PDB","id":"5JIN","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"A/B=916-1189"}]},{"database":"PDB","id":"5JIY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.48 A"},{"key":"Chains","value":"A/B=916-1189"}]},{"database":"PDB","id":"5JJ0","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A/B=916-1189"}]},{"database":"PDB","id":"5T0K","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.70 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"5T0M","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"5TTF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.72 A"},{"key":"Chains","value":"A/B/C/D=913-1193"}]},{"database":"PDB","id":"5TUY","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B=921-1188"}]},{"database":"PDB","id":"5V9I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.74 A"},{"key":"Chains","value":"A/B/C/D=913-1193"}]},{"database":"PDB","id":"5VSC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.40 A"},{"key":"Chains","value":"A/B=916-1190"}]},{"database":"PDB","id":"5VSE","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.60 A"},{"key":"Chains","value":"A/B=917-1190"}]},{"database":"PDB","id":"6MM1","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.90 A"},{"key":"Chains","value":"A/B/C/D=419-552"}]},{"database":"PDB","id":"7BTV","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7BUC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.60 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7DCF","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.80 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7T7L","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.20 A"},{"key":"Chains","value":"A/B/C/D=913-1193"}]},{"database":"PDB","id":"7X73","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.49 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7XUA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.87 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7XUB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7XUC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.67 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"7XUD","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.45 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"8VV8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"8Z7C","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.52 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"8Z7D","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.58 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"8Z7E","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.54 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"9KLB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.81 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"9KLC","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.15 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"9LUS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.70 A"},{"key":"Chains","value":"A/B=913-1193"}]},{"database":"PDB","id":"9WRI","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.85 A"},{"key":"Chains","value":"C=881-893"}]},{"database":"PDBsum","id":"2O8J","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3DM1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3K5K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"3RJW","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"4NVQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JHN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JIN","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JIY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5JJ0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5T0K","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5T0M","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5TTF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5TUY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5V9I","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VSC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"5VSE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6MM1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BTV","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7BUC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7DCF","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7T7L","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7X73","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XUA","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XUB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XUC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7XUD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8VV8","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Z7C","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Z7D","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8Z7E","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KLB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9KLC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9LUS","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9WRI","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116123","properties":[{"key":"Interactions","value":"325"}]},{"database":"CORUM","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-34461N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q96KQ7","properties":[{"key":"Number of interactors","value":"3186"}]},{"database":"IntAct","id":"Q96KQ7","properties":[{"key":"Interactions","value":"193"}]},{"database":"MINT","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-EHMT2","properties":[{"key":"Evidences","value":"7 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000379078","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL6032","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"2652","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q96KQ7","properties":[{"key":"glycosylation","value":"2 sites, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"EHMT2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"116241348","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000379078","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"77102","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KQ7-1"},{"database":"ProteomicsDB","id":"77103","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KQ7-2"},{"database":"ProteomicsDB","id":"77104","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96KQ7-3"},{"database":"Pumba","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q96KQ7","properties":[{"key":"antibodies","value":"2 sequenced antibodies"}]},{"database":"Antibodypedia","id":"27888","properties":[{"key":"antibodies","value":"384 antibodies from 43 providers"}]},{"database":"DNASU","id":"10919","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000375530.8","properties":[{"key":"ProteinId","value":"ENSP00000364680.4"},{"key":"GeneId","value":"ENSG00000204371.13"}],"isoformId":"Q96KQ7-2"},{"database":"Ensembl","id":"ENST00000375537.9","properties":[{"key":"ProteinId","value":"ENSP00000364687.4"},{"key":"GeneId","value":"ENSG00000204371.13"}],"isoformId":"Q96KQ7-1"},{"database":"Ensembl","id":"ENST00000383372.6","properties":[{"key":"ProteinId","value":"ENSP00000372863.2"},{"key":"GeneId","value":"ENSG00000206376.9"}],"isoformId":"Q96KQ7-2"},{"database":"Ensembl","id":"ENST00000383373.8","properties":[{"key":"ProteinId","value":"ENSP00000372864.4"},{"key":"GeneId","value":"ENSG00000206376.9"}],"isoformId":"Q96KQ7-1"},{"database":"Ensembl","id":"ENST00000420336.6","properties":[{"key":"ProteinId","value":"ENSP00000396119.2"},{"key":"GeneId","value":"ENSG00000238134.8"}]},{"database":"Ensembl","id":"ENST00000420874.5","properties":[{"key":"ProteinId","value":"ENSP00000411035.1"},{"key":"GeneId","value":"ENSG00000236759.7"}],"isoformId":"Q96KQ7-2"},{"database":"Ensembl","id":"ENST00000421926.6","properties":[{"key":"ProteinId","value":"ENSP00000416957.2"},{"key":"GeneId","value":"ENSG00000232045.7"}]},{"database":"Ensembl","id":"ENST00000429506.6","properties":[{"key":"ProteinId","value":"ENSP00000406110.2"},{"key":"GeneId","value":"ENSG00000227333.8"}],"isoformId":"Q96KQ7-1"},{"database":"Ensembl","id":"ENST00000450075.6","properties":[{"key":"ProteinId","value":"ENSP00000392305.2"},{"key":"GeneId","value":"ENSG00000236759.7"}],"isoformId":"Q96KQ7-1"},{"database":"Ensembl","id":"ENST00000450229.5","properties":[{"key":"ProteinId","value":"ENSP00000400838.1"},{"key":"GeneId","value":"ENSG00000227333.8"}],"isoformId":"Q96KQ7-2"},{"database":"GeneID","id":"10919","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:10919","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000375537.9","properties":[{"key":"ProteinId","value":"ENSP00000364687.4"},{"key":"RefSeqNucleotideId","value":"NM_006709.5"},{"key":"RefSeqProteinId","value":"NP_006700.3"}]},{"database":"UCSC","id":"uc003nxz.3","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96KQ7-1"},{"database":"AGR","id":"HGNC:14129","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA25267","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"10919","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"10919","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"EHMT2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:14129","properties":[{"key":"GeneName","value":"EHMT2"}]},{"database":"HPA","id":"ENSG00000204371","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"604599","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000204371","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000204371","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1082","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000159459","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"5792673at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96KQ7","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"MetaCyc:HS06313-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.1.1.355","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"BRENDA","id":"2.1.1.356","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"BRENDA","id":"2.1.1.367","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"BRENDA","id":"2.1.1.368","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2559582","properties":[{"key":"PathwayName","value":"Senescence-Associated Secretory Phenotype (SASP)"}]},{"database":"Reactome","id":"R-HSA-3214841","properties":[{"key":"PathwayName","value":"PKMTs methylate histone lysines"}]},{"database":"Reactome","id":"R-HSA-427389","properties":[{"key":"PathwayName","value":"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"}]},{"database":"Reactome","id":"R-HSA-6804760","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Methylation"}]},{"database":"Reactome","id":"R-HSA-73762","properties":[{"key":"PathwayName","value":"RNA Polymerase I Transcription Initiation"}]},{"database":"Reactome","id":"R-HSA-8853884","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by VENTX"}]},{"database":"Reactome","id":"R-HSA-8953750","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by E2F6"}]},{"database":"Reactome","id":"R-HSA-9843970","properties":[{"key":"PathwayName","value":"Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex"}]},{"database":"SignaLink","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000204371","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"10919","properties":[{"key":"hits","value":"106 hits in 1179 CRISPR screens"}]},{"database":"ChiTaRS","id":"EHMT2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"EvolutionaryTrace","id":"Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"GeneWiki","id":"EHMT2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"10919","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96KQ7","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q96KQ7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q96KQ7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000204371","properties":[{"key":"ExpressionPatterns","value":"Expressed in nucleus accumbens and 99 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96KQ7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19144645"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19144645"}]},{"database":"GO","id":"GO:0070742","properties":[{"key":"GoTerm","value":"F:C2H2 zinc finger domain binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16702210"}]},{"database":"GO","id":"GO:0140189","properties":[{"key":"GoTerm","value":"F:H1-4K26 methyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19144645"}]},{"database":"GO","id":"GO:0046976","properties":[{"key":"GoTerm","value":"F:histone H3K27 methyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140759","properties":[{"key":"GoTerm","value":"F:histone H3K56 methyltransferase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22387026"}]},{"database":"GO","id":"GO:0046974","properties":[{"key":"GoTerm","value":"F:histone H3K9 methyltransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0140948","properties":[{"key":"GoTerm","value":"F:histone H3K9 monomethyltransferase activity"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11316813"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20084102"}]},{"database":"GO","id":"GO:0002039","properties":[{"key":"GoTerm","value":"F:p53 binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"20118233"}]},{"database":"GO","id":"GO:1990841","properties":[{"key":"GoTerm","value":"F:promoter-specific chromatin binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23918802"}]},{"database":"GO","id":"GO:0016279","properties":[{"key":"GoTerm","value":"F:protein-lysine N-methyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20118233"}]},{"database":"GO","id":"GO:0000977","properties":[{"key":"GoTerm","value":"F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001222","properties":[{"key":"GoTerm","value":"F:transcription corepressor binding"},{"key":"GoEvidenceType","value":"IPI:ARUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"29628311"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009267","properties":[{"key":"GoTerm","value":"P:cellular response to starvation"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"23918802"}]},{"database":"GO","id":"GO:0030261","properties":[{"key":"GoTerm","value":"P:chromosome condensation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16127177"}]},{"database":"GO","id":"GO:0006346","properties":[{"key":"GoTerm","value":"P:DNA methylation-dependent constitutive heterochromatin formation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0040029","properties":[{"key":"GoTerm","value":"P:epigenetic regulation of gene expression"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19144645"}]},{"database":"GO","id":"GO:0018027","properties":[{"key":"GoTerm","value":"P:peptidyl-lysine dimethylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20118233"}]},{"database":"GO","id":"GO:0006275","properties":[{"key":"GoTerm","value":"P:regulation of DNA replication"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22387026"}]},{"database":"CDD","id":"cd20905","properties":[{"key":"EntryName","value":"EHMT_ZBD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd10533","properties":[{"key":"EntryName","value":"SET_EHMT2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.170.270.10:FF:000005","properties":[{"key":"EntryName","value":"Euchromatic histone-lysine N-methyltransferase 2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.20:FF:000029","properties":[{"key":"EntryName","value":"histone-lysine N-methyltransferase EHMT1 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.20","properties":[{"key":"EntryName","value":"Ankyrin repeat-containing domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.170.270.10","properties":[{"key":"EntryName","value":"SET domain"},{"key":"MatchStatus","value":"1"}]},{"database":"IDEAL","id":"IID00250","properties":[{"key":"Description","value":"-"}]},{"database":"InterPro","id":"IPR002110","properties":[{"key":"EntryName","value":"Ankyrin_rpt"}]},{"database":"InterPro","id":"IPR036770","properties":[{"key":"EntryName","value":"Ankyrin_rpt-contain_sf"}]},{"database":"InterPro","id":"IPR043550","properties":[{"key":"EntryName","value":"EHMT1/EHMT2"}]},{"database":"InterPro","id":"IPR047762","properties":[{"key":"EntryName","value":"EHMT_CRR"}]},{"database":"InterPro","id":"IPR007728","properties":[{"key":"EntryName","value":"Pre-SET_dom"}]},{"database":"InterPro","id":"IPR001214","properties":[{"key":"EntryName","value":"SET_dom"}]},{"database":"InterPro","id":"IPR046341","properties":[{"key":"EntryName","value":"SET_dom_sf"}]},{"database":"InterPro","id":"IPR038034","properties":[{"key":"EntryName","value":"SET_EHMT2"}]},{"database":"PANTHER","id":"PTHR46307","properties":[{"key":"EntryName","value":"G9A, ISOFORM B"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46307:SF1","properties":[{"key":"EntryName","value":"HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00023","properties":[{"key":"EntryName","value":"Ank"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12796","properties":[{"key":"EntryName","value":"Ank_2"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF21533","properties":[{"key":"EntryName","value":"EHMT1-2_CRR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05033","properties":[{"key":"EntryName","value":"Pre-SET"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00856","properties":[{"key":"EntryName","value":"SET"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR01415","properties":[{"key":"EntryName","value":"ANKYRIN"}]},{"database":"SMART","id":"SM00248","properties":[{"key":"EntryName","value":"ANK"},{"key":"MatchStatus","value":"6"}]},{"database":"SMART","id":"SM00468","properties":[{"key":"EntryName","value":"PreSET"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00317","properties":[{"key":"EntryName","value":"SET"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48403","properties":[{"key":"EntryName","value":"Ankyrin repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82199","properties":[{"key":"EntryName","value":"SET domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50297","properties":[{"key":"EntryName","value":"ANK_REP_REGION"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50088","properties":[{"key":"EntryName","value":"ANK_REPEAT"},{"key":"MatchStatus","value":"5"}]},{"database":"PROSITE","id":"PS50867","properties":[{"key":"EntryName","value":"PRE_SET"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50280","properties":[{"key":"EntryName","value":"SET"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT","length":1210,"molWeight":132370,"crc64":"A6C5DC6B72801520","md5":"EC2ABB465F96D671A64B06FA478B9778"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":4,"SUBUNIT":1,"INTERACTION":34,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DOMAIN":3,"PTM":1,"SIMILARITY":1,"CAUTION":2,"SEQUENCE CAUTION":9},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Repeat":7,"Domain":3,"Region":6,"Compositional bias":8,"Binding site":39,"Site":1,"Modified residue":18,"Cross-link":3,"Alternative sequence":3,"Natural variant":2,"Mutagenesis":6,"Sequence conflict":3,"Helix":15,"Turn":5,"Beta strand":28},"uniParcId":"UPI000013D085"}}