{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q96GM5","secondaryAccessions":["A6NN27","Q92924","Q9Y635"],"uniProtkbId":"SMRD1_HUMAN","entryAudit":{"firstPublicDate":"2003-01-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-26","entryVersion":207,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1"}},"alternativeNames":[{"fullName":{"value":"60 kDa BRG-1/Brm-associated factor subunit A"}},{"fullName":{"value":"BRG1-associated factor 60A"},"shortNames":[{"value":"BAF60A"}]},{"fullName":{"value":"SWI/SNF complex 60 kDa subunit"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAD23390.1"}],"value":"SMARCD1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8804307"}],"value":"BAF60A"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12917342"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14698202"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29374058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8804307"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22952240"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26601204"}],"value":"Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058, PubMed:8804307). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q61466"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12917342"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14698202"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18765789"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20460684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29374058"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30879640"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32459350"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8895581"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22952240"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"26601204"}],"value":"Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (PubMed:8895581). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). Component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (PubMed:22952240, PubMed:26601204). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Specifically interacts with the VDR heterodimer complex (PubMed:14698202). Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and SMARCC2 (PubMed:12917342, PubMed:30879640). Interacts with DPF2 (PubMed:20460684). Interacts with DPF3a (isoform 2 of DPF3/BAF45C) and with HDGFL2 in a DPF3a-dependent manner (PubMed:32459350). Interacts with FOS, FOSB isoform 1 and 2, FOSL1 and FOSL2 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q8IZP0-5","geneName":"ABI1","intActId":"EBI-11743294"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q9NYB9-2","geneName":"ABI2","intActId":"EBI-11096309"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q9P2A4","geneName":"ABI3","intActId":"EBI-742038"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q5BKX5-3","geneName":"ACTMAP","intActId":"EBI-11976299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q7Z6V5","geneName":"ADAT2","intActId":"EBI-2809203"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q9NX04","geneName":"AIRIM","intActId":"EBI-8643161"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q86SG2","geneName":"ANKRD23","intActId":"EBI-5661893"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q8WVL7","geneName":"ANKRD49","intActId":"EBI-9381820"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q8N2F6-2","geneName":"ARMC10","intActId":"EBI-12902762"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q96B67","geneName":"ARRDC3","intActId":"EBI-2875665"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"P54253","geneName":"ATXN1","intActId":"EBI-930964"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"P46379-2","geneName":"BAG6","intActId":"EBI-10988864"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"O75934","geneName":"BCAS2","intActId":"EBI-1050106"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q7L4P6","geneName":"BEND5","intActId":"EBI-724373"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q00994","geneName":"BEX3","intActId":"EBI-741753"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q8TDH9","geneName":"BLOC1S5","intActId":"EBI-465861"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q9NSI6-4","geneName":"BRWD1","intActId":"EBI-10693038"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q13137","geneName":"CALCOCO2","intActId":"EBI-739580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q68D86","geneName":"CCDC102B","intActId":"EBI-10171570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q8NCU1","geneName":"CCDC197","intActId":"EBI-750686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q01850","geneName":"CDR2","intActId":"EBI-1181367"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"P40199","geneName":"CEACAM6","intActId":"EBI-4314501"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q96GM5","intActId":"EBI-358489"},"interactantTwo":{"uniProtKBAccession":"Q9Y2V7","geneName":"COG6","intActId":"EBI-3866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