{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96GX8","secondaryAccessions":["R4GN89"],"uniProtkbId":"CLMB_HUMAN","entryAudit":{"firstPublicDate":"2006-12-12","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-04-05","entryVersion":132,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"41224739"}],"value":"Calcimembrin"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"40355556"}],"value":"Microprotein for thermogenesis 1"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:23362"}],"value":"CLMB"},"synonyms":[{"value":"C16orf74"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"40355556"}],"value":"MICT1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8K1L6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Associates with and recruits the catalytic subunit of the calcineurin complex (PPP3CA/Calcineurin A) to the plasma membrane, where it functions as a dynamic scaffold and regulator of PPP3CA activity thereby modulating calcineurin signaling (PubMed:41224739). In brown adipocytes, regulates thermogenesis by binding to PPP3CA, promoting the dephosphorylation of the PKA regulatory subunit, PRKAR2B. This modulation of PRKAR2B phosphorylation enhances PKA activity, thereby stimulating heat thermogenesis (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Interacts (via PxIxIT motif), when phosphorylated on Thr-44 with PPP3CA; leading to enhanced recruitment of PPP3CA to the plasma membrane and modulation of calcineurin signaling"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96GX8","intActId":"EBI-745814"},"interactantTwo":{"uniProtKBAccession":"Q08209","geneName":"PPP3CA","intActId":"EBI-352922"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GX8","intActId":"EBI-745814"},"interactantTwo":{"uniProtKBAccession":"Q08209-2","geneName":"PPP3CA","intActId":"EBI-11959013"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GX8","intActId":"EBI-745814"},"interactantTwo":{"uniProtKBAccession":"Q13432","geneName":"UNC119","intActId":"EBI-711260"},"numberOfExperiments":7,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Associates with membranes via lipidation"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40355556"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Membrane","id":"SL-0162"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28881575"}],"value":"V1"}],"isoformIds":["Q96GX8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28881575"}],"value":"V3"}],"isoformIds":["Q96GX8-2"],"sequenceIds":["VSP_061477"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40355556"}],"value":"Not expressed in pancreatic duct cells (at protein level). Abundantly expressed in the pancreas and weakly expressed in the thyroid. Highly expressed in thermogenic brown adipocytes and beige adipocytes (PubMed:40355556)"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"}],"value":"Not expressed in pancreatic duct cells (at protein level). Abundantly expressed in the lymph node and weakly expressed in the stomach, trachea and bone marrow"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Contains a combination of two SLiMs (short linear interaction motifs) motifs, LxVP and PxIxIT, forming the composite LxVPxIxIT motif. SLiMs motifs are small interaction modules within intrinsically disordered regions of proteins that interact with specific domains. This arrangement facilitates dephosphorylation of CLMB through a multimeric mechanism in which one CLMB recruits PPP3CA via PxIxIT binding to enable dephosphorylation of other CLMB molecules via their LxVP motif"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"N-myristoylation, in combination with reversible S-acylation promote the association of CLMB with membranes"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"value":"Phosphorylated. Phosphorylation and dephosphorylation of CLMB regulate its interaction with PPP3CA, controlling its recruitment to the plasma membrane and modulate calcineurin signaling. Phosphorylation at Thr-44 increases CLMB binding to PPP3CA. Dephosphorylated by PPP3CA requires two CLMB molecules per PPP3CA allowing one CLMB to bind PPP3CA via its PxIxIT and the other CLMB to undergo LxVP-dependent dephosphorylation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"}],"value":"May act as a prognostic marker of median survival time in pancreatic cancer patients"}],"commentType":"MISCELLANEOUS"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BC009078","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed"},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"Calcimembrin","featureId":"PRO_0000264621"},{"type":"Region","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Required for interaction with PPP3CA","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}]},{"type":"Motif","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"LxVPxIxIT motif","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}]},{"type":"Modified residue","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"41224739"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Lipidation","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-myristoyl glycine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}]},{"type":"Lipidation","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}]},{"type":"Lipidation","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"in isoform 2","featureId":"VSP_061477","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"Abolishes localization to membrane. Leads to cytosolic relocalization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"Abolishes localization to membrane. Leads to cytosolic relocalization; when associated with A-14.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":14,"modifier":"EXACT"}},"description":"Abolishes localization to membrane. Leads to cytosolic relocalization.; when associated with A-7.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":33,"modifier":"EXACT"}},"description":"Decreased interaction with PPP3CA; when associated with A-35. Reduced dephosphorylation of Tyr-44 by PPP3CA; when associated with A-35.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":35,"modifier":"EXACT"}},"description":"Decreased interaction with PPP3CA; when associated with A-35. Reduced dephosphorylation of Tyr-44 by PPP3CA; when associated with A-35.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"Abolishes interaction with PPP3CA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Abolished interaction with PPP3CA; when associated with A-40 and A-41. Reduced the localization of PPP3CA to membrane leading to its cytosolic relocalization; when associated with A-40 and A-41.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Abolished interaction with PPP3CA; when associated with A-38 and A-41. Reduced the localization of PPP3CA to membrane leading to its cytosolic relocalization; when associated with A-40 and A-41.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":41,"modifier":"EXACT"}},"description":"No effect on phosphorylation. Abolished interaction with PPP3CA; when associated with A-38 and A-40.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41224739"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Abolished phosphorylation and interaction with PPP3CA.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28881575"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0519","category":"PTM","name":"Myristate"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-F23T9RTJEQD2F","citationType":"submission","authors":["Schaerlinger B.","Frippiat J.P."],"title":"The immunoglobulin heavy chain repertoire of the urodele amphibian Pleurodeles waltl: identification of a new isotype.","publicationDate":"JUL-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)"]},{"referenceNumber":2,"citation":{"id":"15616553","citationType":"journal article","authors":["Martin J.","Han C.","Gordon L.A.","Terry A.","Prabhakar S.","She X.","Xie G.","Hellsten U.","Chan Y.M.","Altherr M.","Couronne O.","Aerts A.","Bajorek E.","Black S.","Blumer H.","Branscomb E.","Brown N.C.","Bruno W.J.","Buckingham J.M.","Callen D.F.","Campbell C.S.","Campbell M.L.","Campbell E.W.","Caoile C.","Challacombe J.F.","Chasteen L.A.","Chertkov O.","Chi H.C.","Christensen M.","Clark L.M.","Cohn J.D.","Denys M.","Detter J.C.","Dickson M.","Dimitrijevic-Bussod M.","Escobar J.","Fawcett J.J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Goodwin L.A.","Grady D.L.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Hildebrand C.E.","Huang W.","Israni S.","Jett J.","Jewett P.B.","Kadner K.","Kimball H.","Kobayashi A.","Krawczyk M.-C.","Leyba T.","Longmire J.L.","Lopez F.","Lou Y.","Lowry S.","Ludeman T.","Manohar C.F.","Mark G.A.","McMurray K.L.","Meincke L.J.","Morgan J.","Moyzis R.K.","Mundt M.O.","Munk A.C.","Nandkeshwar R.D.","Pitluck S.","Pollard M.","Predki P.","Parson-Quintana B.","Ramirez L.","Rash S.","Retterer J.","Ricke D.O.","Robinson D.L.","Rodriguez A.","Salamov A.","Saunders E.H.","Scott D.","Shough T.","Stallings R.L.","Stalvey M.","Sutherland R.D.","Tapia R.","Tesmer J.G.","Thayer N.","Thompson L.S.","Tice H.","Torney D.C.","Tran-Gyamfi M.","Tsai M.","Ulanovsky L.E.","Ustaszewska A.","Vo N.","White P.S.","Williams A.L.","Wills P.L.","Wu J.-R.","Wu K.","Yang J.","DeJong P.","Bruce D.","Doggett N.A.","Deaven L.","Schmutz J.","Grimwood J.","Richardson P.","Rokhsar D.S.","Eichler E.E.","Gilna P.","Lucas S.M.","Myers R.M.","Rubin E.M.","Pennacchio L.A."],"citationCrossReferences":[{"database":"PubMed","id":"15616553"},{"database":"DOI","id":"10.1038/nature03187"}],"title":"The sequence and analysis of duplication-rich human chromosome 16.","publicationDate":"2004","journal":"Nature","firstPage":"988","lastPage":"994","volume":"432"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Colon","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] (ISOFORMS 1 AND 2)","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-44 AND THR-46"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS](ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"28881575","citationType":"journal article","authors":["Nakamura T.","Katagiri T.","Sato S.","Kushibiki T.","Hontani K.","Tsuchikawa T.","Hirano S.","Nakamura Y."],"citationCrossReferences":[{"database":"PubMed","id":"28881575"},{"database":"DOI","id":"10.18632/oncotarget.10912"}],"title":"Overexpression of C16orf74 is involved in aggressive pancreatic cancers.","publicationDate":"2017","journal":"Oncotarget","firstPage":"50460","lastPage":"50475","volume":"8"},"referencePositions":["INTERACTION WITH PPP3CA","TISSUE SPECIFICITY (ISOFORMS 1 AND 2)","PHOSPHORYLATION AT THR-44","MUTAGENESIS OF 36-PRO--THR-41; THR-41 AND THR-44"]},{"referenceNumber":7,"citation":{"id":"40355556","citationType":"journal article","authors":["Dinh J.","Yi D.","Lin F.","Xue P.","Holloway N.D.","Xie Y.","Ibe N.U.","Nguyen H.P.","Viscarra J.A.","Wang Y.","Sul H.S."],"citationCrossReferences":[{"database":"PubMed","id":"40355556"},{"database":"DOI","id":"10.1038/s44318-025-00444-x"}],"title":"The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue.","publicationDate":"2025","journal":"EMBO J.","firstPage":"3381","lastPage":"3412","volume":"44"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":8,"citation":{"id":"41224739","citationType":"journal article","authors":["Bradburn D.A.","Reis J.C.","Moreno R.Y.","Qayyum S.","Viennet T.","Arthanari H.","Cyert M.S."],"citationCrossReferences":[{"database":"PubMed","id":"41224739"},{"database":"DOI","id":"10.1038/s41467-025-64884-z"}],"title":"A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin.","publicationDate":"2025","journal":"Nat. Commun.","firstPage":"9941","lastPage":"9941","volume":"16"},"referencePositions":["FUNCTION","INTERACTION WITH PPP3CA","SUBCELLULAR LOCATION","MOTIF","MYRISTOYLATION AT GLY-2","PALMITOYLATION AT CYS-7 AND CYS-14","PHOSPHORYLATION AT THR-44","MUTAGENESIS OF GLY-2; CYS-7; CYS-14; LEU-33; VAL-35; ILE-38; ILE-40 AND THR-41"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC123908","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC018695","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AB115766","properties":[{"key":"ProteinId","value":"BAS02098.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009078","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BQ672221","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS45540.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q96GX8-1"},{"database":"RefSeq","id":"NP_996850.1","properties":[{"key":"NucleotideSequenceId","value":"NM_206967.3"}],"isoformId":"Q96GX8-1"},{"database":"AlphaFoldDB","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"135663","properties":[{"key":"Interactions","value":"8"}]},{"database":"FunCoup","id":"Q96GX8","properties":[{"key":"Number of interactors","value":"7"}]},{"database":"IntAct","id":"Q96GX8","properties":[{"key":"Interactions","value":"6"}]},{"database":"STRING","id":"9606.ENSP00000284245","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C16orf74","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000284245","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"76680","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"63617","properties":[{"key":"antibodies","value":"5 antibodies from 5 providers"}]},{"database":"DNASU","id":"404550","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000284245.9","properties":[{"key":"ProteinId","value":"ENSP00000284245.3"},{"key":"GeneId","value":"ENSG00000154102.11"}],"isoformId":"Q96GX8-1"},{"database":"Ensembl","id":"ENST00000602583.5","properties":[{"key":"ProteinId","value":"ENSP00000473536.1"},{"key":"GeneId","value":"ENSG00000154102.11"}],"isoformId":"Q96GX8-2"},{"database":"GeneID","id":"404550","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:404550","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000284245.9","properties":[{"key":"ProteinId","value":"ENSP00000284245.3"},{"key":"RefSeqNucleotideId","value":"NM_206967.3"},{"key":"RefSeqProteinId","value":"NP_996850.1"}]},{"database":"UCSC","id":"uc002fjc.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q96GX8-1"},{"database":"AGR","id":"HGNC:23362","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"404550","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"404550","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C16orf74","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:23362","properties":[{"key":"GeneName","value":"CLMB"}]},{"database":"HPA","id":"ENSG00000154102","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (retina)"}]},{"database":"OpenTargets","id":"ENSG00000154102","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000154102","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SEPB","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000015933","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_172665_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MCVSASG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9451159at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q96GX8","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000154102","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"404550","properties":[{"key":"hits","value":"15 hits in 1118 CRISPR screens"}]},{"database":"ChiTaRS","id":"C16orf74","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"404550","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q96GX8","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q96GX8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q96GX8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000154102","properties":[{"key":"ExpressionPatterns","value":"Expressed in oocyte and 117 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q96GX8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"41224739"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40355556"}]},{"database":"GO","id":"GO:1990845","properties":[{"key":"GoTerm","value":"P:adaptive thermogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"40355556"}]},{"database":"InterPro","id":"IPR027864","properties":[{"key":"EntryName","value":"DUF4597"}]},{"database":"PANTHER","id":"PTHR37455","properties":[{"key":"EntryName","value":"GENE, 27021-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR37455:SF1","properties":[{"key":"EntryName","value":"SIMILAR TO 1190005I06RIK PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15366","properties":[{"key":"EntryName","value":"DUF4597"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGLKMSCLKGFQMCVSSSSSSHDEAPVLNDKHLDVPDIIITPPTPTGMMLPRDLGSTVWLDETGSCPDDGEIDPEA","length":76,"molWeight":8118,"crc64":"525DD517D5EA9F12","md5":"94778AFF946B32074D7A8CBEEA26228E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":2,"DOMAIN":1,"PTM":2,"MISCELLANEOUS":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":1,"Motif":1,"Modified residue":2,"Lipidation":3,"Alternative sequence":1,"Mutagenesis":10},"uniParcId":"UPI00001FED24"}}